{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:59:11Z","timestamp":1782968351046,"version":"3.54.5"},"reference-count":106,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T00:00:00Z","timestamp":1372896000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068371","type":"journal-article","created":{"date-parts":[[2013,7,4]],"date-time":"2013-07-04T20:56:40Z","timestamp":1372971400000},"page":"e68371","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["The Metabotropic Glutamate 5 Receptor Modulates Extinction and Reinstatement of Methamphetamine-Seeking in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Rose","family":"Chesworth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn M.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1747-597X-6-3","article-title":"Treatment utilization and barriers to treatment: results of a survey of dependent methamphetamine users","volume":"6","author":"P Kenny","year":"2011","journal-title":"Subst Abuse Treat Prev Policy"},{"key":"ref2","unstructured":"Pennay A, Lee N (2008) Methamphetamine. Prevention Research Quarterly: Current evidence evaluated September: 1\u201310."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"PW Kalivas","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1523\/JNEUROSCI.16-04-01550.1996","article-title":"Repeated cocaine augments excitatory amino acid transmission in the nucleus accumbens only in rats having developed behavioral sensitization","volume":"16","author":"RC Pierce","year":"1996","journal-title":"J Neurosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2011.03.077","article-title":"Group II metabotropic glutamate receptors in the striatum of non-human primates: Dysregulation following chronic cocaine self-administration","volume":"496","author":"TJ Beveridge","year":"2011","journal-title":"Neurosci Lett"},{"key":"ref6","unstructured":"Brown AL, Flynn JR, Smith DW, Dayas CV (2010) Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals. Int J Neuropsychopharmacol: 1\u201312."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2174\/1874473710801030303","article-title":"Hypothesis-driven medication discovery for the treatment of psychostimulant addiction","volume":"1","author":"ZX Xi","year":"2008","journal-title":"Curr Drug Abuse Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/syn.20640","article-title":"Extended daily access to cocaine results in distinct alterations in Homer 1b\/c and NMDA receptor subunit expression within the medial prefrontal cortex","volume":"63","author":"O Ben-Shahar","year":"2009","journal-title":"Synapse"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejphar.2010.01.030","article-title":"Group II metabotropic glutamate receptors (mGlu2\/3) in drug addiction","volume":"639","author":"K Moussawi","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1749-6632.2009.05144.x","article-title":"Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction","volume":"1187","author":"HD Schmidt","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/B978-0-12-385506-0.00009-0","article-title":"Glutamatergic neuroplasticity in cocaine addiction","volume":"98","author":"JD Uys","year":"2010","journal-title":"Prog Mol Biol Transl Sci"},{"key":"ref12","first-page":"9","article-title":"Metabolic Abnormalities in Abstinent Methamphetamine Dependent Subjects","volume":"2010","author":"N Sailasuta","year":"2010","journal-title":"Subst Abuse"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s11481-008-9108-4","article-title":"Adaptation of brain glutamate plus glutamine during abstinence from chronic methamphetamine use","volume":"3","author":"T Ernst","year":"2008","journal-title":"J Neuroimmune Pharmacology"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Yucel M, Lubman DI, Harrison BJ, Fornito A, Allen NB, <etal>et al<\/etal>.. (2007) A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction. Mol Psychiatry 12: 611, 691\u2013702.","DOI":"10.1038\/sj.mp.4001955"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10846","DOI":"10.1523\/JNEUROSCI.2496-04.2004","article-title":"A novel Ca2<sup>+<\/sup>-independent signaling pathway to extracellular signal-regulated protein kinase by coactivation of NMDA receptors and metabotropic glutamate receptor 5 in neurons","volume":"24","author":"L Yang","year":"2004","journal-title":"J Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nn1069","article-title":"Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse","volume":"6","author":"DA Baker","year":"2003","journal-title":"Nat Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopsych.2009.07.018","article-title":"Ceftriaxone restores glutamate homeostasis and prevents relapse to cocaine seeking","volume":"67","author":"LA Knackstedt","year":"2010","journal-title":"Biol Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1073\/pnas.1011265108","article-title":"Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse","volume":"108","author":"K Moussawi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/npp.2010.226","article-title":"Repeated N-acetyl cysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans","volume":"36","author":"SL Amen","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1098-2396(199603)22:3<217::AID-SYN3>3.0.CO;2-F","article-title":"Striatal and cortical NMDA receptors are altered by a neurotoxic regimen of methamphetamine","volume":"22","author":"AJ Eisch","year":"1996","journal-title":"Synapse"},{"key":"ref21","first-page":"107","article-title":"Effects of subchronic treatment of methamphetamine haloperidol on the rat brain levels of GABA, glutamate and aspartate","volume":"37","author":"H Kaiya","year":"1983","journal-title":"Folia Psychiatr Neurol Jpn"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1196\/annals.1441.015","article-title":"Antagonists at metabotropic glutamate receptor subtype 5: structure activity relationships and therapeutic potential for addiction","volume":"1141","author":"FI Carroll","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ejphar.2010.01.029","article-title":"Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction","volume":"639","author":"MF Olive","year":"2011","journal-title":"Eur J Pharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/1874467210902010083","article-title":"Group I metabotropic glutamate receptors: involvement in drug-seeking and drug-induced plasticity","volume":"2","author":"MK