{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:19:06Z","timestamp":1717694346707},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0071718","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T21:17:14Z","timestamp":1376947034000},"page":"e71718","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Erythropoiesis Suppression Is Associated with Anthrax Lethal Toxin-Mediated Pathogenic Progression"],"prefix":"10.1371","volume":"8","author":[{"given":"Hsin-Hou","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung-Pao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Kong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yo-Yin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Hsien","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Kai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Wen","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Bin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Yu","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyh-Hwa","family":"Kau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Hsien","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ling","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Yuan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Der-Shan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","article-title":"Anthrax","volume":"55","author":"M Mock","year":"2001","journal-title":"Annu Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1073\/pnas.90.6.2291","article-title":"Pathology of inhalational anthrax in 42 cases from the Sverdlovsk outbreak of 1979","volume":"90","author":"FA Abramova","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199909093411107","article-title":"Anthrax","volume":"341","author":"TC Dixon","year":"1999","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1378\/chest.116.5.1369","article-title":"Inhalational anthrax: epidemiology, diagnosis, and management","volume":"116","author":"S Shafazand","year":"1999","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0041-0101(01)00161-1","article-title":"Toxins of Bacillus anthracis","volume":"39","author":"F Brossier","year":"2001","journal-title":"Toxicon"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"RJ Collier","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10254-004-0028-2","article-title":"Anthrax toxins","volume":"152","author":"M Mourez","year":"2004","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/bj20031382","article-title":"Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs","volume":"378","author":"AJ Bardwell","year":"2004","journal-title":"Biochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/BJ20061891","article-title":"Manipulation of host signalling pathways by anthrax toxins","volume":"402","author":"BE Turk","year":"2007","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0898-6568(01)00220-0","article-title":"The ups and downs of MEK kinase interactions","volume":"13","author":"C Hagemann","year":"2001","journal-title":"Cell Signal"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"T Wada","year":"2004","journal-title":"Oncogene"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"KA Bradley","year":"2001","journal-title":"Nature"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mib.2003.12.001","article-title":"The roles of anthrax toxin in pathogenesis","volume":"7","author":"M Moayeri","year":"2004","journal-title":"Curr Opin Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"R699","DOI":"10.1152\/ajpregu.00593.2003","article-title":"Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats","volume":"286","author":"X Cui","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI17991","article-title":"Bacillus anthracis lethal toxin induces TNF-alpha-independent hypoxia-mediated toxicity in mice","volume":"112","author":"M Moayeri","year":"2003","journal-title":"J Clin Invest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/jama.287.7.869","article-title":"Cutaneous anthrax associated with microangiopathic hemolytic anemia and coagulopathy in a 7-month-old infant","volume":"287","author":"A Freedman","year":"2002","journal-title":"JAMA"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid0706.010604","article-title":"Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States","volume":"7","author":"JA Jernigan","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1001\/jama.287.7.858","article-title":"Fatal inhalational anthrax with unknown source of exposure in a 61-year-old woman in New York City","volume":"287","author":"B Mina","year":"2002","journal-title":"JAMA"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1086\/378516","article-title":"Anthrax toxin induces hemolysis: an indirect effect through polymorphonuclear cells","volume":"188","author":"AG Wu","year":"2003","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.bbrc.2005.04.049","article-title":"Annexin1 regulates the erythroid differentiation through ERK signaling pathway","volume":"331","author":"XF Huo","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1182\/blood-2004-04-1362","article-title":"Constitutive activation of the MEK\/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors","volume":"104","author":"J Zhang","year":"2004","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1182\/blood-2003-05-1754","article-title":"Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines","volume":"104","author":"SM Jacobs-Helber","year":"2004","journal-title":"Blood"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.biocel.2007.04.016","article-title":"ERK1\/2 inactivation and p38 MAPK-dependent caspase activation during guanosine 5\u2032-triphosphate-mediated terminal erythroid differentiation of K562 cells","volume":"39","author":"MA Moosavi","year":"2007","journal-title":"Int J Biochem Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/35051594","article-title":"Identification of the haemoglobin scavenger receptor","volume":"409","author":"M Kristiansen","year":"2001","journal-title":"Nature"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0021-9258(18)62533-5","article-title":"The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin","volume":"246","author":"RL Nagel","year":"1971","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"RP Rother","year":"2005","journal-title":"JAMA"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jcp.1041120314","article-title":"Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody","volume":"112","author":"IS Trowbridge","year":"1982","journal-title":"J Cell Physiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1182\/blood.V52.2.379.379","article-title":"Expression of the major sialoglycoprotein (glycophorin) on erythroid cells in human bone marrow","volume":"52","author":"CG Gahmberg","year":"1978","journal-title":"Blood"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jbiotec.2006.04.038","article-title":"Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli","volume":"126","author":"HH Chang","year":"2006","journal-title":"J Biotechnol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/153537020322800101","article-title":"Erythropoietin: physiology and pharmacology update","volume":"228","author":"JW Fisher","year":"2003","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Chen PK, Chang HH, Lin GL, Wang TP, Lai YL, <etal>et al<\/etal>.. (2013) Suppressive effects of anthrax lethal toxin on megakaryopoiesis. PLoS ONE 8 e59512.","DOI":"10.1371\/journal.pone.0059512"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"George-Gay B, Parker K (2003) Understanding the complete blood count with differential. J