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Last accessed April 2010."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1073\/pnas.0931379100","article-title":"Complete genome sequence of the Q-fever pathogen <italic>Coxiella burnetii<\/italic>","volume":"100","author":"R Seshadri","year":"2003","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"ref3","first-page":"183","article-title":"Q fever as a biological weapon","volume":"18","author":"FT Kagawa","year":"2003","journal-title":"Seminars in Respiratory Medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1473-3099(03)00804-1","article-title":"Q fever: a biological weapon in your backyard","volume":"3","author":"MG Madariaga","year":"2003","journal-title":"The Lancet Infectious Diseases"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/CMR.12.4.518","article-title":"Q fever","volume":"12","author":"M Maurin","year":"1999","journal-title":"Clinical Microbiology Reviews"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/IAI.48.2.359-365.1985","article-title":"Lipopolysaccharide variation in <italic>Coxiella burnetii<\/italic>: intrastrain heterogeneity in structure and antigenicity","volume":"48","author":"T Hackstadt","year":"1985","journal-title":"Infection and Immunity"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/JCM.02365-05","article-title":"Chronic Q fever in the United States","volume":"44","author":"PC Karakousis","year":"2006","journal-title":"Journal of Clinical Microbiology"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Waag DM, Thompson HA (2005) Pathogenesis of and immunity to Coxiella burnetii. Biological Weapons Defense: Humana Press. pp. 185\u2013207.","DOI":"10.1385\/1-59259-764-5:185"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1046\/j.1462-5822.2003.00293.x","article-title":"Maturation of the <italic>Coxiella burnetii<\/italic> parasitophorous vacuole requires bacterial protein synthesis but not replication","volume":"5","author":"D Howe","year":"2003","journal-title":"Cellular Microbiology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1462-5822.2005.00641.x","article-title":"<italic>Coxiella burnetii<\/italic> inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism","volume":"8","author":"D Howe","year":"2006","journal-title":"Cellular Microbiology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1462-5822.2006.00838.x","article-title":"The autophagic pathway is actively modulated by phase II <italic>Coxiella burnetii<\/italic> to efficiently replicate in the host cell","volume":"9","author":"PS Romano","year":"2007","journal-title":"Cellular Microbiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1128\/IAI.00406-10","article-title":"Coxiella burnetii phase I and II variants replicate with similar kinetics in degradative phagolysosome-like compartments of human macrophages","volume":"78","author":"D Howe","year":"2010","journal-title":"Infection and Immunity"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1086\/425041","article-title":"Link between impaired maturation of phagosomes and defective <italic>Coxiella burnetii<\/italic> killing in patients with chronic Q fever","volume":"19","author":"E Ghigo","year":"2004","journal-title":"The Journal of Infectious Diseases"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1189\/jlb.0407255","article-title":"Securinine, a GABA<sub>A<\/sub> receptor antagonist, enhances macrophage clearance of phase II <italic>C. burnetii<\/italic>: comparison with TLR agonists","volume":"82","author":"K Lubick","year":"2007","journal-title":"The Journal of Leukocyte Biology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1128\/IAI.61.10.4232-4239.1993","article-title":"Acid phosphatase activity in <italic>Coxiella burnetii<\/italic>","volume":"61","author":"OG Baca","year":"1993","journal-title":"Infection and Immunity"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1172\/JCI27544","article-title":"A specific p47phox-serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites","volume":"116","author":"PM Dang","year":"2006","journal-title":"The Journal of Clinical Investigation"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"24113","DOI":"10.1074\/jbc.M100720200","article-title":"G protein independent activation of Tyk2 by the Platelet-Activating Factor receptor","volume":"276","author":"V Lukashova","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1021\/pr070077n","article-title":"Analysis of whole cell lysate from the intercellular bacterium <italic>Coxiella burnetii<\/italic> using two gel-based protein separation techniques","volume":"6","author":"G Samoilis","year":"2007","journal-title":"Journal of Proteome Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1021\/pr025588i","article-title":"Unseen proteome: mining below the tip of the iceberg to find low abundance and membrane proteins","volume":"2","author":"SK Pedersen","year":"2003","journal-title":"Journal of Proteome Research"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1021\/pr050102u","article-title":"<italic>Francisella tularensis<\/italic> proteome: low levels of ASB-14 facilitate the visualization of membrane proteins in total protein extracts","volume":"4","author":"SM Twine","year":"2005","journal-title":"Journal of Proteome Research"},{"key":"ref21","unstructured":"Dratz EA, Grieco PA (2009) Novel Zwitterionic Fluorescent Dyes for Labeling in Proteomics and Other Biological Analyses. #7,582,260 USA patent 9\/1\/2009: Montana State University."