{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:41Z","timestamp":1791388781995,"version":"4.3.3"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0065179","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T03:46:54Z","timestamp":1369799214000},"page":"e65179","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Position of Neocortical Neurons Transfected at Different Gestational Ages with shRNA Targeted against Candidate Dyslexia Susceptibility Genes"],"prefix":"10.1371","volume":"8","author":[{"given":"William T.","family":"Adler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryann P.","family":"Platt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison J.","family":"Mehlhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua L.","family":"Haight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Currier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikel A.","family":"Etchegaray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Galaburda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1086\/429131","article-title":"Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dyslexia","volume":"76","author":"N Cope","year":"2005","journal-title":"American Journal of Human Genetics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"17053","DOI":"10.1073\/pnas.0508591102","article-title":"DCDC2 is associated with reading disability and modulates neuronal development in the brain","volume":"102","author":"H Meng","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/sj.mp.4001904","article-title":"Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia","volume":"11","author":"D Harold","year":"2006","journal-title":"Mol Psychiatry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1086\/498992","article-title":"Strong Genetic Evidence of DCDC2 as a Susceptibility Gene for Dyslexia","volume":"78","author":"J Schumacher","year":"2006","journal-title":"Am J Hum Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11881-008-0020-7","article-title":"The role of gene DCDC2 in German dyslexics","volume":"59","author":"A Wilcke","year":"2009","journal-title":"Annals of Dyslexia"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Lind PA, Luciano M, Wright MJ, Montgomery GW, Martin NG, et al. (2010) Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. Eur J Hum Genet.","DOI":"10.1038\/ejhg.2009.237"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e20580","DOI":"10.1371\/journal.pone.0020580","article-title":"Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons","volume":"6","author":"S Massinen","year":"2011","journal-title":"PLoS ONE"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1086\/426404","article-title":"A 77-kilobase region of chromosome 6p22.2 is associated with dyslexia in families from the United Kingdom and from the United States","volume":"75","author":"C Francks","year":"2004","journal-title":"Am J Hum Genet"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/hmg\/ddl089","article-title":"The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration","volume":"15","author":"S Paracchini","year":"2006","journal-title":"Hum Mol Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.biopsych.2007.03.007","article-title":"A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability","volume":"62","author":"M Luciano","year":"2007","journal-title":"Biol Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00335-007-9051-3","article-title":"Alternative splicing in the dyslexia-associated gene KIAA0319","volume":"18","author":"A Velayos-Baeza","year":"2007","journal-title":"Mamm Genome"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00702-008-0124-6","article-title":"Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample","volume":"115","author":"KU Ludwig","year":"2008","journal-title":"J Neural Transm"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1176\/appi.ajp.2008.07121872","article-title":"Association of the KIAA0319 Dyslexia Susceptibility Gene With Reading Skills in the General Population","volume":"165","author":"S Paracchini","year":"2008","journal-title":"Am J Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/YPG.0b013e32834c0c97","article-title":"Association study of a functional genetic variant in KIAA0319 in German dyslexics","volume":"22","author":"H Kirsten","year":"2012","journal-title":"Psychiatr Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/YPG.0b013e32834acdb2","article-title":"DCDC2 genetic variants and susceptibility to developmental dyslexia","volume":"22","author":"C Marino","year":"2012","journal-title":"Psychiatr Genet"},{"key":"ref16","first-page":"622","article-title":"Association of polymorphisms in the DCDC2 gene with developmental dyslexia in the Han Chinese","volume":"125","author":"PX Zuo","year":"2012","journal-title":"Chin Med J (Engl)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"11553","DOI":"10.1073\/pnas.1833911100","article-title":"A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain","volume":"100","author":"M Taipale","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ajmg.b.30018","article-title":"Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q","volume":"131","author":"NH Chapman","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Bates TC, Lind PA, Luciano M, Montgomery GW, Martin NG, et al. (2009) Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation. Mol Psychiatry.","DOI":"10.1038\/mp.2009.120"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Dahdouh F, Anthoni H, Tapia-Paez I, Peyrard-Janvid M, Schulte-Korne G, et al. (2009) Further evidence for DYX1C1 as a susceptibility factor for dyslexia. Psychiatr Genet.","DOI":"10.1097\/YPG.0b013e32832080e1"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e42969","DOI":"10.1371\/journal.pone.0042969","article-title":"Association of the DYX1C1 Dyslexia Susceptibility Gene with Orthography in the Chinese Population","volume":"7","author":"Y Zhang","year":"2012","journal-title":"PLoS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1210\/me.2011-1376","article-title":"The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor beta and DNA methylation","volume":"26","author":"K Tammimies","year":"2012","journal-title":"Mol Endocrinol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.neuroscience.2006.08.022","article-title":"Dyx1c1 functions in neuronal migration in developing neocortex","volume":"143","author":"Y Wang","year":"2006","journal-title":"Neuroscience"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.neuroscience.2008.01.020","article-title":"Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene DCDC2","volume":"152","author":"T Burbridge","year":"2008","journal-title":"Neuroscience"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.neuroscience.2010.11.002","article-title":"The