Bird","year":"2009","journal-title":"Curr Mol Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tips.2009.09.008","article-title":"The promiscuous mGlu5 receptor\u2013a range of partners for therapeutic possibilities?","volume":"30","author":"MK Bird","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/1874473710902010083","article-title":"Metabotropic glutamate receptor ligands as potential therapeutics for addiction","volume":"2","author":"MF Olive","year":"2009","journal-title":"Curr Drug Abuse Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.pbb.2011.03.015","article-title":"The role of metabotropic glutamate receptors in addiction: Evidence from preclinical models","volume":"100","author":"JR Duncan","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.coph.2008.12.003","article-title":"Glutamate and reinstatement","volume":"9","author":"LA Knackstedt","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90227-C","article-title":"Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain","volume":"163","author":"R Shigemoto","year":"1993","journal-title":"Neurosci Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1460-9568.1996.tb01611.x","article-title":"Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus","volume":"8","author":"R Lujan","year":"1996","journal-title":"Eur J Neurosci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.903550310","article-title":"Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain","volume":"355","author":"C Romano","year":"1995","journal-title":"J Comp Neurol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1124\/jpet.105.090449","article-title":"The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems","volume":"315","author":"MS Cowen","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00213-006-0583-0","article-title":"Assessing appetitive and consummatory phases of ethanol self-administration in C57BL\/6J mice under operant conditions: regulation by mGlu5 receptor antagonism","volume":"190","author":"MS Cowen","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1530-0277.2007.00570.x","article-title":"Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats","volume":"32","author":"J Besheer","year":"2008","journal-title":"Alc Clin Exp Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1124\/jpet.109.151357","article-title":"Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine] on conditioned reinstatement and reinforcement: comparison between cocaine and a conventional reinforcer","volume":"329","author":"R Martin-Fardon","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/npp.2008.140","article-title":"mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats","volume":"34","author":"JT Gass","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1196\/annals.1432.034","article-title":"A role for mGluR5 receptors in intravenous methamphetamine self-administration","volume":"1139","author":"MPH Osborne","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/npp.2008.72","article-title":"A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior","volume":"34","author":"RM Brown","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ejphar.2004.07.056","article-title":"Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking","volume":"499","author":"M Tessari","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.neuropharm.2011.08.028","article-title":"Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats","volume":"61","author":"MS D'Souza","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nn0901-873","article-title":"Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice","volume":"4","author":"C Chiamulera","year":"2001","journal-title":"Nat Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/syn.10166","article-title":"The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse","volume":"47","author":"AJ McGeehan","year":"2003","journal-title":"Synapse"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/j.1460-9568.2004.03609.x","article-title":"Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice","volume":"20","author":"T Aoki","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00213-010-2095-1","article-title":"Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine","volume":"214","author":"MM Veeneman","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.drugalcdep.2006.04.003","article-title":"Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties","volume":"85","author":"KD Lominac","year":"2006","journal-title":"Drug Alc Dep"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/13556210500223272","article-title":"Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats","volume":"10","author":"V Herzig","year":"2005","journal-title":"Addict Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00213-011-2578-8","article-title":"Involvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal","volume":"221","author":"AK Stoker","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"ref48","first-page":"765","article-title":"Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice","volume":"11","author":"MK Bird","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997","article-title":"Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP","volume":"17","author":"YM Lu","year":"1997","journal-title":"J Neurosci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1101\/lm.5.4.331","article-title":"Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5","volume":"5","author":"Z Jia","year":"1998","journal-title":"Learn Mem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0028-3908(99)00123-9","article-title":"DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists","volume":"38","author":"SM Fitzjohn","year":"1999","journal-title":"Neuropharmacology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/npp.2009.30","article-title":"mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning","volume":"34","author":"J Ayala","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1471-4159.1999.0720157.x","article-title":"Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment","volume":"72","author":"MB Ghasemzadeh","year":"1999","journal-title":"J Neurochem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.1187801","article-title":"Transition to addiction is associated with a persistent impairment in synaptic plasticity","volume":"328","author":"F