{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:21:11Z","timestamp":1791177671821,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064878","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T20:56:48Z","timestamp":1369342608000},"page":"e64878","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Self-Help Program for Memory CD8+ T Cells: Positive Feedback via CD40-CD40L Signaling as a Critical Determinant of Secondary Expansion"],"prefix":"10.1371","volume":"8","author":[{"given":"Jessica A.","family":"Shugart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Bambina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro F.","family":"Alice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Montler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith S.","family":"Bahjat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1126\/science.272.5258.54","article-title":"Immunological memory and protective immunity: understanding their relation","volume":"272","author":"R Ahmed","year":"1996","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1084\/jem.184.6.2141","article-title":"Resting memory CD8+ T cells are hyperreactive to antigenic challenge in vitro","volume":"184","author":"M Pihlgren","year":"1996","journal-title":"J Exp Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/76907","article-title":"Response of naive and memory CD8+ T cells to antigen stimulation in vivo","volume":"1","author":"H Veiga-Fernandes","year":"2000","journal-title":"Nat Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1182\/blood-2008-09-181263","article-title":"Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60","volume":"113","author":"SJ Ryu","year":"2009","journal-title":"Blood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/nature01441","article-title":"CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes","volume":"421","author":"EM Janssen","year":"2003","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1126\/science.1082305","article-title":"Requirement for CD4 T cell help in generating functional CD8 T cell memory","volume":"300","author":"DJ Shedlock","year":"2003","journal-title":"Science"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.1083317","article-title":"Defective CD8 T cell memory following acute infection without CD4 T cell help","volume":"300","author":"JC Sun","year":"2003","journal-title":"Science"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.4049\/jimmunol.173.10.5944","article-title":"4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses","volume":"173","author":"W Dawicki","year":"2004","journal-title":"J Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8905","DOI":"10.1128\/JVI.00027-09","article-title":"Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection","volume":"83","author":"L Garidou","year":"2009","journal-title":"J Virol"},{"key":"ref10","first-page":"265","article-title":"Generation of antigen-specific, lacZ-inducible T-cell hybrids","volume":"156","author":"S Malarkannan","year":"2001","journal-title":"Methods Mol Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.4049\/jimmunol.179.10.6494","article-title":"Memory CD8+ T cells require CD28 costimulation","volume":"179","author":"AB Borowski","year":"2007","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"981","DOI":"10.4049\/jimmunol.172.2.981","article-title":"A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo","volume":"172","author":"EM Bertram","year":"2004","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1084\/jem.180.4.1263","article-title":"Activation of human dendritic cells through CD40 cross-linking","volume":"180","author":"C Caux","year":"1994","journal-title":"J Exp Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1084\/jem.20040317","article-title":"The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80\/86 costimulation","volume":"199","author":"S Fujii","year":"2004","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.4049\/jimmunol.163.6.3194","article-title":"CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses","volume":"163","author":"JK Whitmire","year":"1999","journal-title":"J Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.4049\/jimmunol.178.5.2844","article-title":"CD40-CD40 ligand interaction between dendritic cells and CD8+ T cells is needed to stimulate maximal T cell responses in the absence of CD4+ T cell help","volume":"178","author":"MG Hernandez","year":"2007","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1365-3083.2006.01767.x","article-title":"T-cell control of IL-12p75 production","volume":"64","author":"K Abdi","year":"2006","journal-title":"Scand J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(92)90188-I","article-title":"L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein","volume":"68","author":"C Kocks","year":"1992","journal-title":"Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/nbt1215","article-title":"A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus","volume":"24","author":"M Moutaftsi","year":"2006","journal-title":"Nat Biotechnol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/IAI.00390-08","article-title":"Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains","volume":"76","author":"P Lauer","year":"2008","journal-title":"Infect Immun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1126\/science.1139393","article-title":"Asymmetric T lymphocyte division in the initiation of adaptive immune responses","volume":"315","author":"JT Chang","year":"2007","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6387","DOI":"10.1128\/IAI.01088-06","article-title":"Cytosolic entry controls CD8+-T-cell potency during bacterial infection","volume":"74","author":"KS Bahjat","year":"2006","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000568","DOI":"10.1371\/journal.ppat.1000568","article-title":"Suppression of cell-mediated immunity following recognition of phagosome-confined bacteria","volume":"5","author":"KS Bahjat","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1128\/IAI.01274-08","article-title":"Impact of preexisting vector-specific immunity on vaccine potency: characterization of listeria monocytogenes-specific humoral and cellular immunity in humans and modeling studies using recombinant vaccines in mice","volume":"77","author":"ML Leong","year":"2009","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.coi.2009.05.016","article-title":"Heterologous prime-boost vaccination","volume":"21","author":"S Lu","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Devriendt B, Baert K, Dierendonck M, Favoreel H, De Koker S, <etal>et al<\/etal>.. (2012) One-step spray-dried polyelectrolyte microparticles enhance the antigen cross-presentation capacity of porcine dendritic cells. Eur J Pharm Biopharm.","DOI":"10.1016\/j.ejpb.2012.11.016"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1073\/pnas.0308054101","article-title":"Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets","volume":"101","author":"KM Huster","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nri1461","article-title":"Immune responses to Listeria monocytogenes","volume":"4","author":"EG Pamer","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.20021598","article-title":"Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance","volume":"196","author":"L Bonifaz","year":"2002","journal-title":"J Exp Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.coi.2010.02.013","article-title":"Inflammatory cytokines as a third signal for T cell activation","volume":"22","author":"JM Curtsinger","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4049\/jimmunol.0803473","article-title":"CD44high memory CD8 T cells synergize with CpG DNA to activate dendritic cell IL-12p70 production","volume":"183","author":"KL Wong","year":"2009","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1074-7613(00)80067-9","article-title":"Presentation of out-of-frame peptide\/MHC class I complexes by a novel translation initiation mechanism","volume":"10","author":"S Malarkannan","year":"1999","journal-title":"Immunity"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nri3254","article-title":"Cross-presentation by dendritic cells","volume":"12","author":"OP Joffre","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.vaccine.2010.10.041","article-title":"Immune responses against a liver-stage malaria antigen induced by simian adenoviral vector AdCh63 and MVA prime-boost immunisation in non-human primates","volume":"29","author":"S Capone","year":"2010","journal-title":"Vaccine"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1200\/JCO.2009.25.0597","article-title":"Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer","volume":"28","author":"PW Kantoff","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/eji.201040730","article-title":"Secondary CD8+ T-cell responses are controlled by systemic inflammation","volume":"41","author":"TC Wirth","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jmv.1890360111","article-title":"Detection of HPV DNA in archival specimens of cervical cancer using in situ hybridisation and the polymerase chain reaction","volume":"36","author":"CH Thompson","year":"1992","journal-title":"J Med Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1016\/j.vaccine.2009.04.041","article-title":"The first clinical use of a live-attenuated Listeria monocytogenes vaccine: a Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix","volume":"27","author":"PC Maciag","year":"2009","journal-title":"Vaccine"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Le DT, Brockstedt D, Nir-Paz R, Hampl J, Mathur S, <etal>et al<\/etal>.. (2011) A Live-attenuated Listeria Vaccine (ANZ-100) and a Live-attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase 1 Studies of Safety and Immune Induction. Clin Cancer Res.","DOI":"10.1158\/1078-0432.CCR-11-2121"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T22:15:51Z","timestamp":1688249751000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064878"}},"subtitle":[],"editor":[{"given":"Mauricio Martins","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]}}}