{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:13:47Z","timestamp":1785521627726,"version":"3.56.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T00:00:00Z","timestamp":1369872000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064845","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T21:12:55Z","timestamp":1369948375000},"page":"e64845","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Association of TLR4 Gene rs2149356 Polymorphism with Primary Gouty Arthritis in a Case-Control Study"],"prefix":"10.1371","volume":"8","author":[{"given":"Yu-Feng","family":"Qing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Guo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Yue","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Guang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Jun","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0140-6736(09)60883-7","article-title":"Gout","volume":"375","author":"P Richette","year":"2010","journal-title":"Lancet"},{"key":"ref2","first-page":"371","article-title":"Baker JF, Schumacher HR (2010 Update on gout and hyperuricemia. Int. J. Clin","volume":"64","journal-title":"Pract"},{"key":"ref3","first-page":"S9","article-title":"Epidemiology of gout. Cleve. Clin","volume":"75","author":"AL Weaver","year":"2008","journal-title":"J. Med"},{"key":"ref4","first-page":"1859","article-title":"Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China","volume":"35","author":"Z Miao","year":"2008","journal-title":"J. Rheumatol"},{"key":"ref5","first-page":"960","article-title":"Gout in the UK and Germany: prevalence, comorbidies and management in general practice 2000\u20132005. Ann. Rheum","volume":"67","author":"L Annemans","year":"2008","journal-title":"Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1948","DOI":"10.1371\/journal.pone.0001948","article-title":"Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study","volume":"3","author":"K Stark","year":"2008","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature01991","article-title":"Molecular identification of a danger signal that alerts the immune system to dying cells","volume":"425","author":"Y Shin","year":"2003","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11926-011-0162-1","article-title":"The Role of Uric Acid as an Endogenous Danger Signal in Immunity and Inflammation","volume":"13","author":"F Ghaemi-Oskouie","year":"2011","journal-title":"Curr Rheumatol Rep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1093\/rheumatology\/ken460","article-title":"Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout","volume":"48","author":"N Dalbeth","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e1000504","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations","volume":"5","author":"M Kolz","year":"2009","journal-title":"PLoS Genet"},{"key":"ref11","first-page":"421","article-title":"Epidemiological survey of hyperuricemia and gout in coastal areas of Shandong province","volume":"22","author":"ZM Miao","year":"2006","journal-title":"Chin J Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"F Martinon","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"A Poltorak","year":"1998","journal-title":"Science"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor (TLR) 4-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","volume":"162","author":"K Hoshino","year":"1992","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.4049\/jimmunol.164.2.558","article-title":"Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex","volume":"164","author":"K Ohashi","year":"2000","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/art.20114","article-title":"Radstake TR, Franke B, Hanssen S, Netea MG, Welsing P, et al. The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and\/or outcome","volume":"50","journal-title":"Arthritis Rheum"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000260417","article-title":"The Toll-like receptor 4 D299G and T399I polymorphisms are associated with Crohn's disease and ulcerative colitis: a meta-analysis","volume":"81","author":"X Shen","year":"2010","journal-title":"Digestion"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.jaci.2003.12.583","article-title":"The toll-like receptor 2 R753Q polymorphism defines a subgroup of patients with atopic dermatitis having severe phenotype","volume":"11","author":"P Ahmad-Nejad","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1067\/mai.2003.1648","article-title":"TLR4 gene variants modify endotoxin effects on asthma","volume":"112","author":"M Werner","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1203\/PDR.0b013e3181e6a068","article-title":"Role of polymorphic variants as genetic modulators of infection in neonatal sepsis","volume":"68","author":"A Abu-Maziad","year":"2010","journal-title":"Pediatr Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1158\/1055-9965.EPI-09-0618","article-title":"Sequence variants in the TLR4 and TLR6\u20131-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies","volume":"19","author":"S Lindstr\u00f6m","year":"2010","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1167\/iovs.07-1575","article-title":"Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma","volume":"49","author":"E Shibuya","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","article-title":"Preliminary criteria for the classification of the acute arthritis of primary gout","volume":"20","author":"SL Wallace","year":"1977","journal-title":"Arthritis Rheum"},{"key":"ref24","first-page":"146","article-title":"Genetic association studies: design, analysis and interpretation. Brief Bioinform","volume":"3","author":"CM Lewis","year":"2002"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e1948","DOI":"10.1371\/journal.pone.0001948","article-title":"Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study","volume":"3","author":"K Stark","year":"2008","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"RM Cawthon","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1385\/MB:27:2:169","article-title":"Real-time quantitative PCR of telomere length","volume":"27","author":"ME Gil","year":"2004","journal-title":"Mol Biotechnol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C (T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nat Protoc"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T01:21:27Z","timestamp":1688260887000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064845"}},"subtitle":[],"editor":[{"given":"Alberico","family":"Catapano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,30]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064845","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,30]]}}}