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Norfolk, UK: Caister Academic Press. 17\u201338."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/MCB.6.7.2371","article-title":"A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins","volume":"6","author":"DM Knipe","year":"1986","journal-title":"Molecular and cellular biology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1128\/JVI.61.2.276-284.1987","article-title":"Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4","volume":"61","author":"DM Knipe","year":"1987","journal-title":"Journal of Virology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"9528","DOI":"10.1073\/pnas.90.20.9528","article-title":"Herpes simplex virus infected cell polypeptide 4 preferentially represses Sp1-activated over basal transcription from its own promoter","volume":"90","author":"B Gu","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1128\/JVI.67.8.4676-4687.1993","article-title":"ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB","volume":"67","author":"CA Smith","year":"1993","journal-title":"Journal of Virology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1128\/JVI.71.2.1133-1139.1997","article-title":"Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase","volume":"71","author":"R Leopardi","year":"1997","journal-title":"Journal of Virology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1128\/JVI.56.2.558-570.1985","article-title":"Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4","volume":"56","author":"NA DeLuca","year":"1985","journal-title":"J Virol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1093\/nar\/15.11.4491","article-title":"Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides","volume":"15","author":"NA DeLuca","year":"1987","journal-title":"Nucleic Acids Research"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1126\/science.280.5369.1618","article-title":"Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor","volume":"280","author":"RJ Geraghty","year":"1998","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1099\/0022-1317-18-3-329","article-title":"Genetic studies with herpes simplex virus type 1. 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