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Available from: http:\/\/www.who.int\/hiv\/pub\/arv\/adult2010\/en\/index.html<\/ext-link>. Accessed May 2013."},{"key":"ref2","unstructured":"US Department of Health and Human Services. What to Start: Initial Combination Regimens for the Antiretroviral-Naive Patient | Adult and Adolescent ARV Guidelines | AIDSinfo. Available from: http:\/\/aidsinfo.nih.gov\/guidelines\/html\/1\/adult-and-adolescent-arv-guidelines\/11\/what-to-start<\/ext-link>. Accessed May 2013."},{"key":"ref3","first-page":"321","article-title":"Antiretroviral Treatment of Adult HIV Infection: 2010 Recommendations of the International AIDS Society\u2013USA Panel. JAMA: The Journal of the American Medical Association","volume":"304(3)","author":"MA Thompson","year":"2010"},{"key":"ref4","unstructured":"World Health Organisation (2012) WHO | Use of efavirenz during pregnancy: A public health perspective. Available from: http:\/\/www.who.int\/hiv\/pub\/treatment2\/efavirenz\/en\/index.html<\/ext-link>. 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Poster exhibition: 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention: Abstract no. WEPEB032."},{"key":"ref12","first-page":"324","article-title":"Virologic, Immunologic, Clinical, Safety, and Resistance Outcomes from a Long-Term Comparison of Efavirenz-Based Versus Nevirapine-Based Antiretroviral Regimens as Initial Therapy in HIV-1\u2013Infected Persons. HIV clinical trials","volume":"9(5)","author":"M van den Berg-Wolf","year":"2008"},{"key":"ref13","first-page":"171","article-title":"Use of Non-Nucleoside Analogues Together with Rifampin in HIV Patients with Tuberculosis. HIV clinical trials","volume":"12(3)","author":"J Villar","year":"2011"},{"key":"ref14","first-page":"186","article-title":"SENC (Spanish efavirenz vs. nevirapine comparison) trial: a randomized, open-label study in HIV-infected naive individuals. HIV clinical trials","volume":"3(3)","author":"M N\u00fa\u00f1ez","year":"2002"},{"key":"ref15","first-page":"716","article-title":"Efficacy and safety of once-daily nevirapine- or efavirenz-based antiretroviral therapy in HIV-associated tuberculosis: a randomized clinical trial. Clin Infect Dis","volume":"53(7)","author":"S Swaminathan","year":"2011"},{"key":"ref16","first-page":"312","article-title":"Higher virological effectiveness of NNRTI-based antiretroviral regimens containing nevirapine or efavirenz compared to a triple NRTI regimen as initial therapy in HIV-1-infected adults. HIV clinical trials","volume":"6(6)","author":"MJ P\u00e9rez-El\u00edas","year":"2005"},{"key":"ref17","first-page":"428","article-title":"Rates and Predictors of Failure of First-line Antiretroviral Therapy and Switch to Second-line ART in South Africa. JAIDS Journal of Acquired Immune Deficiency Syndromes","volume":"60(4)","author":"MP Fox","year":"2012"},{"key":"ref18","unstructured":"Important Change in SUSTIVA\u00ae (efavirenz) Package Insert \u2013 Change from Pregnancy Category C to D. 2005."},{"key":"ref19","first-page":"1691","article-title":"The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study. AIDS","volume":"26(13)","author":"Collaboration HIV-Causal","year":"2012"},{"key":"ref20","first-page":"1752","article-title":"A Randomized Trial Comparing Plasma Drug Concentrations and Efficacies between 2 Nonnucleoside Reverse-Transcriptase Inhibitor-Based Regimens in HIV-Infected Patients Receiving Rifampicin: The N2R Study. 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Int J Tuberc Lung Dis","volume":"13(3)","author":"LK Shipton","year":"2009"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Manosuthi W, Mankatitham W, Lueangniyomkul A, Chimsuntorn S, Sungkanuparph S (2008) Standard-dose efavirenz vs. standard-dose nevirapine in antiretroviral regimens among HIV-1 and tuberculosis co-infected patients who received rifampicin. HIV medicine. 