{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:54:32Z","timestamp":1791806072711,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066115","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T20:47:07Z","timestamp":1372970827000},"page":"e66115","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":59,"title":["Molecular Analysis of Non-Specific Protection against Murine Malaria Induced by BCG Vaccination"],"prefix":"10.1371","volume":"8","author":[{"given":"Marcela","family":"Parra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Derrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhua","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher","family":"Kolibab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjai","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon L.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature","volume":"271","author":"GA Colditz","year":"1994","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","article-title":"Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness","volume":"367","author":"BB Trunz","year":"2006","journal-title":"Lancet"},{"key":"ref3","first-page":"517","article-title":"Results of BCG immunization in New York City","volume":"53","author":"MI Levine","year":"1946","journal-title":"Am Rev Tuberc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/ije\/20.2.474","article-title":"Childhood mortality among users and non-users of primary health care in a rural west African community","volume":"20","author":"AE Velema JP","year":"1991","journal-title":"Int J Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/ije\/dyh392","article-title":"BCG vaccination scar associated with better childhood survival in Guinea-Bissau","volume":"34","author":"A Roth","year":"2005","journal-title":"Int J Epidemiol"},{"key":"ref6","first-page":"369","article-title":"Prognostic factors of hospital mortality from diarrhea or pneumonia in infants younger than 1 year old. A case-control study","volume":"26","author":"C Post CL Victoria","year":"1992","journal-title":"Rev Saude Publica"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ije\/dyp307","article-title":"Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies","volume":"39","author":"M El-Zein","year":"2010","journal-title":"Int J Epidemiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1517\/14656561003657145","article-title":"Intravesical therapy for bladder cancer","volume":"11","author":"SK Williams","year":"2010","journal-title":"Expert Opin Pharmacother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.4049\/jimmunol.114.4.1424","article-title":"A vaccination procedure against <italic>Trypanosoma cruzi<\/italic> infection in mice by nonspecific immunization","volume":"114","author":"L Ortiz-Ortiz","year":"1975","journal-title":"J Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0002-9394(75)90804-1","article-title":"Effect of immunization with attenuated <italic>Mycobacterium bovis<\/italic> on experimental toxoplasmic retinochoroiditis","volume":"79","author":"KJ Tabbara","year":"1975","journal-title":"Am J Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/259309a0","article-title":"Protection of mice against Babesia and Plasmodium with BCG","volume":"259","author":"AC Clark IA Allison","year":"1976","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.4049\/jimmunol.121.4.1257","article-title":"Rodent malaria: BCG-induced protection and immunosuppression","volume":"121","author":"LL Smrkovski","year":"1978","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1586\/erv.09.161","article-title":"BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control","volume":"9","author":"CS Merle","year":"2010","journal-title":"Expert Rev Vaccines"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0962-8479(94)90080-9","article-title":"Six years\u2019 experience with the discontinuation of BCG vaccination. 4. Protective effect of BCG vaccination against the Mycobacterium avium intracellulare complex","volume":"75","author":"L Trnka","year":"1994","journal-title":"Tuber Lung Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1016\/j.vaccine.2006.02.005","article-title":"Protection against an aerogenic <italic>Mycobacterium tuberculosis<\/italic> infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses","volume":"24","author":"C Goter-Robinson","year":"2006","journal-title":"Vaccine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/CVI.00359-08","article-title":"Early pulmonary cytokine and chemokine responses in mice immunized with three different vaccines against <italic>Mycobacterium tuberculosis<\/italic> determined by PCR array","volume":"16","author":"J Lim","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1128\/CVI.00178-08","article-title":"Expression and secretion of cathelicidin LL-37 in human epithelial cells after infection by <italic>Mycobacterium bovis<\/italic> Bacillus Calmette-Gu\u00e9rin","volume":"15","author":"P M\u00e9ndez-Samperio","year":"2008","journal-title":"Clin Vaccine Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.peptides.2010.06.016","article-title":"The human cathelicidin hCAP18\/LL-37: a multifunctional peptide involved in mycobacterial infections","volume":"31","author":"P M\u00e9ndez-Samperio","year":"2010","journal-title":"Peptides"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1002\/eji.201141606","article-title":"Cathelin-related antimicrobial peptide differentially regulates T- and B-cell function","volume":"41","author":"NW Kin","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(12)60034-8","article-title":"Global malaria mortality between 1980 and 2010: a systematic analysis","volume":"379","author":"CJ Murray","year":"2012","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1080\/00365540310015629","article-title":"Cathelicidins and innate defense against invasive bacterial infection","volume":"35","author":"V Nizet","year":"2003","journal-title":"Scand J Infect Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e46476","DOI":"10.1371\/journal.pone.0046476","article-title":"The antimicrobial peptide cathelicidin protects mice against Escherichia coli O157:H7 mediated disease","volume":"7","author":"CM Arvidsson","year":"2012","journal-title":"PLoS One"},{"key":"ref23","unstructured":"Rivas-Santiago B, Rivas-Santiago CE, Casteneda-Delgado JE, Leon-Contreras JC, Hancock REW, <etal>et al<\/etal>.. (2012) Acivity of LL-37, CRAMP and antimicrobial peptide-derived compounds E2, E6, and CP 26 against <italic>Mycobacterium tuberculosis<\/italic>. Int