{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:35:44Z","timestamp":1792056944431,"version":"4.4.0"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0065070","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T21:14:05Z","timestamp":1370553245000},"page":"e65070","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":104,"title":["CLEC4F Is an Inducible C-Type Lectin in F4\/80-Positive Cells and Is Involved in Alpha-Galactosylceramide Presentation in Liver"],"prefix":"10.1371","volume":"8","author":[{"given":"Chih-Ya","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiun-Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Fen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi-Hui","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui-Ling","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Huey","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shie-Liang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7426","DOI":"10.1016\/S0021-9258(17)38409-0","article-title":"The binding of fucose-containing glycoproteins by hepatic lectins. The binding specificity of the rat liver fucose lectin","volume":"261","author":"MA Lehrman","year":"1986","journal-title":"J Biol Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7433","DOI":"10.1016\/S0021-9258(17)38410-7","article-title":"The distribution and localization of the fucose-binding lectin in rat tissues and the identification of a high affinity form of the mannose\/N-acetylglucosamine-binding lectin in rat liver","volume":"261","author":"RS Haltiwanger","year":"1986","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1C","DOI":"10.1093\/glycob\/cwj126","article-title":"Two categories of mammalian galactose-binding receptors distinguished by glycan array profiling","volume":"16","author":"PJ Coombs","year":"2006","journal-title":"Glycobiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/glycob\/cwg068","article-title":"Molecular characterization of the rat Kupffer cell glycoprotein receptor","volume":"13","author":"AJ Fadden","year":"2003","journal-title":"Glycobiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12252","DOI":"10.1016\/S0021-9258(19)49832-3","article-title":"The binding specificity of normal and variant rat Kupffer cell (lectin) receptors expressed in COS cells","volume":"267","author":"M Tiemeyer","year":"1992","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1016\/S0021-9258(17)38407-7","article-title":"The binding of fucose-containing glycoproteins by hepatic lectins. Re-examination of the clearance from blood and the binding to membrane receptors and pure lectins","volume":"261","author":"MA Lehrman","year":"1986","journal-title":"J Biol Chem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"7487","DOI":"10.1016\/S0021-9258(18)68524-2","article-title":"Molecular cloning and sequencing of a cDNA for a carbohydrate binding receptor unique to rat Kupffer cells","volume":"263","author":"GW Hoyle","year":"1988","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1189\/jlb.0302133","article-title":"Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice","volume":"74","author":"D Dory","year":"2003","journal-title":"J Leukoc Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1182\/blood-2007-02-073841","article-title":"Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages","volume":"110","author":"I Klein","year":"2007","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.148.1.1","article-title":"The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state","volume":"148","author":"RW Crofton","year":"1978","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1084\/jem.154.3.713","article-title":"Expression of the macrophage-specific antigen F4\/80 during differentiation of mouse bone marrow cells in culture","volume":"154","author":"S Hirsch","year":"1981","journal-title":"J Exp Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1084\/jem.158.5.1522","article-title":"The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4\/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs","volume":"158","author":"DA Hume","year":"1983","journal-title":"J Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jlb.59.2.133","article-title":"Development, differentiation, and phenotypic heterogeneity of murine tissue macrophages","volume":"59","author":"M Naito","year":"1996","journal-title":"J Leukoc Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3748\/wjg.15.1708","article-title":"Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells","volume":"15","author":"S Gehring","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3945\/jn.112.171322","article-title":"Docosahexaenoic Acid Attenuates Hepatic Inflammation, Oxidative Stress, and Fibrosis without Decreasing Hepatosteatosis in a Ldlr\u2212\/\u2212 Mouse Model of Western Diet-Induced Nonalcoholic Steatohepatitis","volume":"143","author":"CM Depner","year":"2013","journal-title":"J Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1021\/tx0255976","article-title":"Protective role of Kupffer cells in acetaminophen-induced hepatic injury in mice","volume":"15","author":"C Ju","year":"2002","journal-title":"Chem Res Toxicol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.23337","article-title":"Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity","volume":"51","author":"R Stienstra","year":"2010","journal-title":"Hepatology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1074-7613(00)80425-2","article-title":"The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules","volume":"6","author":"TI Prigozy","year":"1997","journal-title":"Immunity"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1172\/JCI200419655","article-title":"Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells","volume":"113","author":"RE Hunger","year":"2004","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells","volume":"25","author":"A Bendelac","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1084\/jem.180.2.699","article-title":"Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4\u20138- subsets of natural killer 1.1+ T cell receptor-alpha\/beta+ cells in the liver of mice","volume":"180","author":"T Ohteki","year":"1994","journal-title":"J Exp Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"T Kawano","year":"1997","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.coi.2003.09.014","article-title":"Natural killer T cells: natural or unnatural regulators of autoimmunity?","volume":"15","author":"KJ Hammond","year":"2003","journal-title":"Curr Opin Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.4049\/jimmunol.162.11.6410","article-title":"Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells","volume":"162","author":"G