},{"key":"ref22","unstructured":"Dratz EA, Grieco PA (2010) Novel Zwitterionic Fluorescent Dyes for Labeling in Proteomic and Other Biological Analyses, Montana State University: USA patent 1\/16\/2010, 7,833,799."},{"key":"ref23","unstructured":"Dratz EA, Grieco PA (2010) Novel Zwitterionic Fluorescent Dyes for Labeling in Proteomic and Other Biological Analyses. USA patent application, Montana State University: Number 11\/767,406."},{"key":"ref24","unstructured":"G\u00f6rg A (1998) Two-dimensional electrophoresis of proteins using immobilized pH gradients: A laboratory manual. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwweihenstephande\/blm\/deg\" xlink:type=\"simple\">http:\/\/wwwweihenstephande\/blm\/deg<\/ext-link>. Website last accessed April 2010."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1021\/pr050084g","article-title":"Impact of replicate types on proteomic expression analysis","volume":"4","author":"NA Karp","year":"2005","journal-title":"Journal of Proteome Research"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.0030-1299.2004.12777.x","article-title":"When is a correlation between non-independent variables \u201cspurious\u201d?","volume":"105","author":"MT Brett","year":"2004","journal-title":"Oikos"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1074\/mcp.M600274-MCP200","article-title":"Experimental and statistical considerations to avoid false conclusions in proteomics studies using differential in-gel electrophoresis","volume":"6","author":"NA Karp","year":"2007","journal-title":"Molecular and Cellular Proteomics"},{"key":"ref28","unstructured":"Barry R (2003) Proteomic Analysis of <italic>Sulfolobus solfataricus<\/italic>, an Extremophilic <italic>Archaeon<\/italic>. Bozeman: Montana State University."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1002\/elps.200500851","article-title":"Proteomic mapping of the hyperthermophilic and acidophilic archaeon <italic>Sulfolobus solfatarticus<\/italic> P2","volume":"27","author":"RC Barry","year":"2006","journal-title":"Electrophoresis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/pr049945w","article-title":"Proteolysis and mass spectrometric analysis of an integral membrane: Aquaporin 0","volume":"3","author":"J Han","year":"2004","journal-title":"Journal of Proteome Research"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"DN Perkins","year":"1999","journal-title":"Electrophoresis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/pr049882h","article-title":"Open source system for analyzing, validating, and storing protein identification data","volume":"3","author":"R Craig","year":"2004","journal-title":"Journal of Proteome Research"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1002\/rcm.1992","article-title":"The use of proteotypic peptide libraries for protein identification","volume":"19","author":"R Craig","year":"2005","journal-title":"Rapid Communications in Mass Specrometry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/pr0602085","article-title":"Using annotated peptide mass spectrum libraries for protein identification","volume":"5","author":"R Craig","year":"2006","journal-title":"Journal of Proteome Research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1021\/pr070025y","article-title":"Determining the overall merit of protein identification data sets: rho-diagrams and rho-scores","volume":"6","author":"D Fenyo","year":"2007","journal-title":"Journal of Proteome Research"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.jasms.2008.02.011","article-title":"Use of 18O labels to monitor deamidation during protein and peptide sample processing","volume":"19","author":"X Li","year":"2008","journal-title":"Journal of the American Society for Mass Spectrometry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1083\/jcb.200107069","article-title":"Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation","volume":"155","author":"OV Vieira","year":"2001","journal-title":"The Journal of Cell Biology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1128\/MCB.23.7.2501-2514.2003","article-title":"Modulation of Rab5 and Rab7 recruitment to phagosomes by phosphatidylinositol 3-kinase","volume":"23","author":"OV Vieira","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj20020691","article-title":"Phagosome maturation: aging gracefully","volume":"356","author":"OV Vieira","year":"2002","journal-title":"Biochemical Journal"},{"key":"ref40","first-page":"3105","article-title":"Occurrence of two superoxide dismutases in <italic>Aeromonas hydrophila<\/italic>: molecular cloning and differential expression of the sodA and sodB genes","volume":"147","author":"V Lecl\u00e8re","year":"2001","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0014-5793(04)00170-X","article-title":"A thermostable manganese-containing superoxide dismutase from pathogen <italic>Chlamydia pneumoniae<\/italic>","volume":"562","author":"J Yu","year":"2004","journal-title":"FEBS Letters"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/pmic.200500290","article-title":"Proteome analysis of human monocytic THP-1 cells primed with oxidized low-density