{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:13:22Z","timestamp":1787966002711,"version":"build-2784847793"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0067956","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T21:09:55Z","timestamp":1373404195000},"page":"e67956","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Blood Neutrophil Counts in HIV-Infected Patients with Pulmonary Tuberculosis: Association with Sputum Mycobacterial Load"],"prefix":"10.1371","volume":"8","author":[{"given":"Andrew D.","family":"Kerkhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Lawn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.it.2011.10.003","article-title":"Neutrophils in tuberculosis: friend or foe?","volume":"33","author":"DM Lowe","year":"2012","journal-title":"Trends in Immunology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1378\/chest.09-0903","article-title":"Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB","volume":"137","author":"S-Y Eum","year":"2010","journal-title":"Chest"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1172\/JCI31097","article-title":"Neutrophil-mediated innate immune resistance to mycobacteria","volume":"117","author":"AR Martineau","year":"2007","journal-title":"J Clin Invest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0140-6736(10)62173-3","article-title":"Tuberculosis","volume":"378","author":"SD Lawn","year":"2011","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(10)61889-2","article-title":"High-dose vitamin D3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial","volume":"377","author":"AR Martineau","year":"2011","journal-title":"The Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/infdis\/158.2.366","article-title":"Predictors of short-term prognosis in patients with pulmonary tuberculosis","volume":"158","author":"PF Barnes","year":"1988","journal-title":"J INFECT DIS"},{"key":"ref7","first-page":"A114","article-title":"Neutrophilia in Tuberculosis [abstract]","volume":"63","author":"A Bandara","year":"2008","journal-title":"Thorax"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/cid\/cir1039","article-title":"Characteristics and Early Outcomes of Patients With Xpert MTB\/RIF-Negative Pulmonary Tuberculosis Diagnosed During Screening Before Antiretroviral Therapy","volume":"54","author":"SD Lawn","year":"2012","journal-title":"CLIN INFECT DIS"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Lawn SD, Kerkhoff AD, Vogt M, Wood R (2012) High diagnostic yield of tuberculosis from screening urine samples from HIV-infected patients with advanced immunodeficiency using the Xpert MTB\/RIF assay. J Acquir Immune Defic Syndr. doi:10.1097\/QAI.0b013e318258c6af.","DOI":"10.1097\/QAI.0b013e318258c6af"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1097\/QAD.0b013e3283553685","article-title":"Clinical significance of lipoarabinomannan detection in urine using a low-cost point-of-care diagnostic assay for HIV-associated tuberculosis","volume":"26","author":"SD Lawn","year":"2012","journal-title":"AIDS"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"636","DOI":"10.5588\/ijtld.12.0811","article-title":"Diagnostic and prognostic value of serum C-reactive protein for screening for HIV-associated tuberculosis","volume":"17","author":"SD Lawn","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1097\/01.aids.0000238406.93249.cd","article-title":"Burden of tuberculosis in an antiretroviral treatment programme in sub-Saharan Africa: impact on treatment outcomes and implications for tuberculosis control","volume":"20","author":"SD Lawn","year":"2006","journal-title":"AIDS"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1097\/01.aids.0000194802.89540.e1","article-title":"Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design","volume":"19","author":"SD Lawn","year":"2005","journal-title":"AIDS"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/QAD.0b013e328011efac","article-title":"Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa","volume":"21","author":"SD Lawn","year":"2007","journal-title":"AIDS"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e55824","DOI":"10.1371\/journal.pone.0055824","article-title":"Prevalent and Incident Tuberculosis Are Independent Risk Factors for Mortality among Patients Accessing Antiretroviral Therapy in South Africa","volume":"8","author":"A Gupta","year":"2013","journal-title":"PLoS ONE"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1000391","DOI":"10.1371\/journal.pmed.1000391","article-title":"Development of a standardized screening rule for tuberculosis in people living with HIV in resource-constrained settings: individual participant data meta-analysis of observational studies","volume":"8","author":"H Getahun","year":"2011","journal-title":"PLoS Med"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Lawn SD, Kerkhoff AD, Pahlana P, Vogt M, Wood RR (2012) Diagnostic yield of tuberculosis using sputum induction in HIV-positive patients before antiretroviral therapy. Int J Tuberc Lung Dis. doi:10.5588\/ijtld.12.0174.","DOI":"10.5588\/ijtld.12.0174"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Lawn SD, Mwaba P, Bates M, Piatek A, Alexander H, <etal>et al<\/etal>.. (2013) Advances in tuberculosis diagnostics: the Xpert MTB\/RIF assay and future prospects for a point-of-care test. Lancet Infect Dis: 1\u201313. doi:10.1016\/S1473-3099(13)70008-2.","DOI":"10.1016\/S1473-3099(13)70008-2"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1378\/chest.121.2.519","article-title":"Elevated Levels of \u03b1-Defensins in Plasma and BAL Fluid of Patients With Active Pulmonary Tuberculosis","volume":"121","author":"JI Ashitani","year":"2002","journal-title":"Chest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1164\/ajrccm.157.3.9705044","article-title":"Local immune responses correlate with presentation and outcome in tuberculosis","volume":"157","author":"R Condos","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1084\/jem.20110919","article-title":"Regulation of neutrophils by interferon- limits lung inflammation during tuberculosis infection","volume":"208","author":"B Nandi","year":"2011","journal-title":"Journal of Experimental Medicine"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Anbarasu D, Ponnu Raja C, Raja A (2013) Multiplex analysis of cytokines\/chemokines as biomarkers that differentiate healthy contacts from tuberculosis patients in high endemic settings. Cytokine. doi:10.1016\/j.cyto.2012.12.031.","DOI":"10.1016\/j.cyto.2012.12.031"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2567.2008.02950.x","article-title":"Neutrophil mobilization and clearance in the bone marrow","volume":"125","author":"RC Furze","year":"2008","journal-title":"Immunology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1182\/blood.V90.7.2583","article-title":"Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation","volume":"90","author":"F Liu","year":"1997","journal-title":"Blood"},{"key":"ref25","first-page":"41","article-title":"Depressed phagocytosis and oxidative burst in polymorphonuclear leukocytes from individuals with pulmonary tuberculosis with or without human immunodeficiency virus type 1 infection","volume":"5","author":"S Shalekoff","year":"1998","journal-title":"Clinical and Vaccine Immunology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0928-8244(03)00004-X","article-title":"Impaired neutrophil function in patients with pulmonary tuberculosis and its normalization in those undergoing specific treatment, except the HIV-coinfected cases","volume":"35","author":"G Fiorenza","year":"2003","journal-title":"FEMS Immunology & Medical Microbiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.arcmed.2007.01.011","article-title":"Functional characteristics of neutrophils and mononuclear cells from tuberculosis patients stimulated in vitro with heat killed M. tuberculosis","volume":"38","author":"G Fiorenza","year":"2007","journal-title":"Arch Med Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0067956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T06:19:04Z","timestamp":1596089944000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0067956"}},"subtitle":[],"editor":[{"given":"Pere-Joan","family":"Cardona","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0067956","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}