{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:23:09Z","timestamp":1778602989334,"version":"3.51.4"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0065677","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T21:14:59Z","timestamp":1371071699000},"page":"e65677","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":41,"title":["Susceptibility to DNA Damage as a Molecular Mechanism for Non-Syndromic Cleft Lip and Palate"],"prefix":"10.1371","volume":"8","author":[{"given":"Gerson Shigeru","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Alvizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Yumi","family":"Sunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippa","family":"Francis-West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Vin\u00edcius Pimenta","family":"Almada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Gomes","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Carmo","family":"de Andrade-Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Franco","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1ssio Eduardo","family":"Raposo-Amaral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Frederico","family":"Menck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rita","family":"Passos-Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,6,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0140-6736(09)60695-4","article-title":"Cleft lip and palate","volume":"374","author":"PA Mossey","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1002\/ajmg.a.34036","article-title":"Genetic contribution for non-syndromic cleft lip with or without cleft palate (NS CL\/P) in different regions of Brazil and implications for association studies","volume":"155A","author":"LA Brito","year":"2011","journal-title":"Am J Med Genet A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/ng.333","article-title":"Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24","volume":"41","author":"S Birnbaum","year":"2009","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jpeds.2009.06.020","article-title":"A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24","volume":"155","author":"SF Grant","year":"2009","journal-title":"J Pediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/ng.506","article-title":"Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate","volume":"42","author":"E Mangold","year":"2009","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/ng.580","article-title":"A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4","volume":"42","author":"TH Beaty","year":"2009","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nrg2537","article-title":"Mapping complex disease traits with global gene expression","volume":"10","author":"W Cookson","year":"2009","journal-title":"Nat Rev Genet"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/jcp.22006","article-title":"Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism","volume":"222","author":"T Baroni","year":"2010","journal-title":"J Cell Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s12015-010-9197-3","article-title":"Human stem cell cultures from cleft lip\/palate patients show enrichment of transcripts involved in extracellular matrix modeling by comparison to controls","volume":"7","author":"DF Bueno","year":"2010","journal-title":"Stem Cell Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2008.12.002","article-title":"Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture","volume":"257","author":"L Marinucci","year":"2009","journal-title":"Toxicology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/00313020902756899","article-title":"Diphenylhydantoin plays a role in gene expression related to cytoskeleton and protein adhesion in human normal palate fibroblasts","volume":"41","author":"F Pezzetti","year":"2009","journal-title":"Pathology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/dvdy.20646","article-title":"Development of the upper lip: morphogenetic and molecular mechanisms","volume":"235","author":"R Jiang","year":"2006","journal-title":"Dev Dyn"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/bdrc.20180","article-title":"Palate morphogenesis: Current understanding and future directions","volume":"90","author":"RM Greene","year":"2010","journal-title":"Birth Defects Res C Embryo Today"},{"key":"ref14","article-title":"Cleft lip and palate genetics and application in early embryological development","volume":"42","author":"W Yu","year":"2009","journal-title":"Indian J Plast Surg"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/sj.bjc.6600488","article-title":"Do parents of children with congenital malformations have a higher cancer risk? A nationwide study in Denmark","volume":"87","author":"JL Zhu","year":"2002","journal-title":"Br J Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3109\/07357907.2010.483510","article-title":"Cleft lip and palate in family members of cancer survivors","volume":"28","author":"E Taioli","year":"2010","journal-title":"Cancer Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/aje\/kwi132","article-title":"Cancer risk in persons with oral cleft\u2013a population-based study of 8,093 cases","volume":"161","author":"C Bille","year":"2005","journal-title":"Am J Epidemiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/ajmg.a.35359","article-title":"Risk of cancer in relatives of children born with isolated cleft lip and palate","volume":"158A","author":"AR Vieira","year":"2012","journal-title":"Am J Med Genet