effects of embryonic knockdown of the candidate dyslexia susceptibility gene homologue DYX1C1 on the distribution of GABAergic neurons in the cerebral cortex","volume":"172","author":"TA Currier","year":"2011","journal-title":"Neuroscience"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1093\/cercor\/bhl162","article-title":"Disruption of neuronal migration by targeted RNAi knockdown of Dyx1c1 results in neocortical and hippocampal malformations","volume":"17","author":"GD Rosen","year":"2007","journal-title":"Cerebral Cortex"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.brainresbull.2006.11.005","article-title":"Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1","volume":"71","author":"SW Threlkeld","year":"2007","journal-title":"Brain Research Bulletin"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1601-183X.2010.00662.x","article-title":"Persistent spatial working memory deficits in rats following <italic>in utero<\/italic> RNAi of <italic>Dyx1c1<\/italic>","volume":"10","author":"CE Szalkowski","year":"2011","journal-title":"Genes Brain Behav"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Tammimies K, Vitezic M, Matsson H, Le Guyader S, Burglin TR, et al. (2012) Molecular Networks of DYX1C1 Gene Show Connection to Neuronal Migration Genes and Cytoskeletal Proteins. Biol Psychiatry.","DOI":"10.1016\/j.ijdevneu.2012.10.016"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/cercor\/bhp154","article-title":"The effect of variation in expression of the candidate dyslexia susceptibility gene homolog <italic>Kiaa0319<\/italic> on neuronal migration and dendritic morphology in the rat","volume":"20","author":"VJ Peschansky","year":"2010","journal-title":"Cerebral Cortex"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/hmg\/ddm358","article-title":"The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms","volume":"17","author":"A Velayos-Baeza","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"C160","DOI":"10.1152\/ajpcell.00630.2008","article-title":"The dyslexia-associated protein KIAA0319 interacts with adaptor protein 2 and follows the classical clathrin-mediated endocytosis pathway","volume":"297","author":"C Levecque","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref33","first-page":"1","article-title":"Auditory cytoarchitectonic abnormalities in a case of familial developmental dyslexia","volume":"103","author":"AM Galaburda","year":"1978","journal-title":"Trans Amer Neurol Assoc"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ana.410180210","article-title":"Developmental dyslexia: Four consecutive cases with cortical anomalies","volume":"18","author":"AM Galaburda","year":"1985","journal-title":"Ann Neurol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.410280602","article-title":"Developmental dyslexia in women: Neuropathological findings in three cases","volume":"28","author":"P Humphreys","year":"1990","journal-title":"Ann Neurol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1212\/01.wnl.0000286365.41070.54","article-title":"A structural basis for reading fluency: White matter defects in a genetic brain malformation","volume":"69","author":"BS Chang","year":"2007","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuroimage.2010.09.055","article-title":"Structural brain alterations associated with dyslexia predate reading onset","volume":"57","author":"NM Raschle","year":"2011","journal-title":"Neuroimage"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11910-010-0176-5","article-title":"Molecular genetics of neuronal migration disorders","volume":"11","author":"JS Liu","year":"2011","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.nbd.2009.06.019","article-title":"Progress towards a cellular neurobiology of reading disability","volume":"38","author":"LA Gabel","year":"2010","journal-title":"Neurobiol Dis"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Coquelle FM, Levy T, Bergmann S, Wolf SG, Bar-El D, et al. (2006) Common and Divergent Roles for Members of the Mouse DCX Superfamily. Cell Cycle 5.","DOI":"10.4161\/cc.5.9.2715"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1471-2164-7-188","article-title":"The evolving doublecortin (DCX) superfamily","volume":"7","author":"O Reiner","year":"2006","journal-title":"BMC Genomics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/1531-8249(199902)45:2<146::AID-ANA3>3.0.CO;2-N","article-title":"Characterization of mutations in the gene doublecortin in patients with double cortex syndrome [see comments]","volume":"45","author":"JG Gleeson","year":"1999","journal-title":"Ann Neurol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuron.2005.10.038","article-title":"Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth","volume":"49","author":"TA Deuel","year":"2006","journal-title":"Neuron"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuron.2005.10.040","article-title":"Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration","volume":"49","author":"H Koizumi","year":"2006","journal-title":"Neuron"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1356-9597.2004.00742.x","article-title":"Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones","volume":"9","author":"S Hatakeyama","year":"2004","journal-title":"Genes Cells"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature09204","article-title":"Network organization of the human autophagy system","volume":"466","author":"C Behrends","year":"2010","journal-title":"Nature"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1093\/hmg\/ddp215","article-title":"Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia","volume":"18","author":"S Massinen","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10519-012-9532-3","article-title":"The aromatase gene CYP19A1: several genetic and functional lines of evidence supporting a role in reading, speech and language","volume":"42","author":"H Anthoni","year":"2012","journal-title":"Behavior Genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e35618","DOI":"10.1371\/journal.pone.0035618","article-title":"Exploring the transcriptome of ciliated cells using in silico dissection of human tissues","volume":"7","author":"AE Ivliev","year":"2012","journal-title":"PLoS ONE"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0065179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T06:22:45Z","timestamp":1563085365000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0065179"}},"subtitle":[],"editor":[{"given":"Ferdinando","family":"Di Cunto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":49,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0065179","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}