{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:08:59Z","timestamp":1759032539572},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:00:00Z","timestamp":1372982400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067450","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T21:14:49Z","timestamp":1373058889000},"page":"e67450","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cognitive Manic Symptoms in Bipolar Disorder Associated with Polymorphisms in the DAOA and COMT Genes"],"prefix":"10.1371","volume":"8","author":[{"given":"Dzana Sudic","family":"Hukic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Fris\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Backlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Lavebratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Land\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lil","family":"Tr\u00e4skman-Bendz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Edman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schalling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urban","family":"\u00d6sby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cercor\/9.1.20","article-title":"Physiological characteristics of capacity constraints in working memory as revealed by functional MRI","volume":"9","author":"JH Callicott","year":"1999","journal-title":"Cereb Cortex"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/S0006-3223(99)00130-4","article-title":"The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia","volume":"46","author":"PS Goldman-Rakic","year":"1999","journal-title":"Biol Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroscience.2009.05.014","article-title":"Genes, cognition and brain through a COMT lens","volume":"164","author":"D Dickinson","year":"2009","journal-title":"Neuroscience"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jad.2011.11.021","article-title":"COMT Met (158) modulates facial emotion recognition in bipolar I disorder mood episodes","volume":"136","author":"MG Soeiro-de-Souza","year":"2012","journal-title":"J Affect Disord"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/sj.ejhg.5201549","article-title":"Genetics of affective (mood) disorders","volume":"14","author":"N Craddock","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/374822","article-title":"Polymorphisms at the G72\/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series","volume":"72","author":"E Hattori","year":"2003","journal-title":"Am J Hum Genet"},{"key":"ref7","unstructured":"Chen YS, Akula N, Detera-Wadleigh SD, Schulze TG, Thomas J, et al. (2004) Findings in an independent sample support an association between bipolar affective disorder and the G72\/G30 locus on chromosome 13q33. Mol Psychiatry 9: 87\u201392; image 85."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/sj.mp.4001421","article-title":"Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder","volume":"9","author":"J Schumacher","year":"2004","journal-title":"Mol Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/sj.mp.4000385","article-title":"Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder","volume":"3","author":"G Kirov","year":"1998","journal-title":"Mol Psychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/sj.mp.4000410","article-title":"Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele","volume":"3","author":"DF Papolos","year":"1998","journal-title":"Mol Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archpsyc.63.4.366","article-title":"Variation at the DAOA\/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder","volume":"63","author":"NM Williams","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1034\/j.1399-5618.2001.30604.x","article-title":"Association studies of bipolar disorder","volume":"3","author":"N Craddock","year":"2001","journal-title":"Bipolar Disord"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajmg.b.30032","article-title":"COMT: a common susceptibility gene in bipolar disorder and schizophrenia","volume":"128B","author":"S Shifman","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"NC Danbolt","year":"2001","journal-title":"Prog Neurobiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJMcibr0902052","article-title":"Memory and the NMDA receptors","volume":"361","author":"F Li","year":"2009","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.schres.2007.06.012","article-title":"Decreased levels of plasma glutamate in patients with first-episode schizophrenia and bipolar disorder","volume":"95","author":"A Palomino","year":"2007","journal-title":"Schizophr Res"},{"key":"ref17","first-page":"297","article-title":"Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype","volume":"13","author":"S Dalvie","year":"2010","journal-title":"Afr J Psychiatry (Johannesbg)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.biopsych.2010.10.031","article-title":"Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex","volume":"69","author":"DC Nixon","year":"2011","journal-title":"Biol Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s00439-006-0257-3","article-title":"Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia","volume":"120","author":"KK Nicodemus","year":"2007","journal-title":"Hum Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1399-5618.2011.00952.x","article-title":"Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder","volume":"13","author":"L Backlund","year":"2011","journal-title":"Bipolar Disord"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1176\/appi.ajp.163.2.217","article-title":"Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)","volume":"163","author":"RH Perlis","year":"2006","journal-title":"Am J Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1176\/ajp.155.1.30","article-title":"Long-term outcome of lithium prophylaxis in bipolar disorder: a 5-year prospective study of 402 patients at a lithium clinic","volume":"155","author":"M Maj","year":"1998","journal-title":"Am J Psychiatry"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s11920-007-0069-8","article-title":"Genetics of bipolar disorder","volume":"9","author":"JW Smoller","year":"2007","journal-title":"Curr Psychiatry Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/ajmg.b.31076","article-title":"The P-value illusion: how to improve (psychiatric) genetic studies","volume":"153B","author":"AB Niculescu","year":"2010","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1073\/pnas.94.2.587","article-title":"Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus","volume":"94","author":"R Freedman","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/schbul\/20.1.103","article-title":"Neuropsychological risk indicators for schizophrenia: a review of family studies","volume":"20","author":"WS Kremen","year":"1994","journal-title":"Schizophr Bull"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Adler M, Backlund L, Edman G, Osby U (2012) Symptoms and