{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:32:12Z","timestamp":1774686732005,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0066907","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T21:17:26Z","timestamp":1372799846000},"page":"e66907","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cystatin C: A Strong Marker for Lower Limb Ischemia in Chinese Type 2 Diabetic Patients?"],"prefix":"10.1371","volume":"8","author":[{"given":"Fang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengdi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqian","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.2337\/diacare.26.12.3333","article-title":"Peripheral arterial disease in people with diabetes","volume":"26","journal-title":"Diabetes Care"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/01.CIR.97.5.425","article-title":"Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease","volume":"97","author":"PM Ridker","year":"1998","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/ndt\/gfl744","article-title":"Association of cystatin C and estimated GFR with inflammatory biomarkers: the Heart and Soul Study","volume":"22","author":"D Singh","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/clinchem\/48.5.699","article-title":"Cystatin C: an improved estimator of glomerular filtration rate?","volume":"48","author":"OF Laterza","year":"2002","journal-title":"Clin Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/ajkd.2002.34487","article-title":"Serum cystatin C is superior to serum creatinine as a marker of kidney function: a meta-analysis","volume":"40","author":"VR Dharnidharka","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiochem.2004.09.025","article-title":"Cystatin C as a marker of GFR\u2013history, indications, and future research","volume":"38","author":"G Filler","year":"2005","journal-title":"Clin Biochem"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s00467-006-0192-5","article-title":"Cystatin C, kidney function and cardiovascular disease","volume":"21","author":"A Bokenkamp","year":"2006","journal-title":"Pediatr Nephrol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7326\/0003-4819-145-4-200608150-00003","article-title":"Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease","volume":"145","author":"MG Shlipak","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1093\/cvr\/cvq138","article-title":"Cystatin C increases in cardiac injury: a role in extracellular matrix protein modulation","volume":"87","author":"L Xie","year":"2010","journal-title":"Cardiovasc Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"E18","DOI":"10.1002\/clc.20465","article-title":"Association of cystatin C with ischemia in patients with coronary heart disease","volume":"32","author":"R Deo","year":"2009","journal-title":"Clin Cardiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1001\/archinte.165.22.2666","article-title":"Cystatin C and incident peripheral arterial disease events in the elderly: results from the Cardiovascular Health Study","volume":"165","author":"AM O'Hare","year":"2005","journal-title":"Arch Intern Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.atherosclerosis.2011.02.016","article-title":"Higher cystatin C level predicts long-term mortality in patients with peripheral arterial disease","volume":"216","author":"G Urbonaviciene","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2337\/dc12-s011","article-title":"Standards of medical care in diabetes\u20132012","volume":"35","journal-title":"Diabetes Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ijcard.2008.03.039","article-title":"Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999\u20132004","volume":"135","author":"BM Cheung","year":"2009","journal-title":"Int J Cardiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2009.10.028","article-title":"Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives","volume":"210","author":"R Baetta","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.atherosclerosis.2005.11.010","article-title":"Hemoglobin and atherosclerosis in patients with manifest arterial disease. The SMART-study","volume":"188","author":"JM Dijk","year":"2006","journal-title":"Atherosclerosis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.atherosclerosis.2006.06.031","article-title":"Association between serum albumin, carotid atherosclerosis, and metabolic syndrome in Japanese individuals","volume":"193","author":"N Ishizaka","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2005111204","article-title":"Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) Study","volume":"18","author":"K Wattanakit","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.0000114519.75433.DD","article-title":"High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999\u20132000","volume":"109","author":"AM O'Hare","year":"2004","journal-title":"Circulation"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1161\/01.CIR.0000137913.26087.F0","article-title":"Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999\u20132000","volume":"110","author":"E Selvin","year":"2004","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0003319711406709","article-title":"Low estimated glomerular filtration rate is a major determinant of low ankle-brachial index and toe-brachial index in type 2 diabetes","volume":"63","author":"YJ Sheen","year":"2012","journal-title":"Angiology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1093\/eurheartj\/ehp195","article-title":"Kidney function estimated from serum creatinine and cystatin C and peripheral arterial disease in NHANES 1999\u20132002","volume":"30","author":"E Selvin","year":"2009","journal-title":"Eur Heart J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1607-551X(09)70529-7","article-title":"Determinants of peripheral arterial stiffness in patients with chronic kidney disease in southern Taiwan","volume":"25","author":"JH Chen","year":"2009","journal-title":"Kaohsiung J Med Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.amjcard.2012.02.061","article-title":"Risk factors for peripheral arterial disease among patients with chronic kidney disease","volume":"110","year":"2012","journal-title":"Am J Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/01.mnh.0000222694.07336.92","article-title":"Update on cystatin C: new insights into the importance of mild kidney dysfunction","volume":"15","author":"MG Shlipak","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1373\/clinchem.2004.041889","article-title":"Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate","volume":"51","author":"W Koenig","year":"2005","journal-title":"Clin Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/CIRCULATIONAHA.106.644286","article-title":"Association of cystatin C with mortality, cardiovascular events, and incident heart failure among persons with coronary heart disease: data from the Heart and Soul Study","volume":"115","author":"JH Ix","year":"2007","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/j.1523-1755.2004.00517.x","article-title":"Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement","volume":"65","author":"EL Knight","year":"2004","journal-title":"Kidney Int"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.metabol.2009.07.019","article-title":"Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients","volume":"59","author":"SH Lee","year":"2010","journal-title":"Metabolism"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.atherosclerosis.2007.11.025","article-title":"Cystatin C\u2013a marker of peripheral atherosclerotic disease?","volume":"199","author":"J Arpegard","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1172\/JCI7709","article-title":"Cystatin C deficiency in human atherosclerosis and aortic aneurysms","volume":"104","author":"GP Shi","year":"1999","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.ATV.0000117180.57731.36","article-title":"Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease","volume":"24","author":"P Eriksson","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0066907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T15:14:01Z","timestamp":1596035641000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0066907"}},"subtitle":[],"editor":[{"given":"Aimin","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":32,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0066907","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]}}}