{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:51:51Z","timestamp":1790315511225,"version":"4.1.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067324","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T20:59:44Z","timestamp":1372107584000},"page":"e67324","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Assessment of Health Benefits and Cost-Effectiveness of 10-Valent and 13-Valent Pneumococcal Conjugate Vaccination in Kenyan Children"],"prefix":"10.1371","volume":"8","author":[{"given":"Philip","family":"Ayieko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla K.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Ndiritu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Moisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac K.","family":"Mugoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatu","family":"Kamau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"English","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Anthony G.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0140-6736(10)60549-1","article-title":"Global, regional, and national causes of child mortality in 2008: a systematic analysis","volume":"375","author":"R Black","year":"2010","journal-title":"Lancet"},{"key":"ref2","unstructured":"World Health Organisation. Programmes and Projects: Immunization surveillance, assessment and monitoring. Estimated Hib and pneumococcal deaths for children under 5 years of age, 2008. Available: http:\/\/www.who.int\/immunization_monitoring\/burden\/Pneumo_hib_estimates\/en\/index.html<\/ext-link>. Accessed 2012 June 5."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006454-200003000-00003","article-title":"Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group","volume":"19","author":"S Black","year":"2000","journal-title":"Pediatr Infect Dis J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/S0140-6736(05)71876-6","article-title":"Efficacy of nine-valent pneumococcal conjugate vaccine against pneumonia and invasive pneumococcal disease in The Gambia: randomised, double-blind, placebo-controlled trial","volume":"365","author":"FT Cutts","year":"2005","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1056\/NEJMoa035060","article-title":"A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection","volume":"349","author":"KP Klugman","year":"2003","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"KL O\u2019Brien","year":"2009","journal-title":"Lancet"},{"key":"ref7","first-page":"1148","article-title":"Progress in introduction of pneumococcal conjugate vaccine\u2013worldwide, 2000\u20132008","volume":"57","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref8","unstructured":"World Health Organisation New and Under-utilized Vaccines Implementation (NUVI) Available:http:\/\/www.who.int\/nuvi\/pneumococcus\/decision_implementation\/en\/index1.html<\/ext-link>.<\/bold>Accessed 2011 November 29."},{"key":"ref9","first-page":"93","article-title":"Pneumococcal conjugate vaccine for childhood immunization","volume":"82","author":"paper WHO position","year":"2007","journal-title":"Wkly Epidemiol Rec"},{"key":"ref10","unstructured":"GAVI Alliance pledging conference for immunisation London, 13 June 2011. Available: http:\/\/www.gavialliance.org\/funding\/resource-mobilisation\/process\/gavi-pledging-conference-june-2011\/<\/ext-link>.<\/bold> Accessed 2011 October 12."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"d1075","DOI":"10.1136\/bmj.d1075","article-title":"A pneumococcal vaccine is launched in Africa to cut child deaths","volume":"342","author":"P Moszynski","year":"2011","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/1471-2334-10-260","article-title":"Economic evaluation of pneumococcal conjugate vaccination in The Gambia","volume":"10","author":"SY Kim","year":"2010","journal-title":"BMC Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1016\/j.vaccine.2010.12.122","article-title":"Projected health benefits and costs of pneumococcal and rotavirus vaccination in Uganda","volume":"29","author":"JE Tate","year":"2011","journal-title":"Vaccine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1759-8893.2011.00057.x","article-title":"The cost effectiveness of pneumococcal conjugate vaccine in the routine infant immunisation programme of The Gambia","volume":"2","author":"MML Touray","year":"2011","journal-title":"Journal of Pharmaceutical Health Services Research"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0140-6736(07)60195-0","article-title":"Cost-effectiveness of pneumococcal conjugate vaccination in the prevention of child mortality: an international economic analysis","volume":"369","author":"A Sinha","year":"2007","journal-title":"Lancet"},{"key":"ref16","first-page":"1355","article-title":"Convincing or confusing? Economic evaluations of childhood pneumococcal conjugate vaccination\u2013a review (2002\u20132006)","volume":"25","author":"P Beutels","year":"2007","journal-title":"Vaccine"},{"key":"ref17","unstructured":"The GAVI Alliance. Available: http:\/\/www.gavialliance.org\/media_centre\/press_releases\/2010_03_23_amc_commitment.php<\/ext-link>. Accessed 2010 October 1."