{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:56:35Z","timestamp":1780379795768,"version":"3.54.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,31]],"date-time":"2013-05-31T00:00:00Z","timestamp":1369958400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0065124","type":"journal-article","created":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T04:45:54Z","timestamp":1370061954000},"page":"e65124","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stronger T Cell Immunogenicity of Ovalbumin Expressed Intracellularly in Gram-Negative than in Gram-Positive Bacteria"],"prefix":"10.1371","volume":"8","author":[{"given":"Anna","family":"Martner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"\u00d6stman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Lundin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Rask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esbj\u00f6rn","family":"Telemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Vincent","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Axelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes E.","family":"Wold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,31]]},"reference":[{"key":"ref1","first-page":"394","article-title":"Expression of a dietary protein in E. coli renders it strongly antigenic to gut lymphoid tissue","volume":"73","author":"UI Dahlgren","year":"1991","journal-title":"Immunology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.4049\/jimmunol.177.12.8493","article-title":"Phagocytosis induces lysosome remodeling and regulated presentation of particulate antigens by activated dendritic cells","volume":"177","author":"JV Nayak","year":"2006","journal-title":"J Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1016\/j.vaccine.2010.07.056","article-title":"The kinetics of soluble and particulate antigen trafficking in the afferent lymph, and its modulation by aluminum-based adjuvant","volume":"28","author":"M de Veer","year":"2010","journal-title":"Vaccine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.imbio.2011.10.011","article-title":"A balance between tissue-destructive and tissue-protective immunities: a role of toll-like receptors in regulation of adaptive immunity","volume":"217","author":"VI Seledtsov","year":"2012","journal-title":"Immunobiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"T Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"T Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1128\/IAI.68.6.3581-3586.2000","article-title":"Gram-positive bacteria are potent inducers of monocytic interleukin-12 (IL-12) while gram-negative bacteria preferentially stimulate IL-10 production","volume":"68","author":"C Hessle","year":"2000","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1023\/B:IFLA.0000006700.41614.21","article-title":"Gram-negative, but not Gram-positive, bacteria elicit strong PGE2 production in human monocytes","volume":"27","author":"CC Hessle","year":"2003","journal-title":"Inflammation"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cyto.2004.05.008","article-title":"Gram-positive and Gram-negative bacteria elicit different patterns of pro-inflammatory cytokines in human monocytes","volume":"30","author":"CC Hessle","year":"2005","journal-title":"Cytokine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/jir.2009.0033","article-title":"Gram-positive and gram-negative bacteria induce different patterns of cytokine production in human mononuclear cells irrespective of taxonomic relatedness","volume":"30","author":"S Skovbjerg","year":"2010","journal-title":"J Interferon Cytokine Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1128\/IAI.72.5.2671-2678.2004","article-title":"Pattern of cytokine responses to gram-positive and gram-negative commensal bacteria is profoundly changed when monocytes differentiate into dendritic cells","volume":"72","author":"H Karlsson","year":"2004","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1128\/CVI.13.3.365-375.2006","article-title":"Lactic acid bacteria inducing a weak interleukin-12 and tumor necrosis factor alpha response in human dendritic cells inhibit strongly stimulating lactic acid bacteria but act synergistically with gram-negative bacteria","volume":"13","author":"LH Zeuthen","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cellimm.2008.09.002","article-title":"Activation of Toll-like receptors and dendritic cells by a broad range of bacterial molecules","volume":"255","author":"LC Boele","year":"2009","journal-title":"Cell Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1002\/eji.200324815","article-title":"Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development","volume":"34","author":"HH Smits","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1365-2567.2009.03204.x","article-title":"Well-controlled proinflammatory cytokine responses of Peyer&apos;s patch cells to probiotic Lactobacillus casei","volume":"130","author":"Y Chiba","year":"2010","journal-title":"Immunology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1128\/AEM.55.8.1901-1906.1989","article-title":"Antibacterial activity of Lactobacillus sake isolated from meat","volume":"55","author":"U Schillinger","year":"1989","journal-title":"Appl Environ Microbiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0963-9969(92)90121-K","article-title":"Transformation of Lactobacillus strains used in meat and vegetable fermentations","volume":"25","author":"TaH Aurkust","year":"1992","journal-title":"Food Res Int"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JB.154.1.1-9.1983","article-title":"Plasmid complements of Streptococcus lactis NCDO 712 and other lactic streptococci after protoplast-induced curing","volume":"154","author":"MJ Gasson","year":"1983","journal-title":"J Bacteriol"},{"key":"ref19","unstructured":"Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a Laborarory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00260708","article-title":"Distance-dependent translational coupling and interference in Lactococcus lactis","volume":"227","author":"M van de Guchte","year":"1991","journal-title":"Mol Gen Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.2125367","article-title":"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo","volume":"250","author":"KM Murphy","year":"1990","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.157.4.1149","article-title":"The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody","volume":"157","author":"K Haskins","year":"1983","journal-title":"J Exp Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1084\/jem.172.1.383","article-title":"Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins","volume":"172","author":"M Crowley","year":"1990","journal-title":"J Exp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.4049\/jimmunol.141.3.849","article-title":"Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones","volume":"141","author":"X Paliard","year":"1988","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.4049\/jimmunol.181.3.1849","article-title":"Dual signaling of MyD88 and TRIF is critical for maximal TLR4-induced dendritic cell maturation","volume":"181","author":"H Shen","year":"2008","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis","volume":"389","author":"H Groux","year":"1997","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.micinf.2008.08.011","article-title":"Soluble bacterial constituents down-regulate secretion of IL-12 in response to intact Gram-positive bacteria","volume":"10","author":"C Barkman","year":"2008","journal-title":"Microbes Infect"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/275510a0","article-title":"Nucleotide sequence homology at 12 intron\u2013exon junctions in the chick ovalbumin gene","volume":"275","author":"JF Catterall","year":"1978","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/275505a0","article-title":"Synthesis of an ovalbumin-like protein by Escherichia coli K12 harbouring a recombinant plasmid","volume":"275","author":"O Mercereau-Puijalon","year":"1978","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/plas.2001.1531","article-title":"Construction of compatible wide-host-range shuttle vectors for lactic acid bacteria and Escherichia coli","volume":"46","author":"I Perez-Arellano","year":"2001","journal-title":"Plasmid"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0378-1097(03)00798-5","article-title":"Construction of vectors for inducible gene expression in Lactobacillus sakei and L plantarum","volume":"229","author":"E Sorvig","year":"2003","journal-title":"FEMS Microbiol Lett"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1099\/mic.0.28084-0","article-title":"High-level, inducible gene expression in Lactobacillus sakei and Lactobacillus plantarum using versatile expression vectors","volume":"151","author":"E Sorvig","year":"2005","journal-title":"Microbiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1099\/mic.0.28599-0","article-title":"A synthetic promoter library for constitutive gene expression in Lactobacillus plantarum","volume":"152","author":"I Rud","year":"2006","journal-title":"Microbiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0065124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T02:48:32Z","timestamp":1688266112000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0065124"}},"subtitle":[],"editor":[{"given":"Simona","family":"Stager","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,31]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0065124","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,31]]}}}