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Antwerpen, Belgium. pp. 74\u201389."},{"key":"ref18","first-page":"30","article-title":"Evaluation of a Bayesian model-based approach in GA studies","volume":"8","author":"G Hull\u00e1m","year":"2010","journal-title":"Journal of Machine Learning in Systems Biology, Workshop and Conference Proceedings"},{"key":"ref19","unstructured":"Hullam G, Antal P (2012) Estimation of effect size posterior using model averaging over Bayesian network structures and parameters. Proceedings of the Sixth European Workshop on Probabilistic Graphical Models. 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