{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:18:55Z","timestamp":1789996735593,"version":"4.0.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067014","type":"journal-article","created":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T21:09:10Z","timestamp":1375909750000},"page":"e67014","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Microarray-Based Identification of Differentially Expressed Genes in Intracellular Brucella abortus within RAW264.7 Cells"],"prefix":"10.1371","volume":"8","author":[{"given":"Mingxing","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangan","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengqing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S1369-5274(00)00165-X","article-title":"Brucellosis: a worldwide zoonosis","volume":"4","author":"ML Boschiroli","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","article-title":"Brucellosis: an overview","volume":"3","author":"MJ Corbel","year":"1997","journal-title":"Emerg Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.022622699","article-title":"<italic>Brucella melitensis<\/italic>: a nasty bug with hidden credentials for virulence","volume":"99","author":"E Moreno","year":"2002","journal-title":"PNAS"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0378-1135(02)00367-X","article-title":"Intracellular survival of <italic>Brucella<\/italic>: defining the link with persistence","volume":"92","author":"TA Ficht","year":"2003","journal-title":"Vet Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15711","DOI":"10.1073\/pnas.232454299","article-title":"The analysis of the intramacrophagic virulome of <italic>Brucella suis<\/italic> deciphers the environment encountered by the pathogen inside the macrophage host cell","volume":"99","author":"S K\u00f6hler","year":"2002","journal-title":"PNAS"},{"key":"ref6","first-page":"271","article-title":"HSP and apoptosis in leukocytes from infected or vaccinated animals by <italic>Brucella abortus<\/italic>","volume":"23","author":"E Galdiero","year":"2000","journal-title":"New Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1128\/IAI.67.8.4041-4047.1999","article-title":"Early acidification of phagosomes containing <italic>Brucella suis<\/italic> is essential for intracellular survival in murine macrophages","volume":"67","author":"F Porte","year":"1999","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1128\/IAI.66.12.5711-5724.1998","article-title":"<italic>Brucella abortus<\/italic> transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes","volume":"66","author":"J Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1128\/IAI.66.5.2387-2392.1998","article-title":"Virulent <italic>Brucella abortus<\/italic> prevents lysosome fusion and is distributed within autophagosome-like compartments","volume":"66","author":"J Pizarro-Cerd\u00e1","year":"1998","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2007.11.023","article-title":"<italic>Brucella<\/italic>: A pathogen without classic virulence genes","volume":"129","author":"MN Seleem","year":"2008","journal-title":"Vet Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/IAI.71.3.1125-1133.2003","article-title":"Microarray analysis of mRNA levels from RAW264. 7 macrophages infected with <italic>Brucella abortus<\/italic>","volume":"71","author":"L Eskra","year":"2003","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e10216","DOI":"10.1371\/journal.pone.0010216","article-title":"Transcriptome analysis of the <italic>Brucella abortus<\/italic> BvrR\/BvrS two-component regulatory system","volume":"5","author":"C Viadas","year":"2010","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1128\/jb.174.11.3621-3628.1992","article-title":"Anaerobic degradation of 2-aminobenzoic acid (anthranilic acid) via benzoyl-coenzyme A (CoA) and cyclohex-1-enecarboxyl-CoA in a denitrifying bacterium","volume":"174","author":"C Lochmeyer","year":"1992","journal-title":"J Bacteriol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5494","DOI":"10.1128\/jb.173.17.5494-5501.1991","article-title":"Purification and characterization of benzoate-coenzyme A ligase and 2-aminobenzoate-coenzyme A ligases from a denitrifying <italic>Pseudomonas sp<\/italic>","volume":"173","author":"U Altenschmidt","year":"1991","journal-title":"J Bacteriol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6545","DOI":"10.1128\/jb.177.22.6545-6551.1995","article-title":"Benzoate-coenzyme A ligase, encoded by badA, is one of three ligases able to catalyze benzoyl-coenzyme A