{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T11:05:20Z","timestamp":1756897520195},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066685","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T21:14:21Z","timestamp":1372108461000},"page":"e66685","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Mutational Analysis of Hedgehog Signaling Pathway Genes in Human Malignant Mesothelioma"],"prefix":"10.1371","volume":"8","author":[{"given":"Chuan Bian","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia M.","family":"Pr\u00eale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui Min","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuen Yee","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Klebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glen","family":"Reid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Neil","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Baltic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven E.","family":"Mutsaers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Robinson BWS, Chahinian AP (2002) Mesothelioma. London: M. Dunitz. xiii, 366 p.","DOI":"10.3109\/9780203994474"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s10552-009-9328-9","article-title":"Pleural and peritoneal mesotheliomas in SEER: age effects and temporal trends, 1973\u20132005","volume":"20","author":"SH Moolgavkar","year":"2009","journal-title":"Cancer Causes Control"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/aje\/kwh025","article-title":"Mesothelioma trends in the United States: an update based on Surveillance, Epidemiology, and End Results Program data for 1973 through 2003","volume":"159","author":"B Price","year":"2004","journal-title":"Am J Epidemiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.lungcan.2004.04.010","article-title":"Epidemiology of malignant mesothelioma in Australia","volume":"45","author":"AW Musk","year":"2004","journal-title":"Lung Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/sj.bjc.6690105","article-title":"The European mesothelioma epidemic","volume":"79","author":"J Peto","year":"1999","journal-title":"Br J Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1183\/09031936.00000811","article-title":"Predicting survival in malignant mesothelioma","volume":"38","author":"AW Musk","year":"2011","journal-title":"Eur Respir J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/cncr.22552","article-title":"Update on the molecular biology of malignant mesothelioma","volume":"109","author":"AY Lee","year":"2007","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1101\/gad.938601","article-title":"Hedgehog signaling in animal development: paradigms and principles","volume":"15","author":"P Ingham","year":"2001","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.devcel.2008.11.010","article-title":"Hedgehog signaling in development and cancer","volume":"15","author":"J Jiang","year":"2008","journal-title":"Dev Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1101\/gad.1693608","article-title":"Hedgehog: functions and mechanisms","volume":"22","author":"M Varjosalo","year":"2008","journal-title":"Genes Dev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/onc.2009.392","article-title":"Activation of the hedgehog-signaling pathway in human cancer and the clinical implications","volume":"29","author":"L Yang","year":"2010","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"13630","DOI":"10.1073\/pnas.95.23.13630","article-title":"Characterization of two patched receptors for the vertebrate hedgehog protein family","volume":"95","author":"D Carpenter","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nature00989","article-title":"Patched acts catalytically to suppress the activity of Smoothened","volume":"418","author":"J Taipale","year":"2002","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1101\/gad.1902910","article-title":"The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins","volume":"24","author":"EW Humke","year":"2010","journal-title":"Genes Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/13031","article-title":"Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1","volume":"1","author":"P Kogerman","year":"1999","journal-title":"Nature cell biology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/35010610","article-title":"Gli regulation by the opposing activities of fused and suppressor of fused","volume":"2","author":"M Murone","year":"2000","journal-title":"Nature cell biology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/17611","article-title":"Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein","volume":"397","author":"PT Chuang","year":"1999","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.devcel.2005.12.014","article-title":"Divergence of hedgehog signal transduction mechanism between Drosophila and mammals","volume":"10","author":"M Varjosalo","year":"2006","journal-title":"Dev Cell"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"ra29","DOI":"10.1126\/scisignal.2000405","article-title":"The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling","volume":"2","author":"HO Cheung","year":"2009","journal-title":"Sci Signal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.4161\/cbt.4.10.2184","article-title":"Hedgehog signaling pathway and gastric cancer","volume":"4","author":"Y Katoh","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0092-8674(00)81268-4","article-title":"Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome","volume":"85","author":"H Hahn","year":"1996","journal-title":"Cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.272.5268.1668","article-title":"Human homolog of patched, a candidate gene for the basal cell nevus syndrome","volume":"272","author":"RL Johnson","year":"1996","journal-title":"Science"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng0996-78","article-title":"The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas","volume":"14","author":"MR Gailani","year":"1996","journal-title":"Nature genetics"},{"key":"ref24","first-page":"2369","article-title":"Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors","volume":"57","author":"J Xie","year":"1997","journal-title":"Cancer