{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:36:58Z","timestamp":1767181018928,"version":"build-2238731810"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069448","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T19:45:22Z","timestamp":1374695122000},"page":"e69448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical and Laboratory Toxicity after Intra-Arterial Radioembolization with 90Y-Microspheres for Unresectable Liver Metastases"],"prefix":"10.1371","volume":"8","author":[{"given":"Maarten L. J.","family":"Smits","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andor F.","family":"van den Hoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte E. N. M.","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard A.","family":"Zonnenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnix G. E. H.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes F. W.","family":"Nijsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice A. A. J.","family":"van den Bosch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"ref1","first-page":"107","article-title":"Studies on the blood supply of tumors in man. III. Vascular patterns of the liver by hepatic arteriography in vivo","volume":"12","author":"HR Bierman","year":"1951","journal-title":"J Natl Cancer Inst"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/jso.20141","article-title":"Randomised phase 2 trial of SIR-Spheres plus fluorouracil\/leucovorin chemotherapy versus fluorouracil\/leucovorin chemotherapy alone in advanced colorectal cancer","volume":"88","author":"G Van Hazel","year":"2004","journal-title":"J Surg Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1023\/A:1013569329846","article-title":"Randomised trial of SIR-Spheres plus chemotherapy vs. chemotherapy alone for treating patients with liver metastases from primary large bowel cancer","volume":"12","author":"B Gray","year":"2001","journal-title":"Ann Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00330-008-1211-7","article-title":"Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis","volume":"19","author":"MA Vente","year":"2009","journal-title":"Eur Radiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jvir.2009.09.011","article-title":"Yttrium-90 radioembolization for liver malignancies: prognostic factors associated with survival","volume":"21","author":"BL Dunfee","year":"2010","journal-title":"J Vasc Interv Radiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00432-010-0948-y","article-title":"Radioembolization and systemic chemotherapy improves response and survival for unresectable colorectal liver metastases","volume":"137","author":"TC Chua","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s00270-005-0171-4","article-title":"Treatment of unresectable primary and metastatic liver cancer with yttrium-90 microspheres (TheraSphere): assessment of hepatic arterial embolization","volume":"29","author":"K Sato","year":"2006","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ijrobp.2005.12.051","article-title":"Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience","volume":"65","author":"AS Kennedy","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/01.RVI.0000235779.88652.53","article-title":"Radioembolization with 90yttrium microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies. Part 2: special topics","volume":"17","author":"R Salem","year":"2006","journal-title":"J Vasc Interv Radiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MNM.0b013e3280121a8f","article-title":"Management and prevention of adverse effects related to treatment of liver tumours with 90Y microspheres","volume":"28","author":"T Szyszko","year":"2007","journal-title":"Nucl Med Commun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijrobp.2006.11.060","article-title":"Recommendations for radioembolization of hepatic malignancies using yttrium-90 microsphere brachytherapy: a consensus panel report from the radioembolization brachytherapy oncology consortium","volume":"68","author":"A Kennedy","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Riaz A, Lewandowski RJ, Kulik LM, Mulcahy MF, Sato KT, <etal>et al<\/etal>.. (2009) Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature review. J Vasc Interv Radiol 20: 1121\u20131130; quiz 1131.","DOI":"10.1016\/j.jvir.2009.05.030"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1572-0241.2007.01172.x","article-title":"Gastroduodenal injury after radioembolization of hepatic tumors","volume":"102","author":"C Carretero","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s00270-011-0295-7","article-title":"Hepatic toxicity after radioembolization of the liver using (90)Y-microspheres: sequential lobar versus whole liver approach","volume":"35","author":"R Seidensticker","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref15","unstructured":"Sirtex (2013) SIR-Spheres Yttrium-90 Resin Microspheres Package Insert."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00270-010-0088-4","article-title":"Technical solutions to ensure safe yttrium-90 radioembolization in patients with initial extrahepatic deposition of (99m)technetium-albumin macroaggregates","volume":"34","author":"MW Barentsz","year":"2011","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1118\/1.3608909","article-title":"Recommendations of the American Association of Physicists in Medicine on dosimetry, imaging, and quality assurance procedures for 90Y microsphere brachytherapy in the treatment of hepatic malignancies","volume":"38","author":"WA Dezarn","year":"2011","journal-title":"Med Phys"},{"key":"ref18","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) v4.0. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ctep.cancer.gov\" xlink:type=\"simple\">http:\/\/ctep.cancer.gov<\/ext-link>."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"EA Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"ref20","first-page":"597","article-title":"The human liver after radiation injury. A form of veno-occlusive disease","volume":"48","author":"GB Reed Jr","year":"1966","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/0360-3016(94)00418-K","article-title":"Hepatic toxicity resulting from cancer treatment","volume":"31","author":"TS Lawrence","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1067\/mge.2002.120879","article-title":"Diagnostic laparoscopy in radiation-induced liver disease","volume":"55","author":"EB da Silveira","year":"2002","journal-title":"Gastrointest Endosc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.semradonc.2011.05.003","article-title":"Hepatic radiation toxicity: avoidance and amelioration","volume":"21","author":"C Guha","year":"2011","journal-title":"Semin Radiat Oncol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/hep.510260117","article-title":"Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event","volume":"26","author":"C Sempoux","year":"1997","journal-title":"Hepatology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jvir.2011.06.006","article-title":"Toxicities after radioembolization with yttrium-90 SIR-spheres: incidence and contributing risk factors at a single center","volume":"22","author":"PM Piana","year":"2011","journal-title":"J Vasc Interv Radiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1479-5876-5-15","article-title":"Safety and efficacy of Y-90 microsphere treatment in patients with primary and metastatic liver cancer: the tumor selectivity of the treatment as a function of tumor to liver flow ratio","volume":"5","author":"SA Gulec","year":"2007","journal-title":"J Transl Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2298\/VSP1104341A","article-title":"Selective intraarterial radionuclide therapy with Yttrium-90 (Y-90) microspheres for hepatic neuroendocrine metastases: initial experience at a single center","volume":"68","author":"N Arslan","year":"2011","journal-title":"Vojnosanit Pregl"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00270-011-0252-5","article-title":"Effectiveness of repeat angiographic assessment in patients designated for radioembolization using yttrium-90 microspheres with initial extrahepatic accumulation of technitium-99m macroaggregated albumin: a single center\u2019s experience","volume":"35","author":"O Dudeck","year":"2012","journal-title":"Cardiovasc Intervent Radiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S1470-2045(12)70334-0","article-title":"Holmium-166 radioembolisation in patients with unresectable, chemorefractory liver metastases (HEPAR trial): a phase 1, dose-escalation study","volume":"13","author":"ML Smits","year":"2012","journal-title":"Lancet Oncol"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Lam MG, Banerjee S, Louie JD, Abdelmaksoud MH, Iagaru AH, <etal>et al<\/etal>.. (2013) Root Cause Analysis of Gastroduodenal Ulceration After Yttrium-90 Radioembolization. Cardiovasc Intervent Radiol.","DOI":"10.1007\/s00270-013-0579-1"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jvir.2009.01.021","article-title":"Incorporating cone-beam CT into the treatment planning for yttrium-90 radioembolization","volume":"20","author":"JD Louie","year":"2009","journal-title":"J Vasc Interv Radiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1055\/s-0029-1245192","article-title":"Angiography-based C-arm CT for the assessment of extrahepatic shunting before radioembolization","volume":"182","author":"TA Heusner","year":"2010","journal-title":"Rofo"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00259-009-1279-6","article-title":"First experience of hepatic radioembolization using microspheres labelled with yttrium-90 (TheraSphere): practical aspects concerning its implementation","volume":"37","author":"E Garin","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.clon.2007.12.008","article-title":"FOXFIRE: a phase III clinical trial of chemo-radio-embolisation as first-line treatment of liver metastases in patients with colorectal cancer","volume":"20","author":"RA Sharma","year":"2008","journal-title":"Clin Oncol (R Coll Radiol)"}],"updated-by":[{"DOI":"10.1371\/annotation\/559e04cc-b09c-4b5c-9405-56837f6d5627","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T00:00:00Z","timestamp":1382486400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T23:07:53Z","timestamp":1588979273000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069448"}},"subtitle":[],"editor":[{"given":"Natarajan","family":"Aravindan","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,24]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069448","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,24]]}}}