lipoproteins","volume":"6","author":"JH Kang","year":"2006","journal-title":"Proteomics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ncb898","article-title":"Vimentin is secreted by activated macrophages","volume":"5","author":"N Mor-Vaknin","year":"2003","journal-title":"Nature Cell Biology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.4049\/jimmunol.180.5.3366","article-title":"Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in <italic>Streptococcal<\/italic> pneumonia","volume":"180","author":"M-A Raquil","year":"2008","journal-title":"The Journal of Immunology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0171-2985(00)80103-5","article-title":"Ineffective elimination of <italic>Leishmania major<\/italic> by inflammatory (MRP14-positive) subtype of monocytic cells","volume":"202","author":"K Steinbrink","year":"2000","journal-title":"Immunobiology"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Adya R, Tan BK, Chen J, Randeva HS (2009) Pre-B cell colony enhancing factor (PBEF)\/visfatin induces secretion of MCP-1 in human endothelial cells: Role in visfatin-induced angiogenesis. Atherosclerosis epub ahead of print: epub ahead of print.","DOI":"10.1016\/j.atherosclerosis.2008.11.024"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e2267","DOI":"10.1371\/journal.pone.0002267","article-title":"Pharmacological inhibition of nicotinamide phosphoribosyltransferase\/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD","volume":"3","author":"N Busso","year":"2008","journal-title":"PLoS One"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI19930","article-title":"Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis","volume":"113","author":"SH Jia","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.placenta.2006.03.011","article-title":"Pre-B cell colony-enhancing factor (PBEF\/visfatin) gene expression is modulated by NF-kB and AP-1 in human amniotic epithelial cells","volume":"28","author":"CE Kendal","year":"2007","journal-title":"Placenta"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.4049\/jimmunol.178.3.1748","article-title":"Visfatin, an adipocytokine with proinflammatory and immunomodulating properties","volume":"178","author":"AR Moschen","year":"2007","journal-title":"The Journal of Immunology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nature06857","article-title":"Imaging of Rab5 activity identifies essential regulators for phagosome maturation","volume":"453","author":"M Kitano","year":"2008","journal-title":"Nature"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/1521-4141(200107)31:7<2051::AID-IMMU2051>3.0.CO;2-H","article-title":"Heat shock protein as \u201cdanger signals\u201d: eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-\u03b3 production in T cells","volume":"31","author":"M Breloer","year":"2001","journal-title":"European Journal of Immunology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0968-0896(02)00333-4","article-title":"Enoyl-CoA hydratase: Reaction, mechanism, and inhibition","volume":"11","author":"G Agnihotri","year":"2003","journal-title":"Bioorganic and Medicinal Chemistry"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.bbrc.2008.11.084","article-title":"Lap3 is a selective target of autophagy in yeast, <italic>Saccharomyces cerevisiae<\/italic>","volume":"378","author":"T Kageyama","year":"2009","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1534\/genetics.108.088443","article-title":"Genomewide screen for negative regulators of sirtuin activity in <italic>Saccharomyces cerevisiae<\/italic> reveals 40 loci and links to metabolism","volume":"179","author":"RM Raisner","year":"2008","journal-title":"Genetics"},{"key":"ref56","first-page":"2117","article-title":"Yeast bleomycin hydrolase is a DNA-binding cysteine protease","volume":"269","author":"HE Xu","year":"1994","journal-title":"The Journal of Biological Chemistry"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"32994","DOI":"10.1074\/jbc.271.51.32994","article-title":"Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression","volume":"271","author":"K Banki","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/15216540701387188","article-title":"The pathogenesis of transaldolase deficiency","volume":"59","author":"A Perl","year":"2007","journal-title":"IUBMB Life"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.bbrc.2006.01.016","article-title":"Expression of new human inorganic pyrophosphatase in thyroid diseases: its intimate association with hyperthyroidism","volume":"341","author":"E Koike","year":"2006","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref60","article-title":"GOEAST: a web-based software toolkit for Gene Ontology enrichment analysis","author":"Q Zheng","year":"2008","journal-title":"Nucleic Acids Research"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","article-title":"DAVID: Database for annotation, visualization, and integrated discovery","volume":"4","author":"GJ Dennis","year":"2003","journal-title":"Genome Biology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"DW Huang","year":"2009","journal-title":"Nature Protocols"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/cdd.2008.168","article-title":"Autophagy and multivesicular bodies: two closely related partners","volume":"16","author":"CM Fader","year":"2009","journal-title":"Cell