{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:29:22Z","timestamp":1783380562254,"version":"3.54.6"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069067","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T15:48:48Z","timestamp":1374680928000},"page":"e69067","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts"],"prefix":"10.1371","volume":"8","author":[{"given":"James J.","family":"Cray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kameron","family":"Khaksarfard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth M.","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Elsalanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack C.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"ref1","first-page":"383","article-title":"Foetal and neonatal thyroid disorders","volume":"54","author":"G Radetti","year":"2002","journal-title":"Minerva pediatrica"},{"key":"ref2","first-page":"106","article-title":"Premature craniosynostosis associated with hyperthyroidism in 4 children with reference to 5 further cases in the literature","volume":"120","author":"M Menking","year":"1972","journal-title":"Monatsschrift fur Kinderheilkunde"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/01.AOG.0000270157.88896.76","article-title":"Maternal thyroid disease as a risk factor for craniosynostosis","volume":"110","author":"SA Rasmussen","year":"2007","journal-title":"Obstetrics and gynecology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/adc.44.234.252","article-title":"Grave&apos;S&apos;s disease, an unusual complication: raised intracranial pressure due to premature fusion of skull sutures","volume":"44","author":"DC Robinson","year":"1969","journal-title":"Archives of disease in childhood"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1148\/105.3.621","article-title":"Neonatal hyperthyroidism with accelerated skeletal maturation, craniosynostosis, and brachydactyly","volume":"105","author":"W Riggs Jr","year":"1972","journal-title":"Radiology"},{"key":"ref6","unstructured":"Camfield PR, Camfield CS, Cohen MM, Jr. (2000) Neurosurgical aspects of craniosynostosis. In: Cohen MM, Jr, MacLean RE, editors. Craniosynostosis: Diagnosis, Evaluation, and Management. New York: Oxford University Press. 177\u2013183."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/ajmg.a.30757","article-title":"Editorial: perspectives on craniosynostosis","volume":"136A","author":"MM Cohen Jr","year":"2005","journal-title":"Am J Med Genet A"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Jabs EW (2002) Genetic Etiologies of Craniosynostosis. In: Mooney MP, Siegel MI, editors. Understanding Craniofacial Anomalies: The Etiopathogenesis of Craniosynostoses and Facial Clefting. New York: John W. Wiley and Sons. 125\u2013146.","DOI":"10.1002\/0471221953.ch6"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1601-6343.2007.00393.x","article-title":"Genetic analysis of non-syndromic craniosynostosis","volume":"10","author":"SA Boyadjiev","year":"2007","journal-title":"Orthod Craniofac Res"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Richtsmeier JT (2002) Cranial vault dysmorphology and growth in craniosynostosis. In: Mooney MP, Siegel MI, editors. Understanding Craniofacial Anomalies: The Etiopathogenesis of Craniosynostoses and Facial Clefting. New York: John W. Wiley and Sons. 321\u2013342.","DOI":"10.1002\/0471221953.ch14"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00006534-199209000-00003","article-title":"Intracranial pressure and intracranial volume in children with craniosynostosis","volume":"90","author":"DT Gault","year":"1992","journal-title":"Plast Reconstr Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1227\/00006123-199206000-00008","article-title":"The subarachnoid spaces in craniosynostosis","volume":"30","author":"WM Chadduck","year":"1992","journal-title":"Neurosurgery"},{"key":"ref13","unstructured":"Miller MT (2000) Ocular findings in craniosynostosis. In: Cohen MM, Jr, MacLean RE, editors. Craniosynostosis: Diagnosis, Evaluation, and Management. New York: Oxford University Press. 184\u2013196."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00381-006-0251-z","article-title":"Neurodevelopment of children with single suture craniosynostosis: a review","volume":"23","author":"KA Kapp-Simon","year":"2007","journal-title":"Child's nervous system: ChNS: official journal of the International Society for Pediatric Neurosurgery"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1130-1473(08)70201-X","article-title":"Surgical treatment of isolated and syndromic craniosynostosis. Results and complications in 283 consecutive cases","volume":"19","author":"J Esparza","year":"2008","journal-title":"Neurocirugia (Astur)"},{"key":"ref16","unstructured":"Persing JA, Jane JA (2000) Neurosurgical treatment of craniosynostosis. In: Cohen MM, Jr, MacLean RE, editors. Craniosynostosis: Diagnosis, Evaluation, and Management. New York: Oxford University Press. 209\u2013227."