{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T01:14:10Z","timestamp":1785374050830,"version":"3.55.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069301","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T21:10:11Z","timestamp":1375391411000},"page":"e69301","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["A Strategy to Model Nonmonotonic Dose-Response Curve and Estimate IC50"],"prefix":"10.1371","volume":"8","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne","family":"Holden-Wiltse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1056\/NEJM199912163412501","article-title":"Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults","volume":"341","author":"S Staszewski","year":"1999","journal-title":"New England Journal of Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1056\/NEJMoa030264","article-title":"Comparison of sequential three-drug regimens as initial therapy for HIV-1 infection","volume":"349","author":"GK Robbins","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1056\/NEJMoa031772","article-title":"Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection","volume":"350","author":"RM Gulick","year":"2004","journal-title":"New England Journal of Medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.qai.0000222288.90201.33","article-title":"HIV-1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitors do not adversely affect DNA synthesis: pre-steady-state and steady-state kinetic studies","volume":"42","author":"RA Domaoal","year":"2006","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1128\/JVI.75.11.4999-5008.2001","article-title":"Genotypic correlates of phenotypic resistance to efavirenz in virus isolates from patients failing nonnucleoside reverse tran-scriptase inhibitor therapy","volume":"75","author":"L Bacheler","year":"2001","journal-title":"Journal of Virology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1128\/AAC.44.9.2475-2484.2000","article-title":"Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy","volume":"44","author":"LT Bacheler","year":"2000","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.virol.2006.05.021","article-title":"Relative replication fitness of efavirenz-resistant mutants of HIV-1: correlation with frequency during clinical therapy and evidence of compensation for the reduced fitness of K103N+ L100I by the nucleoside resistance mutation L74V","volume":"353","author":"CE Koval","year":"2006","journal-title":"Virology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2307\/2529262","article-title":"A generalization of the probit and logit methods for dose response curves","volume":"32","author":"RL Prentice","year":"1976","journal-title":"Biometrics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jee\/34.2.221","article-title":"Statistical problems in estimating populations of Japanese beetle larvae","volume":"34","author":"C Bliss","year":"1941","journal-title":"Journal of Economic Entomology"},{"key":"ref10","first-page":"24","article-title":"A novel HIV-1 RT mutation (M230L) confers NNRTI resistance and dose-dependent stimulation of replication","volume":"5","author":"W Huang","year":"2000","journal-title":"Antiviral Therapy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.virol.2010.03.018","article-title":"The non-nucleoside reverse transcrip-tase inhibitor efavirenz stimulates replication of human immunodeficiency virus type 1 harboring certain non-nucleoside resistance mutations","volume":"402","author":"J Wang","year":"2010","journal-title":"Virology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1214\/ss\/1177012761","article-title":"Monotone regression splines in action","volume":"3","author":"J Ramsay","year":"1988","journal-title":"Statistical Science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1080\/10618600.1998.10474790","article-title":"Testing monotonicity of regression","volume":"7","author":"A Bowman","year":"1998","journal-title":"Journal of Computational and Graphical Statistics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1214\/aos\/1016120363","article-title":"Testing for monotonicity of a regression mean by calibrating for linear functions","volume":"28","author":"P Hall","year":"2000","journal-title":"Annals of Statistics"},{"key":"ref15","unstructured":"Fan J, Gijbels I (1996) Local Polynomial Modelling And Its Applications, volume 66. Chapman &amp; Hall\/CRC."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1093\/bioinformatics\/btm283","article-title":"Non-parametric quanti_cation of protein lysate arrays","volume":"23","author":"J Hu","year":"2007","journal-title":"Bioinformatics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1289\/ehp.98106s1357","article-title":"Hormesis as a biological hypothesis","volume":"106","author":"EJ Calabrese","year":"1998","journal-title":"Environmental Health Perspectives"},{"key":"ref18","first-page":"521","article-title":"What is hormesis and why haven&apos;t we heard about it before","volume":"52","author":"LA Sagan","year":"1987","journal-title":"Health Physics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0048-9697(82)90066-3","article-title":"Hormesisthe stimulation of growth by low levels of inhibitors","volume":"22","author":"A Stebbing","year":"1982","journal-title":"Science of the Total Environment"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/15287399009531412","article-title":"U-shaped dose-response curves: Their occurrence and implica-tions for risk assessment","volume":"30","author":"JM Davis","year":"1990","journal-title":"Journal of Toxicology and Environmental Health, Part A"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1096\/fj.01-0498fje","article-title":"The estrogen-regulated protein, TFF1, stimulates migration of human breast cancer cells","volume":"16","author":"SJ Prest","year":"2002","journal-title":"The FASEB Journal"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1042\/bj3440921","article-title":"Di_erent roles of protein kinase c alpha and delta isoforms in the regulation of neutral sphingomyelinase activity in HL-60 cells","volume":"344","author":"D Visnji\u0107","year":"1999","journal-title":"Biochemical Journal"},{"key":"ref23","unstructured":"Poland GA, Jacobson RM, Koutsky LA, Tamms GM, Railkar R, <etal>et al<\/etal>.. (2005) Immunogenicity and reactogenicity of a novel vaccine for human papillomavirus 16: a 2-year randomized controlled clinical trial. In: Mayo Clinic Proceedings. Elsevier, volume 80, 601\u2013610."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/bj3420079","article-title":"cDNA cloning and characterization of guinea-pig leukotriene B4 receptor","volume":"342","author":"K Masuda","year":"1999","journal-title":"Biochemical Journal"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0300-483X(95)03042-E","article-title":"Biochemical mechanisms and cancer risk assessment models for dioxin","volume":"102","author":"MC Kohn","year":"1995","journal-title":"Toxicology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.jaci.2006.07.022","article-title":"Initial Fc epsilon RI-mediated signal strength plays a key role in regulating basophil signaling and deactivation","volume":"118","author":"B Gibbs","year":"2006","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/sj.bjp.0706660","article-title":"Substance p-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells","volume":"147","author":"M Gallicchio","year":"2006","journal-title":"British Journal of Pharma-cology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T22:23:45Z","timestamp":1715811825000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069301"}},"subtitle":[],"editor":[{"given":"Shan-Lu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069301","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}