J Antimicrob Agents dx.doi.org\/10.1016"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4161\/hv.7.1.13848","article-title":"Non-specific and sex-differential effects of routine vaccines: what evidence is needed to take these effects into consideration in low-income countries?","volume":"7","author":"P Aaby","year":"2011","journal-title":"Hum Vaccin"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/bmj.311.7003.481","article-title":"Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries","volume":"311","author":"P Aaby","year":"1995","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0300-9475.2004.01471.x","article-title":"The influence of remaining live BCG organisms in vaccinated mice on the maintenance of immunity to tuberculosis","volume":"60","author":"AW Olsen","year":"2004","journal-title":"Scand J Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-3083.2012.02683.x","article-title":"Long-term persistence of BCG Pasteur in lungs of C57BL\/6 mice following intranasal infection","volume":"75","author":"NA Leversen","year":"2012","journal-title":"Scand J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.micinf.2005.06.015","article-title":"Transcriptional responses in mouse lungs induced by vaccination with <italic>Mycobacterium bovis<\/italic> BCG and infection with Mycobacterium tuberculosis","volume":"8","author":"HJ Mollenkopf","year":"2006","journal-title":"Microbes Infect"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/SHK.0b013e31816d2269","article-title":"Efficacy of LL-37 and granulocyte colony-stimulating factor in a neutropenic murine sepsis due to Pseudomonas aeruginosa","volume":"30","author":"O Cirioni","year":"2008","journal-title":"Shock"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1471-2180-11-114","article-title":"Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against <italic>Staphylococcus aureus.<\/italic>","volume":"11","author":"SN Dean","year":"2011","journal-title":"BMC Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1111\/j.1462-5822.2011.01644.x","article-title":"Cathelicidin is involved in the intracellular killing of mycobacteria in macrophages","volume":"13","author":"A Sonawane","year":"2011","journal-title":"Cell Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4049\/jimmunol.1103196","article-title":"Cathelicidin-related antimicrobial Peptide is required for effective lung mucosal immunity in gram-negative bacterial pneumonia","volume":"189","author":"MA Kovach","year":"2012","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1002\/eji.201142055","article-title":"New insights into cathelicidin modulation of adaptive immunity","volume":"41","author":"K Wuerth","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biochi.2008.05.015","article-title":"Antimicrobial properties of lactoferrin","volume":"91","author":"H Jenssen","year":"2009","journal-title":"Biochimie"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1084\/jem.184.5.1699","article-title":"Dual interaction of the malaria circumsporozoite protein with the low density lipoprotein receptor-related protein (LRP) and heparan sulfate proteoglycans","volume":"184","author":"M Shakibaei","year":"1996","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-4894(87)90072-5","article-title":"Plasmodium falciparum: inhibition in vitro with lactoferrin, desferriferrithiocin, and desferricrocin","volume":"63","author":"G Fritsch","year":"1987","journal-title":"Exp Parasitol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1128\/IAI.55.4.877-881.1987","article-title":"Killing of <italic>Plasmodium falciparum<\/italic> by eosinophil secretory products","volume":"55","author":"LS Waters","year":"1987","journal-title":"Infect Immun"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3109\/1040841X.2011.645519","article-title":"Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens","volume":"38","author":"A Malik","year":"2012","journal-title":"Crit Rev Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/jlb.62.6.778","article-title":"Effects of inhibitors of inflammatory mediators and cytokines on eosinophil and neutrophil accumulation induced by <italic>Mycobacterium bovis<\/italic> bacillus Calmette-Gu\u00e9rin in mouse pleurisy","volume":"62","author":"O Menezes-de-Lima-J\u00fanior","year":"1997","journal-title":"J Leukoc Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1128\/IAI.01326-06","article-title":"Toll-like receptor-2-mediated C-C chemokine receptor 3 and eotaxin-driven eosinophil influx induced by <italic>Mycobacterium bovis<\/italic> BCG pleurisy","volume":"75","author":"H D\u2019Avila","year":"2007","journal-title":"Infect Immun"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1016\/j.vaccine.2006.02.005","article-title":"Protection against an aerogenic Mycobacterium tuberculosis infection in BCG-immunized and DNA-vaccinated mice is associated with early type I cytokine responses","volume":"24","author":"C Goter-Robinson","year":"2006","journal-title":"Vaccine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/jbiol34","article-title":"Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function","volume":"5","author":"OR Millington","year":"2006","journal-title":"J Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.micinf.2009.04.021","article-title":"Naturally acquired hemozoin by monocytes promotes suppression of RANTES in children with malarial anemia through an IL-10-dependent mechanism","volume":"11","author":"T Were","year":"2009","journal-title":"Microbes Infect"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.14411\/fp.2009.028","article-title":"CD4+CD25+Foxp3+ regulatory T cells prevent the development of Th1 immune response by inhibition of dendritic cell function during the early stage of <italic>Plasmodium yoelii<\/italic> infection in susceptible BALB\/c mice","volume":"56","author":"W Zheng","year":"2009","journal-title":"Folia Parasitol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1286-4579(03)00096-0","article-title":"Inducible nitric oxide synthase and control of intracellular bacterial pathogens","volume":"5","author":"D Chakravortty","year":"2003","journal-title":"Microbes Infect"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,2]],"date-time":"2023-07-02T22:24:20Z","timestamp":1688336660000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066115"}},"subtitle":[],"editor":[{"given":"Laurent","family":"R\u00e9nia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066115","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}