{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:54:19Z","timestamp":1740146059894,"version":"3.37.3"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066770","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T19:26:56Z","timestamp":1371583616000},"page":"e66770","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Expression of SFRP Family Proteins in Human Keratoconus Corneas"],"prefix":"10.1371","volume":"8","author":[{"given":"Jingjing","family":"You","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena","family":"Roufas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele C.","family":"Madigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S0006-3495(03)74646-3","article-title":"Changes in the refractive index of the stroma and its extrafibrillar matrix when the cornea swells","volume":"85","author":"KM Meek","year":"2003","journal-title":"Biophys J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/bies.201200086","article-title":"The limbal epithelium of the eye \u2013 A review of limbal stem cell biology, disease and treatment","volume":"35","author":"C Osei-Bempong","year":"2012","journal-title":"Bioessays"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1442-9071.2009.02009.x","article-title":"2008 Sir Norman McAlister Gregg Lecture: 150 years of practical observations on the conical cornea \u2013 what have we learned?","volume":"37","author":"CNJ McGhee","year":"2009","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","article-title":"Keratoconus","volume":"42","author":"YS Rabinowitz","year":"1998","journal-title":"Surv Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/02713680490502201","article-title":"Microarray analysis identified differentially expressed genes in keratocytes from keratoconus patients","volume":"28","author":"NT Ha","year":"2004","journal-title":"Curr Eye Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1167\/iovs.07-0968","article-title":"Laser scanning in vivo confocal microscopy reveals reduced innervation and reduction in cell density in all layers of the keratoconic cornea","volume":"49","author":"RL Niederer","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1006\/exer.1999.0719","article-title":"Keratocyte apoptosis associated with keratoconus","volume":"69","author":"W-J Kim","year":"1999","journal-title":"Exp Eye Res"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Burdon KP, Vincent AL (2013) Insights into keratoconus from a genetic perspective. Clin Experiment Ophthalmol <comment>DOI: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/cxo.12024\" xlink:type=\"simple\">10.1111\/cxo.12024<\/ext-link><\/comment>","DOI":"10.1111\/cxo.12024"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Balasubramanian SA, Pye DC, Willcox MDP (2013) Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus. Clin Experiment Ophthalmol <comment>DOI: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/cxo.12038\" xlink:type=\"simple\">10.1111\/cxo.12038<\/ext-link><\/comment>","DOI":"10.1111\/cxo.12038"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1442-9071.2009.02216.x","article-title":"Secreted frizzled-related protein 1 (SFRP1) is highly upregulated in keratoconus epithelium: a novel finding highlighting a new potential focus for keratoconus research and treatment","volume":"38","author":"G Sutton","year":"2010","journal-title":"Clin Experiment Ophthalmol"},{"key":"ref11","unstructured":"Iqbal O, Fisher G, Vira S, Syed D, Sadeghi N, et al.. (2013) Increased expression of secreted frizzled-related protein-1 and microtubule-associated protein light chain 3 in keratoconus. Cornea 26 <comment>DOI:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1097\/ICO.1090b1013e318282987a\" xlink:type=\"simple\">10.1097\/ICO.1090b1013e318282987a<\/ext-link><\/comment>"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1242\/jcs.00623","article-title":"Secreted antagonists of the Wnt signalling pathway","volume":"116","author":"Y Kawano","year":"2003","journal-title":"J Cell Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1098\/rstb.2007.2251","article-title":"From individual Wnt pathways towards a Wnt signalling network","volume":"363","author":"HA Kestler","year":"2008","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1016\/j.febslet.2008.09.052","article-title":"Collagen XVIII and corneal reinnervation following keratectomy","volume":"582","author":"T Sakimoto","year":"2008","journal-title":"FEBS Lett"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4161\/org.4.2.5850","article-title":"Wnt signaling in eye organogenesis","volume":"4","author":"S Fuhrmann","year":"2008","journal-title":"Organogenesis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4734","DOI":"10.1167\/iovs.10-6486","article-title":"Wnt\/\u03b2-Catenin signaling regulates proliferation of human cornea epithelial stem\/progenitor cells","volume":"52","author":"MN Nakatsu","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1074\/jbc.M500374200","article-title":"Wnt-7a up-regulates matrix metalloproteinase-12 expression and promotes cell proliferation in corneal epithelial cells during wound healing","volume":"280","author":"J Lyu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.exer.2011.04.003","article-title":"Modulation of the canonical Wnt pathway by Benzalkonium Chloride in corneal epithelium","volume":"93","author":"Y Zhou","year":"2011","journal-title":"Exp Eye Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/stem.794","article-title":"Limbal epithelial stem cells: role of the niche microenvironment","volume":"30","author":"P Ordonez","year":"2012","journal-title":"Stem cells"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"CY Logan","year":"2004","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref21","first-page":"1297","article-title":"Altered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas","volume":"41","author":"SE Jones","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1038\/sj.onc.1204706","article-title":"WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type","volume":"20","author":"F