{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:49:36Z","timestamp":1789951776115,"version":"4.0.1"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068343","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T20:56:35Z","timestamp":1372971395000},"page":"e68343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":81,"title":["Indolent Small Intestinal CD4+ T-cell Lymphoma Is a Distinct Entity with Unique Biologic and Clinical Features"],"prefix":"10.1371","volume":"8","author":[{"given":"Elizabeth","family":"Margolskee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaidehi","family":"Jobanputra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne K.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H. R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1703","article-title":"Gastrointestinal lymphoma: where morphology meets molecular biology","volume":"205","author":"PG Isaacson","year":"2005","journal-title":"J Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1002\/cncr.11415","article-title":"Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends","volume":"97","author":"S Nakamura","year":"2003","journal-title":"Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00000478-199305000-00001","article-title":"Primary lymphoma of the small intestine. A clinicopathological study of 119 cases","volume":"17","author":"P Domizio","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2559.2003.01659.x","article-title":"Clinicopathological analysis of 143 primary malignant lymphomas in the small and large intestines based on the new WHO classification","volume":"43","author":"S Kohno","year":"2003","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/1097-0142(19800701)46:1<215::AID-CNCR2820460136>3.0.CO;2-6","article-title":"Gastrointestinal involvement in non-Hodgkin\u2019s lymphoma","volume":"46","author":"R Herrmann","year":"1980","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3931","DOI":"10.1182\/blood-2008-10-185256","article-title":"Clinical differences between nasal and extranasal natural killer\/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project","volume":"113","author":"WY Au","year":"2009","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1182\/blood-2011-02-335216","article-title":"Enteropathy-associated T-cell lymphoma: clinical and histological findings from the international peripheral T-cell lymphoma project","volume":"118","author":"J Delabie","year":"2011","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1097\/PAS.0b013e318222dfcd","article-title":"Type II enteropathy-associated T-cell lymphoma: a distinct aggressive lymphoma with frequent gammadelta T-cell receptor expression","volume":"35","author":"JK Chan","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.5858\/arpa.2011-0145-RA","article-title":"Lymphoproliferative disorders of the gastrointestinal tract: a review and pragmatic guide to diagnosis","volume":"135","author":"JS Burke","year":"2011","journal-title":"Arch Pathol Lab Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2559.1998.00394.x","article-title":"Primary intestinal gamma-delta T-cell lymphoma with evidence of Epstein-Barr virus","volume":"32","author":"A Lavergne","year":"1998","journal-title":"Histopathology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/ajcp\/112.5.696","article-title":"Primary anaplastic large cell lymphoma of the small intestine","volume":"112","author":"MJ Carey","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00000478-200002000-00017","article-title":"Spontaneously relapsing clonal, mucosal cytotoxic T-cell lymphoproliferative disorder: case report and review of the literature","volume":"24","author":"EA Ranheim","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/1097-0142(19950401)75:7<1728::AID-CNCR2820750727>3.0.CO;2-9","article-title":"Relapsing oral and colonic ulcers with monoclonal T-cell infiltration. A low grade mucosal T-lymphoproliferative disease of the digestive tract","volume":"75","author":"N Egawa","year":"1995","journal-title":"Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/gut.45.5.662","article-title":"The clinicopathological features of extensive small intestinal CD4 T cell infiltration","volume":"45","author":"F Carbonnel","year":"1999","journal-title":"Gut"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/1097-0142(19940215)73:4<1286::AID-CNCR2820730425>3.0.CO;2-9","article-title":"Extensive small intestinal T-cell lymphoma of low-grade malignancy associated with a new chromosomal translocation","volume":"73","author":"F Carbonnel","year":"1994","journal-title":"Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1023\/B:DDAS.0000026297.25591.62","article-title":"CD4+ T-cell lymphoproliferative disorder of the gut clinically mimicking celiac sprue","volume":"49","author":"J Zivny","year":"2004","journal-title":"Dig Dis Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s00428-007-0475-7","article-title":"Small intestinal CD4+ T-cell lymphoma: a rare distinctive clinicopathological entity associated with prolonged survival","volume":"451","author":"M Svrcek","year":"2007","journal-title":"Virchows Arch"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1053\/gast.1996.v111.pm8780585","article-title":"Primary gastrointestinal T-cell lymphoma resembling multiple lymphomatous polyposis","volume":"111","author":"K Hirakawa","year":"1996","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1182\/blood-2010-08-302737","article-title":"NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series","volume":"117","author":"A Mansoor","year":"2011","journal-title":"Blood"},{"key":"ref20","unstructured":"Isaacson PG CA, Ott G, <etal>et al<\/etal>.. (2008) Enteropathy-associated T-cell lymphoma. In: Swerdlow SH CE HN, <etal>et al<\/etal>.., editor. WHO classification of Tumours of the Haematopoietic and Lymphoid Tissues. 4th ed. Lyon: IARC. 289\u2013291."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98\u20133936","volume":"17","author":"JJ van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1002\/eji.1830170910","article-title":"A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes","volume":"17","author":"N Cerf-Bensussan","year":"1987","journal-title":"Eur J Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ajh.23213","article-title":"Type II enteropathy-associated T-cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group","volume":"87","author":"E Tse","year":"2012","journal-title":"Am J Hematol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/S0002-9440(10)65736-7","article-title":"Most CD56+ intestinal lymphomas are CD8+CD5-T-cell lymphomas of monomorphic small to medium size histology","volume":"153","author":"A Chott","year":"1998","journal-title":"Am J Pathol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.immuni.2006.08.003","article-title":"From vanilla to 28 flavors: multiple varieties of T regulatory cells","volume":"25","author":"EM Shevach","year":"2006","journal-title":"Immunity"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0955-0674(00)00132-0","article-title":"T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines","volume":"12","author":"WW