{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:35:58Z","timestamp":1791210958383,"version":"4.1.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0071633","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T18:23:05Z","timestamp":1383330185000},"page":"e71633","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Reversal Learning and Associative Memory Impairments in a BACHD Rat Model for Huntington Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Yah-se K.","family":"Abada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huu Phuc","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Ellenbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is unstable on Huntington&apos;s disease chromosomes","volume":"72","year":"1993","journal-title":"Cell"},{"key":"ref2","unstructured":"Huntington G (1872) \u201cOn Chorea\u201d. The Medical and Surgical Reporter: A weekly Journal, (Philadelphia: S. Butler), vo. 26, no 15, 317\u2013321."},{"key":"ref3","first-page":"341","article-title":"Clinical and neuropathologic assessment of severity in Huntington&apos;s disease. Neurology","volume":"38(3)","author":"RH Myers","year":"1988"},{"key":"ref4","first-page":"559","article-title":"Neuropathological classification of Huntington&apos;s disease J Neuropathol Exp Neurol","volume":"44(6)","author":"JP Vonsattel","year":"1985"},{"key":"ref5","first-page":"1562","article-title":"Distribution of grey matter atrophy in Huntington&apos;s disease patients: a combined ROI-based and voxel-based morphometric study. Neuroimage","volume":"32(4)","author":"G Douaud","year":"2006"},{"key":"ref6","first-page":"373","article-title":"Pathogenic mechanisms in Huntington&apos;s disease. Int Rev Neurobiol","volume":"98","author":"L Jones","year":"2011"},{"key":"ref7","first-page":"245","article-title":"The pathophysiology and pharmacological treatment of Huntington disease. Behav Neurol","volume":"26(4)","author":"C Pidgeon","year":"2013"},{"key":"ref8","first-page":"633","article-title":"Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron","volume":"21(3)","author":"GR Jackson","year":"1998"},{"key":"ref9","unstructured":"Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, <etal>et al<\/etal>.. (2008) Towards a transgenic model of Huntington&apos;s disease in a non-human primate. Nature. 453(7197): 921\u20134. Epub 2008 May 18."},{"key":"ref10","first-page":"423","article-title":"Huntington&apos;s disease: can mice lead the way to treatment? Neuron","volume":"69(3)","author":"ZR Crook","year":"2011"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Vlamings R, Zeef DH, Janssen ML, Oosterloo M, Schaper F, <etal>et al<\/etal>.. (2012) Lessons learned from the transgenic Huntington&apos;s disease rats. Neural Plast. 2012: 682712. Epub 2012 Jul 18.","DOI":"10.1155\/2012\/682712"},{"key":"ref12","first-page":"657","article-title":"Sting of Alzheimer&apos;s failures offset by upcoming prevention trials. [Review]. Nat Rev Drug Discov","volume":"11(9)","author":"A Mullard","year":"2012"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","article-title":"Executive and mnemonic functions in early Huntington&apos;s disease","volume":"119","author":"AD Lawrence","year":"1996","journal-title":"Brain"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","article-title":"Evidence for specific cognitive deficits in preclinical Huntington&apos;s disease","volume":"121","author":"AD Lawrence","year":"1998","journal-title":"Brain"},{"key":"ref15","first-page":"1359","article-title":"Discrimination, reversal, and shift learning in Huntington&apos;s disease: mechanisms of impaired response selection. Neuropsychologia","volume":"37(12)","author":"AD Lawrence","year":"1999"},{"key":"ref16","first-page":"172","article-title":"Are cognitive changes the first symptoms of Huntington&apos;s disease? A study of gene carriers. J Neurol Neurosurg Psychiatry","volume":"64(2)","author":"V Hahn-Barma","year":"1998"},{"key":"ref17","first-page":"617","article-title":"Transgenic rat model of Huntington&apos;s disease. Hum Mol Genet","volume":"12(6)","author":"S von H\u00f6rsten","year":"2003"},{"key":"ref18","first-page":"223","article-title":"Profiles of motor and cognitive impairment in the transgenic rat model of Huntington&apos;s disease. Brain Res Bull","volume":"88(2\u20133)","author":"SA Fielding","year":"2012"},{"key":"ref19","first-page":"257","article-title":"Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington&apos;s disease transgenic ratmodel. Behav Brain Res","volume":"170(2)","author":"C Cao","year":"2006"},{"key":"ref20","first-page":"538","article-title":"Selective striatal neuron loss and alterations in behavior correlate with impaired striatal function in Huntington&apos;s disease transgenic rats. Neurobiol Dis","volume":"22(3)","author":"O K\u00e1ntor","year":"2006"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Nguyen HP, Kobbe P, Rahne H, W\u00f6rpel T, J\u00e4ger B, <etal>et al<\/etal>.. (2006) Behavioral abnormalities precede neuropathological markers in rats transgenic for Huntington&apos;s disease. Hum Mol Genet. 