{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:30:16Z","timestamp":1778578216896,"version":"3.51.4"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0065966","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T21:42:17Z","timestamp":1375738937000},"page":"e65966","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Protection by an Oral Disubstituted Hydroxylamine Derivative against Loss of Retinal Ganglion Cell Differentiation following Optic Nerve Crush"],"prefix":"10.1371","volume":"8","author":[{"given":"James D.","family":"Lindsey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen X.","family":"Duong-Polk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duy H.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Weinreb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"RN Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/WCO.0b013e3283344461","article-title":"Neuroprotection for optic nerve disorders","volume":"23","author":"AC Bessero","year":"2010","journal-title":"Curr Opin Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.preteyeres.2012.07.001","article-title":"Critical pathogenic events underlying progression of neurodegeneration in glaucoma","volume":"31","author":"DJ Calkins","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"ref4","first-page":"1469","article-title":"Retinal Thy-1 expression during development","volume":"37","author":"CJ Liu","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref5","first-page":"192","article-title":"Changes in Thy1 gene expression associated with damaged retinal ganglion cells","volume":"7","author":"CL Schlamp","year":"2001","journal-title":"Mol Vis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1167\/iovs.05-0921","article-title":"Retinal ganglion cell axotomy induces an increase in intracellular superoxide anion","volume":"47","author":"CJ Lieven","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4580","DOI":"10.1167\/iovs.07-0170","article-title":"Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage","volume":"48","author":"Q Liu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.exer.2009.10.013","article-title":"Neuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load","volume":"90","author":"S Thaler","year":"2010","journal-title":"Exp Eye Res"},{"key":"ref9","first-page":"4169","article-title":"RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection","volume":"41","author":"H Levkovitch-Verbin","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1021\/bi00463a024","article-title":"Biologically active metal- independent superoxide dismutase mimics","volume":"29","author":"JB Mitchell","year":"1990","journal-title":"Biochemistry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.exer.2009.10.013","article-title":"Neuroprotective effects of tempol on retinal ganglion cells in a partial optic nerve crush rat model with and without iron load","volume":"90","author":"S Thaler","year":"2010","journal-title":"Exp Eye Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1167\/iovs.06-1057","article-title":"Protective effect of TEMPOL derivatives against light-induced retinal damage in rats","volume":"48","author":"M Tanito","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jneumeth.2007.10.018","article-title":"In vivo imaging of murine retinal ganglion cells","volume":"168","author":"CK Leung","year":"2008","journal-title":"J Neurosci Methods"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1167\/iovs.07-1447","article-title":"Longitudinal profile of retinal ganglion cell damage after optic nerve crush with blue-light confocal scanning laser ophthalmoscopy","volume":"49","author":"CK Leung","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","first-page":"330","article-title":"Changes in ocular aquaporin expression following optic nerve crush","volume":"16","author":"A Dibas","year":"2010","journal-title":"Mol Vis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1167\/iovs.12-10850","article-title":"Inhibition of histone deacetylases 1 and 3 protects injured retinal ganglion cells","volume":"54","author":"P Chindasub","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref17","first-page":"1559","article-title":"Cyan fluorescent protein expression in ganglion and amacrine cells in a thy1-CFP transgenic mouse retina","volume":"14","author":"ID Raymond","year":"2008","journal-title":"Mol Vis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1017\/S095252380999023X","article-title":"A Thy1-CFP DBA\/2J mouse line with cyan fluorescent protein expression in retinal ganglion cells","volume":"26","author":"ID Raymond","year":"2009","journal-title":"Vis Neurosci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pharmthera.2010.01.003","article-title":"Effects of tempol and redox-cycling nitroxides in models of oxidative stress","volume":"126","author":"CS Wilcox","year":"2010","journal-title":"Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1046\/j.1523-1755.2000.00212.x","article-title":"Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat","volume":"58","author":"PK Chatterjee","year":"2000","journal-title":"Kidney Int"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.nurt.2009.10.021","article-title":"Antioxidant therapies for traumatic brain injury","volume":"7","author":"ED Hall","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref22","unstructured":"Patil G (2008) Hydroxylamine compounds and their methods of use. U.S. Patent No. 2008\/0280890A1."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/glia.20961","article-title":"Involvement of gp130-associated cytokine signaling in M\u00fcller cell activation following optic nerve lesion","volume":"58","author":"M Kirsch","year":"2010","journal-title":"Glia"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1167\/iovs.12-9450","article-title":"Tracking retinal microgliosis in models of retinal ganglion cell damage","volume":"53","author":"S Liu","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/jnr.22584","article-title":"Different spatial and temporal protein expressions of repulsive guidance molecule a and neogenin in the rat optic nerve after optic nerve crush with and without lens injury","volume":"89","author":"S Schnichels","year":"2011","journal-title":"J Neurosci Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neulet.2009.10.077","article-title":"Cyan fluorescent protein (CFP) expressing cells in the retina of Thy1-CFP transgenic mice before and after optic nerve injury","volume":"468","author":"X Wang","year":"2010","journal-title":"Neurosci Lett"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/(SICI)1097-4695(199901)38:1<116::AID-NEU9>3.0.CO;2-F","article-title":"Unilateral injury to the adult rat optic nerve causes multiple cellular responses in the contralateral site","volume":"38","author":"N Bodeutsch","year":"1999","journal-title":"J Neurobiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1002\/ar.1091540406","article-title":"Maturation and water composition of murine cerebrum, cerebellum, brain stem and spinal cord","volume":"154","author":"E Blinderman","year":"1966","journal-title":"Anat Rec"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1471-4159.1968.tb11633.x","article-title":"Developmental changes in mouse brain: weight, water content and free amino acids","volume":"15","author":"HC Agrawal","year":"1968","journal-title":"J Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/neu.480060302","article-title":"Comparison of lipids in total brain tissue from five mouse genotypes","volume":"16","author":"J Sampugna","year":"1975","journal-title":"J Neurobiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF01101715","article-title":"Different levels of acetylcholinesterase and choline acetyltransferase activities in C57Bl\/6 and DBA\/2 mice are not accompanied with different density of cortical acetylcholinesterase reactive fibers","volume":"15","author":"C Schwab","year":"1990","journal-title":"Neurochem Res"},{"key":"ref32","unstructured":"Arsham H. Analysis of covariance: comparing two linear regressions. Website of Merrick School of Business, University of Baltimore. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/home.ubalt.edu\/ntsbarsh\/business-stat\/otherapplets\/ANOCOV.htm\" xlink:type=\"simple\">http:\/\/home.ubalt.edu\/ntsbarsh\/business-stat\/otherapplets\/ANOCOV.htm<\/ext-link>. Accessed 2013 Apr 4."}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0065966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:44:06Z","timestamp":1589046246000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0065966"}},"subtitle":[],"editor":[{"given":"Steven","family":"Barnes","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":32,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0065966","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}