{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:47:53Z","timestamp":1791132473465,"version":"4.1.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069282","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T23:43:56Z","timestamp":1374709436000},"page":"e69282","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Primary Respiratory Chain Disease Causes Tissue-Specific Dysregulation of the Global Transcriptome and Nutrient-Sensing Signaling Network"],"prefix":"10.1371","volume":"8","author":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Tsukikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzsebet","family":"Polyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Nakamaru-Ogiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Ostrovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shana","family":"McCormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Place","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Reiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rappaport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Baur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marni J.","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ymgme.2007.11.018","article-title":"The in-depth evaluation of suspected mitochondrial disease","volume":"94","author":"RH Haas","year":"2008","journal-title":"Mol Genet Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11940-009-0046-0","article-title":"A modern approach to the treatment of mitochondrial disease","volume":"11","author":"S Parikh","year":"2009","journal-title":"Curr Treat Options Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ymgme.2007.11.007","article-title":"Metabolic pathway profiling of mitochondrial respiratory chain mutants in C. elegans","volume":"93","author":"MJ Falk","year":"2008","journal-title":"Mol Genet Metab"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1000061","DOI":"10.1371\/journal.pgen.1000061","article-title":"Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease","volume":"4","author":"M Peng","year":"2008","journal-title":"PLoS Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/emmm.201100149","article-title":"Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice","volume":"3","author":"MJ Falk","year":"2011","journal-title":"EMBO Mol Med"},{"key":"ref6","unstructured":"Garedew A, Haffner B, Hutter E, Gnaiger E (2008) An experiment with high-resolution respirometry: phosphorylation control in cell respiration. Mitochondrial Pathways and Respiratory Control 2nd ed. Innsbruck: Oroboros MiPNet Publications. 55\u201361."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1023\/A:1020322922732","article-title":"Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption","volume":"29","author":"E Hutter","year":"2002","journal-title":"Mol Biol Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-1-61779-382-0_3","article-title":"High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle","volume":"810","author":"D Pesta","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nprot.2008.61","article-title":"Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells","volume":"3","author":"AV Kuznetsov","year":"2008","journal-title":"Nat Protoc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1096\/fj.04-3045fje","article-title":"Skeletal muscle gene expression profiling in mitochondrial disorders","volume":"19","author":"M Crimi","year":"2005","journal-title":"FASEB J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Y Li","year":"1995","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1126\/science.286.5440.771","article-title":"Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein","volume":"286","author":"SL Stroschein","year":"1999","journal-title":"Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Y Sancak","year":"2010","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"24053","DOI":"10.1074\/jbc.M401489200","article-title":"Identification of the CREB-binding protein\/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator","volume":"279","author":"ES Tien","year":"2004","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1210\/me.2009-0117","article-title":"MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1","volume":"23","author":"JC Strum","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/hmg\/ddq310","article-title":"Mitochondrial myopathy induces a starvation-like response","volume":"19","author":"H Tyynismaa","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1101\/gad.1483906","article-title":"Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha\/LRP130 complex","volume":"20","author":"MP Cooper","year":"2006","journal-title":"Genes Dev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13742","DOI":"10.1074\/jbc.M109.098400","article-title":"Mitochondrial and nuclear genomic responses to loss of LRPPRC expression","volume":"285","author":"VM Gohil","year":"2010","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"13291","DOI":"10.1074\/jbc.R900010200","article-title":"The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress","volume":"284","author":"T Nguyen","year":"2009","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6503","DOI":"10.1038\/sj.onc.1204036","article-title":"Signal transduction and the Ets family of transcription factors","volume":"19","author":"JS Yordy","year":"2000","journal-title":"Oncogene"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/nar\/27.14.2947","article-title":"A human Raf-responsive zinc-finger protein that binds to divergent sequences","volume":"27","author":"L Zhang","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/nar\/gkq012","article-title":"Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis","volume":"38","author":"DL van der Meer","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1038\/sj.emboj.7601550","article-title":"Identification of novel functional TBP-binding sites and general factor repertoires","volume":"26","author":"S Denissov","year":"2007","journal-title":"EMBO J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35012097","article-title":"ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation","volume":"405","author":"H Kawasaki","year":"2000","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1101\/gad.12.19.3020","article-title":"Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro","volume":"12","author":"AM Naar","year":"1998","journal-title":"Genes Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/ni1311","article-title":"Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR","volume":"7","author":"I