{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:20:29Z","timestamp":1790670029031,"version":"4.1.0"},"reference-count":22,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0070019","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T21:10:52Z","timestamp":1375391452000},"page":"e70019","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Biomarker Report from the Phase II Lamotrigine Trial in Secondary Progressive MS \u2013 Neurofilament as a Surrogate of Disease Progression"],"prefix":"10.1371","volume":"8","author":[{"given":"Sharmilee","family":"Gnanapavan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Morant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Furby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Hayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Marta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Palace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Giovannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1136\/jnnp.2004.043315","article-title":"Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study","volume":"76","author":"A Petzold","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.bbrc.2005.08.252","article-title":"Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury","volume":"336","author":"G Shaw","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1212\/WNL.0b013e31821432ff","article-title":"Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis","volume":"76","author":"J Kuhle","year":"2011","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1212\/WNL.0b013e3181a0fe3f","article-title":"Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis","volume":"72","author":"CE Teunissen","year":"2009","journal-title":"Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1191\/1352458504ms1021sr","article-title":"Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis","volume":"10","author":"A Petzold","year":"2004","journal-title":"Mult Scler"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1474-4422(10)70131-9","article-title":"Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial","volume":"9","author":"R Kapoor","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(02)00412-4","article-title":"Serum and urine nitrate and nitrite are not reliable indicators of intrathecal nitric oxide production in acute brain injury","volume":"208","author":"K Rejdak","year":"2003","journal-title":"J Neurol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jim.2004.01.015","article-title":"An ELISA for glial fibrillary acidic protein","volume":"287","author":"A Petzold","year":"2004","journal-title":"J Immunol Methods"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1093\/brain\/awn212","article-title":"Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington&apos;s disease","volume":"131","author":"V Leoni","year":"2008","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.neurobiolaging.2011.05.013","article-title":"Serial CSF sampling in Alzheimer&apos;s disease: specific versus non-specific markers","volume":"33","author":"MI Kester","year":"2012","journal-title":"Neurobiol Aging"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00415-006-0415-5","article-title":"N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry","volume":"254","author":"B Jasperse","year":"2007","journal-title":"J Neurol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1191\/1352458505ms1218oa","article-title":"Acute axonal damage predicts clinical outcome in patients with multiple sclerosis","volume":"11","author":"ET Lim","year":"2005","journal-title":"Mult Scler"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.pmrj.2010.09.004","article-title":"Psychometrics of dominant right hand during the 9-hole PEG test: differences between PEG placement and removal","volume":"3","author":"T Koyama","year":"2011","journal-title":"PM R"},{"key":"ref14","first-page":"542691","article-title":"Phosphorylated neurofilament heavy chain correlations to visual function, optical coherence tomography, and treatment","volume":"2010","author":"J Pasol","year":"2010","journal-title":"Mult Scler Int"},{"key":"ref15","first-page":"217802","article-title":"The diagnostic and prognostic value of neurofilament heavy chain levels in immune-mediated optic neuropathies","volume":"2012","author":"A Petzold","year":"2011","journal-title":"Mult Scler Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/NEN.0b013e3181a19a5a","article-title":"Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter","volume":"68","author":"M Vercellino","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref17","first-page":"266","article-title":"The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure","volume":"75","author":"C McGuigan","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1212\/01.WNL.0000036566.00866.26","article-title":"Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions","volume":"59","author":"E Bergers","year":"2002","journal-title":"Neurology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archneurol.2011.674","article-title":"Impact of inflammation on brain volume in multiple sclerosis","volume":"69","author":"J Cheriyan","year":"2012","journal-title":"Arch Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/jaut.2000.0441","article-title":"Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity","volume":"15","author":"G Moalem","year":"2000","journal-title":"J Autoimmun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jneuroim.2004.09.004","article-title":"Plasma osteopontin levels in multiple sclerosis","volume":"158","author":"M Comabella","year":"2005","journal-title":"J Neuroimmunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1559-0275-9-9","article-title":"Development of protein biomarkers in cerebrospinal fluid for secondary progressive multiple sclerosis using selected reaction monitoring mass spectrometry (SRM-MS)","volume":"9","author":"Y Jia","year":"2012","journal-title":"Clin Proteomics"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0070019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:10:09Z","timestamp":1540307409000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0070019"}},"subtitle":[],"editor":[{"given":"Tobias","family":"Derfuss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,1]]},"references-count":22,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0070019","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,1]]}}}