{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:17:42Z","timestamp":1788484662375,"version":"build-2803163510"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0069840","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T05:20:18Z","timestamp":1374902418000},"page":"e69840","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Effect of Orexin-A on Cardiac Dysfunction Mediated by NADPH Oxidase-Derived Superoxide Anion in Ventrolateral Medulla"],"prefix":"10.1371","volume":"8","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e20360","DOI":"10.1371\/journal.pone.0020360","article-title":"Pharmacogenetic modulation of orexin neurons alters sleep\/wakefulness states in mice","volume":"6","author":"K Sasaki","year":"2011","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.neuron.2005.04.035","article-title":"Behavioral correlates of activity in identified hypocretin\/orexin neurons","volume":"46","author":"BY Mileykovskiy","year":"2005","journal-title":"Neuron"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e47032","DOI":"10.1371\/journal.pone.0047032","article-title":"Effects of ambient temperature on sleep and cardiovascular regulation in mice: the role of hypocretin\/orexin neurons","volume":"7","author":"V Lo Martire","year":"2012","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"R581","DOI":"10.1152\/ajpregu.00671.2002","article-title":"Attenuated defense response and low basal blood pressure in orexin knockout mice","volume":"285","author":"Y Kayaba","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e36871","DOI":"10.1371\/journal.pone.0036871","article-title":"Hypothalamic orexin\u2013a neurons are involved in the response of the brain stress system to morphine withdrawal","volume":"7","author":"ML Laorden","year":"2012","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0092-8674(00)80949-6","article-title":"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior","volume":"92","author":"T Sakurai","year":"1998","journal-title":"Cell"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1111\/j.1476-5381.2011.01694.x","article-title":"Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex","volume":"165","author":"IZ Shahid","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0304-3940(98)00977-X","article-title":"Orexin A-like immunoreactivity in the rat brain","volume":"260","author":"CT Chen","year":"1999","journal-title":"Neurosci Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"9996","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998","article-title":"Neurons containing hypocretin (orexin) project to multiple neuronal systems","volume":"18","author":"C Peyron","year":"1998","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev.neuro.24.1.429","article-title":"To eat or to sleep? Orexin in the regulation of feeding and wakefulness","volume":"24","author":"JT Willie","year":"2001","journal-title":"Annu Rev Neurosci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"R692","DOI":"10.1152\/ajpregu.2000.278.3.R692","article-title":"Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats","volume":"278","author":"CT Chen","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref12","first-page":"R1780","article-title":"Sympathetic and cardiovascular actions of orexins in conscious rats","volume":"277","author":"T Shirasaka","year":"1999","journal-title":"Am J Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0006-8993(99)01457-2","article-title":"Cardiovascular regulatory actions of the hypocretins in brain","volume":"831","author":"WK Samson","year":"1999","journal-title":"Brain Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"R1801","DOI":"10.1152\/ajpregu.2001.281.6.R1801","article-title":"Orexins\/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro","volume":"281","author":"VR Antunes","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1124\/jpet.110.167791","article-title":"Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptors","volume":"334","author":"SC Huang","year":"2010","journal-title":"J Pharmacol Exp Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0033-0620(63)80046-8","article-title":"Circulating Levels of Catecholamines in Acute Myocardial Infarction and Angina Pectoris","volume":"6","author":"JA Richardson","year":"1963","journal-title":"Prog Cardiovasc Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1161\/01.CIR.0000025610.14665.21","article-title":"Time course of sympathetic neural hyperactivity after uncomplicated acute myocardial infarction","volume":"106","author":"LN Graham","year":"2002","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuropharm.2012.10.021","article-title":"Orexin A regulates cardiovascular responses in stress-induced hypertensive rats","volume":"67C","author":"F Xiao","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-0115(01)00351-2","article-title":"Pressor response to microinjection of orexin\/hypocretin into rostral ventrolateral medulla of awake rats","volume":"104","author":"BH Machado","year":"2002","journal-title":"Regul Pept"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"S170","DOI":"10.2337\/dc08-s247","article-title":"NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities","volume":"31","author":"TM Paravicini","year":"2008","journal-title":"Diabetes Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2005.07.055","article-title":"Reactive oxygen species in paraventricular nucleus modulates cardiac sympathetic afferent reflex in rats","volume":"1058","author":"Y Han","year":"2005","journal-title":"Brain Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12264-011-1529-z","article-title":"Angiotensin II-derived reactive oxygen species underpinning the processing of the cardiovascular reflexes in the medulla oblongata","volume":"27","author":"VA Braga","year":"2011","journal-title":"Neurosci Bull"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1748-1716.2009.02026.x","article-title":"Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats","volume":"197","author":"MK Zhong","year":"2009","journal-title":"Acta Physiol (Oxf)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.RES.0000146676.04359.64","article-title":"Superoxide mediates sympathoexcitation in heart failure: roles of angiotensin II and NAD(P)H oxidase","volume":"95","author":"L Gao","year":"2004","journal-title":"Circ Res"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, <etal>et al<\/etal>.. (2009) LAD-ligation: a murine model of myocardial infarction. J Vis Exp.","DOI":"10.3791\/1438"},{"key":"ref26","unstructured":"Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Amsterdam; Boston: Academic Press\/Elsevier."