formation during anaerobic growth of Rhodopseudomonas palustris on benzoate","volume":"177","author":"PG Egland","year":"1995","journal-title":"J Bacteriol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1128\/jb.170.4.1709-1714.1988","article-title":"Purification and properties of benzoate-coenzyme A ligase, a <italic>Rhodopseudomonas palustris<\/italic> enzyme involved in the anaerobic degradation of benzoate","volume":"170","author":"J Geissler","year":"1988","journal-title":"J Bacteriol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1128\/JB.185.16.4920-4929.2003","article-title":"Benzoate-coenzyme A ligase from <italic>Thauera aromatica<\/italic>: an enzyme acting in anaerobic and aerobic pathways","volume":"185","author":"K Sch\u00fchle","year":"2003","journal-title":"J Bacteriol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00203-001-0375-1","article-title":"Operon structure and expression of the genes for benzylsuccinate synthase in <italic>Thauera aromatica<\/italic> strain K172","volume":"177","author":"K Hermuth","year":"2002","journal-title":"Arch Microbiol"},{"key":"ref19","unstructured":"Chou HT (2011) L-lysine decarboxylase and cadaverine gamma-glutamylation pathways in <italic>Pseudomonas aeruginosa<\/italic> PAO1."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1128\/JB.01551-07","article-title":"The AraC-like transcriptional regulator DhbR is required for maximum expression of the 2, 3-dihydroxybenzoic acid biosynthesis genes in <italic>Brucella abortus<\/italic> 2308 in response to iron deprivation","volume":"190","author":"ES Anderson","year":"2008","journal-title":"J Bacteriol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1128\/IAI.72.9.5483-5486.2004","article-title":"The AraC family transcriptional regulator Rv1931c plays a role in the virulence of <italic>Mycobacterium tuberculosis<\/italic>","volume":"72","author":"CC Frota","year":"2004","journal-title":"Infect Immun"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1099\/00221287-146-2-487","article-title":"The genes for erythritol catabolism are organized as an inducible operon in <italic>Brucella abortus<\/italic>","volume":"146","author":"FJ Sangari","year":"2000","journal-title":"Microbiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1099\/00221287-38-1-109","article-title":"The metabolism of erythritol by <italic>Brucella abortus<\/italic>","volume":"38","author":"J Anderson","year":"1965","journal-title":"J Gen Microbiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e2193","DOI":"10.1371\/journal.pone.0002193","article-title":"Genome sequence of <italic>Brucella abortus<\/italic> vaccine strain S19 compared to virulent strains yields candidate virulence genes","volume":"3","author":"OR Crasta","year":"2008","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1574-6968.1994.tb07123.x","article-title":"The <italic>Brucella abortus<\/italic> vaccine strain B19 carries a deletion in the erythritol catabolic genes","volume":"121","author":"FJ Sangari","year":"1994","journal-title":"FEMS Microbiol Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/S0264-410X(98)00063-2","article-title":"The defect in the metabolism of erythritol of the <italic>Brucella abortus<\/italic> B19 vaccine strain is unrelated with its attenuated virulence in mice","volume":"16","author":"FJ Sangari","year":"1998","journal-title":"Vaccine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1038\/1831529b0","article-title":"A possible negative feedback phenomenon controlling formation of alkaline phosphomonoesterase in <italic>Escherichia coli<\/italic>","volume":"183","author":"T Horiuchi","year":"1959","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1126\/science.227.4692.1338","article-title":"Bacterial 5-nucleotidase in aquatic ecosystems: a novel mechanism of phosphorus regeneration","volume":"227","author":"JW Ammerman","year":"1985","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/genetics\/96.2.353","article-title":"Mutants affected in alkaline phosphatase expression: evidence for multiple positive regulators of the phosphate regulon in <italic>Escherichia coli<\/italic>","volume":"96","author":"BL Wanner","year":"1980","journal-title":"Genetics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1046\/j.1365-2958.2000.02150.x","article-title":"Identification and characterization of in vivo attenuated mutants of <italic>Brucella melitensis<\/italic>","volume":"38","author":"P Lestrate","year":"2002","journal-title":"Mol Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1462-5822.2005.00502.x","article-title":"The