{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:40:28Z","timestamp":1784900428736,"version":"3.55.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066616","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T21:22:56Z","timestamp":1372454576000},"page":"e66616","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Tamoxifen and Ovarian Function"],"prefix":"10.1371","volume":"8","author":[{"given":"Martine","family":"Berliere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois P.","family":"Duhoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Dalenc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Baurain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Dellevigne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Galant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Van Maanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Piette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pascal","family":"Machiels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"ref1","first-page":"1026","article-title":"Endocrine status of premenopausal node negative breast cancer patients following adjuvant chemotherapy and long-term tamoxifen","volume":"48","author":"PM Rafdim","year":"1988","journal-title":"Cancer Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1200\/JCO.2005.11.050","article-title":"Adjuvant endocrine therapy for premenopausal women with early breast cancer","volume":"(8)","author":"S Dellapasqua","year":"2005","journal-title":"J Clin Oncol; 23"},{"key":"ref3","first-page":"1045","article-title":"Adjuvant endocrine therapy in premenopausal women with breast cancer. Breast Cancer Res. Treat","volume":"10","author":"A Gonzalez Martin","year":"2010"},{"key":"ref4","first-page":"71","article-title":"Systematic treatment of early breast cancer by hormonal, cytotoxic or immune therapy: 133 randomized trials involving 31,000 recurrences and 24,000 deaths among 75,000 women","volume":"339(1)","year":"1992","journal-title":"Lancet"},{"key":"ref5","first-page":"1687","article-title":"Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials","volume":"365(9472)","year":"2005","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1200\/JCO.2005.03.0783","article-title":"Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node positive breast cancer: international breast cancer study group trial 13\u201393","volume":"24","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Ortman O, Pagani O, Jones A, Mass N, Noss D, <etal>et al<\/etal>. (2011) Which factors should be taken into account in perimenopausal women with early breast cancer who may become eligible for an aromatase inhibitor? Recommendations of an expert panel. Cancer Treatment Reviews; 97\u2013104.","DOI":"10.1016\/j.ctrv.2010.05.005"},{"key":"ref8","unstructured":"Guidelines of the NCCN (2011) Definition of menopause. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nccn.org\/professionnels\/physicians\/pdf\/breast.pdf\" xlink:type=\"simple\">http:\/\/www.nccn.org\/professionnels\/physicians\/pdf\/breast.pdf<\/ext-link>."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/dmm020","article-title":"A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women&apos;s Midlife Health Project","volume":"13","author":"HG Burger","year":"2007","journal-title":"Hum Reprod Update"},{"key":"ref10","first-page":"1711","article-title":"Use of luteinising-hormone-releasing hormone agonists as adjuvant treatment in premenopausal patients with hormone-receptor-positive breast cancer: a meta-analysis of individual patient data from randomised adjuvant trials","volume":"369(9574)","author":"J Cuzick","year":"2007","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1200\/JCO.2006.07.2793","article-title":"Amenorrhea in premenopausal women for breast cancer","volume":"24","author":"JM Walshe","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Ganz PA, Land SR, Geyer CE, Cecchini RS, Costantino JP, <etal>et al<\/etal>.. (2011) Menstrual history and quality of life outcomes in women with node positive breast cancer treated with adjuvant therapy on the NSABP B-30 trial. J Clin Oncol (jco.ascopubs.org\/content\/29\/9\/1110.long).","DOI":"10.1200\/JCO.2010.29.7689"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1200\/JCO.2005.03.3969","article-title":"Incidence, time course and determinants of menstrual bleeding after breast cancer treatment: a prospective study","volume":"24","author":"JA Petrek","year":"2006","journal-title":"J Clin Oncol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1056\/NEJM200106283442607","article-title":"Side effect of adjuvant treatment of breast cancer","volume":"344","author":"CL Shapiro","year":"2001","journal-title":"New Engl J Med"},{"key":"ref15","first-page":"779","article-title":"Antiestrogen induced remissions in premenopausal women with stage IV breast cancer: effects on ovarian function","volume":"64","author":"A Manni","year":"1980","journal-title":"Cancer Treat Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1093\/jnci\/83.20.1488","article-title":"Alteration of endocrine parameters in premenopausal women with breast cancer during long-term adjuvant therapy with tamoxifen as the single-agent","volume":"83","author":"VC Jordan","year":"1991","journal-title":"J Natl Cancer in Inst"},{"key":"ref17","first-page":"624","article-title":"Endocrine effects of adjuvant chemotherapy and long-term tamoxifen administration on node-positive patients with breast cancer","volume":"47","author":"VC Jordan","year":"1987","journal-title":"Cancer Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1200\/JCO.2007.11.1633","article-title":"Beware of amenorrhea during tamoxifen: it may be a wolf in sheep&apos;s clothing","volume":"25","author":"MJ Mourits","year":"2007","journal-title":"J Clin Oncol"},{"key":"ref19","unstructured":"Speroff L, Glass RH, Kase NG (1999) Clinical gynaecologic endocrinology and infertility. Ed. Philadelphia PA, Lippincott, Williams and Wilkins."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1093\/humrep\/deg473","article-title":"Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by an anti-M\u00fcllerian hormone, inhibin-B and ovarian ultrasound","volume":"18","author":"LE Bath","year":"2003","journal-title":"Hum Reprod"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/cncr.24746","article-title":"Anti-mullerian hormone and inhibin B are hormone measures of ovarian function in late reproductive-aged breast cancer survivors","volume":"116(3)","author":"HI Su","year":"2010","journal-title":"Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00432-010-0894-8","article-title":"Recovery of menstruation after long-term chemotherapy and endocrine therapy in pre-menopausal patients with breast cancer","volume":"137(4)","author":"K Sakurai","year":"2011","journal-title":"J Cancer Res Chim Oncol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/clpt.2010.196","article-title":"Endoxifen, a new cornerstone of breast cancer therapy: demonstration of safety, tolerability, and systemic bioavailability in healthy human subjects","volume":"(6)","author":"A Ahmad","year":"2010","journal-title":"Clin Pharmacol Ther; 86"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.1200\/JCO.2005.03.3266","article-title":"Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flushes","volume":"23","author":"MP Geutz","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref25","first-page":"111","article-title":"Tamoxifen, cytochrome P450 genes and breast cancer clinical outocomes","volume":"20(2)","author":"MS Singh","year":"2005","journal-title":"Breast"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2217\/14622416.8.1.1","article-title":"Role of CYP2D6 testing in selection of endocrine therapy for breast cancer","volume":"8","author":"J Stebbing","year":"2007","journal-title":"Pharmacogenomics"}],"updated-by":[{"DOI":"10.1371\/annotation\/b6747d3d-f41b-4421-abd8-f32def535dde","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,10,10]],"date-time":"2013-10-10T00:00:00Z","timestamp":1381363200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T18:25:46Z","timestamp":1563301546000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066616"}},"subtitle":[],"editor":[{"given":"Salomon M.","family":"Stemmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066616","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/b6747d3d-f41b-4421-abd8-f32def535dde","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}