{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:20:37Z","timestamp":1771071637476,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068383","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T21:12:17Z","timestamp":1372799537000},"page":"e68383","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Regional Brain Structural Abnormality in Meal-Related Functional Dyspepsia Patients: A Voxel-Based Morphometry Study"],"prefix":"10.1371","volume":"8","author":[{"given":"Fang","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengfeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanrong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10620-011-1822-8","article-title":"Excess Comorbidity Prevalence and Cost Associated with Functional Dyspepsia in an Employed Population","volume":"57","author":"RA Brook","year":"2012","journal-title":"Dig Dis Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5056\/jnm.2011.17.3.235","article-title":"Epidemiology of uninvestigated and functional dyspepsia in Asia: facts and fiction","volume":"17","author":"UC Ghoshal","year":"2011","journal-title":"J Neurogastroenterol Motil"},{"key":"ref3","first-page":"145","article-title":"Functional dyspepsia.Therap Adv Gastroenterol","volume":"3","author":"R Brun","year":"2010"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000092881","article-title":"New directions in brain imaging research in functional gastrointestinal disorders","volume":"24","author":"Y Ringel","year":"2006","journal-title":"Dig Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1053\/j.gastro.2007.03.037","article-title":"Regional cerebral blood flow during gastric balloon distention in functional dyspepsia","volume":"132","author":"J Vandenberghe","year":"2007","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.gastro.2010.04.015","article-title":"Regional brain activity in functional dyspepsia: a H<sub>2<\/sub><sup>15<\/sup>O-PET study on the role of gastric sensitivity and abuse history","volume":"139","author":"L Van Oudenhove","year":"2010","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/ajg.2010.39","article-title":"Abnormal regional brain activity during rest and (anticipated) gastric distension in functional dyspepsia and the role of anxiety: a H<sub>2<\/sub><sup>15<\/sup>O -PET study","volume":"105","author":"L Van Oudenhove","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1053\/j.gastro.2011.05.003","article-title":"Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity","volume":"141","author":"F Zeng","year":"2011","journal-title":"Gastroentology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1212\/01.wnl.0000295509.30630.10","article-title":"Cortical thinning in IBS: implications for homeostatic, attention, and pain processing","volume":"70","author":"KD Davis","year":"2008","journal-title":"Neurology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1053\/j.gastro.2009.12.043","article-title":"Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors","volume":"138","author":"U Blankstein","year":"2010","journal-title":"Gastroenterology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/j.gastro.2010.03.049","article-title":"Regional gray matter density changes in brains of patients with irritable bowel syndrome","volume":"139","author":"DA Seminowicz","year":"2010","journal-title":"Gastroenterology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainres.2011.03.069","article-title":"White matter abnormalities in irritable bowel syndrome and relation to individual factors","volume":"1392","author":"JY Chen","year":"2011","journal-title":"Brain Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1111\/j.1572-0241.1999.01363.x","article-title":"Validity of a new quality of life scale for functional dyspepsia: a United States multicenter trial of the Nepean Dyspepsia Index","volume":"94","author":"NJ Talley","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.3748\/wjg.15.3173","article-title":"Translation and validation of the Nepean Dyspepsia Index for functional dyspepsia in China","volume":"15","author":"XP Tian","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"WW Zung","year":"1971","journal-title":"Psychosomatics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"WW Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"ref17","unstructured":"Wu W (1990) Self-Rating Anxiety Scale (SAS). Shanghai Archives of Psychology 2 (supplement: on Psychological Rating Scale):44."