{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:22:12Z","timestamp":1771482132648,"version":"3.50.1"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064863","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T21:03:14Z","timestamp":1369170194000},"page":"e64863","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Vascular Dysfunction in a Mouse Model of Rett Syndrome and Effects of Curcumin Treatment"],"prefix":"10.1371","volume":"8","author":[{"given":"Anna","family":"Panighini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Duranti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferruccio","family":"Santini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Maffei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Pizzorusso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccola","family":"Funel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Taddei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Ippolito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"RE Amir","year":"1999","journal-title":"Nat Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"M Chahrour","year":"2007","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2217\/epi.09.13","article-title":"Evolving role of MeCP2 in Rett syndrome and autism","volume":"1","author":"JM Lasalle","year":"2009","journal-title":"Epigenomics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: revised diagnostic criteria and nomenclature","volume":"68","author":"JL Neul","year":"2010","journal-title":"Ann Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00019052-200104000-00006","article-title":"Molecular genetics of Rett syndrome and clinical spectrum of MECP2 mutations","volume":"14","author":"MD Shahbazian","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/01.wnl.0000291011.54508.aa","article-title":"Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome","volume":"70","author":"JL Neul","year":"2008","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1093\/hmg\/ddi102","article-title":"MeCP2 in neurons: closing in on the causes of Rett syndrome","volume":"1","author":"IM Caballero","year":"2005","journal-title":"Hum Mol Genet 14 Spec No"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.gde.2006.04.009","article-title":"MeCP2 dysfunction in Rett syndrome and related disorders","volume":"16","author":"P Moretti","year":"2006","journal-title":"Curr Opin Genet Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000337637","article-title":"Rett Syndrome","volume":"2","author":"EE Smeets","year":"2012","journal-title":"Mol Syndromol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/mrdd.20030","article-title":"Rett syndrome: of girls and mice-lessons for regression in autism","volume":"10","author":"DG Glaze","year":"2004","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1600-0404.1997.tb00067.x","article-title":"Brain perfusion SPECT and EEG findings in Rett syndrome","volume":"95","author":"R Lappalainen","year":"1997","journal-title":"Acta Neurol Scand"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Bianciardi G, Acampa M, Lamberti I, Sartini S, Servi M, <etal>et al<\/etal>.. (2013) Microvascular abnormalities in Rett syndrome. Clin Hemorheol Microcirc.","DOI":"10.3233\/CH-131707"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/16501970306107","article-title":"Hydrotherapy for Rett syndrome","volume":"35","author":"G Bumin","year":"2003","journal-title":"J Rehabil Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"J Guy","year":"2001","journal-title":"Nat Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1093\/brain\/awl022","article-title":"Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice","volume":"129","author":"GJ Pelka","year":"2006","journal-title":"Brain"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0896-6273(02)00768-7","article-title":"Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3","volume":"35","author":"M Shahbazian","year":"2002","journal-title":"Neuron"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1242\/dmm.011007","article-title":"Preclinical research in Rett syndrome: setting the foundation for translational success","volume":"5","author":"DM Katz","year":"2012","journal-title":"Dis Model Mech"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1001\/archneurol.2011.149","article-title":"Rett syndrome: exploring the autism link","volume":"68","author":"AK Percy","year":"2011","journal-title":"Arch Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bone.2009.04.251","article-title":"Mecp2 deficiency decreases bone formation and reduces bone volume in a rodent model of Rett syndrome","volume":"45","author":"RD O'Connor","year":"2009","journal-title":"Bone"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"P Moretti","year":"2006","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.neuroscience.2007.02.009","article-title":"Behavioral and anatomical abnormalities in Mecp2 mutant mice: a model for Rett syndrome","volume":"146","author":"NA Stearns","year":"2007","journal-title":"Neuroscience"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10519-011-9501-2","article-title":"Mecp2 truncation in male mice promotes affiliative social behavior","volume":"42","author":"BL Pearson","year":"2012","journal-title":"Behav Genet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.autneu.2007.04.007","article-title":"Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice","volume":"136","author":"JM Bissonnette","year":"2007","journal-title":"Auton Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"113ra125","DOI":"10.1126\/scitranslmed.3002982","article-title":"Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome","volume":"3","author":"MD McCauley","year":"2011","journal-title":"Sci Transl Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"II","DOI":"10.1002\/j.1932-8737.1997.tb00006.x","article-title":"Biology of the endothelium","volume":"20","author":"TF Luscher","year":"1997","journal-title":"Clin Cardiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0033-0620(96)80003-X","article-title":"Vascular endothelium: vasoactive mediators","volume":"39","author":"PM Vanhoutte","year":"1996","journal-title":"Prog Cardiovasc Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"35087","DOI":"10.1074\/jbc.M405063200","article-title":"The cell-specific expression of endothelial nitric-oxide synthase: a role for DNA methylation","volume":"279","author":"Y Chan","year":"2004","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"24824","DOI":"10.1074\/jbc.M502115200","article-title":"The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code","volume":"280","author":"JE