A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4161\/cc.6.3.3796","article-title":"p63-associated disorders","volume":"6","author":"T Rinne","year":"2007","journal-title":"Cell Cycle"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/emboj.2011.325","article-title":"IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes","volume":"30","author":"G Restivo","year":"2011","journal-title":"EMBO J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/0022034512440578","article-title":"Association of AXIN2 with non-syndromic oral clefts in multiple populations","volume":"91","author":"A Letra","year":"2012","journal-title":"J Dent Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1002557","DOI":"10.1371\/journal.pgen.1002557","article-title":"DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress","volume":"8","author":"H Krenzlin","year":"2012","journal-title":"PLoS Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/emmm.201100199","article-title":"Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome","volume":"4","author":"G Ferone","year":"2012","journal-title":"EMBO Mol Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/hmg\/dds497","article-title":"Identification of germline mutations in the cancer predisposing gene CDH1 in patients with orofacial clefts","volume":"22","author":"IP Vogelaar","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ajmg.a.33702","article-title":"Cranial neural crest cells on the move: their roles in craniofacial development","volume":"155A","author":"DR Cordero","year":"2011","journal-title":"Am J Med Genet A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1741-4520.2012.00368.x","article-title":"Sonic hedgehog signaling coordinates the proliferation and differentiation of neural stem\/progenitor cells by regulating cell cycle kinetics during development of the neocortex","volume":"52","author":"M Komada","year":"2012","journal-title":"Congenit Anom (Kyoto)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e27526","DOI":"10.1371\/journal.pone.0027526","article-title":"Isolation and characterization of neural crest-derived stem cells from dental pulp of neonatal mice","volume":"6","author":"K Janebodin","year":"2011","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1158\/1535-7163.MCT-05-0471","article-title":"BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions","volume":"5","author":"RI Yarden","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfn263","article-title":"Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer","volume":"108","author":"PG Wells","year":"2009","journal-title":"Toxicol Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1089\/152308604322899350","article-title":"Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis","volume":"6","author":"R Sharma","year":"2004","journal-title":"Antioxid Redox Signal"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mrrev.2012.04.002","article-title":"The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses","volume":"751","author":"U Weyemi","year":"2012","journal-title":"Mutat Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neulet.2012.09.013","article-title":"JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress","volume":"529","author":"H Yu","year":"2012","journal-title":"Neurosci Lett"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e7091","DOI":"10.1371\/journal.pone.0007091","article-title":"BRCA1 interacts with Smad3 and regulates Smad3-mediated TGF-beta signaling during oxidative stress responses","volume":"4","author":"H Li","year":"2009","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1365-2443.2011.01535.x","article-title":"Efficient expression and purification of human replication fork-stabilizing factor, Claspin, from mammalian cells: DNA-binding activity and novel protein interactions","volume":"16","author":"S Uno","year":"2011","journal-title":"Genes Cells"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"19092","DOI":"10.1074\/jbc.M110.104430","article-title":"Transcriptional regulation of the base excision repair pathway by BRCA1","volume":"285","author":"T Saha","year":"2010","journal-title":"J Biol Chem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1101\/gad.1922610","article-title":"Break-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly","volume":"24","author":"JR Lydeard","year":"2010","journal-title":"Genes Dev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ceb.2006.02.006","article-title":"MCM proteins and DNA replication","volume":"18","author":"D Maiorano","year":"2006","journal-title":"Curr Opin Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1111\/j.1742-4658.2010.07735.x","article-title":"BRCA1 16 years later: risk-associated BRCA1 mutations and their functional implications","volume":"277","author":"RJ Linger","year":"2010","journal-title":"FEBS J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10735-006-9062-5","article-title":"The role of the human DNA mismatch repair gene hMSH2 in DNA repair, cell cycle control and apoptosis: implications for pathogenesis, progression and therapy of cancer","volume":"37","author":"M Seifert","year":"2006","journal-title":"J Mol Histol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.dnarep.2008.09.002","article-title":"Dual role of CDKs in DNA repair: to be, or not to be","volume":"8","author":"K Yata","year":"2009","journal-title":"DNA Repair (Amst)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1158\/0008-5472.CAN-11-2196","article-title":"Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage","volume":"72","author":"AK