{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:52:42Z","timestamp":1740145962062,"version":"3.37.3"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T00:00:00Z","timestamp":1375660800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0071344","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T21:29:07Z","timestamp":1375738147000},"page":"e71344","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Absence of the Common Gamma Chain (\u03b3c), a Critical Component of the Type I IL-4 Receptor, Increases the Severity of Allergic Lung Inflammation"],"prefix":"10.1371","volume":"8","author":[{"given":"Preeta","family":"Dasgupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiulan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth P.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achsah D.","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.4049\/jimmunol.172.7.4545","article-title":"Complex role of the IL-4 receptor alpha in a murine model of airway inflammation: expression of the IL-4 receptor alpha on nonlymphoid cells of bone marrow origin contributes to severity of inflammation","volume":"172","author":"AE Kelly-Welch","year":"2004","journal-title":"J Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"G Grunig","year":"1998","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1126\/science.282.5397.2258","article-title":"Interleukin-13: central mediator of allergic asthma","volume":"282","author":"M Wills-Karp","year":"1998","journal-title":"Science"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.187.6.939","article-title":"Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production","volume":"187","author":"D Kuperman","year":"1998","journal-title":"J Exp Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1146\/annurev.immunol.17.1.701","article-title":"The IL-4 receptor: signaling mechanisms and biologic functions","volume":"17","author":"K Nelms","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1073\/pnas.93.15.7821","article-title":"Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: lymphocytic and eosinophilic inflammation without airway hyperreactivity","volume":"93","author":"JA Rankin","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jaci.2006.06.004","article-title":"IL-4 induces IL-13-independent allergic airway inflammation","volume":"118","author":"C Perkins","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Wills-Karp M, Finkelman FD (2008) Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal 1: pe55. <comment>[DOI: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1126\/scisignal.1.51.pe55\" xlink:type=\"simple\">10.1126\/scisignal.1.51.pe55<\/ext-link>]<\/comment>","DOI":"10.1126\/scisignal.1.51.pe55"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ni.2182","article-title":"Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity","volume":"13","author":"HE Liang","year":"2012","journal-title":"Nat Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1073\/pnas.0802465105","article-title":"Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis","volume":"105","author":"A Munitz","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ni1544","article-title":"Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain","volume":"9","author":"TR Ramalingam","year":"2008","journal-title":"Nat Immunol"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Heller NM, Qi X, Junttila IS, Shirey KA, Vogel SN, <etal>et al<\/etal>.. (2008) Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. Sci Signal 1: ra17. <comment>[DOI: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1126\/scisignal.1164795\" xlink:type=\"simple\">10.1126\/scisignal.1164795<\/ext-link>]<\/comment>","DOI":"10.1126\/scisignal.1164795"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2172-12-60","article-title":"Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Ralpha and STAT6 dependent manner","volume":"12","author":"P Dasgupta","year":"2011","journal-title":"BMC Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis","volume":"208","author":"TA Wynn","year":"2011","journal-title":"J Exp Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1172\/JCI5909","article-title":"Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production","volume":"103","author":"Z Zhu","year":"1999","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/1074-7613(95)90047-0","article-title":"Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain","volume":"2","author":"X Cao","year":"1995","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood-2002-08-2602","article-title":"IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells","volume":"102","author":"JH Bream","year":"2003","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.4049\/jimmunol.176.9.5299","article-title":"IL-4 induces in vivo production of IFN-gamma by NK and NKT cells","volume":"176","author":"SC Morris","year":"2006","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.0105-2896.2004.00203.x","article-title":"Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways","volume":"202","author":"PE Kovanen","year":"2004","journal-title":"Immunol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1084\/jem.180.5.1955","article-title":"Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice","volume":"180","author":"JJ Peschon","year":"1994","journal-title":"J Exp Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1126\/science.1100283","article-title":"A critical role for eosinophils in allergic airways remodeling","volume":"305","author":"AA Humbles","year":"2004","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0002-9440(10)63218-X","article-title":"FIZZ1 stimulation of myofibroblast differentiation","volume":"164","author":"T Liu","year":"2004","journal-title":"Am J Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"17497","DOI":"10.1074\/jbc.M010417200","article-title":"A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin","volume":"276","author":"NC Chang","year":"2001","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1165\/rcmb.2004-0195OC","article-title":"Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells","volume":"31","author":"NM Heller","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1084\/jem.20011732","article-title":"The absence of interleukin 9 does not affect the development of allergen-induced pulmonary inflammation nor airway hyperreactivity","volume":"195","author":"SJ McMillan","year":"2002","journal-title":"J Exp Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1164\/rccm.200909-1462OC","article-title":"IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways","volume":"183","author":"J Kearley","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by gamma(c) family cytokines","volume":"9","author":"Y Rochman","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pt.2011.01.001","article-title":"Nuocytes and beyond: new insights into helminth expulsion","volume":"27","author":"DR Neill","year":"2011","journal-title":"Trends Parasitol"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Barlow JL, Bellosi A, Hardman CS, Drynan LF, Wong SH, <etal>et al<\/etal>.. (2012) Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity. J Allergy Clin Immunol 129: 191\u2013198 e191\u2013194.","DOI":"10.1016\/j.jaci.2011.09.041"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"AE Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.4049\/jimmunol.169.7.3574","article-title":"Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF","volume":"169","author":"MB Lutz","year":"2002","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20051135","article-title":"TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand","volume":"202","author":"T Ito","year":"2005","journal-title":"J Exp Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1164\/rccm.2110066","article-title":"Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma","volume":"166","author":"H Matsuda","year":"2002","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0071344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T15:13:10Z","timestamp":1589037190000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0071344"}},"subtitle":[],"editor":[{"given":"Dominik","family":"Hartl","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,5]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0071344","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2013,8,5]]}}}