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Giftige Gelenke. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sueddeutsche.de\/gesundheit\/2.220\/gefaehrliche-hueftprothesen-giftige-gelenke-1.1297192\" xlink:type=\"simple\">http:\/\/www.sueddeutsche.de\/gesundheit\/2.220\/gefaehrliche-hueftprothesen-giftige-gelenke-1.1297192<\/ext-link>. Accessed 2012 Mar 5."},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Cohen D (2012) How safe are metal-on-metal implants? BMJ 344.","DOI":"10.1136\/bmj.e1410"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Godlee F (2012) Serious risks from metal-on-metal hip implants. BMJ 344.","DOI":"10.1136\/bmj.e1539"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Heneghan C, Langton D, Thompson M (2012) Ongoing problems with metal-on-metal hip implants. 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Annual Report."},{"key":"ref17","unstructured":"National Joint Registry (2011) National Joint Registry for England and Wales. 8th Annual Report. Surgical data to 31st December 2010."},{"key":"ref18","first-page":"1308","article-title":"Sensitivity and specificity of blood cobalt and chromium metal ions for predicting failure of MoM hip replacement","volume":"93-B","author":"AJ Hart","year":"2011","journal-title":"JBJS Br"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jor.21015","article-title":"Lymphocyte proliferation responses in patients with pseudotumors following metal-on-metal hip resurfacing arthroplasty","volume":"28","author":"YM Kwon","year":"2010","journal-title":"J Orthop Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s11999-011-2201-7","article-title":"Pseudotumors are common in well-positioned low-wearing metal-on-metal hips","volume":"470","author":"AK Matthies","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.hlc.2012.03.013","article-title":"Arthroprosthetic cobaltism and cardiomyopathy","volume":"21","author":"C Machado","year":"2012","journal-title":"Heart Lung Circ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.arth.2008.07.017","article-title":"Severe cobalt intoxication due to prosthesis wear in repeated total hip arthroplasty","volume":"24","author":"M Oldenburg","year":"2009","journal-title":"J Arthroplasty"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/oem.2003.009605","article-title":"Exposure to cobalt in the production of cobalt and cobalt compounds and its effect on the heart","volume":"61","author":"A Linna","year":"2004","journal-title":"Occup Environ Med"},{"key":"ref24","unstructured":"Schiele R, editor (2011) BK 1103: Erkrankungen durch Chrom oder seine Verbindungen. 3 ed. Stuttgart: Gentner Verlag."},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Seidler A, J\u00e4hnichen S, Hegewald J, Fishta A, Krug O, <etal>et al<\/etal>.. (2012) Systematic review and quantification of respiratory cancre risk for occupational exposure to hexavalent chromium. Int Arch Occup Environ Health: 19 Oct 2012 [Epub ahead of print].","DOI":"10.1007\/s00420-012-0822-0"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0883-5403(98)90195-4","article-title":"Assessing activity in joint replacement patients","volume":"13","author":"CA Zahiri","year":"1998","journal-title":"J Arthroplasty"},{"key":"ref27","unstructured":"CASP (2011) Critical Appraisal Skills Programme \u2013 Appraising the Evidence. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.casp-uk.net\/find-appraise-act\/appraising-the-evidence\/\" xlink:type=\"simple\">http:\/\/www.casp-uk.net\/find-appraise-act\/appraising-the-evidence\/<\/ext-link>. Accessed 2012 Jun 28."},{"key":"ref28","unstructured":"SIGN (2011) Scottish Intercollegiate Guidelines Network \u2013 Methodology Checklists. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sign.ac.uk\/methodology\/checklists.html\" xlink:type=\"simple\">http:\/\/www.sign.ac.uk\/methodology\/checklists.html<\/ext-link>. Accessed 2012 Jun 28."},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, <etal>et al<\/etal>.. (2011) The Cochrane Collaboration&apos;s tool for assessing risk of bias in randomised trials. 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Clinical and radiological results at ten years","volume":"90-B","author":"V Eswaramoorthy","year":"2008","journal-title":"JBJS Br"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00264-011-1399-z","article-title":"High survival in young patients using a second generation uncemented total hip replacement","volume":"36","author":"MR Streit","year":"2012","journal-title":"Int Orthop"},{"key":"ref77","first-page":"1443","article-title":"Ten year follow-up of the non-porous Allofit cementless acetabular component","volume":"91-B","author":"P Zenz","year":"2009","journal-title":"JBJS Br"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2106\/JBJS.J.01885","article-title":"Comparison of whole-blood metal ion levels in four types of metal-on-metal large-diameter femoral head total hip arthroplasty: The potential influence of the adapter sleeve","volume":"93-A","author":"M Lavigne","year":"2011","journal-title":"J Bone Joint Surg Am"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(12)60353-5","article-title":"Failure rates of stemmed metal-on-metal hip replacements: Analysis of data from the National Joint Registry of England and Wales","volume":"379","author":"AJ Smith","year":"2012","journal-title":"Lancet"},{"key":"ref80","unstructured":"M\u00e4kel\u00e4 KT, Visuri T, Pulkkinen P, Eskelinen A, Remes V, <etal>et al<\/etal>.. (2012) Risk of cancer with metal-on-metal hip replacements: Population based study. BMJ 345."},{"key":"ref81","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2474-11-78","article-title":"A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up","volume":"11","author":"T Visuri","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00016470308540852","article-title":"Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis. A meta-analysis of 6 Nordic cohorts with 73,000 patients","volume":"74","author":"T Visuri","year":"2003","journal-title":"Acta Orthop Scand"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/oxfordjournals.aje.a009631","article-title":"Lung cancer risk in hard-metal workers","volume":"148","author":"JJ Moulin","year":"1998","journal-title":"Am J Epidemiol"},{"key":"ref84","unstructured":"Arbeitsgemeinschaft Endoprothetik (2012) Konsensus-Empfehlungen zur Handhabung von Metall-Metall-Gleitpaarungen. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ae-germany.com\/index.php?option=com_phocadownload&view=category&id=13&Itemid=380\" xlink:type=\"simple\">http:\/\/www.ae-germany.com\/index.php?option=com_phocadownload&amp;view=category&amp;id=13&amp;Itemid=380<\/ext-link>. Accessed 2012 Nov 11."},{"key":"ref85","unstructured":"DGOOC (2012) Metall-Metall-Gleitpaarungen. Aktuelle Konsensus-Empfehlungen. Orthop\u00e4die und Unfallchirurgie \u2013 Mitteilungen und Nachrichten. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.dgooc.de\/images\/stories\/Presse\/Pressemitteilung\/Metall_Metall_Paarungen_OUMN_3_2012.pdf\" xlink:type=\"simple\">http:\/\/www.dgooc.de\/images\/stories\/Presse\/Pressemitteilung\/Metall_Metall_Paarungen_OUMN_3_2012.pdf<\/ext-link>. Accessed 2012 Jul 2."},{"key":"ref86","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.otsr.2013.01.005","article-title":"European multidisciplinary consensus statement on the use and monitoring of metal-on-metal bearings for total hip replacement and hip resurfacing","volume":"99","author":"F Hannemann","year":"2013","journal-title":"Orthop Trauma Surg Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0070359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T18:53:58Z","timestamp":1688410438000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0070359"}},"subtitle":[],"editor":[{"given":"Jo Gagnier el","family":"Joseph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,7]]},"references-count":86,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0070359","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,7]]}}}