Biswas","year":"2011","journal-title":"Cancer Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.ceb.2007.10.006","article-title":"Life and death decisions by the E2F transcription factors","volume":"19","author":"PJ Iaquinta","year":"2007","journal-title":"Curr Opin Cell Biol"},{"key":"ref43","first-page":"267","article-title":"Expression of the E2F family of transcription factors during murine development","volume":"44","author":"JC Kusek","year":"2000","journal-title":"Int J Dev Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.semcancer.2004.06.007","article-title":"Genetic alterations and DNA repair in human carcinogenesis","volume":"14","author":"K Dixon","year":"2004","journal-title":"Semin Cancer Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.canlet.2005.04.037","article-title":"BRCA1 regulation of transcription","volume":"236","author":"EM Rosen","year":"2006","journal-title":"Cancer Lett"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ng0495-444","article-title":"Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression","volume":"9","author":"ME Thompson","year":"1995","journal-title":"Nat Genet"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1365-2559.1999.00578.x","article-title":"Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters","volume":"34","author":"WY Lee","year":"1999","journal-title":"Histopathology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/bcr557","article-title":"Regulation of BRCA1 expression and its relationship to sporadic breast cancer","volume":"5","author":"CR Mueller","year":"2003","journal-title":"Breast Cancer Res"},{"key":"ref49","first-page":"3777","article-title":"The coding region of the Bloom syndrome BLM gene and of the CBL proto-oncogene is mutated in genetically unstable sporadic gastrointestinal tumors","volume":"58","author":"G Calin","year":"1998","journal-title":"Cancer Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/carcin\/bgm268","article-title":"CDC6: from DNA replication to cell cycle checkpoints and oncogenesis","volume":"29","author":"LR Borlado","year":"2008","journal-title":"Carcinogenesis"},{"key":"ref51","first-page":"827","article-title":"RAD51 135G\/C polymorphism and breast cancer risk: a meta-analysis from 21 studies","volume":"125","author":"LB Gao","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.dnarep.2007.02.006","article-title":"DNA double-strand break repair: from mechanistic understanding to cancer treatment","volume":"6","author":"T Helleday","year":"2007","journal-title":"DNA Repair (Amst)"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"859","DOI":"10.4161\/cc.7.7.5613","article-title":"Break-induced replication: what is it and what is it for?","volume":"7","author":"B Llorente","year":"2008","journal-title":"Cell Cycle"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00018-009-8740-3","article-title":"DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship","volume":"66","author":"B Pardo","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1098\/rstb.2011.0070","article-title":"Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair","volume":"366","author":"P Langerak","year":"2011","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.dnarep.2008.06.018","article-title":"Comparison of nonhomologous end joining and homologous recombination in human cells","volume":"7","author":"Z Mao","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.dnarep.2006.01.004","article-title":"Relative contribution of homologous recombination and non-homologous end-joining to DNA double-strand break repair after oxidative stress in Saccharomyces cerevisiae","volume":"5","author":"L Letavayova","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1101\/gad.14.8.927","article-title":"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures","volume":"14","author":"Y Wang","year":"2000","journal-title":"Genes Dev"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3109\/14767058.2010.529970","article-title":"Male gender significantly increases risk of oxidative stress related congenital anomalies in the non-diabetic population","volume":"24","author":"RO Bahado-Singh","year":"2011","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/(SICI)1096-8628(19970110)68:1<18::AID-AJMG4>3.0.CO;2-U","article-title":"Findings in children exposed in utero to phenytoin and carbamazepine monotherapy: independent effects of epilepsy and medications","volume":"68","author":"I Nulman","year":"1997","journal-title":"Am J Med Genet"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1124\/jpet.103.052639","article-title":"Oxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity","volume":"306","author":"LM Winn","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1517\/14740338.4.2.345","article-title":"Teratogenicity of sodium valproate","volume":"4","author":"R Alsdorf","year":"2005","journal-title":"Expert Opin Drug Saf"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/aje\/kwn186","article-title":"First-trimester maternal alcohol consumption and the risk of infant oral clefts in Norway: a population-based case-control study","volume":"168","author":"LA DeRoo","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/S1806-83242009000100006","article-title":"Oral clefts, consanguinity, parental tobacco and alcohol use: a case-control study in Rio de Janeiro, Brazil","volume":"23","author":"IC Leite","year":"2009","journal-title":"Braz