Ugolini","year":"2001","journal-title":"Oncogene"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e54362","DOI":"10.1371\/journal.pone.0054362","article-title":"The Wnt Gatekeeper SFRP4 Modulates EMT, Cell Migration and Downstream Wnt Signalling in Serous Ovarian Cancer Cells","volume":"8","author":"CE Ford","year":"2013","journal-title":"PLoS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1186\/1471-2407-9-224","article-title":"Downregulation of SFRP5 expression and its inverse correlation with those of MMP-7 and MT1-MMP in gastric cancer","volume":"9","author":"C Zhao","year":"2009","journal-title":"BMC Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.ygyno.2008.10.026","article-title":"SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway","volume":"112","author":"M-T Chung","year":"2009","journal-title":"Gynecol Oncol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1158\/0008-5472.CAN-09-1254","article-title":"Functional significance of secreted frizzled-related protein 1 in metastatic renal cell carcinomas","volume":"69","author":"S Saini","year":"2009","journal-title":"Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1158\/0008-5472.CAN-09-3549","article-title":"Role of secreted frizzled-related protein 3 in human renal cell carcinoma","volume":"70","author":"H Hirata","year":"2010","journal-title":"Cancer Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1002\/jcb.20599","article-title":"The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis","volume":"96","author":"PVN Bodine","year":"2005","journal-title":"J Cell Biochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1074\/jbc.M308102200","article-title":"Secreted Frizzled-related Protein 1 (SFRP1) Protects Fibroblasts from Ceramide-induced Apoptosis","volume":"279","author":"X Han","year":"2004","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1177\/154405910708600913","article-title":"Inhibition of SFRP1 Reduces Severity of Periodontitis","volume":"86","author":"CH Li","year":"2007","journal-title":"J Dent Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1242\/jcs.026096","article-title":"Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease","volume":"121","author":"P Bovolenta","year":"2008","journal-title":"J Cell Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1080\/02713680802130354","article-title":"Anatomical and immunological changes of the cornea in patients with pterygium","volume":"33","author":"M Papadia","year":"2008","journal-title":"Curr Eye Res"},{"key":"ref33","unstructured":"McLean I, Pontigo M (2002) Histopathological findings in bullous keratopathy. Invest Ophthalmol Vis Sci 43: E-Abstract 1093."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1158\/1078-0432.CCR-0707-03","article-title":"Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro","volume":"10","author":"LG Horvath","year":"2004","journal-title":"Clin Cancer Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1172\/JCI63604","article-title":"Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition","volume":"122","author":"H Mori","year":"2012","journal-title":"J Clin Invest"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1097\/OPX.0b013e31821ffbd4","article-title":"Quantified histopathology of the keratoconic cornea","volume":"88","author":"JH Mathew","year":"2011","journal-title":"Optom Vis Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/00313020802320648","article-title":"Histopathological study of 49 cases of keratoconus","volume":"40","author":"BF Fernandes","year":"2008","journal-title":"Pathology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PAT.0b013e3283511b42","article-title":"An in depth analysis of histopathological characteristics found in keratoconus","volume":"44","author":"E Sykakis","year":"2012","journal-title":"Pathology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajo.2008.08.001","article-title":"Long-term keratometric changes after penetrating keratoplasty for keratoconus and Fuchs endothelial dystrophy","volume":"147","author":"ME Raecker","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0161-6420(03)00617-1","article-title":"Recurrence of keratoconus characteristics: A clinical and histologic follow-up analysis of donor grafts","volume":"110","author":"J-L Bourges","year":"2003","journal-title":"Ophthalmology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1083\/jcb.57.1.190","article-title":"Secretion of collagen by corneal epithelium. I. Morphology of the collagenous products produced by isolated epithelia grown on frozen-killed lens","volume":"57","author":"ED Hay","year":"1973","journal-title":"J Cell Biol"},{"key":"ref42","first-page":"2192","article-title":"Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types","volume":"16","author":"S Proulx","year":"2010","journal-title":"Mol Vis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/153537020222600711","article-title":"Corneal epithelial wound healing","volume":"226","author":"L Lu","year":"2001","journal-title":"Exp Biol Med"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Mort R, Douvaras P, Morley S, Dor\u00e0 N, Hill R, et al.. (2012) Stem cells and corneal epithelial maintenance: insights from the mouse and other animal models, in: Kubiak, J.Z. (Ed.), Mouse Development. Springer Berlin Heidelberg, 357\u2013394.","DOI":"10.1007\/978-3-642-30406-4_19"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/nature07406","article-title":"Oligopotent stem cells are distributed throughout the mammalian ocular surface","volume":"456","author":"F Majo","year":"2008","journal-title":"Nature"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.287.5457.1427","article-title":"Out of eden: stem cells and their niches","volume":"287","author":"FM Watt","year":"2000","journal-title":"Science"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T17:08:32Z","timestamp":1563210512000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066770"}},"subtitle":[],"editor":[{"given":"Deepak","family":"Shukla","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,18]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066770","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2013,6,18]]}}}