Kasanetz","year":"2010","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"TV Bliss","year":"1993","journal-title":"Nature"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1579","article-title":"Neural systems of reinforcement for drug addiction: from actions to habits to compulsion","volume":"8","author":"BJ Everitt","year":"2005","journal-title":"Nat Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"SE Hyman","year":"2006","journal-title":"Ann Rev Neurosci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1037\/a0022339","article-title":"mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration","volume":"125","author":"RM Cleva","year":"2011","journal-title":"Behav Neurosci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.biopsych.2008.11.001","article-title":"Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory","volume":"65","author":"JT Gass","year":"2009","journal-title":"Biol Psychiatry"},{"key":"ref60","first-page":"1","article-title":"The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats","volume":"S1","author":"JJ Widholm","year":"2011","journal-title":"Add Res Ther"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3389\/fphar.2011.00093","article-title":"Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration","volume":"2","author":"RM Cleva","year":"2012","journal-title":"Front Pharmacol"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Brown R, Duncan J, Stagnitti M, Ledent C, Lawrence A (2012) mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine. Int J Neuropsychopharmacol: 1\u20137.","DOI":"10.1017\/S146114571100126X"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.drugalcdep.2011.11.002","article-title":"The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice","volume":"123","author":"RM Brown","year":"2012","journal-title":"Drug Alcohol Depend"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/npp.2011.35","article-title":"The necessity of \u03b14* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine","volume":"36","author":"E Cahir","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/cercor\/bhp159","article-title":"Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine","volume":"20","author":"CS McPherson","year":"2010","journal-title":"Cereb Cortex"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbr.2005.11.030","article-title":"Relapse of methamphetamine-seeking behavior in C57BL\/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration","volume":"168","author":"Y Yan","year":"2006","journal-title":"Behav Brain Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00213-008-1184-x","article-title":"A reliable method to study cue-, priming-, and stress-induced reinstatement of cocaine self-administration in mice","volume":"199","author":"G Soria","year":"2008","journal-title":"Psychopharmacology (Berl)"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1017\/S1461145709990162","article-title":"Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice","volume":"13","author":"MK Bird","year":"2010","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00213-010-2095-1","article-title":"Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine","volume":"214","author":"MM Veeneman","year":"2011","journal-title":"Psychopharmacology (Berl)"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.euroneuro.2012.05.014","article-title":"mGluR5 is necessary for maintenance of methamphetamine-induced associative learning","volume":"23","author":"AA Herrold","year":"2012","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"11973","DOI":"10.1523\/JNEUROSCI.2550-10.2010","article-title":"Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons","volume":"30","author":"M Novak","year":"2010","journal-title":"J Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1046\/j.1360-0443.2002.00014.x","article-title":"Applying extinction research and theory to cue-exposure addiction treatments","volume":"97","author":"CA Conklin","year":"2002","journal-title":"Addiction"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.lfs.2011.09.014","article-title":"mGlu5 receptor deletion reduces relapse to food-seeking and prevents the anti-relapse effects of mGlu5 receptor blockade in mice","volume":"89","year":"2011","journal-title":"Life Sci"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1369-1600.2010.00296.x","article-title":"Emergence of context-associated GluR(1) and ERK phosphorylation in the nucleus accumbens core during withdrawal from cocaine self-administration","volume":"16","author":"S Edwards","year":"2011","journal-title":"Addiction Biol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1523\/JNEUROSCI.3667-06.2007","article-title":"Cocaine-associated stimuli increase cocaine seeking and activate accumbens core neurons after abstinence","volume":"27","author":"JA Hollander","year":"2007","journal-title":"J Neurosci"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/syn.20486","article-title":"Behavioral responding and nucleus accumbens cell firing are unaltered following periods of abstinence from sucrose","volume":"62","author":"JL Jones","year":"2008","journal-title":"Synapse"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00213-012-2804-z","article-title":"Attenuation of reinstatement of methamphetamine-, sucrose-, and food-seeking behavior in rats by fenobam, a metabotropic glutamate receptor 5 negative allosteric modulator","volume":"225","author":"L Watterson","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00213-007-0753-8","article-title":"Involvement of AMPA\/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats","volume":"192","author":"P Backstrom","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.pbb.2012.01.014","article-title":"mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior","volume":"101","author":"CM Sinclair","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neuropharm.2005.06.007","article-title":"Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats","volume":"49","author":"AY Bespalov","year":"2005","journal-title":"Neuropharmacology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1038\/sj.npp.1300540","article-title":"The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety","volume":"29","author":"CS Busse","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.neuropharm.2010.11.013","article-title":"Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration","volume":"62","author":"S