{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:17Z","timestamp":1787021897521,"version":"build-2736575974"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0071007","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T01:12:16Z","timestamp":1374887536000},"page":"e71007","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Migraine with Aura Is Associated with an Incomplete Circle of Willis: Results of a Prospective Observational Study"],"prefix":"10.1371","volume":"8","author":[{"given":"Brett","family":"Cucchiara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald L.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Nagae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Kasner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritobrato","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey K.","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Detre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/archneur.1995.00540260031012","article-title":"Migraine and subsequent risk of stroke in the Physicians' Health Study","volume":"52","author":"JE Buring","year":"1995","journal-title":"Arch Neurol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/archneur.1997.00550160012009","article-title":"Association between migraine and stroke in a large-scale epidemiological study of the United States","volume":"54","author":"KR Merikangas","year":"1997","journal-title":"Arch Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1212\/01.WNL.0000154528.21485.3A","article-title":"Migraine, headache, and the risk of stroke in women: A prospective study","volume":"64","author":"T Kurth","year":"2005","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Etminan M, Takkouche B, Isorna FC, Samii A (2005) Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 330: 63\u2013.","DOI":"10.1136\/bmj.38302.504063.8F"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/brain\/awh542","article-title":"Infarcts in the posterior circulation territory in migraine. The population-based MRI CAMERA study","volume":"128","author":"MC Kruit","year":"2005","journal-title":"Brain"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1526-4610.1992.hed3206287.x","article-title":"The prevalence of cerebral damage varies with migraine type: a MRI study","volume":"32","author":"F Fazekas","year":"1992","journal-title":"Headache"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1526-4610.1995.hed3505264.x","article-title":"Magnetic resonance imaging in migraine and tension-type headache","volume":"35","author":"G De Benedittis","year":"1995","journal-title":"Headache"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/S1474-4422(09)70107-3","article-title":"Advanced neuroimaging of migraine","volume":"8","author":"TJ Schwedt","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/brain\/116.1.187","article-title":"Ischaemia-induced (symptomatic) migraine attacks may be more frequent than migraine-induced ischaemic insults","volume":"1)","author":"J Olesen","year":"1993","journal-title":"Brain 116 (Pt"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/jcbfm.1994.4","article-title":"Photothrombotic infarction triggers multiple episodes of cortical spreading depression in distant brain regions","volume":"14","author":"WD Dietrich","year":"1994","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1148\/radiology.207.1.9530305","article-title":"Circle of Willis: morphologic variation on three-dimensional time-of-flight MR angiograms","volume":"207","author":"MJ Krabbe-Hartkamp","year":"1998","journal-title":"Radiology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1148\/radiol.2351031799","article-title":"Distribution of cerebral blood flow in the circle of Willis","volume":"235","author":"J Hendrikse","year":"2005","journal-title":"Radiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ejrad.2004.05.010","article-title":"An evaluation of internal carotid artery and cerebral blood flow volume using color duplex sonography in patients with vertebral artery hypoplasia","volume":"53","author":"M Acar","year":"2005","journal-title":"European Journal of Radiology"},{"key":"ref14","first-page":"9","article-title":"The International Classification of Headache Disorders: 2nd edition","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/oxfordjournals.aje.a116014","article-title":"Age- and sex-specific incidence rates of migraine with and without visual aura","volume":"134","author":"WF Stewart","year":"1991","journal-title":"Am J Epidemiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1212\/WNL.42.9.1657","article-title":"Incidence of migraine headache: a population-based study in Olmsted County, Minnesota","volume":"42","author":"PE Stang","year":"1992","journal-title":"Neurology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mrm.21790","article-title":"Continuous flow-driven inversion for arterial spin labeling using pulsed radio frequency and gradient fields","volume":"60","author":"W Dai","year":"2008","journal-title":"Magn Reson Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1046\/j.1468-2982.1998.1810684.x","article-title":"Role of vertebral artery hypoplasia in migraine","volume":"18","author":"A Lovrencic-Huzjan","year":"1998","journal-title":"Cephalalgia"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mri.2007.07.003","article-title":"Empirical optimization of ASL data analysis using an ASL data processing toolbox: ASLtbx","volume":"26","author":"Z Wang","year":"2008","journal-title":"Magn Reson Imaging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/mrm.10559","article-title":"Arterial transit time imaging with flow encoding arterial