294\u20139.","DOI":"10.1111\/j.1468-1293.2008.00563.x"},{"key":"ref25","first-page":"314","article-title":"Treatment outcomes of recommended first-line antiretroviral regimens in resource-limited clinics. J Acquir Immune Defic Syndr","volume":"60(3)","author":"A Amoroso","year":"2012"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Bock P, Fatti G, Grimwood A (2010) Comparing the effectiveness of efavirenz and nevirapine for first-line antiretroviral treatment amongst an adult treatment cohort from South Africa. Journal of the International AIDS Society. 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Poster Exhibition: The XIV International AIDS Conference: Abstract no. TuPeB4452."},{"key":"ref30","first-page":"157","article-title":"Comparative effectiveness of efavirenz-based antiretroviral regimens in resource-limited settings. Journal of comparative effectiveness research","volume":"1(2)","author":"JR Castillo-Mancilla","year":"2012"},{"key":"ref31","first-page":"1403","article-title":"Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis. AIDS","volume":"27(9)","author":"Z Shubber","year":"2013"},{"key":"ref32","first-page":"484","article-title":"Better adherence with once-daily antiretroviral regimens: a meta-analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America","volume":"15(48(4))","author":"JJ Parienti","year":"2009","journal-title":"Feb"},{"key":"ref33","first-page":"1579","article-title":"Adherence, virological and immunological outcomes for HIV-infected veterans starting combination antiretroviral therapies. AIDS","volume":"21(12)","author":"RS Braithwaite","year":"2007"},{"key":"ref34","first-page":"2117","article-title":"Efavirenz versus Nevirapine-based Initial Treatment of HIV Infection: Clinical and Virological Outcomes in Southern African Adults. AIDS (London, England)","volume":"22(16)","author":"JB Nachega","year":"2008"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Nachega JB, Hislop M, Dowdy DW, Chaisson RE, Regensberg L, et al.. (2007) Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Annals of Internal Medicine. 564\u201373.","DOI":"10.7326\/0003-4819-146-8-200704170-00007"},{"key":"ref36","first-page":"2301","article-title":"Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis. AIDS","volume":"25(18)","author":"N Ford","year":"2011"},{"key":"ref37","unstructured":"Campaign for access to essential medicines. M\u00e9decins Sans Fronti\u00e8res. Untangling the Web of Antiretroviral Price Reductions. Available from: http:\/\/utw.msfaccess.org\/<\/ext-link>. Accessed May 2013."},{"key":"ref38","unstructured":"Gaytan JJA, De La Garza ERZ, GarciaMC, Chavez SBV (2004) Nevirapine or efavirenz in combination with two nucleoside analogues in HIV-infected antiretroviral-naive patients. Medicina Interna de Mexico 20(1): 24\u201333. [: CN\u201300641209]."},{"key":"ref39","unstructured":"Landman R, Koulla-Shiro S, Sow PS, Ngolle M, Diallo MB, et al.. (2011) Evaluation of four tenofovir-containing regimens as first-line treatments in Cameroon and Senegal: the DAYANA Trial, IMEA032\/ANRS12115. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention: Abstract noCDB277."},{"key":"ref40","first-page":"296","article-title":"Comparison of Nevirapine- and Efavirenz-Containing Antiretroviral Regimens in Antiretroviral-Na\u00efve Patients: A Cohort Study. HIV clinical trials","volume":"3(4)","author":"P Keiser","year":"2002"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Annan NT, Nelson M, Mandalia S, Bower M, Gazzard BG, et al.. (2009) The nucleoside backbone affects durability of efavirenz- or nevirapine-based highly active antiretroviral therapy in antiretroviral-naive individuals. Journal of Acquired Immune Deficiency Syndromes. 