{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:46:30Z","timestamp":1788522390291,"version":"build-2803163510"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068053","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T21:04:42Z","timestamp":1372799082000},"page":"e68053","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":43,"title":["In Vitro Activity of Sodium New Houttuyfonate Alone and in Combination with Oxacillin or Netilmicin against Methicillin-Resistant Staphylococcus aureus"],"prefix":"10.1371","volume":"8","author":[{"given":"Xi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longyin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefu","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"ref1","first-page":"124","article-title":"\u201cCelbenin\u201d-resistant Staphylococci","volume":"14","author":"MJ Patricia","year":"1961","journal-title":"British Medical Journal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/jac\/dkr437","article-title":"MRSA: the first half century","volume":"67","author":"RC Moellering Jr","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.diagmicrobio.2008.06.003","article-title":"In vitro activity of ceftobiprole, linezolid, tigecycline, and 23 other antimicrobial agents against Staphylococcus aureus isolates in China","volume":"62","author":"H Wang","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijantimicag.2011.09.028","article-title":"New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance","volume":"39","author":"IM Gould","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0140-6736(03)15162-8","article-title":"Artesunate combinations for treatment of malaria: meta-analysis","volume":"363","author":"M Adjuik","year":"2004","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(05)67176-0","article-title":"Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial","volume":"366","author":"MA Faiz","year":"2005","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/infdis\/155.5.979","article-title":"Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae","volume":"155","author":"GH Rabbani","year":"1987","journal-title":"J Infect Dis"},{"key":"ref8","unstructured":"Chinese Pharmacopoeia Commission (2010) Chinese Material Medica and Prepared Slices of Chinese Crude Drugs. Pharmacopoeia of the People\u2019s Republic of China.9 ed. Beijing, China: China Medical Science Press. 208\u2013209."},{"key":"ref9","unstructured":"State Administration of Traditional Chinese Medicine of the People&apos;s Republic of China website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.satcm.gov.cn\/zhuanti\/jbfz\/20060901\/100052.shtml\" xlink:type=\"simple\">http:\/\/www.satcm.gov.cn\/zhuanti\/jbfz\/20060901\/100052.shtml<\/ext-link>. Accessed 2013 Jun 5."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1248\/cpb.54.936","article-title":"Variation in chemical composition and antibacterial activities of essential oils from two species of Houttuynia Thunb","volume":"54","author":"H Lu","year":"2006","journal-title":"Chem Pharm Bull"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1248\/bpb.31.2012","article-title":"Biological and antibacterial activities of the natural herb Houttuynia cordata water extract against the intracellular bacterial pathogen salmonella within the RAW 264.7 macrophage","volume":"31","author":"GS Kim","year":"2008","journal-title":"Biol Pharm Bull"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jep.2005.09.012","article-title":"Anti-inflammatory effect of Houttuynia cordata injection","volume":"104","author":"HM Lu","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1055\/s-2006-958063","article-title":"Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV","volume":"61","author":"K Hayashi","year":"1995","journal-title":"Planta Med"},{"key":"ref14","unstructured":"Chinese Pharmacopoeia Commission (1995) Pharmacopoeia of the People\u2019s Republic of China. Beijing, China: Chemical Industry Press. 411\u2013412."},{"key":"ref15","unstructured":"China Food and Drug Administration website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sda.gov.cn\/bzzzmd9\/50.htm\" xlink:type=\"simple\">http:\/\/www.sda.gov.cn\/bzzzmd9\/50.htm<\/ext-link>. Accessed 2013 Jun 5."