{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:52:41Z","timestamp":1782823961434,"version":"3.54.5"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T00:00:00Z","timestamp":1374624000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069505","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T23:35:39Z","timestamp":1374708939000},"page":"e69505","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nonlinear Mixed-Effects Modelling of In Vitro Drug Susceptibility and Molecular Correlates of Multidrug Resistant Plasmodium falciparum"],"prefix":"10.1371","volume":"8","author":[{"given":"Julie A.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris M.","family":"Jamsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J. C.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Zaloumis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Woodrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Nosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ric N.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jim.2011.01.015","article-title":"Methodology and application of flow cytometry for investigation of human malaria parasites","volume":"367","author":"BT Grimberg","year":"2011","journal-title":"J Immunol Methods"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.exppara.2006.02.006","article-title":"<italic>Plasmodium vivax<\/italic>: isotopic, PicoGreen, and microscopic assays for measuring chloroquine sensitivity in fresh and cryopreserved isolates","volume":"114","author":"V Kosaisavee","year":"2006","journal-title":"Exp Parasitol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1471-4922(03)00028-X","article-title":"Malaria drug-sensitivity testing: new assays, new perspectives","volume":"19","author":"H Noedl","year":"2003","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3109\/03602538409015066","article-title":"Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model","volume":"15","author":"JL Steimer","year":"1984","journal-title":"Drug Metab Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2875-6-4","article-title":"Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach","volume":"6","author":"K Stepniewska","year":"2007","journal-title":"Malar J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1128\/AAC.49.6.2180-2188.2005","article-title":"Are transporter genes other than the chloroquine resistance locus (<italic>pfcrt<\/italic>) and multidrug resistance gene (<italic>pfmdr<\/italic>) associated with antimalarial drug resistance?","volume":"49","author":"TJ Anderson","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"ref7","unstructured":"Davidian M, Giltinan DM (1995) Nonlinear Models for Repeated Measurement Data. London: Chapman &amp; Hall."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S1382-6689(96)00055-5","article-title":"Population approaches\/sparse data analysis for human variability in kinetics and dynamics","volume":"2","author":"L Aarons","year":"1996","journal-title":"Environ Toxicol Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0035-9203(01)90178-6","article-title":"How can we do pharmacokinetic studies in the tropics?","volume":"95","author":"JA Simpson","year":"2001","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1086\/503423","article-title":"Molecular and Pharmacological Determinants of the Therapeutic Response to Artemether-Lumefantrine in Multidrug-Resistant <italic>Plasmodium falciparum<\/italic> Malaria","volume":"42","author":"RN Price","year":"2006","journal-title":"Clin Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0140-6736(04)16767-6","article-title":"Mefloquine resistance in <italic>Plasmodium falciparum<\/italic> and increased <italic>pfmdr1<\/italic> gene copy number","volume":"364","author":"RN Price","year":"2004","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35002615","article-title":"<italic>Pgh1<\/italic> modulates sensitivity and resistance to multiple antimalarials in <italic>Plasmodium falciparum<\/italic>","volume":"403","author":"MB Reed","year":"2000","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0035-9203(00)90080-4","article-title":"<italic>Plasmodium falciparum<\/italic> antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine","volume":"94","author":"A Brockman","year":"2000","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1128\/AAC.43.12.2943","article-title":"The <italic>pfmdr1<\/italic> gene is associated with a multidrug-resistant phenotype in <italic>Plasmodium falciparum<\/italic> from the western border of Thailand","volume":"43","author":"RN Price","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e4551","DOI":"10.1371\/journal.pone.0004551","article-title":"Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment","volume":"4","author":"VI Carrara","year":"2009","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cmpb.2003.11.003","article-title":"Perl-speaks-NONMEM (PsN)\u2013a Perl module for NONMEM related programming","volume":"75","author":"L Lindbom","year":"2004","journal-title":"Comput Methods Programs Biomed"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.cmpb.2005.04.005","article-title":"PsN-Toolkit\u2013a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM","volume":"79","author":"L Lindbom","year":"2005","journal-title":"Comput Methods Programs Biomed"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1128\/AAC.00040-06","article-title":"Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malaria","volume":"50","author":"EA Ashley","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1128\/AAC.01496-09","article-title":"Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy","volume":"54","author":"V Jullien","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1365-2125.2005.02567.x","article-title":"Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil\/dapsone","volume":"61","author":"JA Simpson","year":"2006","journal-title":"Br J Clin Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1128\/AAC.01334-07","article-title":"Determinants of <italic>in vitro<\/italic> drug susceptibility testing of Plasmodium vivax","volume":"52","author":"B Russell","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1128\/AAC.47.8.2418-2423.2003","article-title":"Resistance to antimalarials in Southeast Asia and genetic polymorphisms in <italic>pfmdr1<\/italic>","volume":"47","author":"AL Pickard","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/1475-2875-11-303","article-title":"Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development","volume":"11","author":"S Zaloumis","year":"2012","journal-title":"Malar J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1752-4571.2008.00067.x","article-title":"Probability of emergence of antimalarial resistance in different stages of the parasite life cycle","volume":"2","author":"W Pongtavornpinyo","year":"2009","journal-title":"Evol Appl"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T10:09:17Z","timestamp":1563530957000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069505"}},"subtitle":[],"editor":[{"given":"David J.","family":"Sullivan Jr.","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,24]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069505","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,24]]}}}