research"},{"key":"ref25","first-page":"4677","article-title":"Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis","volume":"57","author":"I Vorechovsky","year":"1997","journal-title":"Cancer research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/(SICI)1098-2264(199803)21:3<276::AID-GCC15>3.0.CO;2-N","article-title":"Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma","volume":"21","author":"C Maesawa","year":"1998","journal-title":"Genes, chromosomes & cancer"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1046\/j.1523-1747.2001.01301.x","article-title":"PTCH mutations in squamous cell carcinoma of the skin","volume":"116","author":"XL Ping","year":"2001","journal-title":"The Journal of investigative dermatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/sj.onc.1202045","article-title":"PTCH gene mutations in invasive transitional cell carcinoma of the bladder","volume":"17","author":"TW McGarvey","year":"1998","journal-title":"Oncogene"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1177\/00220345000790061101","article-title":"PTCH gene mutations in odontogenic keratocysts","volume":"79","author":"DC Barreto","year":"2000","journal-title":"Journal of dental research"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/154405910808700616","article-title":"PTCH1 and SMO gene alterations in keratocystic odontogenic tumors","volume":"87","author":"LS Sun","year":"2008","journal-title":"Journal of dental research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000093054","article-title":"Germline mutations of the PTCH gene in families with odontogenic keratocysts and nevoid basal cell carcinoma syndrome","volume":"27","author":"YL Song","year":"2006","journal-title":"Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1290\/1071-2690(2001)037<0459:MITHHO>2.0.CO;2","article-title":"Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines","volume":"37","author":"E Michimukai","year":"2001","journal-title":"In vitro cellular & developmental biology Animal"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2133.2005.06353.x","article-title":"Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas","volume":"152","author":"J Reifenberger","year":"2005","journal-title":"The British journal of dermatology"},{"key":"ref34","first-page":"1798","article-title":"Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system","volume":"58","author":"J Reifenberger","year":"1998","journal-title":"Cancer research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.onc.1202360","article-title":"A frequent activated smoothened mutation in sporadic basal cell carcinomas","volume":"18","author":"CW Lam","year":"1999","journal-title":"Oncogene"},{"key":"ref36","first-page":"7186","article-title":"Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients","volume":"62","author":"S Couve-Privat","year":"2002","journal-title":"Cancer research"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/34201","article-title":"Activating Smoothened mutations in sporadic basal-cell carcinoma","volume":"391","author":"J Xie","year":"1998","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/hmg\/8.2.291","article-title":"Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32","volume":"8","author":"I Smyth","year":"1999","journal-title":"Human molecular genetics"},{"key":"ref39","first-page":"787","article-title":"PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas","volume":"59","author":"PG Zaphiropoulos","year":"1999","journal-title":"Cancer research"},{"key":"ref40","first-page":"5428","article-title":"A molecular fingerprint for medulloblastoma","volume":"63","author":"Y Lee","year":"2003","journal-title":"Cancer research"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1158\/0008-5472.CAN-06-0505","article-title":"Patched2 modulates tumorigenesis in patched1 heterozygous mice","volume":"66","author":"Y Lee","year":"2006","journal-title":"Cancer research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng916","article-title":"Mutations in SUFU predispose to medulloblastoma","volume":"31","author":"MD Taylor","year":"2002","journal-title":"Nature genetics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1126\/science.276.5313.817","article-title":"Basal cell carcinomas in mice overexpressing sonic hedgehog","volume":"276","author":"AE Oro","year":"1997","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"R McLendon","year":"2008","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature09208","article-title":"Diverse somatic mutation patterns and pathway alterations in human cancers","volume":"466","author":"Z Kan","year":"2010","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ijc.2910470219","article-title":"Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions","volume":"47","author":"LS Manning","year":"1991","journal-title":"Int J Cancer"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1158\/1078-0432.CCR-06-1027","article-title":"A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions","volume":"12","author":"AJ Holloway","year":"2006","journal-title":"Clin Cancer Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/PAT.0b013e328342016c","article-title":"Validation of tissue microarray technology in malignant pleural mesothelioma","volume":"43","author":"SC Kao","year":"2011","journal-title":"Pathology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1126\/science.1164368","article-title":"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses","volume":"321","author":"S Jones","year":"2008","journal-title":"Science"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/ng.826","article-title":"Putoux A, Thomas S, Coene KL, Davis EE, Alanay Y, et al. KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes","volume":"43","journal-title":"Nat Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1126\/science.1133427","article-title":"The consensus coding sequences of human breast and colorectal cancers","volume":"314","author":"T Sjoblom","year":"2006","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1093\/nar\/gkg509","article-title":"SIFT: Predicting amino acid changes that affect protein function","volume":"31","author":"PC