spin tagging (FEAST)","volume":"50","author":"J Wang","year":"2003","journal-title":"Magn Reson Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","article-title":"An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets","volume":"19","author":"JA Maldjian","year":"2003","journal-title":"Neuroimage"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1212\/WNL.50.6.1699","article-title":"Arterial territories of the human brain: cerebral hemispheres","volume":"50","author":"L Tatu","year":"1998","journal-title":"Neurology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with Bonferroni adjustments","volume":"316","author":"TV Perneger","year":"1998","journal-title":"Bmj"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1212\/WNL.15.4.333","article-title":"An Investigation of Complicated Migraine","volume":"15","author":"JM Pearce","year":"1965","journal-title":"Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.mehy.2007.05.057","article-title":"Migraine and circle of Willis anomalies","volume":"70","author":"B Cucchiara","year":"2008","journal-title":"Med Hypotheses"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1468-2982.2007.01502.x","article-title":"The brain is hyperexcitable in migraine","volume":"27","author":"SK Aurora","year":"2007","journal-title":"Cephalalgia"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jcbfm.2010.191","article-title":"Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury","volume":"31","author":"M Lauritzen","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/ana.410140512","article-title":"Regulation of regional cerebral blood flow during and between migraine attacks","volume":"14","author":"M Lauritzen","year":"1983","journal-title":"Ann Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0404.1994.tb01632.x","article-title":"Endothelin 1 in migraine and tension-type headache","volume":"89","author":"V Gallai","year":"1994","journal-title":"Acta Neurol Scand"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/01.wnl.0000260964.28393.ed","article-title":"Altered arterial function in migraine of recent onset","volume":"68","author":"FH Vanmolkot","year":"2007","journal-title":"Neurology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1526-4610.2009.01389.x","article-title":"Incomplete posterior circle of willis: a risk factor for migraine","volume":"49","author":"JM Bugnicourt","year":"2009","journal-title":"Headache"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1017\/S0317167100011926","article-title":"Anatomical variants of the circle of willis and brain lesions in migraineurs","volume":"38","author":"C Cavestro","year":"2011","journal-title":"Can J Neurol Sci"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1526-4610.2009.01559.x","article-title":"Anatomical variations in the circle of Willis and migraine susceptibility: is there an association","volume":"50","author":"GG Schoonman","year":"2010","journal-title":"Headache"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Ikeda K, Iwamoto K, Murata K, Ito H, Kawase Y, et al. (2009) Incomplete Posterior Circle of Willis in Migraineurs With Aura. Headache.","DOI":"10.1111\/j.1526-4610.2009.01540.x"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1056\/NEJM199406023302204","article-title":"The anatomy of the posterior communicating artery as a risk factor for ischemic cerebral infarction","volume":"330","author":"DF Schomer","year":"1994","journal-title":"N Engl J Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S1078-5884(05)80164-9","article-title":"The role of the circle of Willis in carotid occlusion: assessment with phase contrast MR angiography and transcranial duplex","volume":"10","author":"M Miralles","year":"1995","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000071115","article-title":"Absent collateral function of the circle of Willis as risk factor for ischemic stroke","volume":"16","author":"AW Hoksbergen","year":"2003","journal-title":"Cerebrovasc Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1212\/01.wnl.0000250258.76706.98","article-title":"Vertebral artery hypoplasia: A predisposing factor for posterior circulation stroke","volume":"68","author":"F Perren","year":"2007","journal-title":"Neurology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1212\/01.WNL.0000142041.42491.F4","article-title":"A fetal circle of Willis is associated with a decreased deep white matter lesion load","volume":"63","author":"J van der Grond","year":"2004","journal-title":"Neurology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1093\/schbul\/16.2.247","article-title":"Gender differences in regional cerebral blood flow","volume":"16","author":"RE Gur","year":"1990","journal-title":"Schizophr Bull"},{"key":"ref41","first-page":"559","article-title":"Gender differences in cerebral blood flow as a function of cognitive state with PET","volume":"37","author":"G Esposito","year":"1996","journal-title":"J Nucl Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1148\/radiol.2293020782","article-title":"Time-of-Flight MR Angiography: Comparison of 3.0-T Imaging and 1.5-T Imaging--Initial Experience","volume":"229","author":"WA Willinek","year":"2003","journal-title":"Radiology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0071007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T15:43:32Z","timestamp":1563551012000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0071007"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Antal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2013,7,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0071007","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}