Death and Differentiation"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1128\/IAI.01124-08","article-title":"Sustained activation of Akt and Erk 1\/2 is required for <italic>Coxiella burnetii<\/italic> antiapoptotic activity","volume":"77","author":"DE Voth","year":"2009","journal-title":"Infection and Immunity"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/IAI.64.3.796-809.1996","article-title":"Differential interaction with endocytic and exocytic pathways distinguish vacuoles of <italic>Coxiella burnetii<\/italic> and <italic>Chlamydia trachomatis<\/italic>","volume":"64","author":"RA Heinzen","year":"1996","journal-title":"Infection and Immunity"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"G729","DOI":"10.1152\/ajpgi.00132.2007","article-title":"Anti-inflammatory properties of <italic>Lactobacillus gasseri<\/italic>, expressing manganese superoxide dismutase using the interleukin 10-deficient mouse model of colitis","volume":"293","author":"IM Carroll","year":"2007","journal-title":"American Journal of Physiology Gastrointestinal and Liver Physiology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"36664","DOI":"10.1074\/jbc.M105352200","article-title":"Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat","volume":"276","author":"MD Wheeler","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.antiviral.2007.02.002","article-title":"Suppression of virus replication via down-modulation of mitochondrial short chain enoyl-CoA hydratase in human glioblastoma cells","volume":"75","author":"M Takahashi","year":"2007","journal-title":"Antiviral Research"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1159\/000050048","article-title":"Effects of cyclosporin A on cell fusion in a monkey kidney cell line persistently infected with measles virus","volume":"44","author":"E Watari","year":"2001","journal-title":"Intervirology"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00535-007-2119-8","article-title":"Lipopolysaccharide induces adipose differentiation-related protein expression and lipid accumulation in the liver through inhibition of fatty acid oxidation in mice","volume":"42","author":"M Ohhira","year":"2007","journal-title":"Journal of Gasteroenterology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/emboj\/21.6.1289","article-title":"Later endosome motility depends on lipids via the small GTPase Rab7","volume":"21","author":"C Lebrand","year":"2002","journal-title":"The EMBO Journal"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"35818","DOI":"10.1074\/jbc.M104871200","article-title":"The Ca<sup>2+<\/sup>-binding proteins S100A8 and S100A9 are encoded by novel injury-regulated genes","volume":"276","author":"IS Thorey","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00018-004-4339-x","article-title":"Protein kinase C regulation of GABAA receptors","volume":"62","author":"M Song","year":"2005","journal-title":"Cellular and Molecular Life Science"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.molimm.2005.07.025","article-title":"Human peripheral blood mononuclear cells express GABA<sub>A<\/sub> receptor subunits","volume":"43","author":"S Alam","year":"2006","journal-title":"Molecular Immunology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jneuroim.2008.08.017","article-title":"GABA, a natural immunomodulator of T lymphocytes","volume":"205","author":"H Bjurst\u00f6m","year":"2008","journal-title":"Journal of Neuroimmunology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jneuroim.2007.05.013","article-title":"GABA<sub>A<\/sub> receptor subunits RNA expression in mice peritoneal macrophages modulate their IL-6\/IL-12 production","volume":"188","author":"MG Reyes-Garc\u00eda","year":"2007","journal-title":"Journal of Neuroimmunology"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1432-0436.2006.00077.x","article-title":"Role of vimentin in regulation of monocyte\/macrophage differentiation","volume":"74","author":"P Bene\u0161","year":"2006","journal-title":"Differentiation"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1242\/jcs.00906","article-title":"Specific in vivo phosporylation sites determine the assembly dynamics of vimentin intermediate filaments","volume":"117","author":"JE Eriksson","year":"2004","journal-title":"Journal of Cell Science"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1083\/jcb.152.1.165","article-title":"The phagosome proteome: insight into phagosome functions","volume":"152","author":"J Garin","year":"2001","journal-title":"The Journal of Cell Biology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1471-2261-6-44","article-title":"Mitochondrial oxidative stress and nitrate tolerance-comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD +\/\u2212 mice","volume":"6","author":"H Mollnau","year":"2006","journal-title":"BMC Cardiovascular Disorders"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1074\/jbc.M606477200","article-title":"Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity","volume":"282","author":"P Wenzel","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molbiopara.2008.08.004","article-title":"Microarray based analysis of temperature and oxidative stress induced messenger RNA in <italic>Schistosoma mansoni<\/italic>;","volume":"162","author":"AD Aragon","year":"2008","journal-title":"Molecular