{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:32:37Z","timestamp":1790199157941,"version":"4.1.0"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0068871","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T20:57:26Z","timestamp":1373576246000},"page":"e68871","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["MyD88-Dependent Pathways in Leukocytes Affect the Retina in Diabetes"],"prefix":"10.1371","volume":"8","author":[{"given":"Jie","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chieh","family":"Allen Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pearlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Sheibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"J Tang","year":"2011","journal-title":"Prog Retin Eye Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"95103","DOI":"10.1155\/2007\/95103","article-title":"Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy","volume":"95103","author":"TS Kern","year":"2007","journal-title":"Exp Diabetes Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00281-008-0111-x","article-title":"Immunological mechanisms in the pathogenesis of diabetic retinopathy","volume":"30","author":"AP Adamis","year":"2008","journal-title":"Semin Immunopathol"},{"key":"ref4","article-title":"Is Inflammation a Common Retinal-Renal-Nerve Pathogenic Link in Diabetes? Curr Diabetes Rev","author":"K Kaul","year":"2010"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.2337\/db11-1249","article-title":"Marrow-Derived Cells Regulate the Development of Early Diabetic Retinopathy and Tactile Allodynia in Mice","volume":"61","author":"G Li","year":"2012","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1189\/jlb.0112025","article-title":"Leukocytes regulate retinal capillary degeneration in the diabetic mouse via generation of leukotrienes","volume":"93","author":"R Talahalli","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"D Tang","year":"2012","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"T Kawai","year":"2007","journal-title":"Trends Mol Med"},{"key":"ref9","first-page":"3156","article-title":"Beneficial effects of RAGE-Ig fusion protein on early diabetic retinopathy and tactile allodynia","volume":"17","author":"G Li","year":"2011","journal-title":"Mol Vis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2337\/db07-1217","article-title":"5-Lipoxygenase, but not 12\/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy","volume":"57","author":"RA Gubitosi-Klug","year":"2008","journal-title":"Diabetes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1007\/s00125-007-0734-9","article-title":"Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes","volume":"50","author":"L Zheng","year":"2007","journal-title":"Diabetologia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.freeradbiomed.2003.08.018","article-title":"Hyperglycemia increases mitochondrial superoxide in retina and retinal cells","volume":"35","author":"Y Du","year":"2003","journal-title":"Free Radic Biol Med"},{"key":"ref13","first-page":"171","article-title":"Isolation and characterization of murine retinal endothelial cells","volume":"9","author":"X Su","year":"2003","journal-title":"Mol Vis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2337\/db05-1621","article-title":"Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology","volume":"56","author":"TS Kern","year":"2007","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1167\/iovs.09-3674","article-title":"Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function","volume":"51","author":"Y Du","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","first-page":"1629","article-title":"Comparison of three strains of diabetic rats with respect to the rate at which retinopathy and tactile allodynia develop","volume":"16","author":"TS Kern","year":"2010","journal-title":"Mol Vis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1096\/fj.03-1476fje","article-title":"A central role for inflammation in the pathogenesis of diabetic retinopathy","volume":"18","author":"AM Joussen","year":"2004","journal-title":"Faseb J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1167\/iovs.09-3557","article-title":"Increased synthesis of leukotrienes in the mouse model of diabetic retinopathy","volume":"51","author":"R Talahalli","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0068871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T13:07:03Z","timestamp":1746018423000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0068871"}},"subtitle":[],"editor":[{"given":"Bernhard","family":"Ryffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,11]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0068871","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,11]]}}}