sheathed flagellum of <italic>Brucella melitensis<\/italic> is involved in persistence in a murine model of infection","volume":"7","author":"D Fretin","year":"2005","journal-title":"Cell Microbiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2217\/fmb.11.136","article-title":"Brucellosis and type IV secretion","volume":"7","author":"MF de Jong","year":"2012","journal-title":"Future Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1074\/jbc.271.10.5524","article-title":"Homoprotocatechuate 2, 3-dioxygenase from <italic>Brevibacterium fuscum<\/italic> a dioxygenase with catalase activity","volume":"271","author":"MA Miller","year":"1996","journal-title":"J Biol Chem"},{"key":"ref34","unstructured":"Crosby D (1972) Degradation of synthetic organic molecules in the biosphere. Na tional Academy of Sciences: Washington, DC: 260\u2013280."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11780","DOI":"10.1021\/ja0368103","article-title":"Conversion of extradiol aromatic ring-cleaving homoprotocatechuate 2, 3-dioxygenase into an intradiol cleaving enzyme","volume":"125","author":"SL Groce","year":"2003","journal-title":"J Am Chem Soc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1517\/17425255.4.6.697","article-title":"Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily","volume":"4","author":"SA Marchitti","year":"2008","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0968-0004(98)01326-7","article-title":"Sugar transporters from bacteria, parasites and mammals: structure\u2013activity relationships","volume":"23","author":"AR Walmsley","year":"1998","journal-title":"Trends Biochem Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.62.1.1-34.1998","article-title":"Major facilitator superfamily","volume":"62","author":"SS Pao","year":"1998","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref39","first-page":"1709","article-title":"Nickel deficiency gives rise to the defective hydrogenase phenotype of hydC and fnr mutants in <italic>Escherichia coli<\/italic>","volume":"3","author":"LF Wu","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1128\/JB.183.2.426-434.2001","article-title":"Identification of the nik gene cluster of <italic>Brucella suis<\/italic>: regulation and contribution to urease activity","volume":"183","author":"V Jubier-Maurin","year":"2001","journal-title":"J Bacteriol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/IAI.72.1.440-450.2004","article-title":"<italic>Brucella abortus<\/italic> rough mutants are cytopathic for macrophages in culture","volume":"72","author":"J Pei","year":"2004","journal-title":"Infect Immun"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.micinf.2008.01.005","article-title":"Evidence of <italic>Brucella abortus<\/italic> OPS dictating uptake and restricting NF-kappaB activation in murine macrophages","volume":"10","author":"J Pei","year":"2008","journal-title":"Microbes Infect"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.micpath.2004.04.002","article-title":"Lipid raft microdomains mediate class A scavenger receptor-dependent infection of <italic>Brucella abortus<\/italic>","volume":"37","author":"S Kim","year":"2004","journal-title":"Microb Pathog"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1128\/IAI.70.3.1640-1644.2002","article-title":"Role of cholesterol and the ganglioside GM<sub>1<\/sub> in entry and short-term survival of Brucella suis in murine macrophages","volume":"70","author":"A Naroeni","year":"2002","journal-title":"Infect Immun"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1139\/W07-133","article-title":"Microarray analysis of <italic>Streptococcus pneumoniae<\/italic> gene expression changes to human lung epithelial cells","volume":"54","author":"XM Song","year":"2008","journal-title":"Can J Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Zhang M, Han X, Liu H, Tian M, Ding C, <etal>et al<\/etal>.. (2013) Inactivation of the ABC transporter ATPase gene in <italic>Brucella abortus<\/italic> strain 2308 attenuated the virulence of the bacteria. Vet Microbiol.","DOI":"10.1016\/j.vetmic.2013.02.017"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T03:22:14Z","timestamp":1646277734000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067014"}},"subtitle":[],"editor":[{"given":"Jean-Pierre","family":"Gorvel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,7]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067014","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,7]]}}}