and Biochemical Parasitology"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1074\/mcp.M200001-MCP200","article-title":"Complementary profiling of gene expression at the transcriptome and proteome levels in <italic>Saccharomyces cerevisiae<\/italic>","volume":"1","author":"TJ Griffen","year":"2002","journal-title":"Molecular and Cellular Proteomics"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/j.1420-9101.2005.00921.x","article-title":"The biological limitations of transcriptomics in elucidating stress and stress responses","volume":"18","author":"ME Feder","year":"2005","journal-title":"Journal of Evolutionary Biology"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1021\/pr049942j","article-title":"Analyzing alkaline proteins in human colon crypt proteome","volume":"3","author":"X-M Li","year":"2004","journal-title":"Journal of Proteome Research"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1074\/jbc.M606235200","article-title":"Monocyte differentiation, activation, and mycobacterial killing are linked to transsulfuration-dependent redox metabolism","volume":"281","author":"S Garg","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/01.RES.0000089561.87997.CF","article-title":"Homocysteine, a proinflammatory and proatheroscleritic factor","volume":"93","author":"VB Schini-Kerth","year":"2009","journal-title":"Circulation Research"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-3083.2005.01654.x","article-title":"Asprin downregulates homocysteine formation in stimulated human peripheral blood mononuclear cells","volume":"62","author":"K Schroecksnadel","year":"2005","journal-title":"Scandanavian Journal of Immunology"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2249.2003.02251.x","article-title":"Homocysteine accumulates in supernatents of stimulated human peripheral blood mononuclear cells","volume":"134","author":"K Schroecksnadel","year":"2003","journal-title":"Clinical and Experimental Immunology"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/intimm\/dxh186","article-title":"Toll-like receptors in innate immunity","volume":"17","author":"K Takeda","year":"2005","journal-title":"International Immunology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/03008200801913742","article-title":"Homocysteine toxicity in connective tissue: theories, old and new","volume":"49","author":"JI Toohey","year":"2008","journal-title":"Connective Tissue Research"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"22485","DOI":"10.1074\/jbc.M603656200","article-title":"Protective mechanisms against homocysteine toxicity: the role of bleomycin hydrolase","volume":"281","author":"J Zimny","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1042\/BJ20080722","article-title":"Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing","volume":"415","author":"Y Qian","year":"2008","journal-title":"Biochemical Journal"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4049\/jimmunol.162.3.1466","article-title":"Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling","volume":"162","author":"K Banki","year":"1999","journal-title":"The Journal of Immunology"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"11944","DOI":"10.1074\/jbc.273.19.11944","article-title":"Molecular ordering in HIV-induced apoptosis","volume":"273","author":"K Banki","year":"1998","journal-title":"The Journal of Biological Chemistry"},{"key":"ref96","unstructured":"Garrett RH, Grishamm CM (2005) Biochemistry: Thomsom Brooks\/Cole."},{"key":"ref97","first-page":"911","article-title":"Proteomic analysis of resting and activated CD8<sup>+<\/sup> T cells","volume":"16","author":"K Jung-Hui","year":"2006","journal-title":"Journal of Microbiology and Biotechnology"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1128\/IAI.66.1.203-212.1998","article-title":"Induced expression of the Legionella pneumophila gene encoding a 20-kilodalton protein during intracellular infection","volume":"66","author":"Y Abu Kwaik","year":"1998","journal-title":"Infection and Immunity"},{"key":"ref99","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2180-1-3","article-title":"Analysis of stress- and host cell-induced expression of the <italic>Mycobacterium tuburculosis<\/italic> inorganic pyrophosphatase","volume":"1","author":"JA Triccas","year":"2001","journal-title":"BMC Microbiology"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1046\/j.1365-2958.2003.03626.x","article-title":"<italic>Coxiella burnetii<\/italic> express type IV secretion system proteins that function similarly to components of the <italic>Legionella pneumophila<\/italic> Dot\/Icm system","volume":"49","author":"DS Zamboni","year":"2003","journal-title":"Molecular Microbiology"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.micinf.2005.09.007","article-title":"60-kDa heat shock protein of <italic>Chlamydia pneumoniae<\/italic> promotes a T helper type 1 immune response through IL-12\/IL-23 production in monocyte derived dendritic cells","volume":"8","author":"CM Ausiello","year":"2006","journal-title":"Microbes and Infection"},{"key":"ref102","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/shk.0b013e31802dec51","article-title":"Origin of immunomodulation after soft tissue trauma: potential involvement of extracellular heat-shock proteins","volume":"27","author":"SB