Bilic","year":"2006","journal-title":"Nat Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"13564","DOI":"10.1073\/pnas.1109475108","article-title":"Pre-mRNA splicing is a determinant of histone H3K36 methylation","volume":"108","author":"S Kim","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1210\/me.2009-0071","article-title":"Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer","volume":"23","author":"X Zhu","year":"2009","journal-title":"Mol Endocrinol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1194\/jlr.M500504-JLR200","article-title":"Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics","volume":"47","author":"DG Lemay","year":"2006","journal-title":"J Lipid Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1210\/me.2010-0454","article-title":"Species-specific strategies underlying conserved functions of metabolic transcription factors","volume":"25","author":"RE Soccio","year":"2011","journal-title":"Mol Endocrinol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ng.246","article-title":"TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy","volume":"40","author":"A Cizkova","year":"2008","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1179\/1743132810Y.0000000016","article-title":"Whole blood genome-wide expression profiling and network analysis suggest MELAS master regulators","volume":"33","author":"S Mende","year":"2011","journal-title":"Neurol Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7203","DOI":"10.1073\/pnas.0502521102","article-title":"Conservation and evolvability in regulatory networks: the evolution of ribosomal regulation in yeast","volume":"102","author":"A Tanay","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cell.2004.11.047","article-title":"TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1","volume":"119","author":"DE Martin","year":"2004","journal-title":"Cell"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"16945","DOI":"10.1073\/pnas.0504201102","article-title":"Reliable prediction of transcription factor binding sites by phylogenetic verification","volume":"102","author":"X Li","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nature06322","article-title":"mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex","volume":"450","author":"JT Cunningham","year":"2007","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/nm.2049","article-title":"Foxo1 integrates insulin signaling with mitochondrial function in the liver","volume":"15","author":"Z Cheng","year":"2009","journal-title":"Nat Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1152\/physiolgenomics.00061.2006","article-title":"High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO","volume":"29","author":"B Gershman","year":"2007","journal-title":"Physiol Genomics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/msb.2011.36","article-title":"Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling","volume":"7","author":"N Alic","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cmet.2007.11.010","article-title":"Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila","volume":"7","author":"AA Teleman","year":"2008","journal-title":"Cell Metab"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1074\/jbc.M209200200","article-title":"Absence of p21CIP rescues myogenic progenitor cell proliferative and regenerative capacity in Foxk1 null mice","volume":"278","author":"TJ Hawke","year":"2003","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"E799","DOI":"10.1152\/ajpendo.00155.2004","article-title":"Expression of FOXC2 in adipose and muscle and its association with whole body insulin sensitivity","volume":"287","author":"GB Di Gregorio","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"10755","DOI":"10.1074\/jbc.M809115200","article-title":"On the role of FOX transcription factors in adipocyte differentiation and insulin-stimulated glucose uptake","volume":"284","author":"I Gerin","year":"2009","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"20172","DOI":"10.1073\/pnas.1113521108","article-title":"Genome-wide antisense transcription drives mRNA processing in bacteria","volume":"108","author":"I Lasa","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physiolgenomics.00124.2005","article-title":"Natural antisense transcripts: sound or silence?","volume":"23","author":"A Werner","year":"2005","journal-title":"Physiol Genomics"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.18632\/oncotarget.178","article-title":"Natural antisense transcript: a concomitant engagement with protein-coding transcript","volume":"1","author":"K Li","year":"2010","journal-title":"Oncotarget"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1357-2725(98)00134-4","article-title":"The role of the 5\u2032 untranslated region of an mRNA in translation regulation during development","volume":"31","author":"AW van der Velden","year":"1999","journal-title":"Int J Biochem Cell Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1128\/MCB.19.7.4552","article-title":"An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro","volume":"19","author":"Z Wang","year":"1999","journal-title":"Mol Cell Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.tcb.2009.06.001","article-title":"To localize or not to localize: mRNA fate is in 3\u2032UTR ends","volume":"19","author":"C Andreassi","year":"2009","journal-title":"Trends Cell Biol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.1093\/nar\/gki1012","article-title":"AU-rich elements and associated factors: are there unifying principles?","volume":"33","author":"C Barreau","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"D66","DOI":"10.1093\/nar\/gkq990","article-title":"AREsite: a database for the comprehensive investigation of AU-rich elements","volume":"39","author":"AR Gruber","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nature01039","article-title":"A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans","volume":"419","author":"L Wang","year":"2002","journal-title":"Nature"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.virusres.2010.02.001","article-title":"The early noncoding region of human papillomavirus type 16 is regulated by cytoplasmic polyadenylation factors","volume":"149","author":"JA Glahder","year":"2010","journal-title":"Virus Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1097-2765(03)00481-7","article-title":"Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU","volume":"13","author":"H Tran","year":"2004","journal-title":"Mol Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"34626","DOI":"10.1074\/jbc.M806277200","article-title":"G4 