{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:04:53Z","timestamp":1791234293634,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T00:00:00Z","timestamp":1377043200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068547","type":"journal-article","created":{"date-parts":[[2013,8,21]],"date-time":"2013-08-21T17:09:46Z","timestamp":1377104986000},"page":"e68547","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Microbial Products Induce Claudin-2 to Compromise Gut Epithelial Barrier Function"],"prefix":"10.1371","volume":"8","author":[{"given":"Xiaoyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Rui","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Chang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-065X.2011.01078.x","article-title":"Epithelial barrier: an interface for the cross-communication between gut flora and immune system","volume":"245","author":"Y Goto","year":"2012","journal-title":"Immunol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2222.2010.03639.x","article-title":"Gut permeability and food allergies","volume":"41","author":"C Perrier","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jaci.2011.05.038","article-title":"Defective epithelial barrier function in asthma","volume":"128","author":"C Xiao","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2353\/ajpath.2006.050575","article-title":"Chronic Psychological Stress in Rats Induces Intestinal Sensitization to Luminal Antigens","volume":"168","author":"PC Yang","year":"2006","journal-title":"Am J Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/1753465810396539","article-title":"The airway epithelium: more than just a structural barrier","volume":"5","author":"A Tam","year":"2011","journal-title":"Ther Adv Respir Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"19830","DOI":"10.1073\/pnas.1107140108","article-title":"Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation","volume":"108","author":"S Vetrano","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a002907","article-title":"Molecular Basis of the Core Structure of Tight Junctions","volume":"2","author":"M Furuse","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31263","DOI":"10.1074\/jbc.M111.238147","article-title":"Interleukin-6 (IL-6) Regulates Claudin-2 Expression and Tight Junction Permeability in Intestinal Epithelium","volume":"286","author":"T Suzuki","year":"2011","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1128\/JVI.01977-07","article-title":"The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus","volume":"82","author":"L Meertens","year":"2008","journal-title":"Journal of Virology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1681\/ASN.2011040433","article-title":"Net Intestinal Transport of Oxalate Reflects Passive Absorption and SLC26A6-mediated Secretion","volume":"22","author":"F Knauf","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.159.5.2382","article-title":"Superantigen activation of immune cells evokes epithelial (T84) transport and barrier abnormalities via IFN-gamma and TNF alpha: inhibition of increased permeability, but not diminished secretory responses by TGF-beta2","volume":"159","author":"DM McKay","year":"1997","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaci.2008.04.036","article-title":"Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)1\/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model","volume":"122","author":"BS Feng","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1053\/j.gastro.2007.08.006","article-title":"TIM-4 Expressed by Mucosal Dendritic Cells Plays a Critical Role in Food Antigen-Specific Th2 Differentiation and Intestinal Allergy","volume":"133","author":"PC Yang","year":"2007","journal-title":"Gastroenterology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jim.2012.04.007","article-title":"A shorter and more specific oral sensitization-based experimental model of food allergy in mice","volume":"381","author":"E Bail\u00f3n","year":"2012","journal-title":"J Immunol Methods"},{"key":"ref15","first-page":"241","article-title":"Double staining immunohistochemistry","volume":"2","author":"X Chen","year":"2010","journal-title":"N Am J Med Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00125-009-1626-y","article-title":"Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice","volume":"53","author":"A Lee","year":"2010","journal-title":"Diabetologia"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1586\/egh.10.51","article-title":"The enteric nervous system as a regulator of intestinal epithelial barrier function in health and disease","volume":"4","author":"SA Snoek","year":"2010","journal-title":"Expert Rev Gastroenterol Hepatol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature10400","article-title":"Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis","volume":"477","author":"C Gunther","year":"2011","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"20591","DOI":"10.1073\/pnas.1102617108","article-title":"Ouabain modulates ciliogenesis in epithelial cells","volume":"108","author":"I Larre","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/ibd.21787","article-title":"Adherent-invasive Escherichia coli induce claudin-2 expression and barrier defect in CEABAC10 mice and crohn's disease patients","volume":"18","author":"J Denizot","year":"2012","journal-title":"Inflamm Bowel Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/jcb.23067","article-title":"Non-proteolytic house dust mite allergen, Der p 2, upregulated expression of tight junction molecule claudin-2 associated with Akt\/GSK-3b\/b-catenin signaling pathway","volume":"112","author":"WC Wang","year":"2011","journal-title":"J Cell Biochem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1053\/j.gastro.2007.02.043","article-title":"T84-Intestinal Epithelial Exosomes Bear MHC Class II\/Peptide Complexes Potentiating Antigen Presentation by Dendritic Cells","volume":"132","author":"J Mallegol","year":"2007","journal-title":"Gastroenterology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.4049\/jimmunol.1003747","article-title":"Bacterial Superantigens Enhance the In Vitro Proinflammatory Response and In Vivo Lethality of the TLR2 Agonist Bacterial Lipoprotein","volume":"187","author":"DE Kearney","year":"2011","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/jcp.21985","article-title":"Toll-like receptor 2-mediated peptidoglycan uptake by immature intestinal epithelial cells from apical side and exosome-associated transcellular transcytosis","volume":"222","author":"HF Bu","year":"2010","journal-title":"J Cell Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1053\/gast.2001.26470","article-title":"Enhanced Transepithelial Antigen Transport in Intestine of Allergic Mice Is Mediated by IgE\/CD23 and Regulated by Interleukin-4","volume":"121","author":"LCH Yu","year":"2001","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"G1094","DOI":"10.1152\/ajpgi.2000.279.5.G1094","article-title":"Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability","volume":"279","author":"DM McKay","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T19:47:07Z","timestamp":1715888827000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068547"}},"subtitle":[],"editor":[{"given":"Johanna M.","family":"Brandner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,21]]},"references-count":26,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068547","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,21]]}}}