Agace","year":"2000","journal-title":"Curr Opin Cell Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.coi.2011.07.002","article-title":"Histone\/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells","volume":"23","author":"UH Beier","year":"2011","journal-title":"Curr Opin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e19047","DOI":"10.1371\/journal.pone.0019047","article-title":"Rapid temporal control of Foxp3 protein degradation by sirtuin-1","volume":"6","author":"J van Loosdregt","year":"2011","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2009-02-207118","article-title":"Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization","volume":"115","author":"J van Loosdregt","year":"2010","journal-title":"Blood"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PAS.0b013e31818e52fe","article-title":"Primary cutaneous CD4+ small\/medium-sized pleomorphic T-cell lymphoma expresses follicular T-cell markers","volume":"33","author":"SM Rodriguez Pinilla","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.it.2013.01.001","article-title":"T follicular helper cell diversity and plasticity","volume":"34","author":"JL Cannons","year":"2013","journal-title":"Trends Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/cyto.b.20481","article-title":"Aberrant T-lymphocytes in refractory coeliac disease are not strictly confined to a small intestinal intraepithelial localization","volume":"76","author":"WH Verbeek","year":"2009","journal-title":"Cytometry B Clin Cytom"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1136\/gut.52.2.205","article-title":"Refractory coeliac sprue is a diffuse gastrointestinal disease","volume":"52","author":"V Verkarre","year":"2003","journal-title":"Gut"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.dld.2012.12.001","article-title":"Enteropathy associated T cell lymphoma in celiac disease: A large retrospective study","volume":"45","author":"G Malamut","year":"2013","journal-title":"Dig Liver Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2008.09.069","article-title":"Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II","volume":"136","author":"G Malamut","year":"2009","journal-title":"Gastroenterology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s005350050253","article-title":"Immunoblastic lymphadenopathy-like T-cell lymphoma complicated by multiple gastrointestinal involvement","volume":"34","author":"T Kaneki","year":"1999","journal-title":"J Gastroenterol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/1097-0142(19830201)51:3<487::AID-CNCR2820510321>3.0.CO;2-L","article-title":"Angioimmunoblastic lymphadenopathy. A case with an unusual clinical course with marked tumorous infiltration of multiple organs and striking intestinal involvement","volume":"51","author":"J Moreb","year":"1983","journal-title":"Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF02982049","article-title":"T-cell prolymphocytic leukemia with hemorrhagic gastrointestinal involvement and a new chromosomal abnormality","volume":"75","author":"S Toyota","year":"2002","journal-title":"Int J Hematol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/MAJ.0b013e31821389da","article-title":"Small bowel obstruction due to mycosis fungoides: an unusual presentation","volume":"341","author":"P Velagapudi","year":"2011","journal-title":"Am J Med Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/014107688407700209","article-title":"Gastrointestinal complications of mycosis fungoides","volume":"77","author":"DN Slater","year":"1984","journal-title":"J R Soc Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/1097-0142(19930201)71:3<708::AID-CNCR2820710309>3.0.CO;2-P","article-title":"Primary T-cell lymphoma of the gastrointestinal tract associated with human T-cell lymphotropic virus type I. An analysis using in situ hybridization and polymerase chain reaction","volume":"71","author":"O Tokunaga","year":"1993","journal-title":"Cancer"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac disease","volume":"357","author":"PH Green","year":"2007","journal-title":"N Engl J Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0140-6736(97)01042-8","article-title":"Autoimmune enteropathy and villous atrophy in adults","volume":"350","author":"GR Corazza","year":"1997","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1002\/cncr.26700","article-title":"Increasing incidence of enteropathy-associated T-cell lymphoma in the United States, 1973\u20132008","volume":"118","author":"RZ Sharaiha","year":"2012","journal-title":"Cancer"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/j.1460-2075.1992.tb05482.x","article-title":"A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma","volume":"11","author":"Y Laabi","year":"1992","journal-title":"EMBO J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1600-065X.2011.01067.x","article-title":"Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease","volume":"244","author":"RC Rickert","year":"2011","journal-title":"Immunol Rev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1053\/j.gastro.2007.03.036","article-title":"Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes","volume":"132","author":"RJ Deleeuw","year":"2007","journal-title":"Gastroenterology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/S0002-9440(10)64441-0","article-title":"Chromosomal gains at 9q characterize enteropathy-type T-cell lymphoma","volume":"161","author":"A Zettl","year":"2002","journal-title":"Am J Pathol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/01.LAB.0000090157.13040.58","article-title":"High frequency of genetic aberrations in enteropathy-type T-cell lymphoma","volume":"83","author":"AK Baumgartner","year":"2003","journal-title":"Lab Invest"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2567.2005.02091.x","article-title":"Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas","volume":"114","author":"TJ Mitchell","year":"2005","journal-title":"Immunology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cell.2007.03.014","article-title":"Zfx controls the self-renewal of embryonic and hematopoietic stem cells","volume":"129","author":"JM Galan-Caridad","year":"2007","journal-title":"Cell"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e42302","DOI":"10.1371\/journal.pone.0042302","article-title":"ZFX controls the self-renewal of human embryonic stem cells","volume":"7","author":"S Harel","year":"2012","journal-title":"PLoS One"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12038-011-9174-2","article-title":"Differential expression of ZFX gene in gastric cancer","volume":"37","author":"P Nikpour","year":"2012","journal-title":"J Biosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T05:29:37Z","timestamp":1563341377000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068343"}},"subtitle":[],"editor":[{"given":"Dat Quoc","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":53,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068343","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}