resolvase 1 binds both DNA and RNA tetramolecular quadruplex with high affinity and is the major source of tetramolecular quadruplex G4-DNA and G4-RNA resolving activity in HeLa cell lysates","volume":"283","author":"SD Creacy","year":"2008","journal-title":"J Biol Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.yexcr.2008.01.006","article-title":"Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU","volume":"314","author":"F Iwamoto","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1093\/nar\/gkn248","article-title":"Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics","volume":"36","author":"R Yamashita","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nature11083","article-title":"A unifying model for mTORC1-mediated regulation of mRNA translation","volume":"485","author":"CC Thoreen","year":"2012","journal-title":"Nature"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1038\/sj.onc.1207545","article-title":"eIF-4E expression and its role in malignancies and metastases","volume":"23","author":"A De Benedetti","year":"2004","journal-title":"Oncogene"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbadis.2011.09.014","article-title":"AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases","volume":"1822","author":"SB Wu","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/awh447","article-title":"Isolation of transcriptomal changes attributable to LHON mutations and the cybridization process","volume":"128","author":"SR Danielson","year":"2005","journal-title":"Brain"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.bcp.2005.11.019","article-title":"Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways","volume":"71","author":"HJ Knowles","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbrc.2006.04.051","article-title":"Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A","volume":"345","author":"Y Tang","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1677\/jme.1.01499","article-title":"Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes","volume":"33","author":"MJ Watt","year":"2004","journal-title":"J Mol Endocrinol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"C Canto","year":"2012","journal-title":"Cell Metab"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells","volume":"279","author":"JR Revollo","year":"2004","journal-title":"J Biol Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.2174\/138161211798764870","article-title":"Isolated mitochondrial complex I deficiency: explorative data analysis of patient cell parameters","volume":"17","author":"L Blanchet","year":"2011","journal-title":"Curr Pharm Des"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2008.10.002","article-title":"Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy","volume":"8","author":"CF Bentzinger","year":"2008","journal-title":"Cell Metab"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.cmet.2008.09.003","article-title":"Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration","volume":"8","author":"P Polak","year":"2008","journal-title":"Cell Metab"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cmet.2008.10.007","article-title":"Raptor swoops in on metabolism","volume":"8","author":"RJ Shaw","year":"2008","journal-title":"Cell Metab"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-011-0828-9","article-title":"Expression analysis of dopaminergic neurons in Parkinson\u2019s disease and aging links transcriptional dysregulation of energy metabolism to cell death","volume":"122","author":"M Elstner","year":"2011","journal-title":"Acta Neuropathol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"e26883","DOI":"10.1371\/journal.pone.0026883","article-title":"Screening for active small molecules in mitochondrial complex I deficient patient\u2019s fibroblasts, reveals AICAR as the most beneficial compound","volume":"6","author":"A Golubitzky","year":"2011","journal-title":"PLoS One"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cmet.2011.04.011","article-title":"In vivo correction of COX deficiency by activation of the AMPK\/PGC-1alpha axis","volume":"14","author":"C Viscomi","year":"2011","journal-title":"Cell Metab"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"14447","DOI":"10.1073\/pnas.0803790105","article-title":"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis","volume":"105","author":"BH Ahn","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1038\/sj.emboj.7601633","article-title":"Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1\/PGC-1alpha","volume":"26","author":"Z Gerhart-Hines","year":"2007","journal-title":"EMBO J"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1158\/1535-7163.MCT-05-0347","article-title":"Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways","volume":"5","author":"S Han","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"e9199","DOI":"10.1371\/journal.pone.0009199","article-title":"SIRT1 negatively regulates the mammalian target of rapamycin","volume":"5","author":"HS Ghosh","year":"2010","journal-title":"PLoS One"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cell.2008.01.007","article-title":"Mitochondria\u2013a nexus for aging, calorie restriction, and sirtuins?","volume":"132","author":"L Guarente","year":"2008","journal-title":"Cell"},{"key":"ref79","first-page":"143","article-title":"Mitochondrial tRNA-serine (AGY) m.C12264T mutation causes severe multisystem disease with cataracts","volume":"13","author":"SA Schrier","year":"2012","journal-title":"Discov Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ana.410420220","article-title":"Maternally inherited encephalopathy associated with a single-base insertion in the mitochondrial tRNATrp gene","volume":"42","author":"FM Santorelli","year":"1997","journal-title":"Ann Neurol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/1096-8628(20011215)104:4<331::AID-AJMG10054>3.0.CO;2-W","article-title":"Clinical, genetic, and biochemical characterization of a Leber hereditary optic neuropathy family containing both the 11778 and 14484 primary mutations","volume":"104","author":"MD Brown","year":"2001","journal-title":"Am J Med Genet"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:01:45Z","timestamp":1589014905000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069282"}},"subtitle":[],"editor":[{"given":"Michael","family":"Polymenis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,24]]},"references-count":81,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069282","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,24]]}}}