},{"key":"ref16","first-page":"36","article-title":"Observation of sodium new houttuyfonat injection in the treatment of children acute upper respiratory infection","volume":"16","author":"L Liang","year":"2006","journal-title":"Shenzhen Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"ref17","first-page":"39","article-title":"Clinical observation on the treatment of bronchiolitis with nebulized-inhalation of sodium new houttuyfonate injection in 50 cases","volume":"17","author":"X Yu","year":"2005","journal-title":"Tianjin Pharmacy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10286020500035243","article-title":"Relationship between the antibacterial and immunological activities of houttuyfonate homologues and their surface activities","volume":"8","author":"XL Ye","year":"2006","journal-title":"J Asian Nat Prod Res"},{"key":"ref19","first-page":"130","article-title":"Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis","volume":"350","author":"XL Ye","year":"2009","journal-title":"Colloids and Surfaces a-Physicochemical and Engineering Aspects"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1128\/AAC.00804-08","article-title":"Molecular evidence for spread of two major methicillin-resistant Staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals","volume":"53","author":"Y Liu","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref21","unstructured":"Clinical and Laboratory Standards Institute (2007) Performance standards for antimicrobial susceptibility testing; seventeenth informational supplement. CLSI document M100-S17. Wayne, Pennsylvania, USA."},{"key":"ref22","unstructured":"Clinical and Laboratory Standards Institute (2012) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard. CLSI document M07-A9.9 ed. Wayne, Pennsylvania, USA."},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Verma P (2007) Methods for determining bactericidal activity and antimicrobial interactions synergy testing, time-kill curves, and population analysis. In: Schwalbe R, Steele-Moore L, Goodwin AC, editors. Antimicrobial susceptibility testing protocols. Roca Raton, Florida, USA: CRC Press. 275\u2013298.","DOI":"10.1201\/9781420014495.ch12"},{"key":"ref24","unstructured":"Pillai S, Moellering R, Jr Eliopoulos G (2005) Antimicrobial Combinations. In: Lorian V, editor. Antibiotics in Laboratory Medicine. 5 ed. Philadelphia, Pennsylvania, USA: Lippincott Williams and Wilkins. 365\u2013440."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.colsurfa.2007.01.012","article-title":"Interaction of houttuyfonate homologues with the cell membrane of gram-positive and gram-negative bacteria","volume":"301","author":"X Ye","year":"2007","journal-title":"Colloids and Surfaces A: Physicochemical and Engineering Aspects"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.colsurfa.2009.09.017","article-title":"Antibacterial mechanism of houttuyfonate homologues against Bacillus subtilis","volume":"350","author":"X Ye","year":"2009","journal-title":"Colloids and Surfaces A: Physicochemical and Engineering Aspects"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00044-008-9133-0","article-title":"Synthesis of novel analogues on the \u03b1-carbon of houttuyfonate and SAR analysis of antibacterial activity with MOPAC","volume":"18","author":"Z Li","year":"2009","journal-title":"Medicinal Chemistry Research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-6968.2002.tb11448.x","article-title":"Antibacterial properties of cationic steroid antibiotics","volume":"217","author":"PB Savage","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8848","DOI":"10.3390\/molecules16108848","article-title":"Transcriptional and functional analysis shows sodium houttuyfonate-mediated inhibition of autolysis in Staphylococcus aureus","volume":"16","author":"G Liu","year":"2011","journal-title":"Molecules"},{"key":"ref30","first-page":"601","article-title":"Investigation of efficacy of sythesized sodium neo-houttuyfonate in clinical settings","volume":"10","author":"C Qiu","year":"1979","journal-title":"New Medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/jac\/dks071","article-title":"Synergy between oxacillin and manuka honey sensitizes methicillin-resistant Staphylococcus aureus to oxacillin","volume":"67","author":"RE Jenkins","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"ref32","first-page":"1305","article-title":"Clinical studies on the time-difference combination therapy with netilmicin and minocycline in methicillin-resistant Staphylococcus aureus infections","volume":"47","author":"M Nasu","year":"1994","journal-title":"Jpn J Antibiot"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.11150\/kansenshogakuzasshi1970.68.1523","article-title":"A case of MRSA sepsis treated by the sequential combination therapy netilmycin and minocycline","volume":"68","author":"S Maesaki","year":"1994","journal-title":"Kansenshogaku Zasshi"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:52:40Z","timestamp":1588963960000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068053"}},"subtitle":[],"editor":[{"given":"Karsten","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068053","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]}}}