{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:14:48Z","timestamp":1778055288234,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T00:00:00Z","timestamp":1374710400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069712","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T22:21:26Z","timestamp":1374790886000},"page":"e69712","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Autotaxin Signaling Governs Phenotypic Heterogeneity in Visceral and Parietal Mesothelia"],"prefix":"10.1371","volume":"8","author":[{"given":"Elaine L.","family":"Shelton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristi L.","family":"Galindo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Pfaltzgraff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles C.","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Bader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/dbio.1997.8801","article-title":"Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart","volume":"193","author":"RW Dettman","year":"1998","journal-title":"Dev Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/dbio.1996.0068","article-title":"Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ","volume":"174","author":"T Mikawa","year":"1996","journal-title":"Dev Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/jcs.058669","article-title":"Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate","volume":"123","author":"M Morimoto","year":"2010","journal-title":"J Cell Sci"},{"key":"ref4","first-page":"1005","article-title":"Origin of coronary endothelial cells from epicardial mesothelium in avian embryos","volume":"46","author":"JM Perez-Pomares","year":"2002","journal-title":"Int J Dev Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0808649105","article-title":"Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development","volume":"105","author":"J Que","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1242\/dev.02141","article-title":"The serosal mesothelium is a major source of smooth muscle cells of the gut vasculature","volume":"132","author":"B Wilm","year":"2005","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00441-006-0356-4","article-title":"Activated omentum becomes rich in factors that promote healing and tissue regeneration","volume":"328","author":"NO Litbarg","year":"2007","journal-title":"Cell Tissue Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1440-1843.2002.00404.x","article-title":"Mesothelial cells: their structure, function and role in serosal repair","volume":"7","author":"SE Mutsaers","year":"2002","journal-title":"Respirology"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Shelton EL, Poole SD, Reese J, Bader DM (2012) Omental grafting: a cell-based therapy for blood vessel repair. J Tissue Eng Regen Med.","DOI":"10.1002\/term.528"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1046\/j.1365-2249.1998.00592.x","article-title":"Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES","volume":"112","author":"CE Visser","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jcp.22724","article-title":"Malignant mesothelioma: facts, myths, and hypotheses","volume":"227","author":"M Carbone","year":"2012","journal-title":"J Cell Physiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1750-1172-3-34","article-title":"Malignant mesothelioma","volume":"3","author":"AJ Moore","year":"2008","journal-title":"Orphanet J Rare Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1038\/ncb2610","article-title":"Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature","volume":"14","author":"Y Rinkevich","year":"2012","journal-title":"Nat Cell Biol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1357-2725(03)00242-5","article-title":"The mesothelial cell","volume":"36","author":"SE Mutsaers","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/10408448209041321","article-title":"The mesothelium and its reactions: a review","volume":"10","author":"D Whitaker","year":"1982","journal-title":"Crit Rev Toxicol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/path.1312","article-title":"Proteoglycans and WT1 as markers for distinguishing adenocarcinoma, epithelioid mesothelioma, and benign mesothelium","volume":"199","author":"M Gulyas","year":"2003","journal-title":"J Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1177\/089686080702702s19","article-title":"Mesothelial cells","volume":"27","author":"S Yung","year":"2007","journal-title":"Perit Dial Int"},{"key":"ref18","first-page":"E567","article-title":"Human variation in skeletal muscle fiber-type proportion and enzyme activities","volume":"257","author":"JA Simoneau","year":"1989","journal-title":"Am J Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1007\/s00018-009-0056-9","article-title":"Autotaxin","volume":"66","author":"JA Boutin","year":"2009","journal-title":"Cell Mol Life Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/hh1501.094265","article-title":"Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids","volume":"89","author":"K Hayashi","year":"2001","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/sj.onc.1203263","article-title":"Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells","volume":"19","author":"SW Nam","year":"2000","journal-title":"Oncogene"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1083\/jcb.200204026","article-title":"Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production","volume":"158","author":"M Umezu-Goto","year":"2002","journal-title":"J Cell Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1165\/ajrcmb.21.2.3667","article-title":"Autotaxin expression in non-small-cell lung cancer","volume":"21","author":"Y Yang","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1016\/S0021-9258(18)45911-X","article-title":"Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein","volume":"267","author":"ML Stracke","year":"1992","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Huang da W, Sherman BT, Zheng X, Yang J, Imamichi T, <etal>et al<\/etal>.. (2009) Extracting biological meaning from large gene lists with DAVID. Curr Protoc Bioinformatics Chapter 13: Unit 13 11.","DOI":"10.1002\/0471250953.bi1311s27"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/jpet.108.141911","article-title":"S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool","volume":"327","author":"G Ferry","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1002\/dvdy.21334","article-title":"Serosal mesothelium retains vasculogenic potential","volume":"236","author":"M Kawaguchi","year":"2007","journal-title":"Dev Dyn"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH678>3.0.CO;2-E","article-title":"Human peritoneal adhesions are highly cellular, innervated, and vascularized","volume":"192","author":"SE Herrick","year":"2000","journal-title":"J Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"C1409","DOI":"10.1152\/ajpcell.1996.271.4.C1409","article-title":"Activity-dependent induction of slow myosin gene expression in isolated fast-twitch mouse muscle","volume":"271","author":"ER Barton-Davis","year":"1996","journal-title":"Am J Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1002\/(SICI)1097-4598(199711)20:11<1404::AID-MUS8>3.0.CO;2-E","article-title":"Partial transformation from fast to slow muscle fibers induced by deafferentation of capsaicin-sensitive muscle afferents","volume":"20","author":"O Brunetti","year":"1997","journal-title":"Muscle Nerve"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1128\/MCB.23.12.4331-4343.2003","article-title":"Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice","volume":"23","author":"SA Parsons","year":"2003","journal-title":"Mol Cell Biol"},{"key":"ref32","first-page":"515","article-title":"Autotaxin and lysophospholipids in rheumatoid arthritis","volume":"11","author":"SG Bourgoin","year":"2010","journal-title":"Curr Opin Investig Drugs"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00125-004-1660-8","article-title":"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D\/autotaxin expression","volume":"48","author":"J Boucher","year":"2005","journal-title":"Diabetologia"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1074\/jbc.M807820200","article-title":"Autotaxin\/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis","volume":"284","author":"Z Pamuklar","year":"2009","journal-title":"J Biol Chem"},{"key":"ref35","first-page":"1327","article-title":"Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas","volume":"24","author":"Q Li","year":"2004","journal-title":"Anticancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2144\/000113349","article-title":"Linear measurement of cell contraction in a capillary collagen gel system","volume":"48","author":"R Ilagan","year":"2010","journal-title":"Biotechniques"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bioinformatics\/19.2.185","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"BM Bolstad","year":"2003","journal-title":"Bioinformatics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"RA Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1021\/ol060414i","article-title":"Fluorogenic phospholipid substrate to detect lysophospholipase D\/autotaxin activity","volume":"8","author":"CG Ferguson","year":"2006","journal-title":"Org Lett"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T04:34:16Z","timestamp":1646195656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069712"}},"subtitle":[],"editor":[{"given":"Vladimir V.","family":"Kalinichenko","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,25]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069712","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,25]]}}}