treatment of bipolar patients in Sweden. Int J Psychiatry Clin Pract.","DOI":"10.3109\/13651501.2011.653377"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1600-0447.2010.01590.x","article-title":"Neurocognitive dysfunction and psychosocial outcome in patients with bipolar I disorder at 15-year follow-up","volume":"122","author":"KE Burdick","year":"2010","journal-title":"Acta Psychiatr Scand"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Sole B, Bonnin CM, Torrent C, Balanza-Martinez V, Tabares-Seisdedos R, et al. (2011) Neurocognitive impairment and psychosocial functioning in bipolar II disorder. Acta Psychiatr Scand.","DOI":"10.1111\/j.1600-0447.2011.01759.x"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1590\/S1516-44462009000200015","article-title":"Facial emotion recognition in bipolar disorder: a critical review","volume":"31","author":"CC Rocca","year":"2009","journal-title":"Rev Bras Psiquiatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/ajmg.b.30904","article-title":"G72\/G30 (<italic>DAOA<\/italic>) and juvenile-onset mood disorders","volume":"150B","author":"L Gomez","year":"2009","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1176\/appi.ajp.162.11.2101","article-title":"Genotype-phenotype studies in bipolar disorder showing association between the <italic>DAOA<\/italic>\/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes","volume":"162","author":"TG Schulze","year":"2005","journal-title":"Am J Psychiatry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1600-0447.2010.01586.x","article-title":"Manic episodes are associated with grey matter volume reduction - a voxel-based morphometry brain analysis","volume":"122","author":"CJ Ekman","year":"2010","journal-title":"Acta Psychiatr Scand"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1073\/pnas.111134598","article-title":"Effect of <italic>COMT<\/italic> Val108\/158 Met genotype on frontal lobe function and risk for schizophrenia","volume":"98","author":"MF Egan","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1001\/archpsyc.60.9.889","article-title":"Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia","volume":"60","author":"TE Goldberg","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1176\/appi.ajp.159.4.652","article-title":"A functional polymorphism in the <italic>COMT<\/italic> gene and performance on a test of prefrontal cognition","volume":"159","author":"AK Malhotra","year":"2002","journal-title":"Am J Psychiatry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00221-004-2180-y","article-title":"The methionine allele of the <italic>COMT<\/italic> polymorphism impairs prefrontal cognition in children and adolescents with ADHD","volume":"163","author":"MA Bellgrove","year":"2005","journal-title":"Exp Brain Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/archpsyc.1988.01800310013001","article-title":"Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monoaminergic mechanism","volume":"45","author":"DR Weinberger","year":"1988","journal-title":"Arch Gen Psychiatry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1017\/S0033291710001431","article-title":"The impact of the Val158Met catechol-O-methyltransferase genotype on neural correlates of sad facial affect processing in patients with bipolar disorder and their relatives","volume":"41","author":"G Lelli-Chiesa","year":"2011","journal-title":"Psychol Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/mp.2009.36","article-title":"Neural substrates of pleiotropic action of genetic variation in <italic>COMT<\/italic>: a meta-analysis","volume":"15","author":"D Mier","year":"2010","journal-title":"Mol Psychiatry"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0893-133X(95)00137-3","article-title":"NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers","volume":"14","author":"AK Malhotra","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00406-012-0313-z","article-title":"D-amino acid oxidase activator gene (<italic>DAOA<\/italic>) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians","volume":"262","author":"D Andreou","year":"2012","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.biopsych.2004.04.006","article-title":"Is the G72\/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis","volume":"56","author":"M Korostishevsky","year":"2004","journal-title":"Biol Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/mp.2008.47","article-title":"D-amino acid oxidase activity and expression are increased in schizophrenia","volume":"13","author":"PW Burnet","year":"2008","journal-title":"Mol Psychiatry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.biopsych.2008.03.028","article-title":"Association of a nonsynonymous variant of <italic>DAOA<\/italic> with visuospatial ability in a bipolar family sample","volume":"64","author":"P Soronen","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.schres.2004.01.015","article-title":"A family-based study of the association between the G72\/G30 genes and schizophrenia in the Chinese population","volume":"73","author":"F Zou","year":"2005","journal-title":"Schizophr Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1399-5618.2011.00905.x","article-title":"Association between the <italic>DAOA<\/italic>\/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia","volume":"13","author":"DJ Muller","year":"2011","journal-title":"Bipolar Disord"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1471-4159.2007.04840.x","article-title":"Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation","volume":"103","author":"H Jiao","year":"2007","journal-title":"J Neurochem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1385\/MN:25:2:191","article-title":"Glutamate receptor genes: susceptibility factors in schizophrenia and depressive disorders","volume":"25","author":"HH Schiffer","year":"2002","journal-title":"Mol Neurobiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1146\/annurev.pharmtox.42.082701.160735","article-title":"Glutamatergic mechanisms in schizophrenia","volume":"42","author":"G Tsai","year":"2002","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0361-9230(01)00523-8","article-title":"Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder","volume":"55","author":"JH Meador-Woodruff","year":"2001","journal-title":"Brain Res Bull"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0893-133X(01)00370-0","article-title":"Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder","volume":"26","author":"RE McCullumsmith","year":"2002","journal-title":"Neuropsychopharmacology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T08:48:35Z","timestamp":1563353315000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067450"}},"subtitle":[],"editor":[{"given":"Chunyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,5]]},"references-count":54,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067450","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,5]]}}}