{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:45:48Z","timestamp":1791398748106,"version":"4.3.3"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0070817","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T21:24:26Z","timestamp":1375737866000},"page":"e70817","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Analysis of Variations in the Glutamate Receptor, N-Methyl D-Aspartate 2A (GRIN2A) Gene Reveals Their Relative Importance as Genetic Susceptibility Factors for Heroin Addiction"],"prefix":"10.1371","volume":"8","author":[{"given":"Bin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-min","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-hua","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archpsyc.1995.03950130042005","article-title":"Adoption study demonstrating two genetic pathways to drug abuse","volume":"52","author":"RJ Cadoret","year":"1995","journal-title":"Arch Gen Psychiatry"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1316.001","article-title":"Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results","volume":"1025","author":"GR Uhl","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bcp.2007.06.042","article-title":"\u201cHigher order\u201d addiction molecular genetics: convergent data from genome-wide association in humans and mice","volume":"75","author":"GR Uhl","year":"2008","journal-title":"Biochem Pharmacol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1601-183X.2009.00501.x","article-title":"Heroin addiction in African Americans: a hypothesis-driven association study","volume":"8","author":"O Levran","year":"2009","journal-title":"Genes Brain Behav"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1369-1600.2011.00321.x","article-title":"Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism","volume":"17","author":"MC Domart","year":"2012","journal-title":"Addict Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2006.08.011","article-title":"NMDA receptor subunits: function and pharmacology","volume":"7","author":"P Paoletti","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"TV Bliss","year":"1993","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1152\/jn.1999.81.2.781","article-title":"Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation","volume":"81","author":"SN Yang","year":"1999","journal-title":"J Neurophysiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1523\/JNEUROSCI.5531-08.2009","article-title":"NMDA receptor GluN2B (GluR epsilon 2\/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses","volume":"29","author":"K Akashi","year":"2009","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1756-6606-2-4","article-title":"Plasticity of NMDA receptor NR2B subunit in memory and chronic pain","volume":"2","author":"M Zhuo","year":"2009","journal-title":"Mol Brain"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1152\/physrev.1994.74.3.723","article-title":"N-methyl-D-aspartic acid receptor structure and function","volume":"74","author":"CJ McBain","year":"1994","journal-title":"Physiol Rev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/nature715","article-title":"Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits","volume":"415","author":"JE Chatterton","year":"2002","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/373151a0","article-title":"Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit","volume":"373","author":"K Sakimura","year":"1995","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6704","DOI":"10.1523\/JNEUROSCI.18-17-06704.1998","article-title":"Increased thresholds for long-term potentiation and contextual learning in mice lacking the NMDA-type glutamate receptor epsilon1 subunit","volume":"18","author":"Y Kiyama","year":"1998","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","article-title":"Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans","volume":"99","author":"LR Squire","year":"1992","journal-title":"Psychol Rev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00213-006-0448-6","article-title":"Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit","volume":"187","author":"JM Boyce-Rustay","year":"2006","journal-title":"Psychopharmacology (Berl)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/157015905774322499","article-title":"Role of altered structure and function of NMDA receptors in development of alcohol dependence","volume":"3","author":"J Nagy","year":"2005","journal-title":"Curr Neuropharmacol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1196\/annals.1432.028","article-title":"Methamphetamine changes NMDA and AMPA glutamate receptor subunit levels in the rat striatum and frontal cortex","volume":"1139","author":"PF Simoes","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/syn.20640","article-title":"Extended daily access to cocaine results in distinct alterations in Homer 1b\/c and NMDA receptor subunit expression within the medial prefrontal cortex","volume":"63","author":"O Ben-Shahar","year":"2009","journal-title":"Synapse"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/sj.npp.1301033","article-title":"Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration","volume":"32","author":"F Wang","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejphar.2007.01.027","article-title":"Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats","volume":"562","author":"F Murray","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3940(03)00501-9","article-title":"Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans","volume":"345","author":"M Itokawa","year":"2003","journal-title":"Neurosci Lett"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"SB Gabriel","year":"2002","journal-title":"Science"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"JC Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.neulet.2009.06.002","article-title":"NR2A\/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization","volume":"461","author":"J Schumann","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2202-9-39","article-title":"Extensive neuroadaptive changes in cortical gene-transcript expressions of the glutamate system in response to repeated intermittent MDMA administration in adolescent rats","volume":"9","author":"AM Kindlundh-Hogberg","year":"2008","journal-title":"BMC Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s002130000416","article-title":"Are NMDA receptors involved in opiate-induced neural and behavioral plasticity? A review of preclinical studies","volume":"151","author":"KA Trujillo","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.1523\/JNEUROSCI.23-16-06529.2003","article-title":"Locus-specific rescue of GluRepsilon1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence","volume":"23","author":"M Inoue","year":"2003","journal-title":"J Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1124\/jpet.104.067504","article-title":"Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens","volume":"311","author":"G Martin","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.neulet.2004.12.013","article-title":"Extended analyses support the association of a functional (GT)n polymorphism in the GRIN2A promoter with Japanese schizophrenia","volume":"378","author":"Y Iwayama-Shigeno","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neulet.2006.09.022","article-title":"Significant linkage and association between a functional (GT)n polymorphism in promoter of the N-methyl-D-aspartate receptor subunit gene (GRIN2A) and schizophrenia","volume":"409","author":"J Tang","year":"2006","journal-title":"Neurosci Lett"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1001\/archpsyc.65.7.826","article-title":"Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior","volume":"65","author":"G Schumann","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0306-4522(03)00317-8","article-title":"Gonadal hormones differentially modulate cocaine-induced conditioned place preference in male and female rats","volume":"120","author":"SJ Russo","year":"2003","journal-title":"Neuroscience"},{"key":"ref34","first-page":"505","article-title":"Point: population stratification: a problem for case-control studies of candidate-gene associations?","volume":"11","author":"DC Thomas","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0070817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T11:47:11Z","timestamp":1563623231000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0070817"}},"subtitle":[],"editor":[{"given":"Ralf","family":"Krahe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0070817","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}