{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:08:53Z","timestamp":1791299333894,"version":"4.1.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067756","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T17:12:19Z","timestamp":1372439539000},"page":"e67756","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["An Atypical Age-Specific Pattern of Hepatocellular Carcinoma in Peru: A Threat for Andean Populations"],"prefix":"10.1371","volume":"8","author":[{"given":"St\u00e9phane","family":"Bertani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Loli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko","family":"Zimic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deharo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"J Ferlay","year":"2008","journal-title":"Int J Cancer"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/S0140-6736(12)60919-2","article-title":"Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions","volume":"380","author":"I Soerjomataram","year":"2012","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra1001683","article-title":"Hepatocellular carcinoma","volume":"365","author":"HB El-Serag","year":"2011","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0140-6736(11)61347-0","article-title":"Hepatocellular carcinoma","volume":"379","author":"A Forner","year":"2012","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nrgastro.2010.100","article-title":"Hepatocellular carcinoma: A global view","volume":"7","author":"JD Yang","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1470-2045(12)70137-7","article-title":"Global burden of cancers attributable to infections in 2008: a review and synthetic analysis","volume":"13","author":"C de Martel","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref7","unstructured":"Instituto Nacional de Enfermedades Neopl\u00e1sicas (2011) Plan estrat\u00e9gico institucional 2011\u20132015. Resoluci\u00f3n No. 260\u20132011\u2212\/INEN. 62 p. Spanish."},{"key":"ref8","first-page":"179","article-title":"Non-communicable diseases and health systems reform in low-and-middle-income countries","volume":"18","author":"HM Robinson","year":"2012","journal-title":"Pac Health Dialog"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-0030-1247133","article-title":"Current strategy for staging and treatment: the BCLC uptade and future prospects","volume":"30","author":"A Forner","year":"2010","journal-title":"Semin Liver Dis"},{"key":"ref10","unstructured":"American Joint Committee on Cancer (2002) AJCC Cancer Staging Manual. 6th ed. New York, NY: Springer. 421 p."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0039-6109(03)00224-X","article-title":"Preoperative assessment of liver function","volume":"84","author":"PD Schneider","year":"2004","journal-title":"Surg Clin North Am"},{"key":"ref12","first-page":"1171","article-title":"Surgical management of hepatocellular carcinoma. Liver resection and liver transplantation","volume":"28","author":"K Hasegawa","year":"2007","journal-title":"Saudi Med"},{"key":"ref13","first-page":"1393","article-title":"Resection margin in hepatectomy for hepatocellular carcinoma: a systematic review","volume":"59","author":"YH Tang","year":"2012","journal-title":"Hepato-gastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1093\/bioinformatics\/btl174","article-title":"PACK: profile analysis using clustering and kurtosis to find molecular classifiers in cancer","volume":"22","author":"AE Teschendorff","year":"2006","journal-title":"Bioinformatics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1080\/03610920701713286","article-title":"Gamma mixture: bimodality, inflexions and L-moments","volume":"37","author":"SE Ahmed","year":"2008","journal-title":"Commun Stat-Theor M"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4137\/CIN.S2846","article-title":"The bimodality index: a criterion for discovering and ranking bimodal signatures from cancer gene expression profiling data","volume":"7","author":"J Wang","year":"2009","journal-title":"Cancer Inform"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","article-title":"An analysis of variance test for normality (complete samples)","volume":"52","author":"SS Shapiro","year":"1965","journal-title":"Biometrika"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1080\/01621459.1993.10476407","article-title":"Procedures for the identification of multiple outliers in linear models","volume":"88","author":"AS Hadi","year":"1993","journal-title":"J Am Stat Assoc"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"EL Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"ref20","first-page":"163","article-title":"Evaluation of survival data and two new order statistics arising in its consideration","volume":"50","author":"N Mantel","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2307\/2344317","article-title":"Asymptotically efficient rank invariant test procedures","volume":"135","author":"R Peto","year":"1972","journal-title":"J R Statist Soc A"},{"key":"ref22","unstructured":"Waniez P (2011) Universit\u00e9 Bordeaux Segalen, UFR Sciences et Mod\u00e9lisation. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/philcarto.free.fr\" xlink:type=\"simple\">http:\/\/philcarto.free.fr<\/ext-link>. Accessed 2013 Jan 28. French."