Floh\u00e9","year":"2007","journal-title":"Shock"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.1074\/jbc.M608666200","article-title":"Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide","volume":"282","author":"A Osterloh","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1172\/JCI28423","article-title":"Heat shock protein 60 enhances CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cell function via innate TLR2 signaling","volume":"116","author":"A Zanin-Zhorov","year":"2006","journal-title":"The Journal of Clinical Investigation"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1002\/eji.200425108","article-title":"HSP60 induces self-tolerance to repeated HSP60 stimulation and cross-tolerance to other pro-inflammatory stimuli","volume":"34","author":"B Kilmartin","year":"2004","journal-title":"European Journal of Immunology"},{"key":"ref106","doi-asserted-by":"crossref","first-page":"31332","DOI":"10.1074\/jbc.M103217200","article-title":"Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the Toll\/Interleukin-1 receptor signaling pathway in innate immune cells","volume":"276","author":"RM Vabulas","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"ref107","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1099\/jmm.0.46882-0","article-title":"<italic>Helicobacter pylori<\/italic> heat-shock protein 60 induces interluekin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes","volume":"56","author":"Y Zhao","year":"2007","journal-title":"Journal of Medical Microbiology"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbrc.2007.05.167","article-title":"Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation","volume":"359","author":"JM Bangen","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref109","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(02)03772-9","article-title":"Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages","volume":"533","author":"C Habich","year":"2003","journal-title":"FEBS Letters"},{"key":"ref110","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00018-007-6413-7","article-title":"Heat shock protein 60: regulatory role on innate immune cells","volume":"64","author":"C Habich","year":"2007","journal-title":"Cellular and Molecular Life Science"},{"key":"ref111","first-page":"355","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies","volume":"7","author":"RS Flannagan","year":"2009","journal-title":"Nature Reviews: Microbiology"},{"key":"ref112","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1128\/IAI.68.7.3815-3821.2000","article-title":"<italic>Coxiella burnetii<\/italic> exhibits morphological change and delays phagolysosomal fusion after internalization by J774A.1 cells","volume":"68","author":"D Howe","year":"2000","journal-title":"Infection and Immunity"},{"key":"ref113","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.4049\/jimmunol.169.8.4488","article-title":"Coxiella burnetii survival in THP-1 monocytes involves the impairment of phagosome maturation: IFN-\u03b3 mediates its restoration and bacterial killing","volume":"169","author":"E Ghigo","year":"2002","journal-title":"The Journal of Immunology"},{"key":"ref114","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1091\/mbc.11.2.467","article-title":"Rab7: A key to lysosome biogenesis","volume":"11","author":"C Bucci","year":"2000","journal-title":"Molecular Biology of the Cell"},{"key":"ref115","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/pmic.200390067","article-title":"Monocyte lipid rafts contain proteins implicated in vesicular trafficking and phagosome formation","volume":"3","author":"N Li","year":"2003","journal-title":"Proteomics"},{"key":"ref116","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1083\/jcb.131.6.1435","article-title":"Rab7: An important regulator of late endocytic membrane traffic","volume":"131","author":"Y Feng","year":"1995","journal-title":"The Journal of Cell Biology"},{"key":"ref117","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1242\/jcs.01370","article-title":"Role for Rab7 in maturation of late autophagic vacuoles","volume":"117","author":"S J\u00e4ger","year":"2004","journal-title":"Journal of Cell Science"},{"key":"ref118","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1462-5822.1999.00002.x","article-title":"Impaired recruitment of the small GTPase Rab7 correlates with the inhibition of phagosome maturation by <italic>Leishmania donovani<\/italic> promastigotes","volume":"1","author":"S Scianimanico","year":"1999","journal-title":"Cellular Microbiology"},{"key":"ref119","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1074\/jbc.272.7.4391","article-title":"Role of small GTPase Rab7 in the late endocytic pathway","volume":"272","author":"R Vitelli","year":"1997","journal-title":"The Journal of Biological Chemistry"},{"key":"ref120","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1462-5822.2007.00901.x","article-title":"Lounging in a lysosome: the intracellular lifestyle of <italic>Coxiella burnetii<\/italic>","volume":"9","author":"DE Voth","year":"2007","journal-title":"Cellular Microbiology"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S1369-5274(02)00286-2","article-title":"A phagosome of one&apos;s own: a microbial guide to life in the 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