15(21): 3177\u201394. Epub 2006 Sep 19.","DOI":"10.1093\/hmg\/ddl394"},{"key":"ref22","first-page":"194","article-title":"Memory deficits in the transgenic rat model of Huntington&apos;s disease. Behav Brain Res","volume":"227(1)","author":"DH Zeef","year":"2012"},{"key":"ref23","first-page":"493","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell","volume":"87(3)","author":"L Mangiarini","year":"1996"},{"key":"ref24","first-page":"10428","article-title":"Selective discrimination learning impairments in mice expressing the human Huntington&apos;s disease mutation. J Neurosci","volume":"19(23)","author":"LA Lione","year":"1999"},{"key":"ref25","first-page":"15426","article-title":"A Novel BACHD Transgenic Rat Exhibits Characteristic Neuropathological Features of Huntington Disease. J Neurosci","volume":"32(44)","author":"L Yu-Taeger","year":"2012"},{"key":"ref26","first-page":"6182","article-title":"Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. J Neurosci","volume":"28(24)","author":"M Gray","year":"2008"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Abada YS, Nguyen HP, Schreiber R, Ellenbroek B (2013) Assessment of Motor, sensory motor gating and Recognition memory in a novel full-length rat model for Huntington disease. doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0068584\" xlink:type=\"simple\">10.1371\/journal.pone.0068584<\/ext-link>.","DOI":"10.1371\/journal.pone.0068584"},{"key":"ref28","first-page":"743","article-title":"The neuroanatomical and neurochemical basis of conditioned fear. [Review]. Neurosci Biobehav Rev","volume":"23(5)","author":"M Fendt","year":"1999"},{"key":"ref29","first-page":"218","article-title":"Neural substrates mediating human delay and trace fear conditioning. J Neurosci","volume":"24(1)","author":"DC Knight","year":"2004"},{"key":"ref30","first-page":"715","article-title":"Effect of ovarian steroids on footshock avoidance learning and retention in female mice. Physiol Behav","volume":"58(4)","author":"SA Farr","year":"1995"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Pearson R, Lewis MB (2005) Fear recognition across the menstrual cycle. Horm Behav. 47(3): 267\u201371. Epub 2005 Jan 16.","DOI":"10.1016\/j.yhbeh.2004.11.003"},{"key":"ref32","first-page":"221","article-title":"Studies in spatial learning; place learning versus response learning. J Exp Psychol","volume":"36","author":"EC Tolman","year":"1946"},{"key":"ref33","first-page":"243","article-title":"Motor, emotional and cognitive deficits in adult BACHD mice: A model for Huntington&apos;s disease. Behav Brain Res","volume":"238","author":"YS Abada","year":"2013"},{"key":"ref34","first-page":"67","article-title":"Inhibition of prefrontal protein synthesis following recall does not disrupt memory for trace fear conditioning. BMC Neurosci","volume":"7","author":"S Blum","year":"2006"},{"key":"ref35","first-page":"56","article-title":"The relationship between pain sensitivity and conditioned fear response in rats. Acta Neurobiol Exp (Wars)","volume":"70(1)","author":"M Lehner","year":"2010"},{"key":"ref36","first-page":"196","article-title":"\u2018Return to home cage\u2019 as a reward for maze learning in young and old genetically heterogeneous mice. Comp Med","volume":"56(3)","author":"DA Blizard","year":"2006"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Brooks SP, Betteridge H, Trueman RC, Jones L, Dunnett SB (2006) Selective extra-dimensional set shifting deficit in a knock-in mouse model of Huntington&apos;s disease. Brain Res Bull. 69(4): 452\u20137. Epub 2006 Mar 10.","DOI":"10.1016\/j.brainresbull.2006.02.011"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Brooks SP, Janghra N, Higgs GV, Bayram-Weston Z, Heuer A, <etal>et al<\/etal>.. (2012) Selective cognitive impairment in the YAC128 Huntington&apos;s disease mouse. Brain Res Bull. 88(2\u20133): 121\u20139. Epub 2011 May 20.","DOI":"10.1016\/j.brainresbull.2011.05.010"},{"key":"ref39","first-page":"479","article-title":"Early cognitive dysfunction in the HD 51 CAG transgenic rat model of Huntington&apos;s disease. Behav Neurosci","volume":"126(3)","author":"KD Fink","year":"2012"},{"key":"ref40","first-page":"4169","article-title":"Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington&apos;s disease. J Neurosci","volume":"25(16)","author":"JM Van