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(2012) Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations. Mult Scler <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1177\/1352458512457844\" xlink:type=\"simple\">10.1177\/1352458512457844<\/ext-link><\/comment>","DOI":"10.1177\/1352458512457844"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1212\/WNL.0b013e318200d80c","article-title":"Absence of cortical demyelination in neuromyelitis optica","volume":"75","author":"BF Popescu","year":"2010","journal-title":"Neurology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1212\/WNL.0b013e3182648bc8","article-title":"Distinct lesion morphology at T-7 MRI differentiates neuromyelitis optica frommultiple sclerosis","volume":"79","author":"T Sinnecker","year":"2012","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Kister I, Herbert J, Zhou Y, Ge Y (2013) Ultrahigh-Field MR (7 T) Imaging of Brain Lesions in Neuromyelitis Optica. Mult Scler Int <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1155\/2013\/398259\" xlink:type=\"simple\">10.1155\/2013\/398259<\/ext-link><\/comment>","DOI":"10.1155\/2013\/398259"},{"key":"ref40","unstructured":"Ungerleider LG, Mishkin M (1982) Two cortical visual systems. In: Ingle DJ, Goodale MA, Mansfield RJW, editors. Analysis of Visual Behavior. Cambridge, MA: MIT Press. 549\u2013586."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/brain\/124.9.1813","article-title":"Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis","volume":"124","author":"N Evangelou","year":"2001","journal-title":"Brain"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/brain\/awp001","article-title":"Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography","volume":"132","author":"P Jindahra","year":"2009","journal-title":"Brain"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Pfueller CF, Paul F (2011) Imaging the Visual Pathway in Neuromyelitis Optica. Mult Scler Int <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1155\/2011\/869814\" xlink:type=\"simple\">10.1155\/2011\/869814<\/ext-link><\/comment>","DOI":"10.1155\/2011\/869814"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e18019","DOI":"10.1371\/journal.pone.0018019","article-title":"Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis","volume":"(4)","author":"CF Pfueller","year":"2011","journal-title":"PLoS ONE 6"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e50230","DOI":"10.1371\/journal.pone.0050230","article-title":"Secondary Post-Geniculate Involvement in Leber\u2019s Hereditary Optic Neuropathy","volume":"(11)","author":"G Rizzo","year":"2012","journal-title":"PLoS ONE 7"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis optica (Devic&apos;s syndrome)","volume":"53","author":"DM Wingerchuk","year":"1999","journal-title":"Neurology"},{"key":"ref47","first-page":"7","article-title":"Vascular pathology in multiple sclerosis: mind boosting or myth busting? 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