Oral Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/bdrb.20236","article-title":"Characterization of valproic acid-initiated homologous recombination","volume":"89","author":"K Sha","year":"2010","journal-title":"Birth Defects Res B Dev Reprod Toxicol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1124\/mol.111.072314","article-title":"Valproic acid increases formation of reactive oxygen species and induces apoptosis in postimplantation embryos: a role for oxidative stress in valproic acid-induced neural tube defects","volume":"80","author":"EW Tung","year":"2011","journal-title":"Mol Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3892\/mmr.2012.754","article-title":"Ethanol-induced DNA damage and repair-related molecules in human intestinal epithelial Caco-2 cells","volume":"5","author":"SC Park","year":"2012","journal-title":"Mol Med Report"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e11208","DOI":"10.1371\/journal.pone.0011208","article-title":"Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor","volume":"5","author":"SK Kachhap","year":"2010","journal-title":"PLoS One"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1601-0825.2009.01587.x","article-title":"Folic acid and orofacial clefts: a review of the evidence","volume":"16","author":"GL Wehby","year":"2010","journal-title":"Oral Dis"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/S0891-5849(01)00543-3","article-title":"Free radical scavenging behavior of folic acid: evidence for possible antioxidant activity","volume":"30","author":"R Joshi","year":"2001","journal-title":"Free Radic Biol Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"8237","DOI":"10.1021\/jf070986x","article-title":"pH-Dependent radical scavenging activity of folates","volume":"55","author":"A Gliszczynska-Swiglo","year":"2007","journal-title":"J Agric Food Chem"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/bdra.20488","article-title":"Genome-wide pathway analysis of folate-responsive genes to unravel the pathogenesis of orofacial clefting in man","volume":"82","author":"BJ Bliek","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ng985","article-title":"Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes","volume":"32","author":"S Kondo","year":"2002","journal-title":"Nat Genet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-213X-6-18","article-title":"Expression profiles of cIRF6, cLHX6 and cLHX7 in the facial primordia suggest specific roles during primary palatogenesis","volume":"6","author":"BJ Washbourne","year":"2006","journal-title":"BMC Dev Biol"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Rocha CR, Lerner LK, Okamoto OK, Marchetto MC, Menck CF (2012) The role of DNA repair in the pluripotency and differentiation of human stem cells. Mutat Res.","DOI":"10.1016\/j.mrrev.2012.09.001"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e8066","DOI":"10.1371\/journal.pone.0008066","article-title":"Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences","volume":"4","author":"W Feng","year":"2009","journal-title":"PLoS One"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1387\/ijdb.092970da","article-title":"Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration","volume":"55","author":"D Albino","year":"2011","journal-title":"Int J Dev Biol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1097\/scs.0b013e31815c8a54","article-title":"Reconstruction of large cranial defects in nonimmunosuppressed experimental design with human dental pulp stem cells","volume":"19","author":"A de Mendonca Costa","year":"2008","journal-title":"J Craniofac Surg"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"RA Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"VG Tusher","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.febslet.2004.07.055","article-title":"Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments","volume":"573","author":"R Breitling","year":"2004","journal-title":"FEBS Lett"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/nature08781","article-title":"Variability in gene expression underlies incomplete penetrance","volume":"463","author":"A Raj","year":"2010","journal-title":"Nature"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"R39","DOI":"10.1186\/gb-2009-10-4-r39","article-title":"FANTOM4 EdgeExpressDB: an integrated database of promoters, genes, microRNAs, expression dynamics and regulatory interactions","volume":"10","author":"J Severin","year":"2009","journal-title":"Genome Biol"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"RESEARCH0034","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1385\/1-59259-973-7:073","article-title":"Cytometric assessment of histone H2AX phosphorylation: a reporter of DNA damage","volume":"314","author":"X Huang","year":"2006","journal-title":"Methods Mol Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/dvdy.21010","article-title":"Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm","volume":"236","author":"A Dastjerdi","year":"2007","journal-title":"Dev Dyn"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0065677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T09:04:10Z","timestamp":1715504650000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0065677"}},"subtitle":[],"editor":[{"given":"Dale J.","family":"Hedges","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,12]]},"references-count":88,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0065677","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,12]]}}}