Raamsdonk","year":"2005"},{"key":"ref41","first-page":"15","article-title":"Early deficits in declarative and procedural memory dependent behavioral function in a transgenic rat model of Huntington&apos;s disease. Behav Brain Res","volume":"239C","author":"RD Kirch","year":"2012"},{"key":"ref42","first-page":"65","article-title":"Inactivation of hippocampus or caudate nucleus with lidocaine differentially affects expression of place and response learning. Neurobiol Learn Mem","volume":"65(1)","author":"MG Packard","year":"1996"},{"key":"ref43","first-page":"12881","article-title":"Glutamate infused posttraining into the hippocampus or caudate-putamen differentially strengthens place and response learning. Proc Natl Acad Sci U S A","volume":"96(22)","author":"MG Packard","year":"1999"},{"key":"ref44","first-page":"8","article-title":"Ontogeny of neural circuits underlying spatial memory in the rat. Front Neural Circuits","volume":"6","author":"JA Ainge","year":"2012"},{"key":"ref45","first-page":"217","article-title":"Discrimination of cues in mazes: a resolution of the place-vs.-response question. [Review]. Psychol Rev","volume":"64(4)","author":"F Restle","year":"1957"},{"key":"ref46","first-page":"564","article-title":"Acetylcholine release in the hippocampus and striatum during place and response training. Learn Mem","volume":"12(6)","author":"JC Pych","year":"2005"},{"key":"ref47","first-page":"417","article-title":"Progressive imbalance in the interaction between spatial and procedural memory systems in the R6\/2 mouse model of Huntington&apos;s disease. Neurobiol Learn Mem","volume":"92(3)","author":"A Ciamei","year":"2009"},{"key":"ref48","first-page":"791","article-title":"Development of neuropsychological deficits in Huntington&apos;s disease. Arch Neurol","volume":"40(13)","author":"RC Josiassen","year":"1983"},{"key":"ref49","first-page":"142","article-title":"Contrasting cortical and subcortical activations produced by attentional-set shifting and reversal learning in humans. J Cogn Neurosci","volume":"12(1)","author":"RD Rogers","year":"2000"},{"key":"ref50","first-page":"162","article-title":"Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat. Neurobiol Learn Mem","volume":"81(3)","author":"E Baldi","year":"2004"},{"key":"ref51","first-page":"307","article-title":"\u201cConfigural\u201d conditioning in discrete-trial bar pressing. J Comp Physiol Psychol","volume":"79(2)","author":"RA Rescorla","year":"1972"},{"key":"ref52","first-page":"274","article-title":"Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci","volume":"106(2)","author":"RG Phillips","year":"1992"},{"key":"ref53","first-page":"1233","article-title":"Exploratory activity and fear conditioning abnormalities develop early in R6\/2 Huntington&apos;s disease transgenic mice. Behav Neurosci","volume":"117(6)","author":"VJ Bolivar","year":"2003"},{"key":"ref54","first-page":"379","article-title":"Reduced expression of conditioned fear in the R6\/2 mouse model of Huntington&apos;s disease is related to abnormal activity in prelimbic cortex. Neurobiol Dis","volume":"43(2)","author":"AG Walker","year":"2011"},{"key":"ref55","first-page":"280","article-title":"Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington&apos;s disease mice. Neuroscience","volume":"157(1)","author":"MA Hickey","year":"2008"},{"key":"ref56","first-page":"92","article-title":"Altered emotional and motivational processing in the transgenic rat model for Huntington&apos;s disease. Neurobiol Learn Mem","volume":"95(1)","author":"A Faure","year":"2011"},{"key":"ref57","first-page":"155","article-title":"Emotion circuits in the brain. [Review]. Annu Rev Neurosci","volume":"23","author":"JE LeDoux","year":"2000"},{"key":"ref58","first-page":"289","article-title":"Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex. Learn Mem","volume":"17(6)","author":"MR Gilmartin","year":"2010"},{"key":"ref59","first-page":"452","article-title":"Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex. Neurobiol Learn Mem","volume":"97(4)","author":"MR Gilmartin","year":"2012"},{"key":"ref60","first-page":"243","article-title":"Gene therapy for Huntington&apos;s disease. [Review]. Neurobiol Dis","volume":"48(2)","author":"S Ramaswamy","year":"2012"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0071633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T09:17:08Z","timestamp":1540199828000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0071633"}},"subtitle":[],"editor":[{"given":"Yoshitaka","family":"Nagai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":60,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2013,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0071633","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}