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0140-6736(09)61556-7","article-title":"Pricing of pneumococcal vaccines under advance market commitments","volume":"374","author":"T Cernuschi","year":"2009","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/heapol\/15.2.230","article-title":"The real and the nominal? Making inflationary adjustments to cost and other economic data","volume":"15","author":"L Kumaranayake","year":"2000","journal-title":"Health Policy Plan"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/ije\/dys062","article-title":"Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)","volume":"41","author":"J Scott","year":"2012","journal-title":"Int J Epidemiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1001\/jama.296.6.671","article-title":"Effectiveness of Haemophilus influenzae type b Conjugate vaccine introduction into routine childhood immunization in Kenya","volume":"296","author":"K Cowgill","year":"2006","journal-title":"JAMA"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2471\/BLT.10.080796","article-title":"Sensitivity of hospital-based surveillance for severe disease: a geographic information system analysis of access to care in Kilifi district, Kenya","volume":"89","author":"J Mo\u00efsi","year":"2011","journal-title":"Bull World Health Organ"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2471\/BLT.07.049353","article-title":"Delayed care seeking for fatal pneumonia in children aged under five years in Uganda: a case-series study","volume":"86","author":"K K\u00e4llander","year":"2008","journal-title":"Bull World Health Organ"},{"key":"ref24","unstructured":"World Health Organization Pocket Book of Hospital care for children: guidelines for the management of common illnesses with limited resources. Geneva: World Health Organization; 2005."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1016\/S0264-410X(03)00230-5","article-title":"Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants","volume":"21","author":"L Jodar","year":"2003","journal-title":"Vaccine"},{"key":"ref26","unstructured":"Murray C, Lopez A (1996) The global burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries, and risk factors in 1990 and projected to 2020. Boston: Harvard School of Public Health."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1473-3099(10)70048-7","article-title":"Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis","volume":"10","author":"K Edmond","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1478-7547-7-3","article-title":"The economic burden of inpatient paediatric care in Kenya: household and provider costs for treatment of pneumonia, malaria and meningitis","volume":"7","author":"P Ayieko","year":"2009","journal-title":"Cost Eff Resour Alloc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1471-2458-6-314","article-title":"The cost of uncomplicated childhood fevers to Kenyan households: implications for reaching international access targets","volume":"6","author":"B Larson","year":"2006","journal-title":"BMC Public Health"},{"key":"ref30","unstructured":"Gentry B (2008) Getting Started Guide, Release 11.1.1.0.00. Oracle\u00ae Crystal Ball. pp. C-17."},{"key":"ref31","first-page":"434","article-title":"Changing epidemiology of pneumococcal serotypes after introduction of conjugate vaccine: July 2010 report","volume":"85","year":"2010","journal-title":"Wkly Epidemiol Rec"},{"key":"ref32","first-page":"893","article-title":"Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease-United States, 1998\u20132003","volume":"54","year":"2005","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1475-9276-8-15","article-title":"Reducing user fees for primary health care in Kenya: Policy on paper or policy in practice?","volume":"8","author":"J Chuma","year":"2009","journal-title":"Int J Equity Health"},{"key":"ref34","unstructured":"CHOosing Interventions that are Cost Effective (WHO-CHOICE): Available: http:\/\/www.who.int\/choice\/costs\/CER_levels\/en\/index.html<\/ext-link>.Accessed 2010 October 15."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/bmj.38652.550278.7C","article-title":"Cost effectiveness analysis of strategies for child health in developing countries","volume":"331","author":"T Edejer","year":"2005","journal-title":"BMJ"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1136\/bmj.38643.368692.68","article-title":"Cost effectiveness analysis of strategies to combat HIV\/AIDS in developing countries","volume":"331","author":"D Hogan","year":"2005","journal-title":"BMJ"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"K O\u2019Brien","year":"2009","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1473-3099(06)70411-X","article-title":"Bacterial pneumonia vaccines and childhood pneumonia: are we winning, refining, or redefining?","volume":"6","author":"S Obaro","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.vaccine.2006.09.008","article-title":"The preventable burden of pneumococcal disease in the developing world","volume":"25","author":"J Scott","year":"2007","journal-title":"Vaccine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1016\/j.vaccine.2010.06.011","article-title":"Spatial and socio-demographic predictors of time-to-immunization in a rural area in Kenya: Is equity attainable?","volume":"28","author":"J Mo\u00efsi","year":"2010","journal-title":"Vaccine"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1056\/NEJMoa040275","article-title":"Bacteremia among children admitted to a rural hospital in Kenya","volume":"352","author":"JA Berkley","year":"2005","journal-title":"N Engl J Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T05:23:43Z","timestamp":1563254623000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067324"}},"subtitle":[],"editor":[{"given":"John Z.","family":"Metcalfe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067324","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]}}}