Perianesth Nurs 18: 96\u2013114; quiz 115\u2013117.","DOI":"10.1053\/jpan.2003.50013"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1182\/blood.V98.12.3261","article-title":"Ineffective erythropoiesis in Stat5a(\u2212\/\u2212)5b(\u2212\/\u2212) mice due to decreased survival of early erythroblasts","volume":"98","author":"M Socolovsky","year":"2001","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1182\/blood-2003-05-1479","article-title":"Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system","volume":"102","author":"J Zhang","year":"2003","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2141.2000.02037.x","article-title":"The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage","volume":"109","author":"T Kina","year":"2000","journal-title":"Br J Haematol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1182\/blood-2003-09-3237","article-title":"A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution","volume":"105","author":"A Halupa","year":"2005","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.transci.2005.09.005","article-title":"Oxygen carriers: a selected review","volume":"34","author":"MS Inayat","year":"2006","journal-title":"Transfus Apher Sci"},{"key":"ref38","first-page":"241","article-title":"Mathematical analysis of bone marrow erythropoiesis: application to C3H mouse data","volume":"6","author":"JY Mary","year":"1980","journal-title":"Blood Cells"},{"key":"ref39","first-page":"125","article-title":"Effects of human recombinant erythropoietin on differentiation and distribution of erythroid progenitor cells on murine medullary and splenic erythropoiesis during hypoxia and post-hypoxia","volume":"15","author":"SM Mide","year":"2001","journal-title":"In Vivo"},{"key":"ref40","first-page":"768","article-title":"The distribution of erythropoiesis over the various anatomical regions of the erythropoietic system in some inbred strains of mice","volume":"10","author":"J Vacha","year":"1982","journal-title":"Exp Hematol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cyto.2011.10.013","article-title":"Effects by anthrax toxins on hematopoiesis: a key role for cytokines as mediators","volume":"57","author":"P Rameshwar","year":"2012","journal-title":"Cytokine"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1111\/j.1582-4934.2008.00477.x","article-title":"Non-canonical effects of anthrax toxins on haematopoiesis: implications for vaccine development","volume":"13","author":"K Liu","year":"2009","journal-title":"J Cell Mol Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2958.1994.tb00500.x","article-title":"Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity","volume":"13","author":"KR Klimpel","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7326\/0003-4819-144-4-200602210-00009","article-title":"Systematic review: a century of inhalational anthrax cases from 1900 to 2005","volume":"144","author":"JE Holty","year":"2006","journal-title":"Ann Intern Med"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1586\/14787210.7.2.219","article-title":"Anthrax, toxins and vaccines: a 125-year journey targeting Bacillus anthracis","volume":"7","author":"JN Tournier","year":"2009","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1073\/pnas.0502159102","article-title":"Anthrax lethal factor inhibition","volume":"102","author":"WL Shoop","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2796.2008.02024.x","article-title":"Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response","volume":"264","author":"M Brines","year":"2008","journal-title":"J Intern Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2310\/JIM.0b013e3181ed30bf","article-title":"Promises and pitfalls in erythopoietin-mediated tissue protection: are nonerythropoietic derivatives a way forward?","volume":"59","author":"CC Hand","year":"2011","journal-title":"J Investig Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.bcp.2011.06.045","article-title":"Erythropoietin, erythropoiesis and beyond","volume":"82","author":"S Chateauvieux","year":"2011","journal-title":"Biochem Pharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1182\/blood.V73.1.84.84","article-title":"Survival of recombinant erythropoietin in the circulation: the role of carbohydrates","volume":"73","author":"MN Fukuda","year":"1989","journal-title":"Blood"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1365-2141.1997.1802997.x","article-title":"Recombinant human thrombopoietin (TPO) stimulates erythropoiesis by inhibiting erythroid progenitor cell apoptosis","volume":"98","author":"MZ Ratajczak","year":"1997","journal-title":"Br J Haematol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000327173","article-title":"Anemia trials in CKD and clinical practice: refining the approach to erythropoiesis-stimulating agents","volume":"171","author":"AL de Francisco","year":"2011","journal-title":"Contrib Nephrol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0095-5108(18)30418-4","article-title":"Erythropoietin therapy for anemia of prematurity","volume":"20","author":"PG Gallagher","year":"1993","journal-title":"Clin Perinatol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00277-008-0525-5","article-title":"The use of erythropoiesis-stimulating agents in patients with non-myeloid hematological malignancies: a systematic review","volume":"87","author":"N Shehata","year":"2008","journal-title":"Ann Hematol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1182\/blood.V98.12.3241","article-title":"Thrombocytopenia caused by the development of antibodies to thrombopoietin","volume":"98","author":"J Li","year":"2001","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrmicro977","article-title":"Antitoxins: novel strategies to target agents of bioterrorism","volume":"2","author":"GJ Rainey","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00284-001-0059-8","article-title":"Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity","volume":"44","author":"JH Kau","year":"2002","journal-title":"Curr Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.ATV.17.4.802","article-title":"Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis","volume":"17","author":"AS Brown","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1111\/j.1537-2995.2008.01926.x","article-title":"Mesenchymal stem cells from the Wharton\u2019s jelly of umbilical cord segments provide stromal support for the maintenance of cord blood hematopoietic stem cells during long-term ex vivo culture","volume":"48","author":"T Bakhshi","year":"2008","journal-title":"Transfusion"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/scd.2006.15.70","article-title":"Characterization of serum-free ex vivo-expanded hematopoietic stem cells derived from human umbilical cord blood CD133(+) cells","volume":"15","author":"CL Yao","year":"2006","journal-title":"Stem Cells Dev"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1111\/j.1537-2995.2008.01828.x","article-title":"In vitro clinical-grade generation of red blood cells from human umbilical cord blood CD34+ cells","volume":"48","author":"EJ Baek","year":"2008","journal-title":"Transfusion"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0071718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T03:53:11Z","timestamp":1646365991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0071718"}},"subtitle":[],"editor":[{"given":"Nupur","family":"Gangopadhyay","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,8,19]]},"references-count":61,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0071718","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,19]]}}}