Eberl","year":"1999","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1073\/pnas.0408288102","article-title":"Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion","volume":"102","author":"J Schmieg","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.1855","article-title":"An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells","volume":"11","author":"WY Lee","year":"2010","journal-title":"Nat Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.4049\/jimmunol.175.3.1540","article-title":"Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells","volume":"175","author":"M Biburger","year":"2005","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1189\/jlb.0607352","article-title":"Activation-induced NKT cell hyporesponsiveness protects from alpha-galactosylceramide hepatitis and is independent of active transregulatory factors","volume":"84","author":"M Biburger","year":"2008","journal-title":"J Leukoc Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"34479","DOI":"10.1074\/jbc.M109.065961","article-title":"Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins","volume":"284","author":"TL Hsu","year":"2009","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"N Van Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"ref31","first-page":"1271","article-title":"Repopulation of murine Kupffer cells after intravenous administration of liposome-encapsulated dichloromethylene diphosphonate","volume":"149","author":"T Yamamoto","year":"1996","journal-title":"Am J Pathol"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Wang N, Strugnell R, Wijburg O, Brodnicki T (2011) Measuring bacterial load and immune responses in mice infected with Listeria monocytogenes. J Vis Exp.","DOI":"10.3791\/3076"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"12348","DOI":"10.1021\/ja8012787","article-title":"Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production","volume":"130","author":"PH Liang","year":"2008","journal-title":"J Am Chem Soc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0014-5793(82)80054-9","article-title":"Quantitative determination of in vivo endocytosis by rat liver Kupffer and endothelial cells facilitated by an improved cell isolation method","volume":"141","author":"DP Praaning-Van Dalen","year":"1982","journal-title":"FEBS Lett"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/nprot.2007.515","article-title":"Methods for detection, isolation and culture of mouse and human invariant NKT cells","volume":"3","author":"H Watarai","year":"2008","journal-title":"Nat Protoc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00795-003-0228-x","article-title":"Differentiation and function of Kupffer cells","volume":"37","author":"M Naito","year":"2004","journal-title":"Med Electron Microsc"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jlb.45.2.87","article-title":"Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study","volume":"45","author":"K Takahashi","year":"1989","journal-title":"J Leukoc Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.4049\/jimmunol.147.10.3514","article-title":"Dynamics of lymphocytes and inflammatory cells recruited in liver during murine listeriosis. A cytofluorimetric study","volume":"147","author":"PL Goossens","year":"1991","journal-title":"J Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-0528.2002.017407.x","article-title":"Innate defenses in the liver during Listeria infection","volume":"174","author":"LP Cousens","year":"2000","journal-title":"Immunol Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.1073\/pnas.0703824104","article-title":"Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids","volume":"104","author":"YJ Chang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jhep.2009.03.008","article-title":"Kupffer cells in non-alcoholic fatty liver disease: the emerging view","volume":"51","author":"G Baffy","year":"2009","journal-title":"J Hepatol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0165-0378(85)90026-9","article-title":"Detection of macrophages and the characterization of Fc receptor-bearing cells in the mouse decidua, placenta and yolk sac using the macrophage-specific monoclonal antibody F4\/80","volume":"7","author":"CJ Matthews","year":"1985","journal-title":"J Reprod Immunol"},{"key":"ref43","first-page":"71","article-title":"On the yolk sac of the cat. II. Erythropoietic phases, ultrastructure of aging primitive erythroblasts, and blood vessels","volume":"183","author":"K Tiedemann","year":"1977","journal-title":"Cell Tissue Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1365-2141.1976.tb00958.x","article-title":"Growth of mouse yolk sac cells cultured in vivo","volume":"32","author":"SR Weinberg","year":"1976","journal-title":"Br J Haematol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev-immunol-031210-101352","article-title":"Signaling by myeloid C-type lectin receptors in immunity and homeostasis","volume":"30","author":"D Sancho","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.immuni.2011.05.001","article-title":"Myeloid C-type lectin receptors in pathogen recognition and host defense","volume":"34","author":"F Osorio","year":"2011","journal-title":"Immunity"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.4049\/jimmunol.167.3.1413","article-title":"Activating immunity in the liver. I. Liver dendritic cells (but not hepatocytes) are potent activators of IFN-gamma release by liver NKT cells","volume":"167","author":"Z Trobonjaca","year":"2001","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/labinvest.3700603","article-title":"Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers","volume":"87","author":"L Yang","year":"2007","journal-title":"Lab Invest"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/ni.2369","article-title":"C-type lectin receptors orchestrate antifungal immunity","volume":"13","author":"SE Hardison","year":"2012","journal-title":"Nat Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.mib.2006.06.005","article-title":"Candida-host cell receptor-ligand interactions","volume":"9","author":"SG Filler","year":"2006","journal-title":"Curr Opin Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0065070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T07:24:26Z","timestamp":1688282666000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0065070"}},"subtitle":[],"editor":[{"given":"Christian","family":"Schulz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":50,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0065070","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]}}}