Ng","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"IA Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1158\/1078-0432.CCR-12-0599","article-title":"Role of hedgehog signaling in malignant pleural mesothelioma","volume":"18","author":"Y Shi","year":"2012","journal-title":"Clin Cancer Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e57346","DOI":"10.1371\/journal.pone.0057346","article-title":"Gli as a novel therapeutic target in malignant pleural mesothelioma","volume":"8","author":"H Li","year":"2013","journal-title":"PloS one"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"e54415","DOI":"10.1371\/journal.pone.0054415","article-title":"Mutations in the hedgehog pathway genes SMO and PTCH1 in human gastric tumors","volume":"8","author":"XD Wang","year":"2013","journal-title":"PloS one"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tips.2009.03.007","article-title":"Mechanisms of Hedgehog pathway activation in cancer and implications for therapy","volume":"30","author":"SJ Scales","year":"2009","journal-title":"Trends in Pharmacological Sciences"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/gcc.21935","article-title":"Somatic mutations in the Notch, NF-KB, PIK3CA, and Hedgehog pathways in human breast cancers","volume":"51","author":"X Jiao","year":"2012","journal-title":"Genes, chromosomes & cancer"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/humu.20296","article-title":"PTCH mutations: distribution and analyses","volume":"27","author":"E Lindstrom","year":"2006","journal-title":"Human mutation"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.7985023","article-title":"Autoproteolysis in hedgehog protein biogenesis","volume":"266","author":"J Lee","year":"1994","journal-title":"Science"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1101\/gad.1461306","article-title":"The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover","volume":"20","author":"X Lu","year":"2006","journal-title":"Genes Dev"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1097-2765(00)00045-9","article-title":"In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration","volume":"6","author":"RL Johnson","year":"2000","journal-title":"Mol Cell"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/384176a0","article-title":"Biochemical evidence that patched is the Hedgehog receptor","volume":"384","author":"V Marigo","year":"1996","journal-title":"Nature"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"e18638","DOI":"10.1371\/journal.pone.0018638","article-title":"A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1","volume":"6","author":"H Kagawa","year":"2011","journal-title":"PLoS One"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijom.2004.01.013","article-title":"PTC gene mutations and expression of SHH, PTC, SMO and GLI-1 in odontogenic keratocysts","volume":"33","author":"K Ohki","year":"2004","journal-title":"International Journal of Oral and Maxillofacial Surgery"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.humpath.2007.02.015","article-title":"PTCH mutations are not mainly involved in the pathogenesis of sporadic trichoblastomas","volume":"38","author":"C Hafner","year":"2007","journal-title":"Hum Pathol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/1098-1004(200007)16:1<43::AID-HUMU8>3.0.CO;2-7","article-title":"The spectrum of patched mutations in a collection of Australian basal cell carcinomas","volume":"16","author":"T Evans","year":"2000","journal-title":"Human mutation"},{"key":"ref68","first-page":"2581","article-title":"Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system","volume":"57","author":"M Wolter","year":"1997","journal-title":"Cancer Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1365-2133.2005.06464.x","article-title":"PTCH codon 1315 polymorphism and risk for nonmelanoma skin cancer","volume":"152","author":"A Asplund","year":"2005","journal-title":"Br J Dermatol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/ijc.10889","article-title":"The patched polymorphism Pro1315Leu (C3944T) may modulate the association between use of oral contraceptives and breast cancer risk","volume":"103","author":"J Chang-Claude","year":"2003","journal-title":"Int J Cancer"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/sj.jid.5700263","article-title":"MC1R and PTCH gene polymorphism in French patients with basal cell carcinomas","volume":"126","author":"M Liboutet","year":"2006","journal-title":"J Invest Dermatol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1242\/jcs.112.23.4437","article-title":"Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli","volume":"23)","author":"DM Stone","year":"1999","journal-title":"J Cell Sci 112 (Pt"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ng916","article-title":"Mutations in SUFU predispose to medulloblastoma","volume":"31","author":"MD Taylor","year":"2002","journal-title":"Nat Genet"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10689-010-9411-0","article-title":"Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma","volume":"10","author":"I Slade","year":"2011","journal-title":"Fam Cancer"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"N Cancer Genome Atlas","year":"2012","journal-title":"Nature"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1158\/1940-6207.CAPR-10-0035","article-title":"Genetic variations in the sonic hedgehog pathway affect clinical outcomes in non-muscle-invasive bladder cancer","volume":"3","author":"M Chen","year":"2010","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/carcin\/bgs151","article-title":"Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer","volume":"33","author":"D Li","year":"2012","journal-title":"Carcinogenesis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066685","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T05:46:13Z","timestamp":1645854373000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066685"}},"subtitle":[],"editor":[{"given":"Vladimir N.","family":"Uversky","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":77,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066685","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]}}}