{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T07:43:50Z","timestamp":1781855030862,"version":"3.54.5"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066476","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T19:32:06Z","timestamp":1371583926000},"page":"e66476","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":82,"title":["The Composition of Microbiome in Larynx and the Throat Biodiversity between Laryngeal Squamous Cell Carcinoma Patients and Control Population"],"prefix":"10.1371","volume":"8","author":[{"given":"Hong-Li","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Yu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Sheng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Zhu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature11553","article-title":"Genomic approaches to studying the human microbiota","volume":"489","author":"GM Weinstock","year":"2012","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"CA Lozupone","year":"2012","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1111\/j.1753-4887.2012.00493.x","article-title":"Defining the human microbiome","volume":"70","author":"LK Ursell","year":"2012","journal-title":"Nutr Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature06245","article-title":"An ecological and evolutionary perspective on human-microbe mutualism and disease","volume":"449","author":"L Dethlefsen","year":"2007","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1101\/gr.096651.109","article-title":"The NIH Human Microbiome Project","volume":"19","author":"J Peterson","year":"2009","journal-title":"Genome Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1111\/j.1753-4887.2012.00497.x","article-title":"Summary of the 24(th) Marabou Symposium: Nutrition and the human microbiome","volume":"70","author":"WP James","year":"2012","journal-title":"Nutr Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrmicro1720","article-title":"Say hello to our little friends","volume":"5","author":"A Walker","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e34242","DOI":"10.1371\/journal.pone.0034242","article-title":"A Core Human Microbiome as Viewed through 16S rRNA Sequence Clusters","volume":"7","author":"SM Huse","year":"2012","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2165\/00002512-200421040-00003","article-title":"Acute cough in the elderly: aetiology, diagnosis and therapy","volume":"21","author":"J Widdicombe","year":"2004","journal-title":"Drugs Aging"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"13769","DOI":"10.1073\/pnas.1107435109","article-title":"Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota","volume":"109","author":"AF Goddard","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1126\/science.1224203","article-title":"The application of ecological theory toward an understanding of the human microbiome","volume":"336","author":"EK Costello","year":"2012","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global Cancer Statistics, 2002","volume":"55","author":"DM Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00405-010-1395-8","article-title":"Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis","volume":"268","author":"E Rudolph","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s12094-012-0879-y","article-title":"Helicobacter pylori infection of the larynx may be an emerging risk factor for laryngeal squamous cell carcinoma","volume":"14","author":"H Gong","year":"2012","journal-title":"Clin Transl Oncol"},{"key":"ref15","unstructured":"Marur S, D\u2019Souza G, Westra WH, Forastiere AA (2010) HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol 11: <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1016\/S1470-2045(1010)70017-70016\" xlink:type=\"simple\">10.1016\/S1470-2045(1010)70017-70016<\/ext-link>. Epub 72010 May 70015<\/comment>"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.arcmed.2008.04.008","article-title":"Possible association of Helicobacter pylori infection with laryngeal cancer risk: an evidence-based meta-analysis","volume":"39","author":"XL Zhuo","year":"2008","journal-title":"Arch Med Res"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Sobin LH, Wittekind CH (2002) International Union Against Cancer (UICC): TNM classification of malignant tumors: Wiley.","DOI":"10.1002\/0471463752"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF00300234","article-title":"Determination of subcutaneous tumor size in athymic (nude) mice","volume":"24","author":"MM Tomayko","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nmeth.1361","article-title":"Accurate determination of microbial diversity from 454 pyrosequencing data","volume":"6","author":"C Quince","year":"2009","journal-title":"Nat Methods"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"PD Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"D141","DOI":"10.1093\/nar\/gkn879","article-title":"The Ribosomal Database Project: improved alignments and new tools for rRNA analysis","volume":"37","author":"JR Cole","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.1011383107","article-title":"Human oral, gut, and plaque microbiota in patients with atherosclerosis","volume":"108","author":"O Koren","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e17035","DOI":"10.1371\/journal.pone.0017035","article-title":"Variability and diversity of nasopharyngeal microbiota in children: a metagenomic analysis","volume":"6","author":"D Bogaert","year":"2011","journal-title":"Plos one"},{"key":"ref25","unstructured":"Yamanaka W, Takeshita T, Shibata Y, Matsuo K, Eshima N, <etal>et al<\/etal>.. (2012) Compositional Stability of a Salivary Bacterial Population against Supragingival Microbiota Shift following Periodontal Therapy. PLoS One 7: <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0042806\" xlink:type=\"simple\">10.1371\/journal.pone.0042806<\/ext-link>. Epub 0042012 Aug 0042816<\/comment>"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Lemon KP, Klepac-Ceraj V, Schiffer HK, Brodie EL, Lynch SV, <etal>et al<\/etal>.. (2010) Comparative analyses of the bacterial microbiota of the human nostril and oropharynx. MBio 1.","DOI":"10.1128\/mBio.00129-10"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e47305","DOI":"10.1371\/journal.pone.0047305","article-title":"The