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1210\/me.2007-0221","article-title":"A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism","volume":"22","author":"JH Bassett","year":"2008","journal-title":"Molecular endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1023\/A:1010056202122","article-title":"Tissue-specific actions of thyroid hormone: insights from animal models","volume":"1","author":"GA Brent","year":"2000","journal-title":"Reviews in endocrine & metabolic disorders"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.mce.2003.10.037","article-title":"Analysis of thyroid hormone responsive gene expression in osteoblastic cells","volume":"213","author":"CB Harvey","year":"2003","journal-title":"Molecular and cellular endocrinology"},{"key":"ref20","first-page":"380","article-title":"Actions of thyroid hormones in bone","volume":"60","author":"GR Williams","year":"2009","journal-title":"Endokrynologia Polska"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Hashmi SS, Canfield MA, Marengo L, Moffitt KB, Belmont JW, <etal>et al<\/etal>.. (2012) The association between neonatal thyroxine and craniosynostosis, Texas, 2004\u20132007. Birth defects research Part A, Clinical and molecular teratology.","DOI":"10.1002\/bdra.23077"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0022-3476(75)80963-2","article-title":"Premature craniosynostosis-a complication of thyroid replacement therapy","volume":"86","author":"JL Penfold","year":"1975","journal-title":"The Journal of pediatrics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/thy.1999.9.871","article-title":"Special features of Graves&apos; disease in early childhood","volume":"9","author":"M Segni","year":"1999","journal-title":"Thyroid: official journal of the American Thyroid Association"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00006534-199601000-00001","article-title":"Identification of IGF-I in the calvarial suture of young rats: histochemical analysis of the cranial sagittal sutures in a hyperthyroid rat model","volume":"97","author":"S Akita","year":"1996","journal-title":"Plastic and reconstructive surgery"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e26557","DOI":"10.1371\/journal.pone.0026557","article-title":"Differential expression of extracellular matrix-mediated pathways in single-suture craniosynostosis","volume":"6","author":"BD Stamper","year":"2011","journal-title":"PloS one"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neuro.2012.04.021","article-title":"An in vitro method to study the effects of thyroid hormone-disrupting chemicals on neuronal development","volume":"33","author":"Y Xiong","year":"2012","journal-title":"Neurotoxicology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/j.intimp.2007.09.015","article-title":"Inhibitory effects of thyroxine on cytokine production by T cells in mice","volume":"7","author":"C Yao","year":"2007","journal-title":"International immunopharmacology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/endo.134.1.8275930","article-title":"Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption","volume":"134","author":"JM Britto","year":"1994","journal-title":"Endocrinology"},{"key":"ref29","first-page":"355","article-title":"Stimulation of alkaline phosphatase activity by thyroid hormone in mouse osteoblast-like cells (MC3T3-E1): a possible mechanism of hyperalkaline phosphatasia in hyperthyroidism","volume":"4","author":"K Kasono","year":"1988","journal-title":"Bone and mineral"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2010.07.013","article-title":"Pivotal role of Twist in skeletal biology and pathology","volume":"468","author":"H Miraoui","year":"2010","journal-title":"Gene"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0925-4773(99)00278-6","article-title":"Expression patterns of Twist and Fgfr1, \u22122 and \u22123 in the developing mouse coronal suture suggest a key role for twist in suture initiation and biogenesis","volume":"91","author":"D Johnson","year":"2000","journal-title":"Mechanisms of development"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0014-5793(96)01229-X","article-title":"Primary structure of a putative serine protease specific for IGF-binding proteins","volume":"398","author":"J Zumbrunn","year":"1996","journal-title":"FEBS letters"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11010-012-1345-4","article-title":"Regulation of insulin-like growth factors and their binding proteins by thyroid stimulating hormone in human osteoblast-like (SaOS2) cells","volume":"368","author":"G Ramajayam","year":"2012","journal-title":"Molecular and cellular biochemistry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1359\/jbmr.2000.15.2.188","article-title":"Insulin-like growth factor I production is essential for anabolic effects of thyroid hormone in osteoblasts","volume":"15","author":"BK Huang","year":"2000","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11745-011-3605-6","article-title":"Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis","volume":"47","author":"CH Shackleton","year":"2012","journal-title":"Lipids"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s11154-007-9056-y","article-title":"P450 oxidoreductase deficiency and Antley-Bixler syndrome","volume":"8","author":"W Arlt","year":"2007","journal-title":"Reviews in endocrine & metabolic disorders"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.bbrc.2009.12.067","article-title":"Decorin is processed by three isoforms of bone morphogenetic protein-1 (BMP1)","volume":"391","author":"Z von Marschall","year":"2010","journal-title":"Biochemical and biophysical research communications"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2516","article-title":"Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway","volume":"218","author":"D Gomez","year":"2009","journal-title":"The Journal of pathology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.bone.2006.11.003","article-title":"Impaired posterior frontal sutural fusion in the biglycan\/decorin double deficient mice","volume":"40","author":"S Wadhwa","year":"2007","journal-title":"Bone"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0171-9335(99)80066-1","article-title":"A regulatory role of fibroblast growth factor in the expression of decorin, biglycan, betaglycan and syndecan in osteoblasts from patients with Crouzon&apos;s syndrome","volume":"78","author":"M Bodo","year":"1999","journal-title":"European journal of cell