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Walsh","year":"2011","journal-title":"Neuroscience"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"S207","DOI":"10.1016\/S1353-8020(11)70064-5","article-title":"Neurodegeneration and Inflammation in Parkinson&apos;s disease","volume":"18","author":"S Phani","year":"2012","journal-title":"Parkinsonism Relat Disord"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(68)90164-7","article-title":"6-Hydroxy-dopamine induced degeneration of central monoamine neurons","volume":"(1)","author":"U Ungerstedt","year":"1968","journal-title":"Eur J Pharmacol 5"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.2174\/138161210793176527","article-title":"Monoamine oxidase inhibitors as neuroprotective agents in age-dependent neurodegenerative disorders","volume":"(25)","author":"M Naoi","year":"2010","journal-title":"Curr Pharm Des 16"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.2174\/092986710791859324","article-title":"New therapeutic strategy for Parkinson&apos;s and Alzheimer&apos;s disease","volume":"(25)","author":"E Esposito","year":"2010","journal-title":"Curr Med Chem 17"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson&apos;s disease","volume":"(2)","author":"D Blum","year":"2001","journal-title":"Prog Neurobiol 65"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1460-9568.2006.05285.x","article-title":"Time-course of nigrostriatal damage, basal ganglia metabolic changes and behavioural alterations following intrastriatal injection of 6-hydroxydopamine in the rat: new clues from an old model","volume":"(2)","author":"F 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nigra","volume":"(1)","author":"TF Oo","year":"2002","journal-title":"Exp Neurol 175"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1111\/j.1460-9568.2008.06097.x","article-title":"Differential activation of PKC delta in the substantia nigra of rats following striatal or nigral 6-hydroxydopamine lesions","volume":"(5)","author":"K Hanrott","year":"2008","journal-title":"Eur J Neurosci 27"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Shrivastava P, Vaibhav K, Tabassum R, Khan A, Ishrat T, <etal>et al<\/etal>.. (2012) Anti-apoptotic and Anti-inflammatory effect of Piperine on 6-OHDA induced Parkinson&apos;s Rat model. 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Dev Neurosci. <comment>doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1159\/000346155\" xlink:type=\"simple\">10.1159\/000346155<\/ext-link><\/comment>","DOI":"10.1159\/000346155"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnmol.2011.00045","article-title":"GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration","volume":"4","author":"R Gomez-Sintes","year":"2011","journal-title":"Front Mol Neurosci"},{"key":"ref36","first-page":"486","article-title":"[Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease]","volume":"(8)","author":"I Rybakowska","year":"2011","journal-title":"Przegl Lek 68"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jcb.21839","article-title":"Glycogen synthase kinase-3beta regulates DeltaNp63 gene transcription through the beta-catenin signaling pathway","volume":"(2)","author":"WK Chu","year":"2008","journal-title":"J Cell Biochem 105"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1523\/JNEUROSCI.20-07-02567.2000","article-title":"Role of glycogen synthase kinase-3beta in neuronal apoptosis induced by trophic withdrawal","volume":"(7)","author":"M Hetman","year":"2000","journal-title":"J Neurosci 20"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0959-4388(02)00320-3","article-title":"The GSK3 beta signaling cascade and neurodegenerative disease","volume":"(3)","author":"MD Kaytor","year":"2002","journal-title":"Curr Opin Neurobiol 12"},{"key":"ref40","first-page":"189246","article-title":"GSK-3 in Neurodegenerative Diseases","volume":"2011","author":"P Lei","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1096\/fj.04-1551fje","article-title":"Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death","volume":"(10)","author":"G Chen","year":"2004","journal-title":"FASEB J 18"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neulet.2010.09.070","article-title":"Knockdown of glycogen synthase kinase 3 beta attenuates 6-hydroxydopamine-induced apoptosis in SH-SY5Y cells","volume":"(1)","author":"Y Li","year":"2011","journal-title":"Neurosci Lett 487"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e5491","DOI":"10.1371\/journal.pone.0005491","article-title":"Involvment of cytosolic and mitochondrial GSK-3beta in mitochondrial dysfunction and neuronal cell death of MPTP\/MPP-treated neurons","volume":"(5)","author":"A Petit-Paitel","year":"2009","journal-title":"PLoS One 4"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/002215540104900311","article-title":"Identification of apoptotic cells by formamide-induced dna denaturation in condensed chromatin","volume":"(3)","author":"OS Frankfurt","year":"2001","journal-title":"J Histochem Cytochem 49"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1006\/excr.1996.0240","article-title":"Monoclonal antibody to single-stranded DNA is a specific and sensitive cellular marker of apoptosis","volume":"(2)","author":"OS Frankfurt","year":"1996","journal-title":"Exp Cell Res 226"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/00207450490249338","article-title":"Astroglial and microglial activation in the wistar rat ventral tegmental area after a single striatal injection of 6-hydroxydopamine","volume":"(2)","author":"RW Rodrigues","year":"2004","journal-title":"Int J Neurosci 114"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"(3)","author":"J Middeldorp","year":"2011","journal-title":"Prog Neurobiol 93"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"(1)","author":"RJ Mullen","year":"1992","journal-title":"Development 116"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Katsetos CD, Legido A, Perentes E, Mork SJ (2003) Class III beta-tubulin isotype: a key cytoskeletal protein at the crossroads of developmental neurobiology and tumor neuropathology. 