},{"key":"ref18","first-page":"267","article-title":"Self-Rating Depression Scale (SDS): an analysis on 1340 health subjects","volume":"12","author":"C Wang","year":"1986","journal-title":"Chinese Journal of Nervous and Mental Diseases"},{"key":"ref19","first-page":"548","article-title":"The role of circulating sex hormones in menstrual cycle-dependent modulation of pain-related brain activation. Pain","volume":"154(4)","author":"DS Veldhuijzen","year":"2013"},{"key":"ref20","first-page":"e14655","article-title":"Changes in brain size during the menstrual cycle","volume":"6(2)","author":"G Hagemann","year":"2011","journal-title":"4"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/nimg.2001.0786","article-title":"A voxel-based morphometric study of ageing in 465 normal adult human brains","volume":"14","author":"CD Good","year":"2001","journal-title":"Neuroimage"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"SM Smith","year":"2004","journal-title":"Neuroimage"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hbm.10062","article-title":"Fast robust automated brain extraction","volume":"17","author":"SM Smith","year":"2002","journal-title":"Hum Brain Mapp"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm","volume":"20","author":"Y Zhang","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"M Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"ref26","unstructured":"Andersson JLR, Jenkinson M, Smith S. Non-linear optimisation. FMRIB technical report TR07JA1. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fmrib.ox.ac.uk\/analysis\/techrep\" xlink:type=\"simple\">www.fmrib.ox.ac.uk\/analysis\/techrep<\/ext-link>."},{"key":"ref27","unstructured":"Andersson JLR, Jenkinson M, Smith S. Non-linear registration, aka Spatial normalization. FMRIB technical report TR07JA2. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fmrib.ox.ac.uk\/analysis\/techrep\" xlink:type=\"simple\">www.fmrib.ox.ac.uk\/analysis\/techrep<\/ext-link>."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1109\/42.796284","article-title":"Nonrigid registration using free-form deformations: application to breast MR images","volume":"18","author":"D Rueckert","year":"1999","journal-title":"IEEE Trans Med Imaging"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuroimage.2008.03.061","article-title":"Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference","volume":"44","author":"SM Smith","year":"2009","journal-title":"Neuroimage"},{"key":"ref30","first-page":"260","article-title":"White-Matter Microstructural Changes in Functional Dyspepsia: A Diffusion Tensor Imaging Study. American Journal of Gastroenterology","volume":"108(2)","author":"G Zhou","year":"2013"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1586\/egh.09.73","article-title":"Antidepressants in functional dyspepsia","volume":"4","author":"NJ Talley","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref32","first-page":"97","article-title":"What are the real problems for patients with functional dyspepsia? Scand","volume":"30","author":"TT Haug","year":"1995","journal-title":"J. Gastroenterol"},{"key":"ref33","first-page":"281","article-title":"Psychological factors and somatic symptoms in functional dyspepsia. A comparison with duodenal ulcer and healthy controls. J. Psychosom","volume":"38","author":"TT Haug","year":"1994","journal-title":"Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00004836-200403000-00007","article-title":"Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: influence of gender and anxiety","volume":"38","author":"SL Lorena","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00004836-200108000-00007","article-title":"The correlation of depression and gastric dysrhythmia in functional dyspepsia","volume":"33","author":"LT Chou","year":"2001","journal-title":"J Clin Gastroenterol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/j.gastro.2009.03.039","article-title":"Anxiety is associated with uninvestigated and functional dyspepsia (Rome III Criteria) in a Swedish population-based study","volume":"137","author":"P Aro","year":"2009","journal-title":"Gastroenterology"},{"key":"ref37","first-page":"2534","article-title":"Psychopathology and personality trait in subgroups of functional dyspepsia based on Rome III Criteria. Am","volume":"104","author":"YC Hsu","year":"2009","journal-title":"J. Gastroenterol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut\u2013brain communication","volume":"12","author":"EA Mayer","year":"2011","journal-title":"Nature Reviews"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev-med-012309-103958","article-title":"The Brain-Gut Axis in Abdominal Pain Syndromes. Annu. Rev","volume":"62","author":"EA Mayer","year":"2011","journal-title":"Med"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/j.1365-2982.2009.01304.x","article-title":"Brain imaging approaches to the study of functional GI disorders: a Rome working team report","volume":"21","author":"EA Mayer","year":"2009","journal-title":"Neurogastroenterol Motil"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.neuroimage.2007.11.008","article-title":"Gastric distention activates satiety circuitry in the human brain","volume":"39","author":"GJ Wang","year":"2008","journal-title":"Neuroimage"},{"key":"ref42","first-page":"9","article-title":"Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies. J Affect Disord","volume":"138(1\u20132)","author":"E Bora","year":"2012"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068383","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T06:29:30Z","timestamp":1540016970000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068383"}},"subtitle":[],"editor":[{"given":"Friedemann","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,2]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068383","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,2]]}}}