{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:35:21Z","timestamp":1762540521385},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0070808","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T05:11:15Z","timestamp":1374901875000},"page":"e70808","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Brain Signature Characterizing the Body-Brain-Mind Axis of Transsexuals"],"prefix":"10.1371","volume":"8","author":[{"given":"Hsiao-Lun","family":"Ku","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Shu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiang-Tai","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Chi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Ta","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chou-Ming","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tung-Ping","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Chiao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Chuen","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"ref1","unstructured":"Australian Passport Office, Department of Foreign Affairs and Trade, Australian Government (2011) Sex and Gender Diverse Passport Applicants. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.passports.gov.au\/web\/sexgenderapplicants.aspx\" xlink:type=\"simple\">www.passports.gov.au\/web\/sexgenderapplicants.aspx<\/ext-link>. Accessed 2013 Jul 2."},{"key":"ref2","unstructured":"Castillo M (2012 May 11)Argentine law lets people identify own gender. CNN News."},{"key":"ref3","unstructured":"American Psychiatric Association, editor (2000) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Washington, DC.: American Psychiatric Association."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1056\/NEJMcp1008161","article-title":"Clinical practice. Care of transsexual persons","volume":"364","author":"LJ Gooren","year":"2011","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1440-1819.2010.02118.x","article-title":"Psychiatric comorbidity among patients with gender identity disorder","volume":"64","author":"M Hoshiai","year":"2010","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1300\/J082v42n01_05","article-title":"Gender violence: transgender experiences with violence and discrimination","volume":"42","author":"EL Lombardi","year":"2001","journal-title":"J Homosex"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1440-1819.2009.02017.x","article-title":"Stress-coping strategies of patients with gender identity disorder","volume":"63","author":"Y Matsumoto","year":"2009","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.psychres.2011.04.024","article-title":"Suicidal ideation among patients with gender identity disorder","volume":"190","author":"S Terada","year":"2011","journal-title":"Psychiatry Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/cercor\/bhn117","article-title":"Development of anterior cingulate functional connectivity from late childhood to early adulthood","volume":"19","author":"AM Kelly","year":"2009","journal-title":"Cereb Cortex"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.tics.2004.01.004","article-title":"Cortical midline structures and the self","volume":"8","author":"G Northoff","year":"2004","journal-title":"Trends Cogn Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1111\/j.1460-9568.2006.05206.x","article-title":"Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women","volume":"24","author":"JR Georgiadis","year":"2006","journal-title":"Eur J Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"9185","DOI":"10.1523\/JNEUROSCI.23-27-09185.2003","article-title":"Brain activation during human male ejaculation","volume":"23","author":"G Holstege","year":"2003","journal-title":"J Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.neuroimage.2009.04.040","article-title":"An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences","volume":"47","author":"NI Eisenberger","year":"2009","journal-title":"Neuroimage"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"14817","DOI":"10.1073\/pnas.1009164107","article-title":"Neural sensitivity to social rejection is associated with inflammatory responses to social stress","volume":"107","author":"GM Slavich","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.neuroimage.2010.08.039","article-title":"Emotional conflict in interpersonal interactions","volume":"54","author":"M Ruz","year":"2011","journal-title":"Neuroimage"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.neuroimage.2007.04.001","article-title":"Different neural systems adjust motor behavior in response to reward and punishment","volume":"36","author":"J Wrase","year":"2007","journal-title":"Neuroimage"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1073\/pnas.071043098","article-title":"Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function","volume":"98","author":"DA Gusnard","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroimage.2004.01.019","article-title":"Activity in ventromedial prefrontal cortex covaries with sympathetic skin conductance level: a physiological account of a \u201cdefault mode\u201d of brain function","volume":"22","author":"Y Nagai","year":"2004","journal-title":"Neuroimage"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hbm.20113","article-title":"Spontaneous low-frequency BOLD signal fluctuations: an fMRI investigation of the resting-state default mode of brain function hypothesis","volume":"26","author":"P Fransson","year":"2005","journal-title":"Hum Brain Mapp"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17558","DOI":"10.1073\/pnas.0902455106","article-title":"Learning sculpts the spontaneous activity of the resting human brain","volume":"106","author":"CM Lewis","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref21","unstructured":"Bond M (1986) An empirical study of defense styles: The Defense Style Questionnaire, in Vaillant GE; Empirical Studies of Ego Mechanisms of Defense. Washington, D.C.: American Psychiatric Press Inc. 127\u2013158."},{"key":"ref22","unstructured":"Lee YC, Chen YS, Yang CH, Yang YM, Huang SC, et al. (2000) Development of \u201cDefense Style Questionnaire-Chinese version\u201d and normative data establishment. Taipei Veterans General Hospital, Taiwan, R.O.C."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","article-title":"An inventory for measuring depression","volume":"4","author":"AT Beck","year":"1961","journal-title":"Arch Gen Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.euroneuro.2007.10.002","article-title":"Effects of cross-sex hormones on cerebral activation during language and mental rotation: An fMRI study in transsexuals","volume":"18","author":"IE Sommer","year":"2008","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref25","first-page":"13","article-title":"DPARSF: A MATLAB Toolbox for \u201cPipeline\u201d Data Analysis of Resting-State fMRI","volume":"4","author":"Y Chao-Gan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e25031","DOI":"10.1371\/journal.pone.0025031","article-title":"REST: a toolkit for resting-state functional magnetic resonance imaging data processing","volume":"6","author":"XW Song","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1093\/brain\/awn276","article-title":"A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity","volume":"131","author":"A Garcia-Falgueras","year":"2008","journal-title":"Brain"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.neuroimage.2009.03.048","article-title":"Regional gray matter variation in male-to-female transsexualism","volume":"46","author":"E Luders","year":"2009","journal-title":"Neuroimage"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jpsychires.2010.05.006","article-title":"White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study","volume":"45","author":"G Rametti","year":"2011","journal-title":"J Psychiatr Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jpsychires.2010.11.007","article-title":"The microstructure of white matter in male to female transsexuals before cross-sex hormonal treatment. A DTI study","volume":"45","author":"G Rametti","year":"2011","journal-title":"J Psychiatr Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/378068a0","article-title":"A sex difference in the human brain and its relation to transsexuality","volume":"378","author":"JN Zhou","year":"1995","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/cercor\/bhm216","article-title":"Male-to-female transsexuals show sex-atypical hypothalamus activation when smelling odorous steroids","volume":"18","author":"H Berglund","year":"2008","journal-title":"Cereb Cortex"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1743-6109.2008.00981.x","article-title":"Specific cerebral activation due to visual erotic stimuli in male-to-female transsexuals compared with male and female controls: an fMRI study","volume":"6","author":"ER Gizewski","year":"2009","journal-title":"J Sex Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1210\/jcem.85.5.6564","article-title":"Male-to-female transsexuals have female neuron numbers in a limbic nucleus","volume":"85","author":"FP Kruijver","year":"2000","journal-title":"J Clin Endocrinol Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0070808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:17:32Z","timestamp":1588994252000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0070808"}},"subtitle":[],"editor":[{"given":"Marianna","family":"Mazza","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0070808","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}