Parmentier-Batteur","year":"2012","journal-title":"Neuropharmacology"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuropharm.2012.05.005","article-title":"Molecular mechanisms that desensitize metabotropic glutamate receptor signaling: An overview","volume":"66","author":"L Iacovelli","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neulet.2012.07.014","article-title":"mGluR5 knockout mice display increased dendritic spine densities","volume":"524","author":"CC Chen","year":"2012","journal-title":"Neurosci Lett"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Stankeviciute NM, Scofield MD, Kalivas PW, Gipson CD (2013) Rapid, transient potentiation of dendritic spines in context-induced relapse to cocaine seeking. Addict Biol. doi: 10.1111\/adb.12064.","DOI":"10.1111\/adb.12064"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.biopsych.2008.03.007","article-title":"Context-induced relapse of conditioned behavioral responding to ethanol cues in rats","volume":"64","author":"N Chaudhri","year":"2008","journal-title":"Biol Psychiatry"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1523\/JNEUROSCI.2523-10.2010","article-title":"D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens","volume":"30","author":"M Torregrossa","year":"2010","journal-title":"J Neurosci"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0023-9690(72)90021-5","article-title":"Compound tests for excitation in early acquisition and after prolonged extinction of conditioned suppression","volume":"3","author":"D Reberg","year":"1972","journal-title":"Learn Motiv"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1371\/journal.pone.0000698","article-title":"Intense sweetness surpasses cocaine reward","volume":"2","author":"M Lenoir","year":"2007","journal-title":"PLoS One"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"e11592","DOI":"10.1371\/journal.pone.0011592","article-title":"Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction","volume":"5","author":"L Cantin","year":"2010","journal-title":"PLoS One"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/FBP.0b013e3283473be4","article-title":"A comparison of economic demand and conditioned-cued reinstatement of methamphetamine-seeking or food-seeking in rats","volume":"22","author":"CM Galuska","year":"2011","journal-title":"Behav Pharmacol"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.pbb.2008.07.009","article-title":"Demand for cocaine and food over time","volume":"91","author":"CJ Christensen","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s00213-009-1490-y","article-title":"Role of protein kinase C epsilon (PKCvarepsilon) in the reduction of ethanol reinforcement due to mGluR5 antagonism in the nucleus accumbens shell","volume":"204","author":"JT Gass","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"e15889","DOI":"10.1371\/journal.pone.0015889","article-title":"Identification of brain nuclei implicated in cocaine-primed reinstatement of conditioned place preference: a behaviour dissociable from sensitization","volume":"5","author":"RM Brown","year":"2010","journal-title":"PLoS One"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1523\/JNEUROSCI.4933-09.2010","article-title":"Accumbens shell-hypothalamus interactions mediate extinction of alcohol seeking","volume":"30","author":"EZ Millan","year":"2010","journal-title":"J Neurosci"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1038\/npp.2008.111","article-title":"The ventral pallidum is critically involved in the development and expression of morphine-induced sensitization","volume":"34","author":"A Mickiewicz","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/WNR.0b013e32835e11a2","article-title":"Sensitization by ventral pallidal DAMGO: lack of cross-sensitization to morphine","volume":"24","author":"SL Rokosik","year":"2013","journal-title":"Neuroreport"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1523\/JNEUROSCI.1045-08.2008","article-title":"Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats","volume":"28","author":"J Peters","year":"2008","journal-title":"J Neurosci"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/sj.npp.1301564","article-title":"Drug addiction as a pathology of staged neuroplasticity","volume":"33","author":"PW Kalivas","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbr.2008.03.032","article-title":"MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats","volume":"191","author":"GR Christoffersen","year":"2008","journal-title":"Behav Brain Res"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/cercor\/bhq147","article-title":"Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons","volume":"21","author":"DE Fontanez-Nuin","year":"2011","journal-title":"Cereb Cortex"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1460-9568.2012.07991.x","article-title":"Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell","volume":"35","author":"RT LaLumiere","year":"2012","journal-title":"Eur J Neurosci"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00213-010-1890-z","article-title":"Extracellular fluctuations of dopamine and glutamate in the nucleus accumbens core and shell associated with lever-pressing during cocaine self-administration, extinction, and yoked cocaine administration","volume":"211","author":"N Suto","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1523\/JNEUROSCI.1244-10.2010","article-title":"Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking","volume":"30","author":"LA Knackstedt","year":"2010","journal-title":"J Neurosci"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.bbr.2009.03.039","article-title":"Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking","volume":"202","author":"V Kumaresan","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1369-1600.2011.00432.x","article-title":"Role of mGluR5 neurotransmission in reinstated cocaine-seeking","volume":"18","author":"X Wang","year":"2013","journal-title":"Addict Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068371","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T11:25:15Z","timestamp":1645961115000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068371"}},"subtitle":[],"editor":[{"given":"Kazutaka","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,4]]},"references-count":106,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068371","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,4]]}}}