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In: Davis KL, Charney D, Coyle JT, Nemeroff C, editors. Neuropsychopharmacology: The Fifth Generation of Progress: An Official Publication of the American College of Neuropsychopharmacology. Philadelphia: Lippincott Williams &amp; Wilkins. 1039\u20131050."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.psyneuen.2010.05.007","article-title":"Volume of the adrenal and pituitary glands in depression","volume":"36","author":"LV Kessing","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jpsychores.2012.12.016","article-title":"Increased risk of hypothyroidism and hyperthyroidism in patients with major depressive disorder: a population-based study","volume":"74","author":"EL Wu","year":"2013","journal-title":"J Psychosom Res"},{"key":"ref20","first-page":"31","article-title":"The aging male: androgens, erectile dysfunction, and depression","volume":"64","author":"SN Seidman","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1001\/archpsyc.63.4.375","article-title":"Associations of hormones and menopausal status with depressed mood in women with no history of depression","volume":"63","author":"EW Freeman","year":"2006","journal-title":"Arch Gen Psychiatry"},{"key":"ref22","unstructured":"Wang XD, Wang XL, Ma H (Ed.) (1999) Rating scales of mental health (Revised edition, in Chinese). Beijing: Chinese Mental Health Journal Publisher. 375\u2013378, 220\u2013223."},{"key":"ref23","unstructured":"Jin PH, Feng C (Ed.) (2009) Medical Statistical Methods (3rd edition, in Chinese). 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