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Yong","year":"2011","journal-title":"Neurochem Res 36"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/jnc.12038","article-title":"Neuroprotection by urate on 6-OHDA-lesioned rat model of Parkinson&apos;s disease: linking to Akt\/GSK3beta signaling pathway","volume":"(5)","author":"L Gong","year":"2012","journal-title":"J Neurochem 123"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/syn.10307","article-title":"Gene expression profiling in the midbrain of striatal 6-hydroxydopamine-injected mice","volume":"(4)","author":"S Iwata","year":"2004","journal-title":"Synapse 51"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"19929","DOI":"10.1074\/jbc.273.32.19929","article-title":"Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase\/Akt cell survival pathway","volume":"(32)","author":"M Pap","year":"1998","journal-title":"J Biol Chem 273"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF03179878","article-title":"Mitochondrial control of neuron death and its role in neurodegenerative disorders","volume":"(2)","author":"J Jordan","year":"2003","journal-title":"J Physiol Biochem 59"},{"key":"ref57","first-page":"354","article-title":"[The role of the mitochondrial permeability transition pore in neurodegenerative processes]","volume":"(4)","author":"D Tornero","year":"2002","journal-title":"Rev Neurol 35"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-6-2","article-title":"6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death","volume":"(1)","author":"AI Bernstein","year":"2011","journal-title":"Mol Neurodegener 6"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s11064-005-6877-5","article-title":"Puma and p53 play required roles in death evoked in a cellular model of Parkinson 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256"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-8993(99)02459-2","article-title":"6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra","volume":"(1)","author":"Y He","year":"2000","journal-title":"Brain Res 858"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.brainres.2003.10.035","article-title":"6-Hydroxydopamine increases the level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats","volume":"(2)","author":"A Mladenovic","year":"2004","journal-title":"Brain Res 996"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.brainres.2007.01.130","article-title":"NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53","volume":"1145","author":"ZQ Liang","year":"2007","journal-title":"Brain 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89"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1471-4159.2007.04699.x","article-title":"Mechanism of 6-hydroxydopamine neurotoxicity: the role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons","volume":"(1)","author":"J Rodriguez-Pallares","year":"2007","journal-title":"J Neurochem 103"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1126\/science.1227901","article-title":"Microglia: scapegoat, saboteur, or something else?","volume":"(6116)","author":"A Aguzzi","year":"2013","journal-title":"Science 339"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/j.1471-4159.2009.06189.x","article-title":"Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson&apos;s disease","volume":"(3)","author":"L Marinova-Mutafchieva","year":"2009","journal-title":"J Neurochem 110"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ceca.2012.12.003","article-title":"Microglial calcium signaling in the adult, aged and diseased brain","volume":"(3)","author":"B Brawek","year":"2013","journal-title":"Cell Calcium 53"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneuroim.2010.02.018","article-title":"Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression","volume":"(1\u20132)","author":"MC Pott Godoy","year":"2010","journal-title":"J Neuroimmunol 222"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.nbd.2009.11.018","article-title":"Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia\/macrophage activation","volume":"(3)","author":"AL De Lella Ezcurra","year":"2010","journal-title":"Neurobiol Dis 37"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0006-8993(99)01950-2","article-title":"Calretinin and calbindin-D28k in dopaminergic neurons of the rat midbrain: a triple-labeling immunohistochemical study","volume":"(1)","author":"C Nemoto","year":"1999","journal-title":"Brain Res 846"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-8993(00)02219-8","article-title":"Calretinin-containing axons and neurons are resistant to an intrastriatal 6-hydroxydopamine lesion","volume":"(1\u20132)","author":"K Tsuboi","year":"2000","journal-title":"Brain Res 866"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(90)91236-A","article-title":"Relative sparing in Parkinson&apos;s disease of substantia nigra dopamine neurons containing calbindin-D28K","volume":"(2)","author":"T Yamada","year":"1990","journal-title":"Brain Res 526"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/exnr.2000.7624","article-title":"Dopamine cell degeneration induced by intraventricular administration of 6-hydroxydopamine in the rat: similarities with cell loss in parkinson&apos;s disease","volume":"(1)","author":"M Rodriguez","year":"2001","journal-title":"Exp Neurol 169"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Luk KC, Rymar VV, van den Munckhof P, Nicolau S, Steriade C, <etal>et al<\/etal>.. (2013) The transcription factor Pitx3 is expressed selectively in midbrain dopaminergic neurons susceptible to neurodegenerative stress. J Neurochem. <comment>doi:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1111\/jnc.12160\" xlink:type=\"simple\">10.1111\/jnc.12160<\/ext-link><\/comment>","DOI":"10.1111\/jnc.12160"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1096-9861(20000522)421:1<107::AID-CNE7>3.0.CO;2-F","article-title":"Compartmental organization and chemical profile of dopaminergic and GABAergic neurons in the substantia nigra of the rat","volume":"(1)","author":"T Gonzalez-Hernandez","year":"2000","journal-title":"J Comp Neurol 421"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0070951","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T02:06:48Z","timestamp":1715825208000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0070951"}},"subtitle":[],"editor":[{"given":"Mark R.","family":"Cookson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":82,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0070951","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}