Fish","year":"2005","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.expneurol.2005.09.004","article-title":"Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition","volume":"197","author":"A Wu","year":"2006","journal-title":"Exp Neurol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"BB Aggarwal","year":"2009","journal-title":"Int J Biochem Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.brainres.2008.01.104","article-title":"Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB","volume":"1210","author":"R Wang","year":"2008","journal-title":"Brain Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.pbb.2010.06.009","article-title":"Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat","volume":"96","author":"A Ataie","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1471-4159.2007.04613.x","article-title":"Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model","volume":"102","author":"M Garcia-Alloza","year":"2007","journal-title":"J Neurochem"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3940(01)01677-9","article-title":"Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1\u201342) insult","volume":"303","author":"DS Kim","year":"2001","journal-title":"Neurosci Lett"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1016\/j.bmc.2009.05.042","article-title":"Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies","volume":"17","author":"G Bora-Tatar","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1742-7843.2007.00142.x","article-title":"Curcumin, both histone deacetylase and p300\/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells","volume":"101","author":"Y Chen","year":"2007","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11920-010-0097-7","article-title":"The role of MeCP2 in brain development and neurodevelopmental disorders","volume":"12","author":"ML Gonzales","year":"2010","journal-title":"Curr Psychiatry Rep"},{"key":"ref39","first-page":"28","article-title":"Synaptic determinants of rett syndrome","volume":"2","author":"EM Boggio","year":"2010","journal-title":"Front Synaptic Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.biopsych.2009.12.022","article-title":"Early environmental enrichment moderates the behavioral and synaptic phenotype of MeCP2 null mice","volume":"67","author":"G Lonetti","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/hmg\/ddq563","article-title":"Reduced AKT\/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model","volume":"20","author":"S Ricciardi","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/mnfr.201100818","article-title":"Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration","volume":"56","author":"D Coban","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1667\/RR1522.1","article-title":"Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice","volume":"173","author":"JC Lee","year":"2010","journal-title":"Radiat Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1016\/j.ejca.2005.05.009","article-title":"Curcumin: the story so far","volume":"41","author":"RA Sharma","year":"2005","journal-title":"Eur J Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/bmc.1244","article-title":"A rapid and simple HPLC method for the determination of curcumin in rat plasma: assay development, validation and application to a pharmacokinetic study of curcumin liposome","volume":"23","author":"J Li","year":"2009","journal-title":"Biomed Chromatogr"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.HYP.0000253085.56217.11","article-title":"Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice","volume":"49","author":"A Virdis","year":"2007","journal-title":"Hypertension"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: from research into clinical practice","volume":"126","author":"AJ Flammer","year":"2012","journal-title":"Circulation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0022-3565(25)23106-8","article-title":"Inhibition of endothelium-dependent relaxations by phorbol myristate acetate in canine coronary arteries: role of a pertussis toxin-sensitive G-protein","volume":"256","author":"NA Flavahan","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Virdis A, Iglarz M, Neves MF, Amiri F, Touyz RM, <etal>et al<\/etal>.. (2003) Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice. Arterioscler Thromb Vasc Biol 23: 1352\u20131357. Epub 2003 Jun 1326.","DOI":"10.1161\/01.ATV.0000083297.47245.DA"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jacc.2011.01.050","article-title":"Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients","volume":"58","author":"A Virdis","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref51","first-page":"64","article-title":"Regional cerebral blood flow abnormalities in Rett syndrome","volume":"6","author":"J Bjure","year":"1997","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00406-004-0484-3","article-title":"Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment","volume":"254","author":"M Atmaca","year":"2004","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.freeradbiomed.2009.05.016","article-title":"Systemic oxidative stress in classic Rett syndrome","volume":"47","author":"C De Felice","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"S236","DOI":"10.1016\/S0387-7604(01)00369-2","article-title":"Oxidative stress in Rett syndrome","volume":"23","author":"C Sierra","year":"2001","journal-title":"Brain Dev"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/01.fjc.0000183720.85014.24","article-title":"Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin","volume":"46","author":"JB Majithiya","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ejphar.2009.06.014","article-title":"Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice","volume":"616","author":"K Sompamit","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"III27","DOI":"10.1161\/01.CIR.0000131515.03336.f8","article-title":"Role of endothelial dysfunction in atherosclerosis","volume":"109","author":"J Davignon","year":"2004","journal-title":"Circulation"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064863","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T10:51:01Z","timestamp":1746010261000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064863"}},"subtitle":[],"editor":[{"given":"Nicoletta","family":"Landsberger","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064863","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}