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/bjc.1985.107","article-title":"Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei","volume":"51","author":"SJ Van Rensburg","year":"1985","journal-title":"Brit J Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jhep.2006.02.003","article-title":"Staging systems for hepatocellular carcinoma: should we all use the BCLC system?","volume":"44","author":"JA Marrero","year":"2006","journal-title":"J Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nrgastro.2012.199","article-title":"Medical therapies for hepatocellular carcinoma: a critical view of the evidence","volume":"10","author":"A Villanueva","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"DM Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1056\/NEJMe0807581","article-title":"Recurrence of hepatocellular carcinoma","volume":"359","author":"M Sherman","year":"2008","journal-title":"N Engl J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.amjsurg.2008.09.019","article-title":"Outcome after curative resection for a huge (&gt;or = 10cm) hepatocellular carcinoma and prognostic significance of gross tumor classification","volume":"198","author":"GH Choi","year":"2009","journal-title":"Am J Surg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/jso.21931","article-title":"Outcomes of hepatic resection for huge hepatocellular carcinoma (\u226510 cm in diameter)","volume":"104","author":"Y Yamashita","year":"2011","journal-title":"J Surg Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1007\/s00268-012-1723-9","article-title":"Long-term outcome after liver resection for hepatocellular carcinoma larger than 10 cm","volume":"36","author":"P Allemann","year":"2012","journal-title":"World J Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.surg.2006.11.006","article-title":"A revised scoring system utilizing serum alphafetoprotein levels to expand candidates for living donor transplantation in hepatocellular carcinoma","volume":"141","author":"SH Yang","year":"2007","journal-title":"Surgery"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.jhep.2010.02.006","article-title":"The resurrection of alphafetoprotein","volume":"52","author":"M Sherman","year":"2010","journal-title":"J Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-230X-12-64","article-title":"Hepatitis B vs. hepatitis C infection on viral hepatitis-associated hepatocellular carcinoma","volume":"12","author":"SP Hiotis","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/j.1460-2075.1983.tb01461.x","article-title":"Tissue specificity of alpha-fetoprotein messenger RNA expression during mouse embryogenesis","volume":"2","author":"MA Dziadek","year":"1983","journal-title":"EMBO J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.110.4.915","article-title":"The ontogeny of alpha-fetoprotein gene expression in the mouse gastrointestinal tract","volume":"110","author":"AL Tyner","year":"1990","journal-title":"J Cell Biol"},{"key":"ref36","first-page":"2611","article-title":"Cell lineages and oval cell progenitors in rat liver development","volume":"51","author":"N Shiojiri","year":"1991","journal-title":"Cancer Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1101\/gad.10.13.1670","article-title":"Hepatic specification of the gut endoderm <italic>in vitro<\/italic>: cell signalling and transcriptional control","volume":"10","author":"R Gualdi","year":"1996","journal-title":"Gene Dev"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"T Reya","year":"2001","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","article-title":"Wnt signalling in stem cells and cancer","volume":"434","author":"T Reya","year":"2005","journal-title":"Nature"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nature07213","article-title":"Regulatory networks define phenotypic classes of human stem cell lines","volume":"455","author":"FJ M\u00fcller","year":"2008","journal-title":"Nature"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.stem.2008.02.009","article-title":"Module map of stem cell genes guides creation of epithelial cancer stem cells","volume":"2","author":"DJ Wong","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"R Krumlauf","year":"1994","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08975","article-title":"Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis","volume":"464","author":"RA Gupta","year":"2010","journal-title":"Nature"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.molcel.2011.08.019","article-title":"The noncoding RNA <italic>Mistral<\/italic> activates <italic>Hoxa6<\/italic> and <italic>Hoxa7<\/italic> expression and stem cell differentiation by recruiting MLL1 to chromatin","volume":"43","author":"S Bertani","year":"2011","journal-title":"Mol Cell"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1476-4598-10-60","article-title":"Functional analysis of HOXD9 in human glioma cancer stem cells","volume":"10","author":"M Tabuse","year":"2011","journal-title":"Mol Cancer"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S0140-6736(09)60207-5","article-title":"Hepatitis B virus infection","volume":"373","author":"YF Liaw","year":"2009","journal-title":"Lancet"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Averhoff FM, Glass N, Holtzman D (2012) Global burden of hepatitis C: considerations for heathcare providers in United States. Clin Infect Dis (Suppl 1): 10\u201315.","DOI":"10.1093\/cid\/cis361"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults","volume":"348","author":"EE Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"D Schuppan","year":"2008","journal-title":"Lancet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(00)04860-1","article-title":"The pan-asian paan problem","volume":"357","author":"TM Mack","year":"2001","journal-title":"Lancet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12029-010-9195-3","article-title":"Non-viral causes of hepatocellular carcinoma","volume":"42","author":"DH Van Thiel","year":"2011","journal-title":"J Gastrointest Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s11262-008-0261-x","article-title":"A new clade of hepatitis B virus subgenotype F1 from Peru with unusual properties","volume":"37","author":"M von Meltzer","year":"2008","journal-title":"Virus Genes"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T14:24:42Z","timestamp":1563287082000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067756"}},"subtitle":[],"editor":[{"given":"Jung Weon","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067756","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}