{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:23:54Z","timestamp":1790256234378,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066649","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T23:01:29Z","timestamp":1371769289000},"page":"e66649","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ocular Injury by Transient Formaldehyde Exposure in a Rabbit Eye Model"],"prefix":"10.1371","volume":"8","author":[{"given":"Li-Ju","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Hsiu","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June H.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/10590501.2011.629972","article-title":"Exposure to formaldehyde and its potential human health hazards","volume":"29","author":"KH Kim","year":"2011","journal-title":"J Environ Sci & Health Part C Environ Carcinogenesis & Ecotoxical Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.chemosphere.2012.03.029","article-title":"Formaldehyde personal exposure measurement and time weighted exposure estimates in children","volume":"88","author":"V Lazenby","year":"2012","journal-title":"Chemosphere"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1080\/15287394.2011.582293","article-title":"Occupational exposure to formaldehyde: genotoxic risk evaluation by comet assay and micronucleus test using human peripheral lympocytes","volume":"74","author":"S Costa","year":"2011","journal-title":"J Toxicol & Environ Health Part A"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/oem.2010.059352","article-title":"Anatomy laboratory instruction and occupational exposure to formaldehyde","volume":"68","author":"MC Mirabelli","year":"2011","journal-title":"Occupat & Environ Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1539-6924.2011.01640.x","article-title":"Validation of novel air toxic risk model with air monitoring","volume":"32","author":"GC Pratt","year":"2012","journal-title":"J Risk Analy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mrrev.2011.07.003","article-title":"Reproductive and developmental toxicity of formaldehyde: a systematic review","volume":"728","author":"A Duong","year":"2011","journal-title":"Mut Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/em.20534","article-title":"Formaldehyde and leukemia: epidemiology, potential mechanisms, and implication for risk assessment","volume":"51","author":"L Zhang","year":"2010","journal-title":"Environ & Mol Mutag"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2131\/jts.35.721","article-title":"Early changes to oxidative stress levels following exposure to formaldehyde in ICR mice","volume":"35","author":"T Matsuoka","year":"2010","journal-title":"J Toxicol Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1440-1681.2011.05485.x","article-title":"Formaldehyde induces neurotoxicity to PC12 cells involving inhibition of paraoxonase-1 expression and activity","volume":"38","author":"XQ Tang","year":"2011","journal-title":"Clin & Exp Pharmacol & Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/109158101750300955","article-title":"Final report on the safety assessment of methyl alcohol","volume":"20","author":"S Lanigan","year":"2001","journal-title":"Internat J Toxicol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/019262301317052468","article-title":"Pathology of ocular irritation with acetone, cyclohexanol, parafluoroaniline, and formaldehyde in the rabbit low-volume eye test","volume":"29","author":"JK Maurer","year":"2001","journal-title":"Toxicol Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0887-2333(00)00065-5","article-title":"Extent of initial corneal injury as a basis for alternative eye irritation tests","volume":"15","author":"JV Jester","year":"2001","journal-title":"Toxicol in Vitro"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0022-1759(86)90183-3","article-title":"An improved colorimetric assay for interleukin 2","volume":"93","author":"H Tada","year":"1986","journal-title":"J Imm Methods"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1001\/archopht.121.10.1364","article-title":"Evaluation of the clinical course of dry eye syndrome","volume":"121","author":"J Horwath-Winter","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"23337","DOI":"10.1074\/jbc.M700194200","article-title":"Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition","volume":"282","author":"M Zeisberg","year":"2007","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"M Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0002-9440(10)62983-5","article-title":"Intrastromal invasion by limbal epithelial cells is mediated by epithelial-mesenchymal transition activated by air exposure","volume":"167","author":"T Kawakita","year":"2005","journal-title":"Am J Pathol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1001\/archopht.125.10.1337","article-title":"Phenotypic study after cultivated limbal epithelial transplantation for limbal stem cell deficiency","volume":"125","author":"M Kawashima","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00055735-200208000-00004","article-title":"Ocular surface reconstruction update","volume":"13","author":"S Shimmura","year":"2002","journal-title":"Curr Opin Ophthalmol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0012-1606(91)90300-R","article-title":"Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodeling cornea","volume":"147","author":"M Matsubara","year":"1991","journal-title":"Dev Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.preteyeres.2007.12.002","article-title":"Fibrotic disorders in the eye: targets of gene therapy","volume":"27","author":"S Saika","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0378-4274(98)00379-8","article-title":"Effect of environmental pollutants on the production of pro-inflammatory cytokines by normal human dermal keratinocytes","volume":"105","author":"H Ushio","year":"1999","journal-title":"Toxicol Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0092-8674(95)90401-8","article-title":"Specificity of receptor tyrosine kinase signaling: transient <italic>versus<\/italic> sustained extracellular signal-regulated kinase activation","volume":"80","author":"CJ Marshall","year":"1995","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"19067","DOI":"10.1016\/S0021-9258(17)32275-5","article-title":"Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by Raf and MEK kinase","volume":"269","author":"M Yan","year":"1994","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/372798a0","article-title":"Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1","volume":"372","author":"M Yan","year":"1994","journal-title":"Nature"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1126\/science.275.5296.90","article-title":"Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways","volume":"275","author":"H Ichijo","year":"1997","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1074\/jbc.272.24.15167","article-title":"MST\/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase\/stress activated protein kinase","volume":"272","author":"SI Hirai","year":"1997","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1093\/emboj\/16.23.7045","article-title":"A novel SAPK\/JNK kinase, MKK7, stimulated by TNF-\u03b1 and cellular stresses","volume":"16","author":"T Moriguchi","year":"1997","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"31929","DOI":"10.1074\/jbc.271.50.31929","article-title":"The role of c-Jun N-terminal kinase in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation","volume":"271","author":"YR Chen","year":"1996","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/S0960-9822(02)00547-X","article-title":"The stress-activated protein kinase pathway mediates cell death following injury induced by <italic>cis<\/italic>-platinum, UV irradiation or heat","volume":"6","author":"BW Zanke","year":"1996","journal-title":"Curr Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1167\/iovs.06-1007","article-title":"Pathway-specific effect of caffeine on protection against UV irradiation - induced apoptosis in corneal epithelial cells","volume":"48","author":"L Wang","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1167\/iovs.03-0591","article-title":"UV-induced signaling pathways associated with corneal epithelial cell apoptosis","volume":"44","author":"L Lu","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1038\/sj.onc.1208547","article-title":"Ultraviolet irradiation-induced K(+) channel activity involving p53 activation in corneal epithelial cells","volume":"24","author":"L Wang","year":"2005","journal-title":"Oncogene"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T18:33:36Z","timestamp":1715538816000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066649"}},"subtitle":[],"editor":[{"given":"Demetrios","family":"Vavvas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066649","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]}}}