biology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1251\/bpo126","article-title":"Microarray validation: factors influencing correlation between oligonucleotide microarrays and real-time PCR","volume":"8","author":"JS Morey","year":"2006","journal-title":"Biological procedures online"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.imlet.2011.02.017","article-title":"IFN-gamma directly inhibits TNF-alpha-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas\/Fas ligand interactions","volume":"137","author":"H Kohara","year":"2011","journal-title":"Immunology letters"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1158\/0008-5472.CAN-11-3123","article-title":"Epithelial-mesenchymal transition induced by TNF-alpha requires NF-kappaB-mediated transcriptional upregulation of Twist1","volume":"72","author":"CW Li","year":"2012","journal-title":"Cancer research"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.bbrc.2012.01.064","article-title":"Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification","volume":"418","author":"JH Oh","year":"2012","journal-title":"Biochemical and biophysical research communications"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/jcp.22013","article-title":"Impact of growth factors and PTHrP on early and late chondrogenic differentiation of human mesenchymal stem cells","volume":"223","author":"S Weiss","year":"2010","journal-title":"Journal of cellular physiology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/jcb.24115","article-title":"A novel Phex mutation in a new mouse model of hypophosphatemic rickets","volume":"113","author":"C Owen","year":"2012","journal-title":"Journal of cellular biochemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e35280","DOI":"10.1371\/journal.pone.0035280","article-title":"Targeted overexpression of osteoactivin in cells of osteoclastic lineage promotes osteoclastic resorption and bone loss in mice","volume":"7","author":"MH Sheng","year":"2012","journal-title":"PloS one"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/ng1905","article-title":"Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism","volume":"38","author":"JQ Feng","year":"2006","journal-title":"Nature genetics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1432-0436.2007.00244.x","article-title":"Identification of genes differentially expressed by prematurely fused human sutures using a novel in vivo \u2013 in vitro approach","volume":"76","author":"AK Coussens","year":"2008","journal-title":"Differentiation; research in biological diversity"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ydbio.2008.03.037","article-title":"Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure","volume":"318","author":"J Connerney","year":"2008","journal-title":"Developmental biology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/dvdy.20430","article-title":"Foxc1 integrates Fgf and Bmp signalling independently of twist or noggin during calvarial bone development","volume":"233","author":"R Rice","year":"2005","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/SCS.0b013e3181cfe9a0","article-title":"Dura in the pathogenesis of syndromic craniosynostosis: fibroblast growth factor receptor 2 mutations in dural cells promote osteogenic proliferation and differentiation of osteoblasts","volume":"21","author":"BU Ang","year":"2010","journal-title":"The Journal of craniofacial surgery"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0002-9440(10)63987-9","article-title":"In vivo modulation of FGF biological activity alters cranial suture fate","volume":"158","author":"JA Greenwald","year":"2001","journal-title":"The American journal of pathology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1242\/dev.125.7.1241","article-title":"FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development","volume":"125","author":"HJ Kim","year":"1998","journal-title":"Development"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1469-7580.2005.00475.x","article-title":"Growth of the normal skull vault and its alteration in craniosynostosis: insights from human genetics and experimental studies","volume":"207","author":"GM Morriss-Kay","year":"2005","journal-title":"J Anat"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000115036","article-title":"Roles of FGFR2 and twist in human craniosynostosis: insights from genetic mutations in cranial osteoblasts","volume":"12","author":"PJ Marie","year":"2008","journal-title":"Frontiers of oral biology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.127.9.1845","article-title":"Integration of FGF and TWIST in calvarial bone and suture development","volume":"127","author":"DP Rice","year":"2000","journal-title":"Development"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbadis.2009.11.006","article-title":"A single-point mutation in FGFR2 affects cell cycle and Tgfbeta signalling in osteoblasts","volume":"1802","author":"KM Lee","year":"2010","journal-title":"Biochimica et biophysica acta"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1083\/jcb.149.6.1297","article-title":"Signaling by fibroblast growth factors (FGF) and fibroblast growth factor receptor 2 (FGFR2)-activating mutations blocks mineralization and induces apoptosis in osteoblasts","volume":"149","author":"A Mansukhani","year":"2000","journal-title":"The Journal of cell biology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T07:39:17Z","timestamp":1715758757000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069067"}},"subtitle":[],"editor":[{"given":"Xing-Ming","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":59,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069067","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}