140\u20136.","DOI":"10.1097\/QAI.0b013e3181a56e81"},{"key":"ref42","first-page":"259","article-title":"A comparison of the long-term durability of nevirapine, efavirenz and lopinavir in routine clinical practice in Europe: a EuroSIDA study. HIV medicine","volume":"12(5)","author":"J Reekie","year":"2011"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Hamers RL, Schuurman R, Sigaloff KCE, Wallis CL, Kityo C, et al.. (2012) Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: A multicentre cohort study. The Lancet infectious diseases. 307\u201317.","DOI":"10.1016\/S1473-3099(11)70255-9"},{"key":"ref44","first-page":"e242","article-title":"Comparison of efavirenz and nevirapine based HAART regimens in 4187 patients with up to 6 years of follow up, a prospective, open label observational study. 14th International Congress on Infectious Diseases (ICID) Abstracts","volume":"2010","author":"C Cortes","year":"2010"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Castelnuovo B, Sempa J, Agnes KN, Kamya MR, Manabe YC (2011) Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings. AIDS Research and Treatment, vol. 2011, Article ID 736938. doi: 10.1155\/2011\/736938<\/ext-link><\/comment>","DOI":"10.1155\/2011\/736938"},{"key":"ref46","first-page":"612","article-title":"Rates of disease progression according to initial highly active antiretroviral therapy regimen: a collaborative analysis of 12 prospective cohort studies. The Journal of infectious diseases","volume":"194(5)","year":"2006"},{"key":"ref47","unstructured":"Mugavero MJ, May M, Harris R, Saag MS, Costagliola D, et al.. (2008) Does short-term virologic failure translate to clinical events in antiretroviral-naive patients initiating antiretroviral therapy in clinical practice? The Antiretroviral Therapy Cohort Collaboration (ART-CC). AIDS. 2481\u201392."},{"key":"ref48","first-page":"404","article-title":"Comparison of efavirenz and nevirapine in HIV-infected patients (NEEF Cohort). International journal of STD & AIDS","volume":"16(6)","author":"M Hartmann","year":"2005"},{"key":"ref49","first-page":"492","article-title":"Efavirenz Versus Nevirapine in Current Clinical Practice: A Prospective, Open-Label Observational Study. J Acquir Immune Defic Syndr","volume":"35(5)","author":"RMD Manfredi","year":"2004"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"De Beaudrap P, Etard JF, Gueye FN, Gueye M, Landman R, et al.. (2008) Long-term efficacy and tolerance of efavirenz- and nevirapine-containing regimens in adult HIV type 1 Senegalese patients. AIDS research and human retroviruses. 753\u201360.","DOI":"10.1089\/aid.2007.0295"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Wallis CL, Papathanasopolous MA, Fox M, Conradie F, Ive P, et al.. (2012) Low rates of nucleoside reverse transcriptase inhibitor resistance in a well-monitored cohort in South Africa on antiretroviral therapy. Antiviral therapy. 313\u201320.","DOI":"10.3851\/IMP1985"},{"key":"ref52","unstructured":"Darin K, Scarsi K, Meloni S, Rawizza H, Chang C, et al.. (2010) Clinical and virologic outcomes of six first-line regimens in a large ART program in Nigeria. XVIII International AIDS Conference: Abstract no THPE01172010."},{"key":"ref53","first-page":"382","article-title":"Long-term safety and efficacy of NNRTI within the central nervous system. HIV clinical trials","volume":"4(6)","author":"HJ von Giesen","year":"2003"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Cescon AM, Cooper C, Chan K, Palmer AK, Klein MB, et al.. (2011) Factors associated with virological suppression among HIV-positive individuals on highly active antiretroviral therapy in a multi-site Canadian cohort. HIV medicine. 352\u201360.","DOI":"10.1111\/j.1468-1293.2010.00890.x"},{"key":"ref55","first-page":"105","article-title":"Nevirapine- versus efavirenz-based highly active antiretroviral therapy regimens in antiretroviral-na\u00efve patients with advanced HIV infection. 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