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1440-1681.2010.05411.x","article-title":"Orexin-A and respiration in a rat model of smoke-induced chronic obstructive pulmonary disease","volume":"37","author":"ZB Liu","year":"2010","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.lfs.2011.06.003","article-title":"Adenosine A(2A)R modulates cardiovascular function by activating ERK1\/2 signal in the rostral ventrolateral medulla of acute myocardial ischemic rats","volume":"89","author":"M Jiang","year":"2011","journal-title":"Life Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1440-1681.2011.05521.x","article-title":"Nitric oxide modulates cardiovascular function in the rat by activating adenosine A2A receptors and inhibiting acetylcholine release in the rostral ventrolateral medulla","volume":"38","author":"MY Jiang","year":"2011","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.brainresbull.2012.06.008","article-title":"Protective effects of electroacupuncture on cardiac function in rats subjected to thoracic surgery trauma","volume":"89","author":"HH Zhang","year":"2012","journal-title":"Brain Res Bull"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-5273(02)00057-8","article-title":"Functional assessment of heart rate variability: physiological basis and practical applications","volume":"84","author":"J Pumprla","year":"2002","journal-title":"Int J Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/1099800406289775","article-title":"Detection of cardiac variability in the isolated rat heart","volume":"8","author":"AM Schumacher","year":"2006","journal-title":"Biol Res Nurs"},{"key":"ref33","first-page":"73","article-title":"Measurement of vascular reactive oxygen species production by chemiluminescence","volume":"108","author":"TJ Guzik","year":"2005","journal-title":"Methods Mol Med"},{"key":"ref34","first-page":"II71","article-title":"Role of the sympathetic nervous system in the pathogenesis of chronic stable angina. Implications for the mechanism of action of beta-blockers","volume":"82","author":"S Chierchia","year":"1990","journal-title":"Circulation"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/j.1460-9568.2009.06952.x","article-title":"Hypocretin\/orexin contributes to the expression of some but not all forms of stress and arousal","volume":"30","author":"TM Furlong","year":"2009","journal-title":"Eur J Neurosci"},{"key":"ref36","first-page":"19","article-title":"[Role of orexin in the cholinergic ascending arousal system\u2013orexin-induced arousal from anesthesia]","volume":"56","author":"S Fukuda","year":"2007","journal-title":"Masui"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.2337\/db09-0385","article-title":"A major role for perifornical orexin neurons in the control of glucose metabolism in rats","volume":"58","author":"CX Yi","year":"2009","journal-title":"Diabetes"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e39982","DOI":"10.1371\/journal.pone.0039982","article-title":"Acid sensing ion channel 1 in lateral hypothalamus contributes to breathing control","volume":"7","author":"N Song","year":"2012","journal-title":"PLoS One"},{"key":"ref39","first-page":"1075","article-title":"Thoracic epidural anesthesia during coronary artery bypass surgery: effects on cardiac sympathetic activity, myocardial blood flow and metabolism, and central hemodynamics","volume":"79","author":"K Kirno","year":"1994","journal-title":"Anesth Analg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/cne.902280204","article-title":"Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons","volume":"228","author":"CA Ross","year":"1984","journal-title":"J Comp Neurol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"V80","DOI":"10.1161\/01.HYP.5.6_Pt_3.V80","article-title":"Lesions of epinephrine neurons in the rostral ventrolateral medulla abolish the vasodepressor components of baroreflex and cardiopulmonary reflex","volume":"5","author":"AR Granata","year":"1983","journal-title":"Hypertension"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-0115(00)00202-0","article-title":"Orexins: a role in medullary sympathetic outflow","volume":"96","author":"NJ Dun","year":"2000","journal-title":"Regul Pept"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00702-010-0407-6","article-title":"The sympathetic-vagal balance against endotoxemia","volume":"117","author":"J Huang","year":"2010","journal-title":"J Neural Transm"},{"key":"ref44","first-page":"H333","article-title":"Left ventricular systolic dysfunction precedes diastolic dysfunction during myocardial ischemia in conscious dogs","volume":"267","author":"T Ihara","year":"1994","journal-title":"Am J Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0006-8993(03)03002-6","article-title":"Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats","volume":"981","author":"K Hirota","year":"2003","journal-title":"Brain Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2007.04.021","article-title":"Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction","volume":"43","author":"F Qin","year":"2007","journal-title":"Free Radic Biol Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1161\/01.CIR.0000128695.49900.12","article-title":"Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats","volume":"109","author":"T Kishi","year":"2004","journal-title":"Circulation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"H695","DOI":"10.1152\/ajpheart.00619.2003","article-title":"Reactive oxygen species stimulate central and peripheral sympathetic nervous system activity","volume":"287","author":"VM Campese","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0069840","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T19:45:19Z","timestamp":1563565519000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0069840"}},"subtitle":[],"editor":[{"given":"Zhe","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0069840","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}