lung microbiome in moderate and severe chronic obstructive pulmonary disease","volume":"7","author":"AA Pragman","year":"2012","journal-title":"Plos one"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1462-2920.2009.02051.x","article-title":"Wrinkles in the rare biosphere: pyrosequencing errors can lead to artificial inflation of diversity estimates","volume":"12","author":"V Kunin","year":"2010","journal-title":"Environ Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/ni.2403","article-title":"Lymphotoxin regulates commensal responses to enable diet-induced obesity","volume":"13","author":"V Upadhyay","year":"2012","journal-title":"Nat Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e53115","DOI":"10.1371\/journal.pone.0053115","article-title":"Pyrosequencing the canine faecal microbiota: breadth and depth of biodiversity","volume":"8","author":"D Hand","year":"2013","journal-title":"Plos one"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/nature11228","article-title":"ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation","volume":"487","author":"T Hashimoto","year":"2012","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e42806","DOI":"10.1371\/journal.pone.0042806","article-title":"Compositional stability of a salivary bacterial population against supragingival microbiota shift following periodontal therapy","volume":"7","author":"W Yamanaka","year":"2012","journal-title":"Plos one"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1073\/pnas.1011383107","article-title":"Human oral, gut, and plaque microbiota in patients with atherosclerosis","volume":"108","author":"O Koren","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e23352","DOI":"10.1371\/journal.pone.0023352","article-title":"High diversity of the saliva microbiome in Batwa Pygmies","volume":"6","author":"I Nasidze","year":"2011","journal-title":"Plos one"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/0022034510370026","article-title":"Analyzing endodontic infections by deep coverage pyrosequencing","volume":"89","author":"L Li","year":"2010","journal-title":"J Dent Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e28088","DOI":"10.1371\/journal.pone.0028088","article-title":"Comparing the bacterial diversity of acute and chronic dental root canal infections","volume":"6","author":"AL Santos","year":"2011","journal-title":"Plos one"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.joen.2008.08.037","article-title":"Profiling of root canal bacterial communities associated with chronic apical periodontitis from Brazilian and Norwegian subjects","volume":"34","author":"JF Siqueira Jr","year":"2008","journal-title":"J Endod"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e1000255","DOI":"10.1371\/journal.pgen.1000255","article-title":"Exploring microbial diversity and taxonomy using SSU rRNA hypervariable tag sequencing","volume":"4","author":"SM Huse","year":"2008","journal-title":"PLoS Genet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"12115","DOI":"10.1073\/pnas.0605127103","article-title":"Microbial diversity in the deep sea and the underexplored \u201crare biosphere\u201d","volume":"103","author":"ML Sogin","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2180-9-259","article-title":"Defining the healthy \u201ccore microbiome\u201d of oral microbial communities","volume":"9","author":"E Zaura","year":"2009","journal-title":"BMC Microbiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature10213","article-title":"Human nutrition, the gut microbiome and the immune system","volume":"474","author":"AL Kau","year":"2011","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1111\/j.1753-4887.2012.00498.x","article-title":"Microbiome and immunological interactions","volume":"70","author":"D Kelly","year":"2012","journal-title":"Nutr Rev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1224820","article-title":"Intestinal inflammation targets cancer-inducing activity of the microbiota","volume":"338","author":"JC Arthur","year":"2012","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrmicro2878","article-title":"Bacterial pathogenesis: E. coli claims the driving seat for cancer","volume":"10","author":"CT Kahrstrom","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2559.2008.03111.x","article-title":"Current review on squamous intraepithelial lesions of the larynx","volume":"54","author":"N Gale","year":"2009","journal-title":"Histopathology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1126\/science.1206095","article-title":"The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota","volume":"332","author":"JL Round","year":"2011","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cyto.2011.12.016","article-title":"Oral microbial biofilm stimulation of epithelial cell responses","volume":"58","author":"R Peyyala","year":"2012","journal-title":"Cytokine"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Peyyala R, Kirakodu SS, Novak KF, Ebersole JL (2013) Oral Epithelial Cell Responses to Multispecies Microbial Biofilms. J Dent Res.","DOI":"10.1177\/0022034512472508"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2180-12-211","article-title":"Proteomics of Streptococcus gordonii within a model developing oral microbial community","volume":"12","author":"EL Hendrickson","year":"2012","journal-title":"BMC Microbiol"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"El-Sharif A, Elkhatib WF, Ashour HM (2012) Nosocomial infections in leukemic and solid-tumor cancer patients: distribution, outcome and microbial spectrum of anaerobes. Future Microbiol Dec: 1423\u20131429.","DOI":"10.2217\/fmb.12.125"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.mehy.2013.01.024","article-title":"Efficient tumor targeting by anaerobic butyrate-producing bacteria","volume":"80","author":"H Tirandaz","year":"2013","journal-title":"Med Hypotheses"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T17:08:54Z","timestamp":1563210534000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066476"}},"subtitle":[],"editor":[{"given":"Michael R.","family":"Emmert-Buck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,18]]},"references-count":51,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066476","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,18]]}}}