{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:05:42Z","timestamp":1788282342037,"version":"build-2803163510"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069782","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T15:44:42Z","timestamp":1374680682000},"page":"e69782","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":63,"title":["The C57BL\/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts"],"prefix":"10.1371","volume":"8","author":[{"given":"Cristina","family":"Cudalbu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie A.","family":"McLin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joao M. N.","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Rougemont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Oldani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Terraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Toso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Gruetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11248-010-9403-8","article-title":"Genetic polymorphisms among C57BL\/6 mouse inbred strains","volume":"20","author":"E Zurita","year":"2011","journal-title":"Transgenic Res"},{"key":"ref2","first-page":"29","article-title":"Behavioral profiles of three C57BL\/6 substrains","volume":"4","author":"N Matsuo","year":"2010","journal-title":"Front Behav Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnins.2011.00010","article-title":"All (C57BL\/6) Mice are not Created Equal","volume":"5","author":"C Kiselycznyk","year":"2011","journal-title":"Front Neurosci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2011.06325.x","article-title":"The blessings and curses of C57BL\/6 substrains in mouse genetic studies","volume":"1245","author":"CD Bryant","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/01677060802357388","article-title":"Behavioral differences among C57BL\/6 substrains: implications for transgenic and knockout studies","volume":"22","author":"CD Bryant","year":"2008","journal-title":"J Neurogenet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/tera.1420010208","article-title":"Sporadic congenital malformations of newborn inbred mice","volume":"1","author":"H Kalter","year":"1968","journal-title":"Teratology"},{"key":"ref7","unstructured":"Dagg CP (1966) Teratogenesis, in Biology of the laboratory mouse; EL G, editor. New-York: McGraw-Hill."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1023\/A:1021974321874","article-title":"Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy","volume":"17","author":"L Spahr","year":"2002","journal-title":"Metabolic brain disease"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.3174\/ajnr.A1139","article-title":"MR imaging findings in hepatic encephalopathy","volume":"29","author":"A Rovira","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0168-8278(03)00267-8","article-title":"Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies","volume":"39","author":"RF Butterworth","year":"2003","journal-title":"Journal of hepatology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/hep.21126","article-title":"Noncirrhotic portal vein thrombosis exhibits neuropsychological and MR changes consistent with minimal hepatic encephalopathy","volume":"43","author":"B Minguez","year":"2006","journal-title":"Hepatology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1023\/A:1020632708154","article-title":"Proton magnetic resonance spectroscopy in portal-systemic encephalopathy","volume":"13","author":"H Kostler","year":"1998","journal-title":"Metabolic brain disease"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/MPG.0b013e3181ecaf62","article-title":"Effect of surgical portosystemic shunt on prevalence of minimal hepatic encephalopathy in children with extrahepatic portal venous obstruction: assessment by magnetic resonance imaging and psychometry","volume":"51","author":"A Srivastava","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref14","first-page":"919","article-title":"Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema","volume":"24","author":"J Cordoba","year":"1996","journal-title":"Hepatology"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Braissant O, McLin VA, Cudalbu C (2012) Ammonia toxicity to the brain. Journal of Inherited Metabolic Disease in press.","DOI":"10.1007\/s10545-012-9546-2"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jfms.2011.01.010","article-title":"Congenital portosystemic shunts in cats: investigation, diagnosis and stabilisation","volume":"13","author":"M Tivers","year":"2011","journal-title":"J Feline Med Surg"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1748-5827.2011.01144.x","article-title":"Treatment of extrahepatic congenital portosystemic shunts in dogs - what is the evidence base?","volume":"53","author":"MS Tivers","year":"2012","journal-title":"J Small Anim Pract"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cvsm.2009.02.004","article-title":"Portosystemic vascular anomalies","volume":"39","author":"AC Berent","year":"2009","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s00335-011-9364-0","article-title":"Inherited liver shunts in dogs elucidate pathways regulating embryonic development and clinical disorders of the portal vein","volume":"23","author":"FG van Steenbeek","year":"2012","journal-title":"Mamm Genome"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Mlynarik V, Cudalbu C, Xin L, Gruetter R (2008) (1)H NMR spectroscopy of rat brain in vivo at 14.1Tesla: Improvements in quantification of the neurochemical profile. J Magn Reson.","DOI":"10.1016\/j.jmr.2008.06.019"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/(SICI)1522-2594(200002)43:2<319::AID-MRM22>3.0.CO;2-1","article-title":"Field mapping without reference scan using asymmetric echo-planar techniques","volume":"43","author":"R Gruetter","year":"2000","journal-title":"Magn Reson Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"104034","DOI":"10.1088\/0957-0233\/20\/10\/104034","article-title":"Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum","volume":"20","author":"C Cudalbu","year":"2009","journal-title":"Measurement Science & Technology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.3233\/JAD-2012-120100","article-title":"Handling macromolecule signals in the quantification of the neurochemical profile","volume":"31","author":"C Cudalbu","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/jcbfm.2011.173","article-title":"Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy","volume":"32","author":"C Cudalbu","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/j.1471-4159.2010.07051.x","article-title":"Neurochemical profile of the developing mouse cortex determined by in vivo 1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia","volume":"115","author":"A Kulak","year":"2010","journal-title":"J Neurochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/mrm.20184","article-title":"Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T","volume":"52","author":"I Tkac","year":"2004","journal-title":"Magn Reson Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/PAS.0b013e3182230ce4","article-title":"Congenital extrahepatic portosystemic shunts (Abernethy malformation): a histopathologic evaluation","volume":"35","author":"M Lisovsky","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.nurt.2010.05.015","article-title":"Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy","volume":"7","author":"SW Brusilow","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1152\/physrev.1987.67.2.440","article-title":"Biochemistry and physiology of brain ammonia","volume":"67","author":"AJ Cooper","year":"1987","journal-title":"Physiol Rev"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jpedsurg.2010.11.009","article-title":"Management and classification of type II congenital portosystemic shunts","volume":"46","author":"TB Lautz","year":"2011","journal-title":"J Pediatr Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1067\/mpd.2003.93","article-title":"Surgical restoration of portal flow corrects procoagulant and anticoagulant deficiencies associated with extrahepatic portal vein thrombosis","volume":"142","author":"CL Mack","year":"2003","journal-title":"J Pediatr"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/MPG.0b013e3181d9cb92","article-title":"Complications of congenital portosystemic shunts in children: therapeutic options and outcomes","volume":"51","author":"S Franchi-Abella","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"10442","DOI":"10.1073\/pnas.190256997","article-title":"Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice","volume":"97","author":"GP Lahvis","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1016\/j.jpeds.2006.06.064","article-title":"Epigenetic mechanisms and gastrointestinal development","volume":"149","author":"RA Waterland","year":"2006","journal-title":"J Pediatr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.nutr.27.061406.093705","article-title":"Epigenetic epidemiology of the developmental origins hypothesis","volume":"27","author":"RA Waterland","year":"2007","journal-title":"Annu Rev Nutr"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1002\/ajmg.a.33726","article-title":"Genetic drift. \u201cOmics\u201d as the filtering gateway between environment and phenotype: The inflammatory bowel diseases example","volume":"152A","author":"R Kellermayer","year":"2010","journal-title":"Am J Med Genet A"},{"key":"ref37","unstructured":"Tkac I, Zacharoff L, Dubinsky JM (2011) Longitudinal study of neurochemical changes in Q140 mouse model of Huntington\u2019s disease. 2288."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jnr.10268","article-title":"GeneChip((R)) analysis shows altered mRNA expression of transcripts of neurotransmitter and signal transduction pathways in the cerebral cortex of portacaval shunted rats","volume":"68","author":"GQ Song","year":"2002","journal-title":"Journal of Neuroscience Research"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.cyto.2011.08.033","article-title":"Multiple organ inflammatory response to portosystemic shunt in the rat","volume":"56","author":"C Garcia","year":"2011","journal-title":"Cytokine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1023\/A:1020741226752","article-title":"Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle","volume":"14","author":"P Desjardins","year":"1999","journal-title":"Metabolic brain disease"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0197-0186(99)00075-3","article-title":"Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues","volume":"35","author":"P Desjardins","year":"1999","journal-title":"Neurochemistry international"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0006-8993(97)00652-5","article-title":"Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis","volume":"765","author":"VL Rao","year":"1997","journal-title":"Brain research"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0168-8278(02)00165-4","article-title":"Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors","volume":"37","author":"CR Gandhi","year":"2002","journal-title":"Journal of hepatology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1136\/gut.2010.236083","article-title":"p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts","volume":"60","author":"A Agusti","year":"2011","journal-title":"Gut"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-0773.1997.tb00388.x","article-title":"Increased expression of cholecystokinin-a receptor mRNA in pancreas and cholecystokinin-B receptor mRNA in oxyntic mucosa after porta-caval shunting in rats","volume":"80","author":"AG Nylander","year":"1997","journal-title":"Pharmacology & Toxicology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"G1105","DOI":"10.1152\/ajpgi.00529.2006","article-title":"Altered expression of genes regulating skeletal muscle mass in the portacaval anastamosis rat","volume":"292","author":"S Dasarathy","year":"2007","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:48:08Z","timestamp":1646182088000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069782"}},"subtitle":[],"editor":[{"given":"Grainne M.","family":"McAlonan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,23]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069782","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,23]]}}}