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In: Zimmerman J, Karriker L, Ramirez A, Schwartz K, Stevenson G, editors. Diseases of Swine, Tenth Edition. Ames, IA: John Wiley &amp; Sons, Inc."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0378-1135(00)00188-7","article-title":"Distribution of capsular types and production of muramidase-released protein (MRP) and extracellular factor (EF) of <italic>Streptococcus suis<\/italic> strains isolated from diseased pigs in seven European countries","volume":"74","author":"HJ Wisselink","year":"2000","journal-title":"Vet Microbiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2217\/fmb.10.2","article-title":"<italic>Streptococcus suis<\/italic>: a new emerging or an old neglected zoonotic pathogen?","volume":"5","author":"M Gottschalk","year":"2010","journal-title":"Future Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.clineuro.2004.10.006","article-title":"Bacterial meningitis in Hong Kong: 10-years&apos; experience","volume":"107","author":"AC Hui","year":"2005","journal-title":"Clin 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